Gnrh receptor. Medical search. Frequent questions

Therefore, hGHR106 can serve as a long-acting alternative to the current decapeptide GnRH antagonists for therapeutic treatments in the immunotherapy of human cancers, including those of gynecologic origin. (annexpublishers.co)
Analogs of this decapeptide provides both GnRH agonists and antagonists. (frontiersin.org)
Degarelix injection is in a class of medications called gonadotropin-releasing hormone (GnRH) receptor antagonists. (medlineplus.gov)
Degarelix may solve some key problems associated with currently available GnRH agonists and antagonists", Dr Weston said. (ferring.com)
Learn about the limitations with conventional EM treatment options and surgery as well as with the promising role of newer GnRH receptor antagonists in managing EM-related pain. (freecme.com)

By using semi-quantitative reverse transcription polymerase chain reaction (RT-PCR), both GHR106 Mabs and the GnRH decapeptide antagonist, Antide, were shown to be bioequivalent in terms of their respective effects on genes involved in the proliferation and apoptosis of cancer cells. (annexpublishers.co)
Based on the results of these studies, it can be concluded that both mGHR106 and hGHR106 are bioequivalent to the GnRH decapeptide antagonist, Antide, in many biological and functional properties. (annexpublishers.co)
BASEL, Switzerland and NEW YORK, Dec. 28, 2020 (GLOBE NEWSWIRE) -- Myovant Sciences (NYSE: MYOV) and Pfizer Inc. (NYSE: PFE) today announced a collaboration to develop and commercialize relugolix - a once-daily, oral gonadotropin-releasing hormone (GnRH) receptor antagonist - in oncology and women's health in the U.S. and Canada. (pfizer.com)
The active substance in Yselty, linzagolix choline, is a gonadotropin-releasing hormone (GnRH) receptor antagonist. (europa.eu)
Linzagolix has the potential to be a best-in-class GnRH receptor antagonist for the treatment of uterine fibroids due to its efficacy and favorable tolerability profile. (biospace.com)
1,2,3 If approved, it would be the only GnRH antagonist for uterine fibroids with unique and flexible dosing options, as well as the first to offer a low dose option to address the needs of women who cannot or do not want to take hormones. (biospace.com)
Linzagolix is a novel, once daily, oral GnRH receptor antagonist with a potentially best-in-class profile 1,2,3 . (biospace.com)
Relugolix is a non-peptide GnRH receptor antagonist that competitively binds to pituitary GnRH receptors, thereby reducing the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to decreased serum concentrations of the ovarian sex hormones estradiol and progesterone and reduced bleeding associated with uterine fibroids. (centerwatch.com)

Similar to decapeptide GnRH analogs, both Mabs were shown to induce apoptosis to cultured cancer cells of various tissue origins, including those from the ovary, breast, prostate, and lung. (annexpublishers.co)
However, both Mabs were also found to induce complement-dependent cytotoxicity (CDC) reaction for lysis of cancer cells, an immune property which is not shared by peptide analogs of GnRH. (annexpublishers.co)
In addition, GHR106 Mabs have a much longer circulating half-life than GnRH peptide analogs (days versus hours). (annexpublishers.co)
Anti-proliferation effects of GnRH or its analogs on cancer cells of different human tissue origins have been reported and have been the molecular basis for cancer therapy [ 4 , 7-9 ]. (annexpublishers.co)
Numerous clinical studies have also reported the use of cytotoxic GnRH analogs or GnRH analogs alone as anti-cancer drugs [ 10 ]. (annexpublishers.co)
To improve efficacy, GnRH analogs are sometimes formulated by covalently linking cytotoxic anti-cancer agents, such as AN-152 or AN-207, to GnRH or its analogs. (annexpublishers.co)
In the conversation that follows, the faculty discuss the importance of staging scans in patients with larger tumors and lymph node involvement, choosing the most appropriate endocrine therapy and CDK4/6 inhibitor for first-line therapy, and monthly vs every-3-month dosing of GnRH analogs. (ascopost.com)
Patients were required to have undergone a prior orchiectomy or be receiving gonadotropin-releasing hormone (GnRH) analogs. (ascopost.com)
Unlike GnRH analogs, UPA is not associated with hypoestrogenic side effects. (medscape.com)

