• Secretory proteins exit the endoplasmic reticulum (ER) in coat protein complex II (COPII)-coated vesicles and then progress through the Golgi complex before delivery to their final destination. (biologists.com)
  • Coated vesicles are transport vesicles that bud off from specialized regions of the cell membrane. (jove.com)
  • Based on the type of protein coats, these vesicles can be of three types: coat protein or COP-coated vesicles, COPI and COPII, and clathrin-coated vesicles. (jove.com)
  • COPI vesicles transport molecules between different parts of the Golgi body and from the Golgi back to the rough ER. (jove.com)
  • COPII vesicles are formed in the ER membranes and mediate transport from ER to the Golgi. (jove.com)
  • COPI and COPII vesicles are composed of similar coat protein complexes called coatomers. (jove.com)
  • Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. (jove.com)
  • Coated vesicles are spherical, protein-coated carriers with a 50-100 nm diameter that mediate bidirectional transport between the ER and the Golgi. (jove.com)
  • The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. (jove.com)
  • Contributors examine how proteins translocate across the ER membrane, the processes that occur inside the ER lumen (e.g., folding, glycosylation, and disulfide bond formation), and how the proteins are packaged into vesicles and transported to the Golgi. (cshlpress.com)
  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (nih.gov)
  • Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. (nih.gov)
  • Clathrin and cargo molecules are assembled into clathrin-coated pits on the plasma membrane together with an adaptor complex called AP-2 that links clathrin with transmembrane receptors, concluding in the formation of mature clathrin-coated vesicles (CCVs). (wormbook.org)
  • The adaptor protein 1 (AP-1) complex of clathrin-coated vesicles (CCVs) mediates protein transport between the trans-Golgi-network and endosomes. (uni-goettingen.de)
  • These vesicles contain the mannose 6-phosphate receptor involved in targeting proteins to the lysosome, and the actin nucleating Arp2/3 complex. (rupress.org)
  • In attempts to attribute pathology of COVID-19 patients directly to tissue damage caused by SARS-CoV-2, investigators have inaccurately reported subcellular structures, including coated vesicles, multivesicular bodies, and vesiculating rough endoplasmic reticulum, as coronavirus particles. (cdc.gov)
  • Using a real-time imaging method, we show that TMEM176A/B accumulate in dynamic post-Golgi vesicles preferentially linked to the late endolysosomal system and strongly colocalize with HLA-DM. (bvsalud.org)
  • Non-clathrin-coated vesicles mediate membrane traffic through the Golgi complex. (uni-luebeck.de)
  • The proteins that constitute the coats of these vesicles have similar molecular weights to the clathrin coat proteins. (uni-luebeck.de)
  • A major component of the coat of non-clathrin-coated vesicles, β-COP, has significant homology with the clathrin coat protein β-adaptin, indicating that the coats of the two different classes of vesicles may be structurally and functionally homologous. (uni-luebeck.de)
  • Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. (univ-amu.fr)
  • mediates STX5 packaging into COPII-coated vesicles (PubMed:18843296). (cansar.ai)
  • The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)
  • Vesicles formed when cell-membrane coated pits (COATED PITS, CELL-MEMBRANE) invaginate and pinch off. (lookformedical.com)
  • The outer surface of these vesicles is covered with a lattice-like network of the protein CLATHRIN. (lookformedical.com)
  • Shortly after formation, however, the clathrin coat is removed and the vesicles are referred to as ENDOSOMES. (lookformedical.com)
  • The pits are then internalized into the cytoplasm to form the COATED VESICLES. (lookformedical.com)
  • An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE. (lookformedical.com)
  • A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. (lookformedical.com)
  • The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS. (lookformedical.com)
  • Cytoplasmic vesicles formed when COATED VESICLES shed their CLATHRIN coat. (lookformedical.com)
  • A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES. (lookformedical.com)
  • COPI is a conserved protein complex that coats vesicles which mediate the trafficking within the Golgi apparatus and from the Golgi to the endoplasmatic reticulum. (sne-chembio.ch)
  • In situ, they observed that vesicles are only incompletely coated, with each vesicle containing a gap in the coat at the site of scission. (sne-chembio.ch)
  • COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport. (umassmed.edu)
  • Transport vesicles can move molecules between locations inside the cell, e.g., proteins from the rough endoplasmic reticulum to the Golgi apparatus . (wikipedia.org)
  • These proteins travel within the cell inside of transport vesicles. (wikipedia.org)
