Endoplasmic reticulumEndosomesPlasma membraneApparatusBiogenesisComplexRetrograde transportEndosome-derivedIntracellular transportBuddingTransportCompartmentSecretionCCVsEndocytosisComplexesSecretoryCoated pitsCargoDeformationExocytosisMembranesMitoticLysosomesCytosolicMoleculesCisternaBiosyntheticSpecificityFormationEnrichment
Endoplasmic reticulum6
- The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. (nih.gov)
- In attempts to attribute pathology of COVID-19 patients directly to tissue damage caused by SARS-CoV-2, investigators have inaccurately reported subcellular structures, including coated vesicles, multivesicular bodies, and vesiculating rough endoplasmic reticulum, as coronavirus particles. (cdc.gov)
- The small molecule Retro-2 prevents ricin toxicity through a poorly-defined mechanism of action (MOA), which involves halting retrograde vesicle transport to the endoplasmic reticulum (ER). (elifesciences.org)
- Caveolins are found predominantly at the plasma membrane but also in the Golgi, the endoplasmic reticulum, in vesicles, and at cytosolic locations. (biomedcentral.com)
- Most of this trafficking involves the endoplasmic reticulum (or ER) and the golgi apparatus. (vcell.science)
- APP is normally synthesized in the endoplasmic reticulum (ER) and transported to the Golgi apparatus. (biomedcentral.com)
Endosomes12
- The general consensus on the TVP23A protein indicate that it has some function in the late Golgi apparatus and is involved in retrograde transport from endosomes back into the Golgi apparatus. (wikipedia.org)
- The hypothesized function of TVP23A is a transmembrane protein involved in retrograde transport of vesicles from early endosomes into the late Golgi apparatus. (wikipedia.org)
- WIPI1 localizes to cytoplasmic vesicles, endosomes, clathrin-coated vesicles and the trans-Golgi network. (bd-ibr.org)
- The OCRL1 protein is an inositol polyphosphate 5-phosphatase primarily located in the trans- Golgi network (TGN), on endosomes, and at the endocytic clathrin coated pits. (medscape.com)
- OCRL1 has been localized to the trans -Golgi network and various compartments of the endocytic pathway (traffic), where it is found in the clathrin-coated pits, clathrin-coated vesicles, variable functioning endosomes (early, signaling, recycling), and the basal body of primary cilia. (medscape.com)
- The adaptor protein 1 (AP-1) complex of clathrin-coated vesicles (CCVs) mediates protein transport between the trans-Golgi-network and endosomes. (uni-goettingen.de)
- σ1B -/- mice have fewer synaptic vesicles (SV), reduced SV recycling, but more synaptic CCV and large endosomes. (uni-goettingen.de)
- Shortly after formation, however, the clathrin coat is removed and the vesicles are referred to as ENDOSOMES. (lookformedical.com)
- An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE. (lookformedical.com)
- Only minor portion of Aβ was colocalized with trans-Golgi network, Golgi-derived vesicles, early and late endosomes, lysosomes, and synaptic vesicles, while the majority of Aβ granules were not colocalized with any of these structures. (biomedcentral.com)
- Our results indicate that most Aβ is not localized to Golgi-related structures, endosomes, lysosomes secretory vesicles or other organelles, while the suppression of Aβ secretion increases intracellular intra- and extralysosomal Aβ. (biomedcentral.com)
- Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. (lu.se)
Plasma membrane4
- In some cases, the exocytotic vesicles derive from the Golgi apparatus and consist of newly synthesized materials, while in others the vesicles derive from the plasma membrane and cycle locally. (sdbonline.org)
- Most plasma membrane proteins are sorted by the trans -Golgi network (TGN) in the conventional secretory pathway. (jneurosci.org)
- Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. (univ-amu.fr)
- The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces. (planteome.org)
Apparatus4
- In the absence of the region required for cilia targeting, P/rds was prohibited from entering the secretory pathways and was retained in the Golgi apparatus. (jneurosci.org)
- As glycoproteins pass through the Golgi apparatus, most receive a mature, complex oligosaccharide. (jneurosci.org)
- A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane. (lookformedical.com)
- Those proteins can be packaged into vesicles which depart the ER and migrate to the golgi apparatus. (vcell.science)
Biogenesis1
- A molecular understanding of membrane traffic has broad implications for our understanding of growth control in cancer, receptor trafficking errors in heart disease, regulation of insulin secretion in diabetes and synaptic vesicle biogenesis and transport in neurological disorders. (stanford.edu)
Complex10
- These vesicles contain the mannose 6-phosphate receptor involved in targeting proteins to the lysosome, and the actin nucleating Arp2/3 complex. (rupress.org)
- Golgi fragmentation is a highly regulated process that allows division of the Golgi complex between the two daughter cells. (biologists.com)
- The Molecular Complex Detection (MCODE) was used to create the PPI networks. (researchsquare.com)
- A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK. (lookformedical.com)
- The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS. (lookformedical.com)
- The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (nih.gov)
- The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (nih.gov)
- the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). (nih.gov)
- Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. (nih.gov)
- Component of the coat surrounding the cytoplasmic face of coated vesicles located at the golgi complex. (lu.se)
Retrograde transport1
- interacts genetically with the yeast SNARE and functions in retrograde transport from the early endosome to the late Golgi" (PDF). (wikipedia.org)
Endosome-derived1
