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  • salts
  • gold salts decrease cellular proliferation, reduce antibody and cytokine release, and inhibit collagenase action (Doan 2005). (drugs.com)
  • The use of gold salts was then a controversial treatment and was not immediately accepted by the international community. (wikipedia.org)
  • Ligated gold(I) complexes are typically prepared and stored as the bench-stable (but unreactive) chlorides, LAuCl, e.g., chloro(triphenylphosphine)gold(I), which are typically activated via halide abstraction with silver salts like AgOTf, AgBF4, or AgSbF6 to generate a cationic gold(I) species. (wikipedia.org)
  • toxicity
  • US Boxed Warning]: Signs of gold toxicity include pruritus, rash, and stomatitis. (drugs.com)
  • Metabolism, toxicity and manner of action of gold compounds used in the treatment of arthritis. (wikipedia.org)
  • Some practical advantages of gold(I) catalysis include: 1) air stability (due to the high oxidation potential of Au(I)), 2) tolerance towards adventitious moisture (due its low oxophilicity), and 3) relatively low toxicity compared to other pi-acids (e.g. (wikipedia.org)
  • phosphine
  • The development of well-defined phosphine- or NHC-ligated gold(I) complexes was an important advance and led to significant increase in interest in the synthetic applications of gold catalysis. (wikipedia.org)
  • platinum
  • Gold is certainly not the only metal showing this type of bonding and reactivity, several metal ions isolobal with the simple proton (i.e., an empty s-orbital) do as well: for example, mercury(II) and platinum(II). (wikipedia.org)
  • Cationic
  • Although the coordinatively unsaturated complex "LAu+" is notionally generated from a LAuCl/AgX mixture, the exact nature of the cationic gold species and the role of the silver salt remains somewhat contentious. (wikipedia.org)
  • Cationic gold(I) forms π-complexes with alkene or alkyne bonds, following the Dewar-Chatt-Duncanson model. (wikipedia.org)
  • toxicities
  • The toxicities of gold therapy, the initial treatment of RA with disease-modifying antirheumatic drugs (DMARDs), and the treatment of RA resistant to initial DMARD therapy are discussed in detail separately. (uptodate.com)
  • 1929
  • It is also known that it inhibits the following enzymes: Acid phosphatase Beta-glucuronidase Elastase Cathepsin G Thrombin Microsomal prostaglandin E synthase-1 Reports of favorable use of the compound were published in France in 1929 by Jacques Forestier. (wikipedia.org)
  • catalytic
  • In the case of gold, protonolysis of the Au-C bond closes the catalytic cycle, allowing the coordination of another substrate. (wikipedia.org)