Treatment with degarelix, a novel gonadotrophin-releasing hormone (GnRH) blocker, causes significant reductions in testosterone and prostate-specific antigen (PSA) levels. (ferring.com)
For it has been found that signalling between kisspeptin and its cell receptor GPR54 was essential to activate gonadotrophin-releasing hormone (GnRH) neurons, the nerve cells known to initiate ovulation. (medindia.net)

Neurokinin B (NKB) neurons in the arcuate nucleus of the hypothalamus are considered to play an essential role in generating the pulsatile mode of GnRH/luteinizing hormone (LH) secretion. (bioone.org)
The gonadotropin-releasing hormone (GnRH) neurons represent the final output neurons of the neural network controlling fertility and are suspected to be the primary locus of kisspeptin-GPR54 signaling. (jneurosci.org)
Using mouse models, the present study addressed whether kisspeptin and GPR54 have a key role in the activation of GnRH neurons to generate the luteinizing hormone (LH) surge responsible for ovulation. (jneurosci.org)
Dual-label immunocytochemistry experiments showed that 40-60% of kisspeptin neurons in the rostral periventricular area of the third ventricle (RP3V) expressed estrogen receptor α and progesterone receptors. (jneurosci.org)
A strong correlation was found between the percentage of c-FOS-positive kisspeptin neurons and the percentage of c-FOS-positive GnRH neurons. (jneurosci.org)
Whereas wild-type littermates all exhibited LH surges and c-FOS in ∼50% of their GnRH neurons, none of the mutant mice from either line showed an LH surge or any GnRH neurons with c-FOS. (jneurosci.org)
as well as a role in activation of the GnRH neurons to generate the preovulatory luteinizing hormone (LH) surge. (jneurosci.org)
First, we set out to determine whether kisspeptin neurons in mice expressed the appropriate receptors required for gonadal steroid positive feedback, and whether they were activated at the time of the LH surge, as had been found previously in the rat. (jneurosci.org)
Gnrh neurons which occur because of 9, some of hypercalcemia. (lorenzopetrantoni.com)
Even if obtained in vitro, our findings support the idea of a deleterious direct contribution of hyperglycemia on human GnRH neurons, thus providing new insights into the pathogenic mechanisms linking hypogonadotropic hypogonadism to metabolic disorders", the researchers write. (ironmagazine.com)
Metabolic disorders are often associated with male hypogonadotropic hypogonadism, suggesting that hypothalamic defects involving GnRH neurons may impair the reproductive function. (ironmagazine.com)
To date, little is known about the direct effects of pathological high glucose concentrations on human GnRH neurons. (ironmagazine.com)

Unlike degarelix, these therapies stimulate the natural hormone's receptor on the pituitary gland. (ferring.com)
By attaching to GnRH receptors (targets) in the pituitary gland, it blocks the action of GnRH, leading to decreased blood concentrations of estrogen and progesterone, two hormones that promote the growth of uterine fibroids. (europa.eu)

Block estrogen's negative feedback in the hypothalamus , inducing the secretion of gonadotropin-releasing hormone (GnRH). (rxlist.com)
Pulsatile gonadotropin-releasing hormone (GnRH) secretion, which is indispensable for follicular development, is suppressed in lactating dairy and beef cattle. (bioone.org)
The present study aimed to clarify the role of NKB-neurokinin 3 receptor (NK3R) signaling in the pulsatile pattern of GnRH/gonadotropin secretion in postpartum lactating cattle.We examined the effects of the administration of an NK3R-selective agonist, senktide, on gonadotropin secretion in lactating cattle. (bioone.org)
Deficient hypothalamic GnRH secretion underlies the markedly abnormal gonadotropin secretion patterns in most patients with Kallmann syndrome or idiopathic hypogonadotropic hypogonadism. (medscape.com)
At least 2 bulls and possibly a 3rd showed behavioural improvement following GnRH vaccination and in all 3 temporal gland secretion ceased. (scielo.org.za)
Goserelin is a synthetic decapeptide analogue of GnRH that inhibits pituitary gonadotropin secretion if administered long-term. (medscape.com)
In contrast, GFAP-Tk female rats have increased corticosterone secretion at nadir, a heightened, yet delayed, response to an acute stress stimulus, accompanied by neuronal hypertrophy in the basal lateral amygdala and increased expression of the glucocorticoid receptors in the ventral DG. (bvsalud.org)

