IIIaPlateletsTransmembrane glycoproteinFibrinProteinsReceptorsFibronectinHumansWillebrandAntibodiesCoagulation factorCongenital fibrinogenEndothelial cellsDeficiencyAcute phase reCD54FactorAbnormalAdhesionCollagenBindDefectInflammatoryMetabolismPartial throPercutaneousCoronaryPlasmaInflammationQuantitativeActivationHumanClinicalInsightsResultsComponent
IIIa16
- Platelet Glycoprotein GPIIb-IIIa Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- This graph shows the total number of publications written about "Platelet Glycoprotein GPIIb-IIIa Complex" by people in Harvard Catalyst Profiles by year, and whether "Platelet Glycoprotein GPIIb-IIIa Complex" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Platelet Glycoprotein GPIIb-IIIa Complex" by people in Profiles. (harvard.edu)
- Exploratory Use of Glycoprotein IIb/IIIa Inhibition in Prevention of Blalock-Taussig Shunt Thrombosis. (harvard.edu)
- Glycoprotein IIb/IIIa receptor antagonists block a receptor on the platelet for fibrinogen and von Willebrand factor. (wikidoc.org)
- Aspirin, glycoprotein (GP) IIb/IIIa inhibitors, and clopidogrel have an inhibitory effect on platelet activation and aggregation. (medscape.com)
- Platelet membrane glycoprotein IIb-IIIa forms a calcium-dependent heterodimer and constitutes the fibrinogen receptor on stimulated platelets. (rupress.org)
- The platelet integrin αIIbβ3, also known as the glycoprotein GPIIb/IIIa (CD41/CD61) complex, is essential for normal platelet function. (medscape.com)
- Disintegrins contain an RGD (Arg-Gly-Asp) or KGD (Lys-Gly-Asp) sequence motif that binds specifically to integrin IIb-IIIa receptors on the platelet surface, thereby blocking the binding of fibrinogen to the receptor-glycoprotein complex of activated platelets. (embl.de)
- Whatever the initial stimulus, the final common event is a cross-linking of platelets by binding of fibrinogen to a membrane-binding site, glycoprotein IIb/IIIa (GPIIb/IIIa). (justia.com)
- This active metabolite selectively inhibits adenosine diphosphate (ADP) binding to its platelet P2Y12 receptor and subsequently the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. (itopmeds.com)
- The active metabolite of clopidogrel prevents binding of adenosine diphosphate (ADP) to its platelet receptor, impairing the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (itopmeds.com)
- As the glycoprotein GPIIb/IIIa complex is the major receptor for fibrinogen, its impaired activation prevents fibrinogen binding to platelets and inhibits platelet aggregation. (itopmeds.com)
- Clopidogrel selectively inhibits adenosine diphosphate (ADP) binding to platelet receptors and subsequent ADP-mediated activation of glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. (medscape.com)
- With provisional use of glycoprotein IIb/IIIa inhibitor (GP IIb/IIIa inhibitor), bivalirudin is indicated for use as an anticoagulant in patients undergoing PCI. (medscape.com)
- Soon thereafter, platelet aggregation occurs, whereby additional platelets are recruited from the bloodstream and aggregate via adenosine diphosphate (ADP) and thromboxane A2 and bind to each other by binding to fibrinogen using GP IIb-IIIa, thus forming a fibrin-platelet plug. (medscape.com)
Platelets6
- This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. (wikipedia.org)
- Integrin alpha 2b (ITGA2b), also known as CD41 and GPIIb, is a transmembrane glycoprotein that is expressed by megakaryocytes and platelets. (rndsystems.com)
- Glanzmann thrombasthenia (GT) is a rare platelet disorder in which the platelets have qualitative or quantitative deficiencies of the fibrinogen receptor αIIbβ3. (medscape.com)
- Download Citation on ResearchGate \textbar Arachidonate induced fibrinogen binding to thrombin degranulated platelets is independent of released ADP \textbar When human or rabbit platelets are stimulated with ADP, fibrinogen (Fbg) binding sites are revealed, the platelets bind Fbg and aggregate. (mcmaster.ca)
- A very rare disorder in which a person's platelets do not have enough of the receptor (glycoprotein Tb/TX) needed to bind von Willebrand factor. (curegt.org)
- Platelets then adhere to vWF via glycoprotein Ib. (medscape.com)
Transmembrane glycoprotein4
- CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin αx and CR4. (biolegend.com)
- CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin α X and CR4. (biolegend.com)
- TF is a transmembrane glycoprotein receptor found in extravascular tissues, including organ capsules and the adventitia of blood vessel walls. (merckvetmanual.com)
- Human CD41 is a member of a major platelet transmembrane glycoprotein complex (CD41/CD61) which mediates platelet aggregation and adhesion by serving as the receptor for fibrinogen and von Willebrand factor, fibronectin and vitronectin. (ancell.com)
