Thus, the two substrates of this enzyme are urate D-ribonucleotide and phosphate , whereas its two products are urate and alpha-D-ribose 1-phosphate . (wikipedia.org)
Pursuing his interest in kinetic characterization of enzymes on complex substrates he advanced the use of enzyme calorimetry with chip based devices. (tudelft.nl)
Lyases1
In recent years Hagedoorn ventured together with prof. Hanefeld into enzyme immobilization and flow biocatalys using Mn2+ dependent aldolases and hydroxynitrile lyases as well as thermophilic glycosyl transferases and hydratases (including FeS cluster containing enzymes). (tudelft.nl)
Gene3
Neither a gene encoding a maltose phosphorylase (MalP) nor MalP enzyme activity were detected in the wild type. (frontiersin.org)
This gene encodes the enzyme responsible for formation of the blood group I antigen. (nih.gov)
this gene encodes for the transferases necessary to produce ABO antigens (mainly glycoproteins) that are affiliated with bodily fluids other than blood (eg, saliva). (medscape.com)
Blood group1
Results Initial discovery GWAS detected SNPs within or near genes encoding the ABO blood group specifying transferases A/B ( ABO ), Fucosyltransferase-2 ( FUT2 ), and Chymotrypsinogen-B2 ( CTRB2 ), to be significantly associated with lipase activity levels in asymptomatic subjects. (bmj.com)
Family1
A new glycosyltransferase enzyme from family 91, ugt91p3, is responsible for the final glucosylation step of crocins in saffron (Crocus sativus l. (uclm.es)
Responsible2
The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. (nih.gov)
Alpha-2-L-fucosyltransferase is the enzyme responsible for adding fructose to the primary galactose of the oligosaccharide chain. (medscape.com)
Activity1
A group of enzymes with the general activity CMP-N-acetylneuraminate:acceptor N-acetylneuraminyl transferase. (bvsalud.org)
The enzymes exhibit broad substrate specificities. (unl.edu)
It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. (unl.edu)
Catalyse2
Some of these enzymes also catalyse hydrolysis, which can be regarded as transfer of a glycosyl group from the donor to water. (enzyme-database.org)
These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. (embl.de)
Golgi3
This enzyme differs from other beta4GalTs because it lacks the conserved Cys residues found in beta4GalT1-beta4GalT6 and it is located in cis-Golgi instead of trans-Golgi. (nih.gov)
Mucin-type O-linked glycosylation is abundant in the extracellular matrix and is initiated in the Golgi by the UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase family of enzymes (pGalNAc-T in mammals and PGANT in Drosophila), which adds a GalNAc sugar to serines or threonines of secreted and membrane-bound proteins. (nih.gov)
There are several types of glycosylation with various carbohydrate structures, and biosynthesis of each sugar chain, in general, is an elaborate process of addition and processing of carbohydrates in the endoplasmic reticulum (ER) and Golgi, where a number of glycosyltransferases and glycosidases are involved in these reactions. (intechopen.com)
Biosynthesis9
My group has been working on the biosynthetic enzymes of AG glycans to understand the developmentally regulated biosynthesis of AG glycans. (hindawi.com)
In this review, the progresses of study on relevant enzymes, genes, and regulation mechanism in biosynthesis pathway of stilbenes are described. (scirp.org)
The application of knowledge of relative enzymes, genes and regulation mechanisms in stilbenes biosynthesis in metabolic engineering which is used as a tool of improving the disease resistance of plants and health caring quality of crops is also discussed. (scirp.org)
However, their detailed biosynthesis pathways and metabolic regulation, especially complicated regulation mechanism and expressing of genes and enzymes are unknown. (scirp.org)
So it is significant to shift focus from previous research priorities to search relevant enzymes, genes, abiotic stress and biotic signals so as to elucidate their detailed biosynthesis pathway and understand metabolic regulation networks. (scirp.org)
