DigoxinLanataToxicityPurpureaDiureticsBeta-blockersInhibitorsPotassiumAlkaloidsWilliam WitheringFoxglove plantPoisoningBradycardiaSerumRhamnoseGastrointestinalConductionToxicFoxglovesOuabainSpeciesAmountsDecrease heart rateTherapeuticNaturallyPlantPlantsIrregularChemicalIncreasesWangSteroidLaboratoryIncreaseSourceMedicine
Digoxin8
- Convallaria majalis (Lily of the Valley): convallatoxin Antiaris toxicaria (upas tree): antiarin Strophanthus kombe (Strophanthus vine): ouabain (g-strophanthin) and other strophanthins Digitalis lanata and Digitalis purpurea (Woolly and purple foxglove): digoxin, digitoxin Nerium oleander (oleander tree): oleandrin Asclepias sp. (wikipedia.org)
- The medicine digoxin contains cardiac glycosides. (medlineplus.gov)
- Digoxin is a cardiac glycoside with direct inotropic effects, as well as indirect effects, on the cardiovascular system. (medscape.com)
- Digitalis lanata plants are used for the isolation of digoxin. (nzdl.org)
- Anti-digoxin immunotherapy is an effective antidote for digitalis intoxication. (pharmacology2000.com)
- Digitalis lanata is cultivated for medicine because it makes a cardiac glycoside called digoxin. (futurity.org)
- Consult a health care practitioner before use if you are taking cardiac glycosides such as digitalis/digoxin or blood pressure medication. (stfrancisherbfarm.com)
- Digoxin and digitoxin are the main digitalis products. (medscape.com)
Lanata7
- For example, cardenolides have been primarily derived from the foxglove plants Digitalis purpurea and Digitalis lanata, while bufadienolides have been derived from the venom of the cane toad Rhinella marina (formerly known as Bufo marinus), from which they receive the "bufo" portion of their name. (wikipedia.org)
- Digitalis lanata , grown in a greenhouse. (futurity.org)
- and Digitalis lanata , which is grown for medicinal purposes. (futurity.org)
- In the first paper, published in the Journal of Chromatography A , the researchers describe methods for assessing the exact mass and structure of cardiac glycosides, and compares compounds found in Digitalis purpurea and Digitalis lanata . (futurity.org)
- Download a high-resolution photo showing a Digitalis lanata plant. (buffalo.edu)
- This foxglove species is often grown as an ornamental plant in gardens, whereas its relative, Digitalis lanata, is often farmed for medicine production. (buffalo.edu)
- Download a high-resolution photo showing Digitalis lanata seedlings grown in a greenhouse. (buffalo.edu)
Toxicity9
- Kanji S, Maclean RD. Cardiac glycoside toxicity: More than 200 years and counting. (cdc.gov)
- Electrocardiographic manifestations: Digitalis toxicity. (cdc.gov)
- Toxicity from herbal cardiac glycosides was well recognized by 1785, when William Withering published his classic work describing therapeutic uses and toxicity of foxglove, D purpurea . (medscape.com)
- Therapeutic use of herbal cardiac glycosides continues to be a source of toxicity today. (medscape.com)
- Cardiac glycosides have been also found in Asian herbal products and have been a source of human toxicity. (medscape.com)
- Toxicity may occur after consuming teas brewed from plant parts or after consuming leaves, flowers, or seeds from plants containing cardiac glycosides. (medscape.com)
- Any dysrhythmia characterized by both increased automaticity and depressed conduction is suggestive of cardiac glycoside toxicity. (medscape.com)
- Although acute and chronic plant cardiac glycoside toxicity are treated in similar manners, their noncardiac clinical manifestations differ. (medscape.com)
- Digitalis toxicity is not a laboratory diagnosis but a clinical diagnosis. (medscape.com)
Purpurea2
- Digitalis purpurea, grown by UB biological sciences researcher Zhen Wang. (buffalo.edu)
- Download a high-resolution photo of flowering Digitalis purpurea. (buffalo.edu)
Diuretics1
- and digitalis and diuretics, for symptoms of heart failure. (medscape.com)
Beta-blockers1
- Most common side effects were related with beta-blockers (22.9%), digitalis glycosides (18.8%), antiarrhythmics (17.2%), ACE inhibitors (13.5%) and calcium canal blocker (12.8%) consumption. (dergisi.org)
Inhibitors1
Potassium3
- Cardiac glycosides are a class of organic compounds that increase the output force of the heart and decrease its rate of contractions by inhibiting the cellular sodium-potassium ATPase pump. (wikipedia.org)
- hellebore) Cardiac glycosides affect the sodium-potassium ATPase pump in cardiac muscle cells to alter their function. (wikipedia.org)
- With regard to potassium ion movement, because both cardiac glycosides and potassium compete for binding to the ATPase pump, changes in extracellular potassium concentration can potentially lead to altered drug efficacy. (wikipedia.org)
Alkaloids1
- Foxglove, oleander and lily of the valley contain digitalis glycosides and alkaloids that can cause a slow, irregular heartbeat, intense vomiting, and abdominal pain within a few hours after ingestion. (catwatchnewsletter.com)
William Withering1
- Therapeutic and toxic effects of digitalis: William Withering, 1785. (medscape.com)
Foxglove plant2
- Cardiac glycosides are found in several plants, including the leaves of the foxglove plant. (medlineplus.gov)
- Besides the foxglove plant, cardiac glycosides also occur naturally in plants such as Lily-of-the-Valley and oleander , among several others. (medlineplus.gov)
Poisoning5
- In addition, the venom gland of cane toad ( Bufo marinus ) contains large quantities of a purported aphrodisiac substance that has resulted in cardiac glycoside poisoning. (medscape.com)
