Although roots are the primary material harvested for medical use, the biosynthesis of the bioactive compounds and its regulation in A. mongolicus are not well understood. (biomedcentral.com)
The first committed enzyme in triterpene saponin biosynthesis from A. mongolicus , cycloartenol synthase (AmCAS), which belongs to the oxidosqualene cyclase family, was cloned by us to study the astragalosides biosynthesis. (biomedcentral.com)
The eCB system is comprised of eCBs, anandamide, and 2-arachidonoyl glycerol, their cannabinoid-1 and cannabinoid-2 receptors (CB 1 and CB 2 , respectively), and the enzymes involved in their biosynthesis and degradation. (degruyter.com)
Metabolic2
The manuscript evaluated an under appreciated aspect of tissue regeneration which is the need to synthesize and assemble huge amounts of contractile machinery and supporting structures and metabolic enzymes. (elifesciences.org)
Compartmentalization of enzymes and their reactants optimizes reaction flux within multiple metabolic networks and manages toxic effects of reaction by-products ( Chen and Silver, 2012 ). (biorxiv.org)
Genes1
Twenty-six strains from 16 hospitals harbored 16S rRNA methylase genes, which suggests sparse but diffuse spread of pan-aminoglycoside-resistant microbes in Japan. (cdc.gov)
Structures1
This process is mediated by various enzymes modifying chromatin structures to achieve the diversity of epigenetic space and the intricacy in gene expression files. (frontiersin.org)
Regulation1
In this study, we demonstrate that miR-23a participates in the regulation of cardiomyocyte apoptosis in vitro and in vivo . (molcells.org)
Clinical2
However, 16S rRNA methylase-producing microbes can adapt to this agent, and its prescription may well be a selective pressure on the kind of microbes in the clinical environment. (cdc.gov)
This article reviews current anticancer small-molecule inhibitors targeting epigenetic modified enzymes and displays their performances in different stages of clinical trials. (frontiersin.org)
Mechanism1
Although the production of aminoglycoside-modifying enzymes is the most common mechanism of resistance in aminoglycosides, the emergence of pan-aminoglycoside-resistant, 16S rRNA methylase-producing, gram-negative bacteria has been increasingly reported in recent years. (cdc.gov)
MRNA1
In intron retention (IR), introns that are supposed to be spliced appear in mature mRNA and subsequently participate in the translation process. (researchsquare.com)
Study3
His research has been focused on the biochemistry and molecular biology of lysosomal enzymes and to study the pathophysiology of the lysosomal storage disorders. (ebtna.eu)
However, the function of IR in fungi has not been well studied, as compared to the extensive study of IR in animals and plants. (researchsquare.com)
In a study to determine how well contrast-enhanced ultrasonographic scans can characterize focal liver lesions in patients with GSD type Ia, Nguyen et al examined images from 8 benign hepatic adenomas associated with the disease. (medscape.com)
Cells5
Cells in the pancreas make enzymes to help the body digest food. (cancercare.org)
To characterize factors affecting milciclib pharmacokinetics, we investigated whether milciclib is a substrate of the multidrug effluX and uptake trans- porters ABCB1 (P-gp), ABCG2 (BCRP), and OATP1A/1B, and the drug-metabolizing enzyme CYP3A, using genetically-modified mouse models and Madin-Darby Canine Kidney (MDCK-II) cells. (srcinhibitors.com)
It has been suggested that the dual activity of ritlecitinib toward JAK3 and the TEC kinase family block cytokine signaling as well as the cytolytic activity of T cells, both implicated in the pathogenesis of alopecia areata. (drugbank.com)
In normal conditions, hair follicles are immune-privileged sites characterized by the presence of well-suppressed natural killer cells. (drugbank.com)
Intestinal epithelial cells ('dock workers') are good at moving stuff. (helmberg.at)
Important1
Manganese superoxide dismutase (MnSOD) is an important antioxidant enzyme that converts cellular ROS into harmless products. (molcells.org)
Development2
More recently his laboratory has participated to the development of a therapy for the lysosomal storage disease, alpha-mannosidosis. (ebtna.eu)
During organismal development, peroxisomes may alter their functions by compartmentalizing distinct sets of enzymes. (biorxiv.org)
System1
