Glycoprotein expression of extracellular matrix components fibronectin and laminin. Medical search. Frequent questions

citation needed] The basement membrane that separates the epidermis from the dermal layer and the endothelial basement membrane mainly contains collagen IV that forms a sheet and binds to other extracellular matrix molecules like laminin and proteoglycans. (wikipedia.org)
In addition to collagen IV, the epidermal and endothelial basement membrane also contains laminin, perlecan and nidogen. (wikipedia.org)
It constitutes fibrous proteins such as collagen and elastin, elongated glycoproteins such as fibronectin and laminin, which provide cell matrix adhesion. (biomedcentral.com)
One particular distinguishing feature is in the expression of genes encoding extracellular matrix components, perhaps best illustrated by the extensive family of collagen genes (SI Appendix, Fig. S6A). (ack1inhibitor.com)
The collagen and laminin of basement mb, and the adhesive glycoprotein of the ECM like fibronectin and laminin hold the cells via integrins in the cell mb. (medicinembbs.org)
Migration and proliferation of parenchymal and connective tissue cellsBasement membrane crucial to wound healing: collagen in the bm binds to cells via proteins like integrins, fibronectin and laminin. (medicinembbs.org)
Collagen-I (Col) and hyaluronic acid (HA) are two of the most important extracellular matrix (ECM) components. (bvsalud.org)
While collagen serves as the main structural feature of the ECM and is an important ligand for integrin-based adhesions, HA acts as a ligand for the transmembrane glycoprotein CD44. (bvsalud.org)
Contrary to reef building corals, the red coral organic matrix possesses a large number of collagen-like proteins. (biomedcentral.com)
Several molecules are involved in the process of cell adhesion to bone grafts, highlighting the role of integrins, the focal adhesion mechanism, the influence of the collagen matrix, and the activity of alkaline phosphatase in bone matrix formation. (bvsalud.org)
To occur the adhesion of CAMs to the biomaterial, it is necessary their interaction with some components of extracellular matrix, such as proteoglycans, collagen and proteins 23 . (bvsalud.org)
In DNA microarray results, compared to control, CaG treated mouse group showed upregulation of 192 genes including collagen,typeI,alpha1 (Col1a1), consistent with the highly increased in vitro extracellular matrix (ECM) adhesion on collagen 1 and up-regulation of heparanase (Hpse). (biomedcentral.com)

For example, sortase-dependent pili from the PRL2010 strain have been shown to bind epithelial Caco-2 cells and the extracellular matrix (ECM) proteins fibronectin and laminin [15], while type IVb tight adherence (Tad) pili have been proven to be essential for UCC2003 colonization of the murine gut [16, 17]. (citiesofdata.org)

This growth factor also stimulates production of collagens, proteoglycans, elastin, fibronectin, tenascin and thrombospondin, diminishes production of extracellularly active neutral endoproteinases belonging to the matrix metalloproteinase (MMP) and serine proteinase families, and stimulates production of endogenous MMP inhibitors (tissue inhibitor of metallo-proteinase [TIMP]) and serpins (plasminogen activator inhibitor-1). (biomedcentral.com)
A nanoscale modular design strategy was employed to synthesize six engineered, recombinant proteins intended to mimic aspects of the extracellular matrix proteins fibronectin, laminin, and elastin as well as the cell-cell adhesive protein neural cell adhesion molecule. (frontiersin.org)

No colocalisation of mast cells was found with fibronectin or vitronectin. (bmj.com)