  • By means of its interaction with microtubule-associated proteins, we propose novel roles for AP-1 adaptors in modulating the dynamics of the cytoskeleton, the stability and shape of coated organelles, and the loading of nascent AP-1-coated vesicles onto appropriate microtubular tracks. (huji.ac.il)
  • Component of the coat surrounding the cytoplasmic face of coated vesicles located at the golgi complex. (lu.se)
  • OCRL1 has been localized to the trans -Golgi network and various compartments of the endocytic pathway (traffic), where it is found in the clathrin-coated pits, clathrin-coated vesicles, variable functioning endosomes (early, signaling, recycling), and the basal body of primary cilia. (medscape.com)
  • Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. (cansar.ai)
  • A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane. (lookformedical.com)
  • A high-mannose oligosaccharide precursor is synthesized and transferred to proteins in the endoplasmic reticulum and then processed in the Golgi apparatus ( 4 ). (frontiersin.org)
  • Located in Golgi apparatus. (nih.gov)
  • Most of these proteins mature in the Golgi apparatus before going to their final destination which may be to lysosomes , peroxisomes , or outside of the cell. (wikipedia.org)
  • For instance, how can cells control the diverse patterns of glycosylation of various secretory proteins in the endoplasmic reticulum and Golgi in an orderly manner with high accuracy? (go.jp)
  • The endoplasmic reticulum (ER) is an extensive network of membranes that folds, modifies, and transports proteins in eukaryotic cells. (cshlpress.com)
  • Mechanistically, the antiviral activity of TMEM120A is dependent on STING, as TMEM120A interacts with STING, promotes the translocation of STING from the endoplasmic reticulum (ER) to ER-Golgi intermediate compartment (ERGIC) and enhances the phosphorylation of downstream TBK1 and IRF3, resulting in the expression of multiple antiviral cytokines and interferon-stimulated genes. (bvsalud.org)
  • The COPII coat mediates Endoplasmic Reticulum (ER) to Golgi trafficking for thousands of proteins. (bris.ac.uk)
  • Previously, we reported the structure of the yeast Dsl1 complex, the simplest known MTC, which is essential for coat protein I (COPI) mediated transport fromthe Golgi to the endoplasmic reticulum(ER). (princeton.edu)
  • Membrane-bound and secreted proteins are made on ribosomes found in the rough endoplasmic reticulum . (wikipedia.org)
  • I am a plant cell biologist and protein biochemist at Oxford Brookes University with expertise in the structure and function of the plant endoplasmic reticulum (ER), membrane proteins and auxin biosynthesis using biochemical techniques as well as high-resolution live cell imaging. (brookes.ac.uk)
  • We hypothesized that Hip1R might also coordinate actin assembly with clathrin budding at the trans-Golgi network (TGN). (rupress.org)
  • Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. (univ-amu.fr)
  • A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK. (lookformedical.com)
  • In the present study, we provide biochemical and morphological evidence that the adaptor protein 1 (AP-1) adaptor of the trans-Golgi network clathrin interacts with microtubules. (huji.ac.il)
  • Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. (lu.se)
  • The OCRL1 protein is an inositol polyphosphate 5-phosphatase primarily located in the trans- Golgi network (TGN), on endosomes, and at the endocytic clathrin coated pits. (medscape.com)
  • The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (nih.gov)
  • Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the mode in which the molecules are transported. (lookformedical.com)
  • The ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (lu.se)
  • I am committed to interdisciplinary research, and an example of the successes gained from this approach is the project with Prof A Nabok (Engineering Sheffield Hallam University) using total internal reflection ellipsometry to quantify protein-membrane interactions on native plant membranes and human cell lines. (brookes.ac.uk)
  • Their formation is driven by the assembly of different classes of coat proteins, namely COPI, COPII, clathrin, or retromer complex. (jove.com)
  • The COPI and COPII coat proteins share similar structural features with Clathrin but differ in cargo sorting and vesicle formation mechanisms. (jove.com)
  • Here, we use an established reconstitution system to visualise the complete, membrane-assembled COPII coat with unprecedented detail by cryo-electron tomography and subtomogram averaging. (bris.ac.uk)
  • Our results suggest these interactions collectively contribute to coat organisation and membrane curvature, providing a structural framework to understand regulatory mechanisms of COPII trafficking and secretion. (bris.ac.uk)
  • We suggest that p53/58 function may be required for the coupled exchange of COPII for COPI coats during segregation of anterograde and retrograde transported proteins. (wikigenes.org)