- Long-term (chronic) poisoning can occur in people who take cardiac glycosides every day. (medlineplus.gov)
- Older people are especially likely to suffer from problems of long-term (chronic) cardiac glycoside poisoning. (medlineplus.gov)
- Eddleston M, Ariaratnam CA, Sjostrom L, Jayalath S, Rajakanthan K, Rajapakse S. Acute yellow oleander (Thevetia peruviana) poisoning: cardiac arrhythmias, electrolyte disturbances, and serum cardiac glycoside concentrations on presentation to hospital. (medscape.com)
- Antidotes for acute cardenolide (cardiac glycoside) poisoning. (medscape.com)
Bradycardia1
- Cardiac glycosides also have vagotonic effects, resulting in bradycardia and heart block. (medscape.com)
Serum2
- A case in which digitalis in serum samples is detected, as determined by a commercial laboratory. (cdc.gov)
- Serum concentrations might be detectable after an exposure to plant-derived cardiac glycosides, some of which can cross-react with the various hospital laboratory assays used. (cdc.gov)
Rhamnose1
- Several biologically active derivatives of the cardiotonic steroid ouabain have been made containing NMR isotopes ((13)C, (2)H, and (19)F) in the rhamnose sugar and steroid moieties, and examined at the digitalis receptor site of renal Na(+)/K(+)-ATPase by a combination of solid-state NMR methods. (ox.ac.uk)
Gastrointestinal1
- Cardiac glycosides primarily affect cardiovascular, neurologic, and gastrointestinal systems. (medscape.com)
Conduction1
- Both digitalis glycosides and β-blockers slow atrioventricular conduction and decrease heart rate. (nih.gov)
Toxic1
- These plants and lily of the valley (which is similar but less toxic) contain digitalis glycosides. (msdmanuals.com)
Foxgloves1
- If Wang's team can figure out, step-by-step, how foxgloves make cardiac glycosides, scientists could leverage that information to explore a variety of improvements. (futurity.org)
Ouabain1
Species2
- milkweed): oleandrin Adonis vernalis (Spring pheasant's eye): adonitoxin Kalanchoe daigremontiana and other Kalanchoe species: daigremontianin Erysimum cheiranthoides (wormseed wallflower) and other Erysimum species Cerbera manghas (suicide tree): cerberin Periploca sepium: periplocin some species of Chrysolina beetles, including Chrysolina coerulans, have cardiac glycosides (including Xylose) in their defensive glands. (wikipedia.org)
- In the second study, published in the journal Data in Brief , they expand on the first, providing additional data on characteristics of cardiac glycosides in both species. (futurity.org)
Amounts2
- As by- products, they always contain high amounts of digitoxigenin glycosides. (nzdl.org)
- In the industrial strain that's grown for medicine, you see much higher amounts of cardiac glycosides, with much more diversity. (futurity.org)
Decrease heart rate1
- The refractory period of the AV node is increased, so cardiac glycosides also function to decrease heart rate. (wikipedia.org)
Therapeutic1
- At therapeutic doses, cardiac glycosides also may increase inotropy. (medscape.com)
Naturally1
- More than 200 naturally occurring cardiac glycosides have been identified. (medscape.com)
Plant4
- Cardiac glycosides can be more specifically categorized based on the plant they are derived from, as in the following list. (wikipedia.org)
- This plant is the original source of the medicine digitalis. (medlineplus.gov)
- Plant poisonings: common plants that contain cardiac glycosides. (medscape.com)
- Like many other medications, digitalis was originally derived from a plant (foxglove). (medscape.com)
Plants3
- Ancient Egyptians and Romans first used plants containing cardiac glycosides medicinally as emetics and for heart ailments. (medscape.com)
- Plants belonging to this genus, Digitalis , also harbor a less visible asset, however: Chemicals called cardiac glycosides, which have been recorded to treat heart failure since the 1780s, says Zhen Wang, assistant professor of biological sciences at the University at Buffalo. (futurity.org)
- Specifically, her lab is investigating the chemical processes the plants use to create cardiac glycosides: what steps take place, what genes turn on, and what enzymes deploy. (futurity.org)
Irregular1
- Cardiac glycosides are medicines for treating heart failure and certain irregular heartbeats. (medlineplus.gov)
Chemical1
- Cardiac glycoside is a chemical that has effects on the heart, stomach, intestines, and nervous system. (medlineplus.gov)
Increases1
- Cardiac glycosides, however, inhibit this pump by stabilizing it in the E2-P transition state, so that sodium cannot be extruded: intracellular sodium concentration therefore increases. (wikipedia.org)
Wang1
- When we looked at the cardiac glycosides in each of them, we found drastic differences," Wang says. (futurity.org)
Steroid2
- The general structure of a cardiac glycoside consists of a steroid molecule attached to a sugar (glycoside) and an R group. (wikipedia.org)
- Cardiac glycosides also vary in the groups attached at either end of the steroid. (wikipedia.org)
Laboratory1
Increase1
- Digitalis glycosides have long been used to increase myocardial contractility and reverse the detrimental changes seen in congestive heart failure. (justia.com)
Source1
- Foxglove was the original source of the drug digitalis. (msdmanuals.com)
Medicine1
- Cardiac glycoside overdose occurs when someone takes more than the normal or recommended amount of this medicine. (medlineplus.gov)