We propose that compartmentalized biosynthetic reactions are sensitive to the size of the compartment, likely due to scaling-dependent changes within the system, such as enzyme packing density. (biorxiv.org)
Show1
We show that compartmentalization of these NAD + dependent reactions together with a dedicated NADH/NAD + recycling enzyme supports optimal growth when an increased demand for anabolic reactions taxes cellular redox balance. (biorxiv.org)
Glucose2
This enzyme has also been identified in a glucose nonfermentative Acinetobacter sp. (cdc.gov)
Hexokinase II is the first enzyme in glucose utilization and its location on the outer membrane pores allows for the massive utilization of glucose to feed the rapidly growing tumor mass. (greenmedinfo.com)
Metabolism2
The CYP 2D6 and CYP 2C19 enzymes play a role in the metabolism of about 25% of all prescription drugs. (psychiatrictimes.com)
Recently, a novel and efficient mutation tool called atmospheric and room-temperature plasma (ARTP) has been successfully employed to cause some significant changes in enzyme activity, biochemical productivity, and metabolism without lethal damages (Guo et al. (springer.com)
Mitochondrial3
Although pregnenolone is synthesized by CYP11A1 in peripheral steroidogenic organs, our recent study showed that pregnenolone must be synthesized by another mitochondrial cytochrome P450 (CYP450) enzyme other than CYP11A1 in human glial cells. (bvsalud.org)
Upon screening for CYP450s expressed in the human brain that have mitochondrial localization, we identified three enzyme candidates: CYP27A1, CYP1A1, and CYP1B1. (bvsalud.org)
In sum, these data demonstrated an unrecognized regulating mechanism of GCN5L1 on TFAM acetylation and its intracellular trafficking, and a potential intervening target for AKI associated mitochondrial disorders as well. (biomedcentral.com)
Investigation2
The pathophysiology of Churg-Strauss disease (CSD), now known as eosinophilic granulomatosis with polyangiitis (EGPA), particularly the triggering circumstances, is not well understood and still under investigation. (medscape.com)
From September 1 to October 31, 2004, 169 medical facilities with in-house microbiology laboratories participated in this investigation. (cdc.gov)
Proteins2
TGases from animal tissues are Ca 2+ -dependent enzymes that lead to the precipitation of proteins from food containing casein, soybean globulin, or myosin (Martins et al. (springer.com)
The cellular enzymes involved in DNA replication generate thousands of copies of DNA with greater fidelity. (techscience.com)
Presence2
Measurement of liver enzymes and determination of the presence of alcohol intolerance and abdominal pain did not provide evidence that overexposure to DMF existed in the past. (cdc.gov)
The presence of hydrolytic enzymes in amoebocytes was also investigated. (unimore.it)
Survival1
Based on the risk score and other independent prognostic indicators, a nomogram with a good ability to predict the survival of PAAD patients was developed. (hindawi.com)
Exposure2
In January, 1989, the Amalgamated Clothing and Textile Workers Union (ACTWU) requested that NIOSH evaluate the potential for occupational exposure to hazardous chemicals in the finishing department of the Pan American Tannery in Gloversville, New York, and to perform testicular cancer screening for current and former Pan American finishing department workers. (cdc.gov)
All samples were well below the most stringent exposure criteria, with the exception of 2-ethoxyethanol which exceeded the NIOSH REL of the 'lowest feasible limit. (cdc.gov)
Common2
Although the production of aminoglycoside-modifying enzymes is the most common mechanism of resistance in aminoglycosides, the emergence of pan-aminoglycoside-resistant, 16S rRNA methylase-producing, gram-negative bacteria has been increasingly reported in recent years. (cdc.gov)
The most common sources of choline in foods are the fat-soluble phospholipids phosphatidylcholine and sphingomyelin as well as the water-soluble compounds phosphocholine, glycerolphosphocholine, and free choline [ 1 ]. (nih.gov)
Ability1
Belonging to the ubiquitin-conjugating enzymes (E2s) family, UBE2V2 demonstrated a remarkable tumourigenic ability in many kinds of cancers. (researchsquare.com)
Health1
The National Institute of Environmental Health Sciences (NIEHS) is expanding and accelerating its contributions to scientific knowledge of human health and the environment, and to the health and well-being of people everywhere. (nih.gov)