Androgen receptor (AR) is one of the predominant nuclear hormone receptors in invasive breast cancer and can be explored as a biomarker of response for targeted anti-androgen therapy, especially in the setting of triple negative breast cancer (TNBC). (ecancer.org)
The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21. (harvard.edu)
2]The premise of androgen ablationrelies on growth of most prostate carcinomacells being androgen-dependent.The androgen receptor expressedby these cells binds dihydrotestosterone,which is then transported intothe nucleus, leading to a cascade ofevents that induces cellular growth. (cancernetwork.com)
This study investigated the relationship between faecal androgen metabolites (FAM) and faecal cortisol metabolites (FCM) concentrations and aggressive behaviour and tested a GnRH vaccine as a means of down-regulating aggressive behaviour and musth in 1 free-ranging and 5 captive elephant bulls. (scielo.org.za)
Antiandrogens bind to androgen receptors and competitively inhibit their interaction with testosterone and dihydrotestosterone. (medscape.com)
Patients could have received prior docetaxel or androgen receptor-targeted therapies in earlier disease settings. (ascopost.com)
Random assignment was stratified by prior receipt of docetaxel, prior receipt of androgen receptor-targeted therapy, prior receipt of abiraterone acetate plus prednisone, and BRCA status. (ascopost.com)
Small Indels in the Androgen Receptor Gene: Phenotype Implications and Mechanisms of Mutagenesis. (medscape.com)

Currently used hormonal treatments for prostate cancer include GnRH agonists. (ferring.com)
GnRH agonists provide medical castration in patients with prostate cancer. (medscape.com)

Triple negative breast cancer (TNBC) is defined by the absence of expression for oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2) which has limited targeted therapeutic options. (ecancer.org)
Recently new agents have shown promising effects in symptom improvement and fibroid regression, like aromatase inhibitors, mifepristone, selective estrogen receptor modulators, and selective progesterone receptor modulators. (hindawi.com)
Ulipristal acetate (UPA) is a progesterone receptor modulator that has been shown to have similar beneficial effects on fibroid volume and fibroid-related bleeding. (medscape.com)

The stimulation of the GnRH receptors leads to an increase in FSH and LH, and consequently to an increased release of sex hormones (i.e., testosterone in male or estrogenes in females) ( 8 ). (frontiersin.org)
In our study, injection with degarelix rapidly reduced levels of testosterone without the hormonal flare associated with GnRH agonists, and it maintained target levels, resulting in a fast decrease in PSA levels. (ferring.com)
GnRH agonists bind to the GnRH receptors on pituitary gonadotropin-producing cells, causing an initial release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) and consequently a rise in testosterone levels for a few weeks. (medscape.com)
Like other GnRH agonists, goserelin provides a medical castration that deprives hormonally-dependent tumors of testosterone or estrogen. (medscape.com)
GnRH [structural formula shown below] plays a key role in the body's release of testosterone. (ironmagazine.com)

40?mM) significantly reduced gene and protein expression of GnRH, KISS1R, KISS1, and leptin receptor, as compared to normal glucose (5?mM). (ironmagazine.com)
[ 10 ] Mutations of genes encoding either leptin or the leptin receptor underlie isolated cases of autosomally transmitted idiopathic hypogonadotropic hypogonadism associated with early-onset obesity. (medscape.com)

Genetic drift and selective forces have shaped the individual structure of a given receptor gene but also of the species-specific receptor repertoire - a process that is still ongoing. (springer.com)
GnRH Transactivates Human AMH Receptor Gene via Egr1 and FOXO1 in Gonadotrope Cells. (harvard.edu)
Loss-of-function mutations of the gene encoding fibroblast growth factor receptor 1 (FGFR1) have been described in patients with autosomal dominant Kallmann syndrome. (medscape.com)
Gene expression profiling by qRT-PCR, confirmed that FNC-B4 cells express GnRH and several genes relevant for GnRH neuron function (KISS1R, KISS1, sex steroid and leptin receptors, FGFR1, neuropilin 2, and semaphorins), along with glucose transporters (GLUT1, GLUT3, and GLUT4). (ironmagazine.com)
[ 11 ] Several loss-of-function mutations of the GnRH receptor gene leading to GnRH resistance and autosomally transmitted hypogonadotropic hypogonadism have been described. (medscape.com)
[ 12 ] . In addition, autosomal recessive mutations of the GnRH gene may underlie hypogonadotropic hypogonadism. (medscape.com)
In one patient, isolated bioinactive luteinizing hormone (LH) was present as a result of a homozygous mutation in the LH beta subunit gene, which prevented binding of LH to its receptor. (medscape.com)

