• Their protein backbones are linked to different glycosaminoglycans, such as dermatan-, chondroitin-, keratan- or heparan sulphate. (lu.se)
  • In medium of EA.hy926 cells subjected to GAG-degrading enzymes various GAG-specific disaccharides indicating the degradation of keratan sulphate (KS), heparan sulphate (HS), chondroitin sulphate (CHS) or hyaluronan (HA) were detected as predicted based on the characteristics of individual enzyme activity. (uni-luebeck.de)
  • Immunohistochemical staining was performed to research the appearance of chondroitin sulphate (CS)/dermatan sulphate (DS)-GAG heparan sulphate (HS)-GAG keratan sulphate (KS)-GAG in liver organ tissue. (researchhunt.com)
  • HTA samples contained keratan sulfate (KS), chondroitin/dermatan sulfate (CS/DS), and hyaluronan (HA), whereas heparan sulfate (HS) was not detected. (nih.gov)
  • Attached to each aggrecan molecule are glycosaminoglycan (GAG) chains of chondroitin sulfate and keratan sulfate. (wikipedia.org)
  • The presence of this fluid imparts incompressibility, but at the same time due to the negative charges on the glycosaminoglycans, the chains repel each other, eventually, resulting in a slick and slippery fluid (mucus, synovial fluid). (biologywise.com)
  • Schematic representation of glycosaminoglycan chains (Merida-de-Barros, D.A. (bioglyco.com)
  • Five glycosaminoglycan chains were identified, viz. (caslab.com)
  • The signaling complex at the cell surface is believed to be a ternary complex formed between two identical FGF ligands, two identical FGFR subunits and either one or two heparan sulfate chains. (beauty104.com.tw)
  • Recently, advanced microscopy techniques have enabled direct visualization of the GCX in vivo, most of which use fluorescent-labeled lectins that bind to specific disaccharide moieties of glycosaminoglycan (GAG) chains. (biomedcentral.com)
  • OBJECTIVES: The expression patterns of various cell-associated heparan and chondroitin/dermatan-sulphate PGs in human skin and chronic venous ulcers were investigated. (lu.se)
  • Aggrecan belongs to the chondroitin sulfate (CS) proteoglycan family, which also includes Versican, Brevican, and Neurocan. (rndsystems.com)
  • Each Aggrecan molecule contains approximately 100 and 30 keratan sulfate and glycosaminoglycan (GAG) sidechains, respectively. (rndsystems.com)
  • Depletion of glycosaminoglycan bearing aggrecan fragments is one of the earliest events in cartilage destruction. (mdbioproducts.com)
  • Glycosaminoglycan (GAG) is a class of highly sulfated, negatively charged and dispersed linear polysaccharides, usually composed of a backbone of repeating disaccharide units formed by uronic acid and glycosamine residue. (bioglyco.com)
  • We have previously reported that the keratan sulfate (KS) disaccharide was branched to the C-3 position of glucuronate in chondroitin sulfate (CS)-E derived from the Mactra chinensis. (rpi.edu)
  • These hair brush bristles consist of keratin sulfate and chondroitin sulfate, both of which are included in many popular over-the-counter joint supplements. (vin.com)
  • These abundant biopolymers contain a number of glycosaminoglycan stores covalently mounted on a primary proteins [7 8 and so are categorized predicated PD173074 on the nature from the glycosaminoglycan structure (heparan sulfate chondroitin sulfate/dermatan sulfate or keratan sulfate). (globaltechbiz.com)
  • Here we show that PNN abundance within the Arc is markedly reduced in the Zucker diabetic fatty (ZDF) rat model of T2D, compared with normoglycaemic rats, correlating with altered PNN-associated sulfation patterns of chondroitin sulfate glycosaminoglycans in the MBH. (nature.com)
  • Soares da Costa, D., Reis, R. L. & Pashkuleva, I. Sulfation of glycosaminoglycans and its implications in human health and disorders. (nature.com)
  • Quantitative real-time PCR (qRT-PCR) and flow cytometry assays were used to detect the expression of genes involved in the sulfation and presentation of chondroitin in several human breast cancer cell lines. (biomedcentral.com)
  • Glycosaminoglycans are unusual molecules that, due to their very important biological and physiological functions, have found wide application in medicine. (humanandpets.com)
  • OMIM 253010), based on a deficiency of different lysosomal enzymes-N-acetylgalactosamine-6-sulfate sulfatase (GALNS) and β-galactosidase, respectively. (medscape.com)
  • In 1974, the GALNS enzyme and its deficiency were discovered and identified using oligosaccharide substrate prepared from C6S containing N-acetylgalactosamine-6-sulfate. (medscape.com)
  • GALNS deficiency causes a block in the sequential breakdown of glycosaminoglycans N-acetylgalactosamine-6-sulfatase (GALNS) Morquio A (MPS IVA) Morquio B (MPS IVB) -D-Galactosidase Neufeld, EF and Muenzer, J. The Mucopolysaccharidoses. (slideserve.com)
  • Chondroitin sulfate monoclonal antibody (mouse, clone 1B5) to detect the zero sulphated Chondroitin Sulphate stub neoepitope generated by chondroit. (mdbioproducts.com)
  • Chondroitin-4-sulfate (C-4-S) monoclonal antibody that's also specific to dermatan-sulfate (DS) neoepitope (mouse, clone 2B6). (mdbioproducts.com)
  • In humans, about 90 percent of glucosamine, administered as an oral dose of glucosamine sulfate, is absorbed from the digestive tract. (com.bd)
  • Glycosaminoglycans are substances that function as very efficient shock absorbers and as lubricant for the joints. (mypetneedsthat.com)
  • C57Bl/6 mice were given 3% dextran sulfate sodium (DSS) to induce acute or chronic UC. (bvsalud.org)
  • High dietary fiber intake associates with lower indoxyl sulfate concentrations in chronic kidney illness TH-PO578). (bcrablinhibitor.com)
  • The results indicate that vitreous inhibition of retinal extract-induced neovascularization is dose dependent, while the sulfated glycosaminoglycans tested had no antiangiogenic activity. (johnshopkins.edu)
  • Transient transfection of the human breast cancer cell line MDA-MB-231 with the siRNAs for carbohydrate (chondroitin 4) sulfotransferase-11 ( CHST11 ) and chondroitin sulfate proteoglycan 4 ( CSPG4 ) was used to investigate the involvement of these genes in expression of surface P-selectin ligands. (biomedcentral.com)
  • Y-27632 eye drops (or vehicle only) were administered to eyes after a superficial keratectomy, and the tissue was examined by immunohistochemistry for α-SMA, collagen types I, II, and III, and keratan sulfate. (molvis.org)
  • Chondroitin is involved in tissue repair. (mypetneedsthat.com)
  • Chrondroitin sulfate is an important glycosaminoglycan that plays a role in tissue repair by promoting the faster growth of cells. (mypetneedsthat.com)
  • Indoxyl sulfate and p-cresyl sulfate could possibly be viewed as candidate biomarkers of your human microbiome enterotype and may perhaps help to DNA Methyltransferase Purity & Documentation explain the link involving eating plan and cardiovascular disease burden. (bcrablinhibitor.com)