• In some cases, the exocytotic vesicles derive from the Golgi apparatus and consist of newly synthesized materials, while in others the vesicles derive from the plasma membrane and cycle locally. (sdbonline.org)
  • Most plasma membrane proteins are sorted by the trans -Golgi network (TGN) in the conventional secretory pathway. (jneurosci.org)
  • Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. (univ-amu.fr)
  • The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces. (planteome.org)
  • A molecular understanding of membrane traffic has broad implications for our understanding of growth control in cancer, receptor trafficking errors in heart disease, regulation of insulin secretion in diabetes and synaptic vesicle biogenesis and transport in neurological disorders. (stanford.edu)
  • These vesicles contain the mannose 6-phosphate receptor involved in targeting proteins to the lysosome, and the actin nucleating Arp2/3 complex. (rupress.org)
  • Golgi fragmentation is a highly regulated process that allows division of the Golgi complex between the two daughter cells. (biologists.com)
  • The Molecular Complex Detection (MCODE) was used to create the PPI networks. (researchsquare.com)
  • A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK. (lookformedical.com)
  • The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS. (lookformedical.com)
  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (nih.gov)
  • The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (nih.gov)
  • the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). (nih.gov)
  • Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. (nih.gov)
  • Component of the coat surrounding the cytoplasmic face of coated vesicles located at the golgi complex. (lu.se)
  • interacts genetically with the yeast SNARE and functions in retrograde transport from the early endosome to the late Golgi" (PDF). (wikipedia.org)
  • The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)
  • They play a role in the intracellular transport of molecules contained within membrane vesicles. (lookformedical.com)
  • Taken together, these experiments revealed that Vapyrin-bodies have an endosomal identity with trans-Golgi features, and that VAPYRIN interacts with a symbiotic R-SNARE of the VAMP721 family, that localizes to the same compartment. (frontiersin.org)
  • Link to all direct and indirect annotations to vesicle targeting, trans-Golgi to periciliary membrane compartment. (planteome.org)
  • Cilium trafficking of P/rds was sustained even when the Golgi functions, including trans -Golgi-mediated conventional secretion, were inhibited by the small molecules brefeldin A, 30N12, and monensin. (jneurosci.org)
  • A region essential for this Golgi retention was also found in the C-terminal tail of P/rds and supported the cilia targeting of P/rds mediated by unconventional secretion. (jneurosci.org)
  • Silencing of Hip1R expression by RNAi resulted in disruption of Golgi organization and accumulation of F-actin structures associated with CCVs on the TGN. (rupress.org)
  • In diverse species, actin assembly facilitates clathrin-coated vesicle (CCV) formation during endocytosis. (rupress.org)
  • Pawlowski, N. Dynamin self-assembly and the vesicle scission mechanism: how dynamin oligomers cleave the membrane neck of clathrin-coated pits during endocytosis. (nature.com)
  • These findings demonstrate that AP-1/σ1B deficiency strongly effects the AP-2 CCV endocytotic pathway and its functions indicating an interdependent regulation of AP-1 and AP-2 mediated synaptic vesicle recycling and that AP-1 complexes also regulate the endosomal sorting of SV proteins. (uni-goettingen.de)
  • In ciliated cells, including bovine and Xenopus laevis rod photoreceptors, P/rds was robustly sensitive to endoglycosidase H, which is consistent with its bypassing the medial Golgi and traversing the unconventional secretory pathway. (jneurosci.org)
  • Vesicles formed when cell-membrane coated pits (COATED PITS, CELL-MEMBRANE) invaginate and pinch off. (lookformedical.com)
  • Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. (univ-amu.fr)
  • Here, we present a visual screen to search for proteins involved in cargo sorting and vesicle formation. (ox.ac.uk)
  • This visual screening method can now be used for different cargo proteins to search in a genome-wide fashion for machinery involved in post-Golgi sorting. (ox.ac.uk)
  • Clathrin light chain diversity regulates membrane deformation in vitro and synaptic vesicle formation in vivo. (academictree.org)
  • Two important pathways were examined in the current study: (1) a basic pathway of exocytosis that brings new proteins to the cell surface and permits the cell to grow, and (2) synaptic transmission, a specialized form of exocytosis, regulated by Ca 2+ entry, in which vesicles already present at synapses fuse with the membrane and recycle locally (Murthy, 2003). (sdbonline.org)
  • Recently synthesized proteins are sorted at the trans-Golgi network into specialized routes for exocytosis. (ox.ac.uk)
  • Our group has previously demonstrated the involvement of the alternatively spliced variants ERK1c and MEK1b (ERK1 is also known as MAPK3, and MEK1 as MAP2K1) in mitotic Golgi fragmentation. (biologists.com)
  • The impaired function of specific organelles indicates that the causative genes encode proteins operative in the formation of lysosomes and vesicles. (medscape.com)
  • As the copper is concentrated into vesicles for excretion from the cell, the cytosolic copper concentration decreases and ATP7A returns to the trans-Golgi network. (medscape.com)
  • Systematic analysis of SNARE molecules in Arabidopsis: dissection of the post-Golgi network in plant cells. (kegg.jp)
  • Here, the vesicles merge to form a golgi cisterna with the proteins located inside the cisterna's membrane. (vcell.science)
  • Eventually, the cisterna will mature into the trans golgi network. (vcell.science)
  • The specificity of vesicle trafficking: coat proteins and SNAREs. (kegg.jp)
  • We then performed the gene enrichment and protein-protein interaction (PPI) network analysis to obtain the interacting map. (researchsquare.com)