Collectively, enzymes that modulate glycoprotein carbohydrates during their biosynthesis and degradation are called glycoenzymes, which play critical roles in maintaining cellular structure and function. (intechopen.com)
Finally, 3 cytochrome P450 enzymes and 6 glycosyltransferases were selected as the candidates most likely to be involved in glycyrrhizin biosynthesis through an organ-specific expression pattern analysis based on real-time PCR. (biomedcentral.com)
With the assistance of organ-specific expression pattern analysis, 3 unigenes encoding cytochrome P450s and 6 unigenes encoding glycosyltransferases were selected as the candidates most likely to be involved in glycyrrhizin biosynthesis. (biomedcentral.com)
This gene codes for an amino acid glycosyl transferase enzyme, and absence of this enzyme may lead to abnormal glycosylation of proteins and lipids, resulting in tumor formation. (medscape.com)
Acceptor1
The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS. (unl.edu)
Intermediates1
This phenomenon involves the physical organization of successive pathway enzymes into complexes through which metabolic intermediates are channeled [15]. (scirp.org)
Catalytic2
However, the catalytic activity of the enzyme encoded by CG30463 had not been identified previously. (nih.gov)
This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. (nih.gov)
Metabolism3
PAL, the first and key enzyme of the phenylpropanoid sequence, is the bridge between primary metabolism and secondary metabolism. (scirp.org)
With respect to the genes related to glycyrrhizin metabolism, genes encoding 16 enzymes of the 18 total steps of the glycyrrhizin skeleton synthesis pathway were found. (biomedcentral.com)
To identify novel genes that encode cytochrome P450 enzymes and glycosyltransferases, which are related to glycyrrhizin metabolism, a total of 125 and 172 unigenes were found to be homologous to cytochrome P450s and glycosyltransferases, respectively. (biomedcentral.com)
Genes3
Here we introduce a holistic and systematic method of researching relevant enzymes, genes and other regulatory factors in bio-synthesis pathway of stilbenes-Systems biology. (scirp.org)
The cytochrome P450 candidate genes were classified into 32 CYP families, while the glycosyltransferase candidate genes were classified into 45 categories by GO analysis. (biomedcentral.com)
Based on the EST analysis, novel candidate genes related to the secondary metabolite pathway of glycyrrhizin, including novel genes encoding cytochrome P450s and glycosyltransferases, were found. (biomedcentral.com)
Molecules2
Placental cells secrete extracellular vesicles-tiny, balloon-like structures containing proteins, enzymes, DNA, and other molecules capable of transmitting chemical messages between cells-that appear to help regulate glucose uptake by maternal cells, according to a mouse study funded by the National Institutes of Health. (nih.gov)
This family includes enzymes that transfer sugar residues to donor molecules. (unl.edu)
Degradation1
Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. (nih.gov)
Extracellular1
Lowering the level of the enzyme also reduced the processing of proteins needed to produce extracellular vesicles. (nih.gov)
Pathway1
Phenylalanine ammonialyase (PAL), cinnamic acid 4-hydroxylase (C4H) and 4- coumarate: CoA ligase (4CL) are key enzymes in this pathway [6]. (scirp.org)
Synthesis1
In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. (nih.gov)
Transfer1
This subclass contains enzymes that transfer glycosyl groups. (enzyme-database.org)
Sugar2
In contrast to the widely held belief that one enzyme transfers one sugar, the HASs co-polymerize both N -acetylglucosamine [GlcNAc] and glucuronic acid [GlcUA] into the hyaluronan chain. (gr.jp)
A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates ([intenz:2.4.1. (embl.de)
Found1
In a series of experiments, the researchers found evidence that release of the vesicles follows placental release of the enzyme O-glycosyl transferase (OGT) after glucose levels rise. (nih.gov)
Chain1
The enzyme catalysts that create the hyaluronan polysaccharide chain are called hyaluronan synthases [HASs]. (gr.jp)