GnRH is a decapeptide synthesized by the hypothalamus and has a very stable sequence in all mammals ( 7 ). (frontiersin.org)
In the brain the hypothalamus releases GnRH a couple of times a day. (ironmagazine.com)

Gonadotropin releasing hormone (GnRH), both types I and II, is a decapeptide hormone that stimulates the release of gonadotropin, luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the anterior pituitary through specific binding to the GnRH receptor located on the external membrane of selected cell types [ 1-3 ]. (annexpublishers.co)
Triptorelin is a synthetic decapeptide agonist analogue of GnRH. (medscape.com)

How Do Selective Estrogen Receptor Modulators Work? (rxlist.com)
Selective estrogen receptor modulators (SERM) are a class of medications used to relieve postmenopausal symptoms and to prevent bone loss ( osteoporosis ) associated with menopause . (rxlist.com)
Selective estrogen receptor modulators work by modulating the activity of estrogen receptors, proteins in cells that are activated by estrogen. (rxlist.com)
Selective estrogen receptor modulators have both estrogen agonistic and antagonistic properties, depending on the type of tissue. (rxlist.com)
Selective estrogen receptor modulators may also be combined with estrogen for postmenopausal women with an intact uterus, who are undergoing estrogen replacement therapy. (rxlist.com)
How are selective estrogen receptor modulators used? (rxlist.com)
What are side effects of selective estrogen receptor modulators? (rxlist.com)
DACT appeared to cause a selective decrease in caffeine-sensitive ryanodine receptor-operated calcium stores in LbetaT2 cells, rather than in thapsigargin-sensitive ER calcium stores. (cdc.gov)

To evaluate whether kisspeptin and/or GPR54 were essential for GnRH neuron activation and the LH surge, Gpr54 - and Kiss1 -null mice were examined. (jneurosci.org)
These observations provide the first evidence that kisspeptin-GPR54 signaling is essential for GnRH neuron activation that initiates ovulation. (jneurosci.org)
Given the importance of the kisspeptin-GPR54-GnRH neuron axis in puberty, it has been logical to explore other potential roles of this signaling cascade in the control of reproduction. (jneurosci.org)
have shown that injection of kisspeptin antisera into the vicinity of the GnRH neuron cell bodies prevents the LH surge in both proestrous and ovariectomized estrogen-treated (OVX+E) rats. (jneurosci.org)

Most patients have gonadotropin-releasing hormone (GnRH) deficiency, as suggested by their response to pulsatile GnRH therapy. (medscape.com)

SERMs bind to estrogen receptors and activate estrogen pathways in some tissue while blocking its effects in other types of tissue. (rxlist.com)
Kim JY, Haastert PV, Devreotes PN (1996) Social senses: G-protein-coupled receptor signaling pathways in Dictyostelium discoideum . (springer.com)

Both Mabs in murine (mGHR106) or humanized (hGHR106) forms were shown to have comparable specificity and affinity to intact GnRH receptor on cancer cells or to N1-29 synthetic peptides from humans and monkeys. (annexpublishers.co)

Suprelorin ® has two major effects: a stimulation or the GnRH receptors, followed by a desensitization of the same receptors to GnRH. (frontiersin.org)
This initial stimulation of the receptors stimulate hormone-dependent tumour growth rather than inhibit it, and may lead to a worsening of cancer symptoms or flare. (ferring.com)
Receptor binding of GnRH is connected with the stimulation of pituitary gonadotropic cells leading to both the release and bio. (nel.edu)

Encodes the G protein-coupled receptor tachykinin receptor 3 (TACR3) also called neurokinin B (NKB) receptor. (chuv.ch)
Nordstrom KJ, Sallman Almen M, Edstam M et al (2011) Independent HHsearch, Needleman-Wunsch-based, and motif analyses reveal the overall hierarchy for most of the G protein-coupled receptor families. (springer.com)