- The plant toxin ricin, however, evades this fate by being sorted into early endosome-derived vesicles destined for fusion with the trans-Golgi network (TGN). (elifesciences.org)
Intracellular transport2
- The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)
- They play a role in the intracellular transport of molecules contained within membrane vesicles. (lookformedical.com)
Budding1
- We hypothesized that Hip1R might also coordinate actin assembly with clathrin budding at the trans-Golgi network (TGN). (rupress.org)
Transport7
- Two of these proteins, YIPF1 and YIPF2, are believed to be Golgi transport proteins. (wikipedia.org)
- The mitotic reorganization of the Golgi is accompanied by a temporary block in Golgi functioning, as protein transport in and out of the Golgi stops. (biologists.com)
- Syntaxins are type II integral membrane proteins localized to membranes that regulate vesicle transport, protein maturation, and exocytosis. (enzolifesciences.com)
- Interestingly, VIP21 was isolated as an integral membrane protein component of transport vesicles derived from the trans-Golgi network in Madin-Darby canine kidney (MDCK) cells, suggesting that Cav-1/VTP21 may have a role in molecular trafficking as well as oncogenesis. (biomedcentral.com)
- A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. (lookformedical.com)
- A family of high molecular weight GTP phosphohydrolases that play a direct role in vesicle transport. (lookformedical.com)
- A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES. (lookformedical.com)
Compartment2
- Taken together, these experiments revealed that Vapyrin-bodies have an endosomal identity with trans-Golgi features, and that VAPYRIN interacts with a symbiotic R-SNARE of the VAMP721 family, that localizes to the same compartment. (frontiersin.org)
- Link to all direct and indirect annotations to vesicle targeting, trans-Golgi to periciliary membrane compartment. (planteome.org)
Secretion2
- Cilium trafficking of P/rds was sustained even when the Golgi functions, including trans -Golgi-mediated conventional secretion, were inhibited by the small molecules brefeldin A, 30N12, and monensin. (jneurosci.org)
- A region essential for this Golgi retention was also found in the C-terminal tail of P/rds and supported the cilia targeting of P/rds mediated by unconventional secretion. (jneurosci.org)
CCVs1
- Silencing of Hip1R expression by RNAi resulted in disruption of Golgi organization and accumulation of F-actin structures associated with CCVs on the TGN. (rupress.org)
Endocytosis2
- In diverse species, actin assembly facilitates clathrin-coated vesicle (CCV) formation during endocytosis. (rupress.org)
- Pawlowski, N. Dynamin self-assembly and the vesicle scission mechanism: how dynamin oligomers cleave the membrane neck of clathrin-coated pits during endocytosis. (nature.com)
Complexes1
- These findings demonstrate that AP-1/σ1B deficiency strongly effects the AP-2 CCV endocytotic pathway and its functions indicating an interdependent regulation of AP-1 and AP-2 mediated synaptic vesicle recycling and that AP-1 complexes also regulate the endosomal sorting of SV proteins. (uni-goettingen.de)
Secretory1
- In ciliated cells, including bovine and Xenopus laevis rod photoreceptors, P/rds was robustly sensitive to endoglycosidase H, which is consistent with its bypassing the medial Golgi and traversing the unconventional secretory pathway. (jneurosci.org)
Coated pits2
- Vesicles formed when cell-membrane coated pits (COATED PITS, CELL-MEMBRANE) invaginate and pinch off. (lookformedical.com)
- Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. (univ-amu.fr)
Cargo2
Deformation1
- Clathrin light chain diversity regulates membrane deformation in vitro and synaptic vesicle formation in vivo. (academictree.org)
Exocytosis2
- Two important pathways were examined in the current study: (1) a basic pathway of exocytosis that brings new proteins to the cell surface and permits the cell to grow, and (2) synaptic transmission, a specialized form of exocytosis, regulated by Ca 2+ entry, in which vesicles already present at synapses fuse with the membrane and recycle locally (Murthy, 2003). (sdbonline.org)
- Recently synthesized proteins are sorted at the trans-Golgi network into specialized routes for exocytosis. (ox.ac.uk)
Membranes1
- Syntaxin 6 is primarily localized to the trans-Golgi network, and partially co-localizes with AP-1 on clathrin-coated membranes. (enzolifesciences.com)
Mitotic1
- Our group has previously demonstrated the involvement of the alternatively spliced variants ERK1c and MEK1b (ERK1 is also known as MAPK3, and MEK1 as MAP2K1) in mitotic Golgi fragmentation. (biologists.com)
Lysosomes1
- The impaired function of specific organelles indicates that the causative genes encode proteins operative in the formation of lysosomes and vesicles. (medscape.com)
Cytosolic1
- As the copper is concentrated into vesicles for excretion from the cell, the cytosolic copper concentration decreases and ATP7A returns to the trans-Golgi network. (medscape.com)
Molecules1
- Systematic analysis of SNARE molecules in Arabidopsis: dissection of the post-Golgi network in plant cells. (kegg.jp)
Cisterna2
- Here, the vesicles merge to form a golgi cisterna with the proteins located inside the cisterna's membrane. (vcell.science)
- Eventually, the cisterna will mature into the trans golgi network. (vcell.science)
Biosynthetic1
- Acidosomes originate from the biosynthetic pathway that includes the ER, the Golgi stack and the trans-Golgi network (TGN). (ucsd.edu)
Specificity1
- The specificity of vesicle trafficking: coat proteins and SNAREs. (kegg.jp)
Formation2
- Hermansky-Pudlak syndrome results from the abnormal formation of intracellular vesicles. (medscape.com)
- ADTB3A is known to assist in vesicle formation from the trans-Golgi network or late endosome. (medscape.com)
Enrichment1
- We then performed the gene enrichment and protein-protein interaction (PPI) network analysis to obtain the interacting map. (researchsquare.com)