Fibrin5
- Dysfibrinogenemias involve structural defects in fibrinogen that alter the conversion of fibrinogen to fibrin. (medscape.com)
- Fibrinogen is activated to fibrin by the newly activated thrombin. (medscape.com)
- Plasmin lyses clots by breaking down the fibrinogen and fibrin contained in a clot. (medscape.com)
- It functions as a bridge between Fibrinogen and Fibrin, enabling Fibrin attachment to the platelet cell surface via Integrin alpha 2 beta 3. (rndsystems.com)
- Fibrinogen is proteolytically cleaved to form fibrin, producing a firm clot. (merckvetmanual.com)
Proteins1
- Serum amyloid A and alpha-1 acid glycoprotein are transport proteins, and fibrinogen is a coagulation factor. (msdmanuals.com)
Receptors1
- A large family of glycoproteins mediates cell adhesion by binding to cellular receptors. (elsevierpure.com)
Fibronectin2
- Integrin alpha 2b associates with Integrin beta 3 to form complexes that interact with Fibrinogen, von Willebrand factor, Fibronectin, and Vitronectin. (rndsystems.com)
- To illustrate this concept, conformational alterations of thrombospondin, fibrinogen and fibronectin are shown to modulate their adhesive potential. (elsevierpure.com)
Humans1
- Histidine-rich glycoprotein (HRG) is a glycoprotein that in humans is encoded by the HRG gene. (wikipedia.org)
Willebrand1
- [ 4 ] With platelet activation, the αIIbβ3 complex shifts into its active configuration, which allows the binding of fibrinogen and/or von Willebrand factor (vWF). (medscape.com)
Antibodies1
- lupus anticoagulant is negative, and beta 2 glycoprotein and cardiolipin antibodies are normal. (medpagetoday.com)
Coagulation factor1
- Afibrinogenemia is defined as a deficiency or absence of fibrinogen (coagulation factor I) in the blood. (medscape.com)
Congenital fibrinogen6
- The true prevalence of congenital fibrinogen disorders is unknown. (medscape.com)
- The 2011 launch of the clinical trial to investigate the use of our high-purity human fibrinogen concentrate in congenital fibrinogen deficiency was the start of a clinical development programme in a very rare disease. (octapharma.com)
- This approval extends the original 2017 marketing authorisation for Octapharma's high-purity human fibrinogen concentrate for use in congenital fibrinogen deficiency. (octapharma.com)
- Reduced or dysfunctional fibrinogen occurs in various congenital fibrinogen-related disorders. (octapharma.com)
- However, unlike in congenital fibrinogen deficiencies, AFD arises due to consumption of fibrinogen after excessive blood loss. (octapharma.com)
- After Octapharma's high-purity human fibrinogen concentrate obtained regulatory approval in the USA, Canada and the EU in 2017 for the treatment of very rare congenital fibrinogen deficiencies (with further approval obtained in Switzerland in 2018 for both acquired and congenital fibrinogen deficiencies), clinical initiatives continued with FORMA-05, the first new clinical study in AFD. (octapharma.com)
Endothelial cells2
- Fibrinogen is a ligand for Intercellular Adhesion Molecule-1 (ICAM-1), and enhances monocyte-endothelial cell interaction by coupling Mac-1 on monocytes to ICAM-1 on endothelial cells. (amsterdamumc.org)
- Incubation of TNF alpha-stimulated endothelial cells with fibrinogen resulted in binding of fibrinogen to ICAM-1 on these cell projections. (amsterdamumc.org)
Deficiency3
- Acquired fibrinogen deficiency can be associated with several clinical conditions including excessive blood loss in the setting of surgery, trauma or postpartum hemorrhage, hemodilution from from massive transfusion, liver disease, increased consumption in the setting of cancer, DIC or tPA therapy, or assay interference with direct or other thrombin inhibitors. (medscape.com)
- Today, scientific progress allows us to produce high-purity human fibrinogen concentrate to treat acquired fibrinogen deficiency (AFD). (octapharma.com)
- But it also became an early step in one of the most audacious clinical programmes which Octapharma has conducted, targeting acquired fibrinogen deficiency (AFD). (octapharma.com)
Acute phase re1
- Plasma fibrinogen is an acute phase reactant with known inflammatory mechanism, but it also affects platelet aggregation and blood viscosity (3, 4). (hvt-journal.com)
CD542
- CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b. (biolegend.com)
- Interacts with fibrinogen, CD54, and iC3b. (biolegend.com)
Factor3
- This glycoprotein acts as a coagulating factor and helps wounds heal faster. (diethealthclub.com)
- Fibrinogen, also known as factor I, is a naturally occurring blood plasma glycoprotein. (octapharma.com)