  • Endosomes (receptor-mediated endocytosis) Membrane transport protein Wikipedia:MeSH D12.776#MeSH D12.776.543.990 --- vesicular transport proteins Vesicular+Transport+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Yasushi Sako (1 October 2010). (wikipedia.org)
  • In early endosomes some ligand-receptor complexes dissociate due to the reduced pH of the endosomal lumen. (wormbook.org)
  • Down-regulation of MHC class I involves Nef-mediated connection in the endosomes between MHC-I's cytoplasmic tail and the phosphofurin acidic cluster sorting protein-1 (PACS-1)-dependent protein-sorting pathway. (uni-freiburg.de)
  • Arf1 and Arf6 are the most divergent and most studied human Arf proteins that localize predominantly to the Golgi complex and plasma membrane respectively. (portlandpress.com)
  • Endocytosis is the vesicle-mediated process used by all cells to internalize extracellular macromolecules, plasma membrane lipids, and plasma membrane proteins ( Figure 1 ). (wormbook.org)
  • Current research goals in the lab relate to the spatio-temporal coordination of FGF2 secretion in living cells, the analysis of the molecular mechanism by which FGF2 physically traverses the plasma membrane and the relevance of this process for other unconventional secretory proteins such as HIV Tat. (db-engine.de)
  • Arfs accomplish this task through modification of membrane lipids and the recruitment of proteins, including coat proteins and actin, to membrane surfaces. (portlandpress.com)
  • We found that the FERM domain in the tail region, which is known to bind to lipids as well as other proteins, is essential for both nuclear and chloroplast positioning, whereas the proximal MyTH4 domain plays a supporting role in chloroplast transport. (go.jp)
  • One important model for mechanistic studies of endocytosis in C. elegans focuses on oocytes, which internalize huge quantities of yolk proteins and their associated lipids by clathrin-mediated endocytosis ( Grant and Hirsh, 1999 ). (wormbook.org)
  • Specific coat proteins cover their cytosolic surface. (jove.com)
  • The classical view suggests that adaptor proteins of the clathrin coat mediate the sorting of cargo protein passengers into clathrin-coated pits and the recruitment of clathrin into budding areas in the donor membrane. (huji.ac.il)
  • An overexpressed γ-subunit of the AP-1 complex associated with microtubules, suggesting that this subunit may mediate the interaction of AP-1 with the cytoskeleton. (huji.ac.il)
  • This suggests that type 1a microtubule-associated protein may mediate the association of AP-1 with microtubules in the cytoplasm. (huji.ac.il)
  • Many receptors and their associated ligands cluster into clathrin-coated pits by association with clathrin adaptor proteins such as the four-subunit complex AP2. (wormbook.org)
  • RME-2 contains a typical NPXY internalization motif in its intracellular domain that is known to direct other members of the LDL-receptor family into clathrin-coated pits. (wormbook.org)
  • Specialized regions of the cell membrane composed of pits coated with a bristle covering made of the protein CLATHRIN. (lookformedical.com)
  • Pawlowski, N. Dynamin self-assembly and the vesicle scission mechanism: how dynamin oligomers cleave the membrane neck of clathrin-coated pits during endocytosis. (nature.com)
  • Loss of GORAB causes impairment of COPI-mediated retrieval of trans-Golgi enzymes, resulting in a deficit in glycosylation of secretory cargo proteins. (univ-lille.fr)
  • It consists of the two large adaptins γ1 and β1, both of which bind clathrin and accessory proteins, and the two smaller adaptins, μ1 and σ1, both of which bind cargo proteins. (uni-goettingen.de)
  • Five essential coat proteins assemble at the ER into a characteristic two-layer architecture, which recruits cargo proteins whilst sculpting membrane carriers with diverse morphologies. (bris.ac.uk)
  • Arf1 can also stimulate the activity of phosphatidylinositol kinases and recruit coat proteins and actin cytoskeletal elements to the Golgi complex. (portlandpress.com)
  • In diverse species, actin assembly facilitates clathrin-coated vesicle (CCV) formation during endocytosis. (rupress.org)
  • Proteins of the Sla2p/Hip1R family bind to actin and clathrin at endocytic sites in yeast and mammals. (rupress.org)
  • Silencing of Hip1R expression by RNAi resulted in disruption of Golgi organization and accumulation of F-actin structures associated with CCVs on the TGN. (rupress.org)
  • Chemotaxis of neutrophils involves movement of pseudopodia and polymerization of cytoskeletal proteins or actin. (medscape.com)
  • Trafficking of yolk and yolk receptors also depends critically upon the activities of the endocytic Rab proteins RAB-5 , RAB-7 , and RAB-11 , known modulators of endocytosis in all eukaryotes ( Grant and Hirsh, 1999 ). (wormbook.org)
  • The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis. (univ-amu.fr)
  • The protein is thought to be involved in clathrin-mediated endocytosis. (utsouthwestern.edu)