The effect of valproate (VPA) treatment on inositol phosphates (IPs) accumulation in non-stimulated and GnRH-treated female rat anterior pituitary cells in vitro. (nel.edu)
Wasilewska-Dziubinska E, Gajewska A, Herman A, Wolinska-Witort E, Skrzypska J, Martynska L, Kalisz M, Chmielowska M. The effect of valproate (VPA) treatment on inositol phosphates (IPs) accumulation in non-stimulated and GnRH-treated female rat anterior pituitary cells in vitro. (nel.edu)
Valproate inhibits GnRH-induced gonadotropin release from anterior pituitary cells of male rat in vitro. (nel.edu)
Wasilewska-Dziubinska E, Gajewska A, Wolinska-Witort E, Chmielowska M, Martynska L, Elbanowski J, Kochman K. Valproate inhibits GnRH-induced gonadotropin release from anterior pituitary cells of male rat in vitro. (nel.edu)

The valuable source of large-scale genomic information initiated attempts to identify the origin(s) of G protein-coupled receptors (GPCR), count and categorize those genes, and follow their evolutionary history. (springer.com)
The chapter summarizes evolutionary processes working on GPCR genes and sheds light on their consequences at the levels of receptor structure and function. (springer.com)

A monoclonal antibody (Mab) designated as GHR106 was generated against the extracellular domain (N1-29 synthetic peptide) of human gonadotropin releasing hormone (GnRH) receptor. (annexpublishers.co)
Gonadotropin-releasing hormone (GnRH) agonists slow-release implants such as deslorelin or azaglynafarelin have become more and more popular in veterinary medicine since their commercialization in the European Union in 2008 ( 1 , 2 ). (frontiersin.org)
They experimented with human cells that produce the gonadotropin-releasing hormone [GnRH]. (ironmagazine.com)
KISS-1 is really a hormone and it boosts the release of GnRH. (ironmagazine.com)

Sequence comparison does not support an evolutionary link between halobacterial retinal proteins including bacteriorhodopsin and eukaryotic G-protein-coupled receptors. (springer.com)
DACT is a reactive electrophile known to form covalent protein adducts both in vitro and in vivo following ATRA exposure and might therefore target proteins involved in GnRH-induced calcium signaling and subsequent LH release. (cdc.gov)
These data suggest that DACT forms adducts on proteins involved in calcium handling within the ER and that dysfunction in this critical signaling system is associated with loss of normal sensitivity to GnRH and subsequent decreased release of LH. (cdc.gov)

[ 7 ] Homozygous, heterozygous or compound heterozygous mutations of the prokineticin receptor 2 have also been associated with Kallmann syndrome. (medscape.com)
[ 8 ] Digenic inheritance has been suggested in an individual carrying heterozygous mutations of prokineticin receptor 2 and KAL1 . (medscape.com)

The bulls were injected with a GnRH vaccine-adjuvant combination 3 or 4 times at 3-to 7-week intervals. (scielo.org.za)

The figures below show that high concentrations of glucose reduce the release of GnRH. (ironmagazine.com)
The figure below shows that high concentrations of glucose inhibited the production of GnRH through leptin. (ironmagazine.com)
Consistent with previous studies, leptin treatment significantly induced GnRH mRNA expression at 5?mM glucose, but not in the presence of high glucose concentrations. (ironmagazine.com)

Recent research also has thrown lights upon a significant role of orexins, especially orexin A, in regulation of male reproductive functions owing to their receptor expressions in vital testicular cells, such as Leydig cells, Sertoli cells as well as spermatozoa at different developmental stages, even in the epididymis and penis. (researchgate.net)

Consequently, GnRH agonists may either stimulate estrus or effectively sterilize the dog, depending on the expected effect, i.e. (frontiersin.org)

Kisspeptin and its receptor GPR54 have recently been identified as key signaling partners in the neural control of fertility in animal models and humans. (jneurosci.org)
To provide a thorough evaluation of the role of kisspeptin-GPR54 signaling in the GnRH surge mechanism, we have undertaken a series of cellular and whole-animal investigations in mice. (jneurosci.org)
The study indicates that disorders affecting the signalling between kisspeptin and the GPR54 receptors will result in women being unable to ovulate, he says. (medindia.net)

