• however, many target multiple kinase receptors in addition to AXL. (wikipedia.org)
  • Steve's research interests focus on mechanisms of platelet activation by tyrosine kinase-linked receptors (notably CLEC-2, FcgammaRIIA, GPVI and PEAR1) and in developing novel antiplatelet agents that target these receptors in thrombi-inflammatory disease. (birmingham.ac.uk)
  • Steve's undertakes a multi- and inter-disciplinary to investigate the molecular mechanisms underlying platelet activation by tyrosine kinase linked glycoprotein receptors. (birmingham.ac.uk)
  • This transactivation could be triggered by multiple G-protein coupled receptors (GPCRs), cytokine receptors, integrins and other tyrosine kinase receptors (TKRs) [13-15]. (exposed-skin-care.net)
  • ErbB4, also called Her4 (human epidermal growth factor receptor 4), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. (rndsystems.com)
  • First identified during PCR-based cloning of a human neuroblastoma cell line in search of tyrosine kinases similar to tropomyosin-receptor-kinase (Trk) neurotropic receptors, ROR1, along with the related receptor tyrosine kinase (RTK) ROR2, was catalogued as an "orphan" receptor due to the fact its related ligand remained elusive. (peprotech.com)
  • DDR1, also known as CAK, CD167a, RTK6, and TrkE, is a 120-140 kDa type I transmembrane glycoprotein that belongs to the discoidin-like domain containing subfamily of receptor tyrosine kinases and serve as receptors for collagen. (rndsystems.com)
  • 2.?The EGFR System EGFR, also called ErbB1/HER1, is a 170 kDa transmembrane glycoprotein that defines a family group of tyrosine kinase. (exposed-skin-care.net)
  • This ~145 kDa type I transmembrane glycoprotein is encoded by Kit (KIT proto-oncogene receptor tyrosine kinase) which belongs to the receptor tyrosine kinase family (RTK) within the immunoglobulin superfamily (IgSF). (bdbiosciences.com)
  • CD4 (T4) is a single chain transmembrane glycoprotein and belongs to immunoglobulin supergene family. (exbio.cz)
  • In lots of tumor cells these inter-receptor communications have already been from the resistance to tyrosine kinase inhibitors [18]. (exposed-skin-care.net)
  • 8. Chen Y, Fu L. Mechanisms of acquired resistance to tyrosine kinase inhibitors. (innovareacademics.in)
  • Targeted drugs such as thyrosine kinase inhibitors and cyclin-dependent kinase inhibitors are widely used in cancer patients. (researchsquare.com)
  • It has been reported that long-term acid suppression by PPIs reduces the antitumor efficacy of pazopanib and capecitabine, while this effect of PPIs has not been found in clinical outcomes on patients treated with epidermal growth factor receptor (EGFR) thyrosine kinase inhibitors [6-8]. (researchsquare.com)
  • Ribociclib and palbociclib are oral cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors that arrest the cell cycle by inhibiting DNA synthesis inhibition[9]. (researchsquare.com)
  • Glycans are chains of sugars mounted on proteins (glycoproteins and proteoglycans) or lipids (glycolipids). (scienceexhibitions.org)
  • Among the range of proteins shown to co-localize to WPB is angiopoietin-2 (Angpt-2), a ligand of the receptor tyrosine kinase Tie-2. (imperial.ac.uk)
  • A proteomics approach revealed that several proteins in the endoplasmic reticulum, the site of N -glycoprotein synthesis, are down-regulated upon apratoxin A exposure. (aspetjournals.org)
  • The present invention relates to antigen-binding proteins, or antigen-binding fragments thereof that bind to a glycan on the AXL receptor tyrosine kinase. (justia.com)
  • The present invention also relates to antigen-binding proteins, or antigen-binding fragment conjugated to a radioisotope or cytotoxin, and wherein said antigen-binding proteins, or antigen-binding fragment is internalised into a cell upon binding to AXL receptor tyrosine kinase. (justia.com)
  • The enhanced mobile build up and activation of HIF- proteins subunit which may be induced through the stimulation of different receptor tyrosine kinases (RTKs) in cancer cells under normoxic and hypoxic conditions are also illustrated. (mycareerpeer.com)
  • Ephrin type-A receptor 2 (EphA2) is a member of the tyrosine receptor kinases, a family of membrane proteins recognized as potential anticancer targets. (ijbs.com)
  • Lectins are proteins or glycoproteins that bind specifically and reversibly to the carbohydrate or glycoconjugates. (bvsalud.org)
  • Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. (wikipedia.org)
  • The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. (wikipedia.org)
  • AXL receptor tyrosine kinase belongs to the TAM subfamily of receptor tyrosine kinases (RTKs) and overexpression has been detected in various cancers. (justia.com)
  • Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. (wikipedia.org)
  • The AXL protein is characterized by an extracellular structure consisting of two fibronectin type 3-like repeats and two immunoglobulin-like repeats along with its intracellular tyrosine kinase domain. (wikipedia.org)
  • ROR1 is expressed as a glycoprotein containing extracellular immunoglobulin (Ig)-like, Frizzled, and Kringle domains, as well as an intracellular region containing a tyrosine kinase domain. (peprotech.com)
  • The antibody MEM-241 recognizes an extracellular epitope of CD4 antigen, a 55 kDa transmebrane glycoprotein expressed on a subset of T lymphocytes ("helper" T-cells) and also on monocytes, tissue macrophages and granulocytes. (exbio.cz)
  • It signals through the receptor tyrosine kinase Tie-2 and binds a variety of integrins and the extracellular matrix. (bio-techne.com)
  • Furthermore, GPCR-ligands [15,18] and cytokines such as for example growth hormones (GH) and prolactin (PRL) [19] have the ability to phosphorylate the EGFR in the lack of EGFR-ligand shedding upon the activation of Src and Janus tyrosine kinase 1 (Jak1), respectively. (exposed-skin-care.net)
  • Apratoxin A inhibits Janus kinase (JAK)/STAT signaling through rapid down-regulation of interleukin 6 signal transducer (gp130). (aspetjournals.org)
  • Canonical Notch signaling activates the transcription of BMI1 proto‑oncogene polycomb ring finger, cyclin D1, CD44, cyclin dependent kinase inhibitor 1A, hes family bHLH transcription factor 1, hes related family bHLH transcription factor with YRPW motif 1, MYC, NOTCH3, RE1 silencing transcription factor and transcription factor 7 in a cellular context‑dependent manner, while non‑canonical Notch signaling activates NF‑κB and Rac family small GTPase 1. (spandidos-publications.com)
  • Particularly, the stimulation of RTKs may Sofalcone lead to the sustained activation of phosphatidylinositol 3-kinase (PI3K)/Akt/molecular target of rapamycin (mTOR) pathway that in turn may induce the translational machinery and HIF protein synthesis and/or enhanced stabilization of HIF- subunit. (mycareerpeer.com)
  • DLL-4, in turn, instigated neighbouring platelets to switch to 'activated' phenotype through cleavage of Notch receptor and release of its intracellular domain (NICD), which was averted by inhibition of γ-secretase and phosphatidylinositol-3-kinase (PI3K). (elifesciences.org)
  • The intracellular domain of CD4 is associated with p56Lck, a Src-like protein tyrosine kinase. (exbio.cz)
  • Key drug efflux transporters operational in preserving the BBB are the P-glycoprotein (Pgp) transporter, which belongs to the ATP-binding cassette (ABC) transporter family, and the breast cancer resistance protein (BCRP) ABCG2 ( 4 , 5 ). (jcancer.org)
  • SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. (nih.gov)
  • Another isoform lacks the phosphoinositide 3-kinase activation sequence present in the ErbB4 cytoplasmic domain. (rndsystems.com)
  • However, these drugs have little effect on brain metastasis due to the combined effects of poor penetration of the blood-brain barrier and their removal from the central nervous system (CNS) by the p-glycoprotein (Pgp) drug efflux pump. (jcancer.org)
  • At the end of the fourth week, mRNA expressions of drug efflux transporters (P-glycoprotein and breast cancer resistance protein [BCRP] and MRP2 [multidrug resistance-associated protein-2]) were examined. (innovareacademics.in)
  • There were increased mRNA expressions of P-glycoprotein, BCRP, and MRP2 after four weeks of treatment with sorafenib, while treatment with quercetin decreased the drug efflux transporters expressions. (innovareacademics.in)
  • We suggest that decreased expressions of both drug efflux transporters, P-glycoprotein and BCRP, mediated by quercetin ameliorate the efficacy of sorafenib in TNBC. (innovareacademics.in)
  • PeproTech's Recombinant Human ROR1 is a glycoprotein containing 377 amino acid residues, and has a calculated molecular weight of approximately 42.4 kDa. (peprotech.com)
  • Little is known about molecular mecha- desmosomal glycoproteins, resulting in the nisms affecting mast cell and T lympho- loss of keratinocyte cell-cell adhesion [ 1 ]. (who.int)
  • carbamazepine decreases levels of nintedanib by P-glycoprotein (MDR1) efflux transporter. (medscape.com)
  • erdafitinib will increase the level or effect of nintedanib by P-glycoprotein (MDR1) efflux transporter. (medscape.com)
  • erythromycin lactobionate increases levels of nintedanib by P-glycoprotein (MDR1) efflux transporter. (medscape.com)
  • primidone decreases levels of nintedanib by P-glycoprotein (MDR1) efflux transporter. (medscape.com)