  • The absorption of LMW proteins occurs in the PTC through clathrin-mediated endocytosis via 2 multiligand receptors (megalin and cubilin) present in the PTC apical border. (medscape.com)
  • The low number of megalin at the PTC apical border explains the reduced endocytosis of low-molecular weight proteins that occur in Lowe syndrome. (medscape.com)
  • For membrane proteins, a third mechanism, based on the interaction of their transmembrane domain (TMD) with lipid microdomains, must also be considered. (biologists.com)
  • Ap-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. (lu.se)
  • Three CD11 alpha chains and a common CD18 beta chain form heterodimer transmembrane complexes (CD11a/CD18, CD11b/CD18, CD11c/CD18). (medscape.com)
  • The combination of such self-organizational phenomena with canonical intermolecular interactions is most likely to control the release of membrane proteins from the ER into the secretory pathway. (biologists.com)
  • This process depends on the general physico-chemical features of the cargo membrane protein and on the interactions of these features with the collective properties of the bilayer, instead of the one-to-one intermolecular interactions that exist between discrete signals and their receptors. (biologists.com)
  • Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of ER morphology and function, as well as its interactions with the nucleus, Golgi, and mitochondria. (cshlpress.com)
  • GORAB forms stable domains at the trans-Golgi that, via interactions with the COPI-binding protein Scyl1, promote COPI recruitment to these domains. (univ-lille.fr)
  • We discover a network of interactions within and between coat layers, including multiple interfaces that were previously unknown. (bris.ac.uk)
  • The pathway maps illustrate protein interactions and regulation to provide a comprehensive picture of signaling and disease processes. (bio-rad.com)
  • Program access grant to the STFC Harwell Laser Facility 'The Plant Cell Initiative: Protein interactions in the higher plant secretory pathway' 2017-2021 (approximate value of £200K). (brookes.ac.uk)
  • The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)
  • An adaptor protein complex found primarily on perinuclear compartments. (lookformedical.com)
  • The product of this gene is an epsilon subunit of coatomer protein complex. (nih.gov)
  • This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. (utsouthwestern.edu)
  • The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found. (lookformedical.com)
  • Orthologous to human COPB2 (COPI coat complex subunit beta 2). (nih.gov)
  • The γ-adaptin subunit of AP-1 specifically co-immunoprecipitated with a microtubule-associated protein of type 1a from rat brain cytosol. (huji.ac.il)
  • Belongs to the adaptor complexes large subunit family. (lu.se)
  • This interaction is altered in "ko" synapse, leading to enhanced Rab5 activation and thus enhanced early endosome to endolysosome protein transport and SV protein degradation. (uni-goettingen.de)
  • Arf (ADP-ribosylation factor) GTP-binding proteins function in cells to regulate membrane traffic and structure. (portlandpress.com)
  • A newly resolved Sec31 C22 terminal domain provides order to the coat and is essential to drive membrane curvature in cells. (bris.ac.uk)
  • A family of proteins that play a role as cofactors in the process of CLATHRIN recycling in cells. (lookformedical.com)
  • pioneered the application of cryo-focused ion beam milling, cryo-electron tomography and reference-free subtomogram averaging to determine the structure of a protein complex, COPI, directly in its native environment, in C. reinhardtii cells. (sne-chembio.ch)
  • White fat cells secrete many proteins acting as adipokines such as resistin , adiponectin , leptin and apelin . (ipfs.io)
  • Our lab investigates unconventional mechanisms of protein secretion from mammalian cells. (db-engine.de)
  • The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
  • Membrane trafficking defects caused by mutation in OCRL may explain renal tubular defects observed in Lowe syndrome, including the inability of proximal tubular cells (PTC) to reabsorb low-molecular weight (LMW) proteins and other solutes such as phosphorus and bicarbonate from the glomerular filtrate. (medscape.com)
  • In this Commentary, I review evidence in favor of the idea that partitioning of TMDs into bilayer domains that are endowed with distinct physico-chemical properties plays a pivotal role in the transport of membrane proteins within the early secretory pathway. (biologists.com)
  • The PI3K/Akt/mTOR signaling pathway is a key regulator of diverse physiological functions such as proliferation, global protein, and lipid synthesis as well as many metabolic pathways interacting to increase secretory capabilities. (go.jp)
  • is the clathrin-coated pit pathway ( Figure 2 ). (wormbook.org)
  • COPI is a key mediator of protein trafficking within the secretory pathway. (univ-lille.fr)