Insulin signaling through the insulin receptor increases linear growth through effects on bone and the GH-IGF-1 axis. (medscape.com)

Ciona vasopressin family peptide (CiVP) directly upregulated the phosphorylation of extracellular signal-regulated kinase (CiErk1/2) via its receptor. (elifesciences.org)
This is probably because, in large quantities, glucose reduces the production of the receptor for the KISS-1 peptide as well as the release of KISS-1. (ironmagazine.com)

LbetaT2 cells exposed to DACT had markedly diminished GnRH-induced intracellular calcium transients and a significant decreased LH release in response to GnRH. (cdc.gov)

Estradiol acts by binding to nuclear receptors that are expressed in estrogen-responsive tissues. (centerwatch.com)

Conversely, the desensitization of the GnRH receptors to GnRH lead to a long term fully reversible downregulation of testicular endocrine function in male dogs ( 4 , 5 ). (frontiersin.org)

They do not cause hypoestrogenic symptoms associated with GnRH analogues [ 5 ]. (hindawi.com)

Degarelix is designed to target and block the GnRH receptor. (ferring.com)

Because of the efficacy of tropomyosin receptor kinase (TRK) inhibitor therapy and the recent Food and Drug Administration approval of larotrectinib, it is now clinically important to accurately and efficiently identify patients with neurotrophic TRK (or fuse with any of a number of N-terminal partners. (ecologicalsgardens.com)

The atrazine metabolite diaminochlorotriazine suppresses LH release from murine LbetaT2 cells by suppressing GnRH-induced intracellular calcium transients. (cdc.gov)
To test this hypothesis, LbetaT2 pituitary cells were exposed to 300 microM DACT for 24 h and examined by fluorescence microscopy for GnRH-induced changes in intracellular calcium and LH release. (cdc.gov)
ERp57 was identified by mass spectrometry as a target of DACT adduction in the ER that could potentially mediate the effects of DACT on inhibition of GnRH-induced calcium signaling and inhibition of LH release. (cdc.gov)
Intracellular calcium responses to GnRH and release of LH were restored in DACT-treated cells with the addition of a calcium ionophore (A23187). (cdc.gov)

Progestins such as norethindrone act by binding to nuclear receptors that are expressed in progesterone responsive tissues. (centerwatch.com)

Subsequent studies revealed that GnRH and its receptor also play extra-pituitary roles in numerous normal and malignant cells or tissues, the mechanisms of which are still being actively explored [ 4-6 ]. (annexpublishers.co)

The Italians tested their theory by exposing their GnRH-producing cells to synthetic leptin. (ironmagazine.com)

In this video, Drs. Jame Abraham, Erin Roesch, and Azka Ali discuss the management of a patient with de novo metastatic estrogen receptor-positive breast cancer. (ascopost.com)

It was then demonstrated that both ROS and TRPA1 are required in a subset of anterior enteroendocrine cells for the release of the DH31 neuropeptide which activates its receptor in the neighboring visceral muscles. (sdbonline.org)

Patients receiving niraparib and abiraterone acetate plus prednisone should also receive a GnRH analog concurrently or should have had bilateral orchiectomy. (ascopost.com)

Anatomy13

Organisms7

Diseases1

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes22

Information Science4

Health Care1

Antagonists5

Antagonist8

Analogs9

Gonadotrophin-releasi2

Neurons12

Pituitary gland2

Secretion7

Androgen8

Prostate cancer2

Progesterone receptor3

Testosterone5

Leptin receptor2

Gene7

Hypothalamus2

Decapeptide2

Selective8

Neuron4

Pulsatile1

Pathways2

Specificity1

Stimulation3

Protein-coupled receptor2

Anterior pituitary4

Genes2

Hormone4

Proteins3

Prokineticin2

Vaccine1

Concentrations3

Reproductive1

Stimulate1

Gpr543

Insulin1

Peptide2

Markedly1

Estradiol1

Reversible1

Hypoestrogenic1

Degarelix1

Efficacy1

Calcium4

Norethindrone1

Subsequent1

Synthetic1

Breast cancer1

Release1

Acetate1