  • IL-16 (binds to CD4 domain 3), human seminal plasma glycoprotein gp17 (binds to CD4 domain 1), L-selectin. (exbio.cz)
  • Metabolic regulation of UDP-GlcNAc supply to Golgi N-glycan remodeling regulates glycoprotein affinities for galectins -and in turn, trafficking and presentation at the cell surface. (gr.jp)
  • Our biosensor permits analysis of human serum without conventional time-consuming IgG purification steps or pretreatment using enzyme digestion to cut the sugars from the glycoprotein molecule. (bvsalud.org)
  • Tested against a panel of 96 kinases, TAK-285 showed specificity for inhibition of HER family kinases. (jcancer.org)
  • Glycans could be seen as a a structural evaluation of glycans released from glycoproteins or by an evaluation of glycopeptides from proteolysed Gps navigation (Novotny & Alley Jr 2013 However these methods need chemical substance or enzymatic alteration of the glycoconjugate molecule and therefore can cause lack of some information regarding the framework or a binding site of glycan. (scienceexhibitions.org)
  • In one aspect, there is provided an antigen-binding protein, or an antigen-binding fragment thereof that competes with the antigen binding protein as defined herein for binding to AXL receptor tyrosine kinase. (justia.com)
  • Collagen binding also results in the proteolytic cleavage of a tyrosine phosphorylated 60 kDa C-terminal fragment (CTF), and a 60 kDa ECD fragment. (rndsystems.com)
  • It is a glycoprotein responsible for cell signaling AZD8330 but its function in cell processes or tumorigenesis has not been fully clarified yet (Raff sources were found to be of a complex type lacking polylactosamine structures. (scienceexhibitions.org)
  • IL9 antibody Intro P-glycoprotein (P-gp) is definitely a 170 kDa ATP-dependent transmembrane protein belonging to the ATP binding cassette (ABC) superfamily which promotes the outward transport of a wide spectrum of structurally unrelated compounds from numerous cell types [1]. (bioxorio.com)
  • AXL is a cell surface receptor tyrosine kinase, part of the TAM family of kinases including TYRO3 and MERTK. (wikipedia.org)
  • Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated, surface protein predominantly expressed during embryogenesis, where it is involved in organ morphogenesis, nervous system development, and neural progenitor cell maintenance and survival. (peprotech.com)
  • The galectin lattice is a multi-valent interaction of galectins with glycoproteins at the cell surface that displays rapid exchange of binding partners with properties of liquid-liquid phase transitions, thereby acting as an intermediary between freely diffusing glycoproteins and stable complexes in the membrane. (gr.jp)
  • Here, we show that plexin-B family members stably associate with the receptor tyrosine kinase ErbB-2. (rupress.org)
  • Several myelin-associated factors that inhibit axon growth of mature neurons, including Nogo66, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp), can associate with a common GPI-linked protein Nogo-66 receptor (NgR). (johnshopkins.edu)
  • BACKGROUND: The von Willebrand factor (VWF) is a multimeric plasma glycoprotein essential for hemostasis, inflammation, and angiogenesis. (imperial.ac.uk)
  • Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)
  • We have previously shown that excretory-secretory product-62 (ES-62), a homologue of phosphorylcholine-containing molecules that are secreted by human parasites and which is active in rodent models of filarial infection, is able to polyclonally activate certain protein tyrosine kinase and mitogen-activating protein kinase signal transduction elements in B lymphocytes. (eurekamag.com)
  • Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
  • It is a metal ion-independent glycoprotein of 1.87% carbohydrate content, stable upto 40 °C and pH from 5.5 to 9. (bvsalud.org)
  • Streptavidin gold nanoparticles (GNP) were conjugated to biotinylated lectin bonded to the carbohydrate in the glycoprotein to magnify the change in impedance signal and enhance detection sensitivity. (bvsalud.org)
  • CD4 is primary receptor for HIV-1 surface glycoprotein gp120). (exbio.cz)
  • Lectin-based strategies enable evaluation of intact glycoproteins as well as intact practical cells and therefore RGS3 lectin-based glycoprofiling strategies is definitely an option to instrumental evaluation. (scienceexhibitions.org)
  • Apratoxin A also depletes cancer cells of several cancer-associated receptor tyrosine kinases by preventing their N -glycosylation, leading to their rapid proteasomal degradation. (aspetjournals.org)
  • Two additional kinase deficient splice forms are expressed in colon cancer. (rndsystems.com)