- Previous studies showed that fibrinogen-to-albumin ratio (FAR) regarded as a novel inflammatory and thrombotic biomarker was the risk factor for coronary artery disease (CAD). (hindawi.com)
Abnormal1
- Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. (wikipedia.org)
Adhesion1
- Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. (harvard.edu)
Collagen1
- Collagen has been proposed to bind to a unique epitope in dimeric glycoprotein VI (GPVI) and the number of GPVI dimers has been reported to increase upon platelet activation. (nih.gov)
Bind1
- Further fibrinogen has been reported to bind to monomeric but not dimeric GPVI. (nih.gov)
Defect1
- A defect in either glycoprotein can lead to a bleeding disorder. (medscape.com)
Inflammatory1
- 3 Offered along with inflammatory parameters calprotectin, α1-acid glycoprotein, CRP, fibrinogen and SAA, 1 it supports testing for a comprehensive disease-state picture. (siemens-healthineers.com)
Metabolism1
- Moreover, protein metabolism appeared to be extremely sensitive to a mild stress since leucine kinetics and fibrinogen synthesis were affected. (portlandpress.com)
Partial thro2
- Pertinent laboratory results on ICU admission included leukocytosis, thrombocytopenia, an elevated prothrombin time and partial thromboplastin time, and elevated levels of fibrinogen and D-dimer. (medscape.com)
- Lactate dehydrogenase level was 698 IU/L (reference range 211-423 IU/L) and d -dimer was 3,414 μg/L (reference range 68-494 IU/L). Fibrinogen levels, prothrombin time, and partial thromboplastin time were normal. (cdc.gov)
Percutaneous1
- The current study demonstrates that higher baseline and post procedural fibrinogen, is an independent predictor of 6 months major adverse cardiac and cerebrovascular events after elective percutaneous coronary intervention. (hvt-journal.com)
Coronary1
- This study was undertaken to study the predictive significance of periprocedural plasma fibrinogen levels for coronary stenting outcomes. (hvt-journal.com)
Plasma1
- HRG is a glycoprotein of 70-75kDa present at a relatively high concentration in the plasma of vertebrates. (wikipedia.org)
Inflammation1
- Increased fibrinogen levels are the main reason the erythrocyte sedimentation rate (ESR) is elevated in acute inflammation. (msdmanuals.com)
Quantitative1
- Fibrinogen disorders can be quantitative (afibrinogenemia) or qualitative (dysfibrinogenemia), and they may be congenital or acquired. (medscape.com)
Activation1
- Activation of protein kinase C with 12-O-tetradecanoyl phorbol-13-acetate resulted in simultaneous loss of both stress fibers and fibrinogen binding. (amsterdamumc.org)
Human6
- The ambitious goal of this programme was to show that our high-purity human fibrinogen concentrate is at least as effective as cryoprecipitate for AFD - and is a more practical and reliable alternative to it. (octapharma.com)
- Eight years on, and after the detailed design, planning and conduct of clinical trials by a dedicated Octapharma team, our high-purity human fibrinogen concentrate has now been approved for use in AFD in 15 countries of the EU. (octapharma.com)
- Members of the dedicated Octapharma human fibrinogen concentrate team. (octapharma.com)
- The FORMA-05 clinical study was a prospective, randomised, single-blind, controlled, non-inferiority study which compared the efficacy of Octapharma's high-purity human fibrinogen concentrate to that of cryoprecipitate during cytoreductive surgery to treat pseudomyxoma peritonei, a rare cancer that usually starts in the appendix. (octapharma.com)
- In 2017, Octapharma started discussing another study using Octapharma's high-purity human fibrinogen concentrate in cardiac surgery with a group of Canadian physicians led by Dr Keyvan Karkouti in Toronto. (octapharma.com)
- We investigated the role of the cytoskeleton in fibrinogen binding to the human endothelial cell line EA.hy 926 using immunofluorescence techniques. (amsterdamumc.org)
Clinical1
- Recently, numerous studies have shown that the fibrinogen-to-albumin ratio (FAR) does not only have a high prognostic value in certain types of cancer including gastric, colorectal, and gallbladder cancer [ 8 - 10 ] but also have an association with the presence and poor clinical outcome of cardiovascular disease [ 11 - 14 ]. (hindawi.com)
Insights1
- New insights into the functions of histidine-rich glycoprotein. (wikipedia.org)
Results1
- These results suggest that a connection between ICAM-1 and the cytoskeleton results in clustering of ICAM-1 on cell projections, which is required for fibrinogen binding. (amsterdamumc.org)
Component1
- Fibulin 1 is a matricellular glycoprotein component of the elastic fiber core in connective tissues. (rndsystems.com)