  • These findings demonstrate that AP-1/σ1B deficiency strongly effects the AP-2 CCV endocytotic pathway and its functions indicating an interdependent regulation of AP-1 and AP-2 mediated synaptic vesicle recycling and that AP-1 complexes also regulate the endosomal sorting of SV proteins. (uni-goettingen.de)
  • Over the last 15 years I have developed a research pathway in auxin biosynthesis going back to my degree and PhD work at the Technical University of Munich where I studied the nitrilase pathway in maize auxin biosynthesis and maize tryptophan synthase complex. (brookes.ac.uk)
  • A vesicular transport protein, or vesicular transporter, is a membrane protein that regulates or facilitates the movement of specific molecules across a vesicle's membrane. (wikipedia.org)
  • Examples include: Archain ARFs Clathrin Caveolin Dynamin and related proteins, such as the EHD protein family Rab proteins SNAREs Vesicular transport adaptor proteins e.g. (wikipedia.org)
  • The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport. (lookformedical.com)
  • To solve this problem, the cell membrane contains proteins that are selective for unique, water soluble molecules. (wikibooks.org)
  • The COPI coat structure that the authors find in situ is remarkably similar to the COPI coat modelled from in vitro studies using mouse proteins, which suggests that the COPI architecture is highly conserved in distantly related species. (sne-chembio.ch)
  • Experimental down-regulation of Tango1, a highly conserved regulator of ER-to Golgi transport, partially rescued GA400 toxicity, suggesting that misregulation of this process contributes to polyGA toxicity. (biomedcentral.com)
  • The eukaryotic proteins are more complicated than the bacterial enzyme complexes. (tcdb.org)
  • the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). (nih.gov)
  • Continuous protein pathways are composed of carrier proteins , channels and pumps . (wikibooks.org)
  • The transport may be active transport by carrier proteins with an energy source, or it may be facilitated diffusion or passive transport via channels. (wikibooks.org)
  • They also inferred the relative dynamics of vesicle uncoating from the distribution of COPI coat completeness in the proximity of the Golgi: the coat disassembly starts after budding but it is not catastrophic and it is not related to structural changes in the COPI coat. (sne-chembio.ch)
  • They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 2. (lookformedical.com)
  • Adaptor protein complex 3 (ap-3) is an heterotetramer composed of two large adaptins (delta/ap3d1 and beta3a/ap3b2 or beta3b/ap3b1), a medium adaptin (mu3a/ap3m1 or mu3b/ap3m2) and a small adaptin (sigma3a/ap3s1 or sigma3b/ap3s2). (lu.se)
  • While several factors may be causal for pathogenesis, including loss of function of the C9ORF72 protein and accumulation of G 4 C 2 transcripts, expression of DPRs is thought to be a key driver of toxicity. (biomedcentral.com)
  • Our results therefore identify GORAB as a COPI scaffolding factor, and support the view that defective protein glycosylation is a major disease mechanism in gerodermia osteodysplastica. (univ-lille.fr)
  • Glycosylation of those proteins was proven to influence their subcellular locations. (frontiersin.org)
  • Glycosylation is an important post-translational modification of proteins, and glycoproteins are widely involved in various important cellular biological processes and diseases ( 1 ). (frontiersin.org)
  • My additional independent research on ER localisation and splicing in auxin biosynthesis showed for the first time ER-localisation for an auxin biosynthetic protein. (brookes.ac.uk)
  • The large GTPase dynamin is then involved in pinching off the coated pit to form a clathrin-coated vesicle. (wormbook.org)
  • Coat proteins can help sort the cargo and assemble on the donor membrane to initiate vesicle formation. (jove.com)
  • Here I pursued my scientific interests in subcellular protein localisation, bioinformatics, and mathematical modelling. (brookes.ac.uk)
  • each organelle has functionally distinct zones, and zones in different organelles closely interact each other in order to perform complex cellular functions. (go.jp)
  • The cytoskeleton is a highly dynamic network of filamentous proteins that enables the active transport of cellular cargo, transduces force, and when assembled into higher-order structures, forms the basis for motile cellular structures that promote cell movement. (mechanobio.info)
  • The results revealed that the levels of a number of proteins involved in various cellular processes were regulated by JA during tuber development. (biomedcentral.com)
  • [ 2 ] and (2) Mehta ZB, Pietka G, Lowe M. The cellular and physiological functions of the Lowe syndrome protein OCRL1. (medscape.com)
  • Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
  • 2017). Moreover, Golgi-associated Rab29 can recruit LRRK2 to the surface of the Golgi and activate it there for both auto- and Rab substrate phosphorylation. (stanford.edu)