however, in the corneal stroma, excessive infiltration of monocytes/macrophages is considered to be unfavorable because they secrete matrix metalloproteinases (MMPs) and other proteins undesirable for tissue healing. (medscape.com)
Tissue inhibitors of matrix metallo-proteinases (TIMPs) are known to have the ability to inhibit the catalytic activity of MMPs. (biomedcentral.com)
Turpeenniemi-Hujanen et al suggested that the expressions of matrix expression of MMPs as well as their tissue inhibitors the TIMPs are associated with the clinical behaviour in head and neck malignancy [ 12 ]. (biomedcentral.com)
However, during injury, the equilibrium between production and degradation of fibrous tissue is disrupted leading to excessive deposition of extracellular matrix proteins resulting in fibrosis. (pancreapedia.org)
Characterization of TSP-4 expression under development and pathogenesis of disorders has yielded important insights into mechanisms underlying the unique role of TSP-4 in mediating various processes including cell-cell, cell-extracellular matrix interactions, cell migration, proliferation, tissue remodeling, angiogenesis, and synaptogenesis. (bvsalud.org)
In addition to connective tissue and ECM components, proteinase inhibitors such as α1-proteinase inhibitor, antithrombin-III and α2-macroglobulin are selectively cleaved by MMPs. (periobasics.com)
Fibrosis is characterised by an excessive production of extracellular matrix components, and cells in the tissue are constantly interacting with these extracellular matrix proteins. (bmj.com)
Notwithstanding, to achieve the effectiveness and integration of the grafted tissue to the receptor site, it is necessary a strong cell adhesion, so that it demands many molecules interaction to induce cell differentiation and the bone matrix mineralization formed onto the graft. (bvsalud.org)
stimulate extracellular matrix synthesis and have been implicated in embryogenesis, wound healing, and fibroproliferative responses to tissue injury. (eurekamag.com)
We confirmed that TGF-.beta.1 increases the expression of fibronectin, an adhesive glycoprotein expression during embryogenesis and tissue remodeling. (eurekamag.com)
Quantitative comparisons of adhesive molecule on extracellular matrix and activities of tissue inhibitor of metalloprotease 2 (TIMP-2) were also investigated. (biomedcentral.com)
Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
The IHC tests showed that the ECM of the mice testicular interstitial tissue showed reaction to anti-laminin-α5 antibody. (biomedres.info)
High concentration of sodium nitrate did not change the laminin α5 expression in the ECM of the testicular interstitial tissue. (biomedres.info)
Extracellular matrix (ECM) is a dynamic tissue that contributes to organ integrity and function, and its regulation of cell phenotype is a major aspect of cell biology. (atsjournals.org)
Synthetic peptides or recombinant fragments containing bio- logically active motifs have been shown to partially mimic the effects of native laminin in various cellular functions, such as cell adhesion, spreading, migration, neurite outgrowth, and tumor metastasis [6-10], suggesting that laminin-derived-short peptide- modified biomaterials may have therapeutic potential in tissue regeneration applications. (mirnamimic.com)
The tissue model thereby mimics structure and function of human soft tissue with endothelial cell-coated larger vessels for perfusion and micro-vessel networks within the hydrogel-matrix. (regenhu.com)

citation needed] Through the interaction of a cell with its extracellular matrix (transmitted through the anchoring molecules classed as integrins) there forms a continuous association between the cell interior, cell membrane and its extracellular matrix components that helps drive various cellular events in a regulated fashion. (wikipedia.org)
Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. (embl.de)
The multidomain, pentameric structure of TSP-4 allows its interactions with numerous extracellular matrix components, proteins and signaling molecules that enable its modulation to various physiological and pathological processes. (bvsalud.org)
These cell adhesion molecules (CAM) will mediate the contact between two cells or between cells and the extracellular matrix, an essential process to the success of the implant. (bvsalud.org)
The main reported mechanisms involve cell adhesion molecules (CAMs) and extracellular matrix components. (bvsalud.org)
Some of these molecules are glycoproteins expressed on the cell surface, socalled cell adhesion molecules (CAM), which mediate either the contact between two cells or the contact among cells and the extracellular matrix, being therefore of fundamental importance for adhesion 3 . (bvsalud.org)

It is influenced by angiogenesis, cell-cell and cell-extra cellular matrix (ECM) interactions. (biomedcentral.com)
Mammalian epithelia are critically dependent on interactions with components in the underlying basal lamina for proper morphogenesis and function. (embl.de)
SPARC (secreted protein,acidic and rich in cysteine) is a matricellular glycoprotein that regulates cell-cell and cell-matrix interactions, cellular proliferation and differentiation, and the expression of genes encoding extracellular matrix components. (silverchair.com)
SPARC, which is also termed osteonectin or BM-40, belongs to the matricellular class of secreted glycoproteins (thrombospondins 1 and 2,osteopontin, tenascins C and X) that function as modulators of cell-cell and cell-matrix interactions. (silverchair.com)
Integrin-mediated interactions with the extracellular matrix (ECM) are required for the attachment, cytoskeletal organization, mechanosensing, migration, proliferation, differentiation and survival of cells in the context of a multitude of biological processes including fertilization, implantation and embryonic development, immune response, bone resorption and platelet aggregation. (thno.org)
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. (affbiotech.cn)

Functional analyses indicated that some of the genes induced by dragonfly larvae caused an increase in laminins necessary for cell adhesion in the extracellular matrix. (biomedcentral.com)
Overall strength of adhesion is thought to be mediated by a combinatorial mechanism, involving adhesion of a cell to a variety of binding sites on the target glycoproteins. (silverchair.com)
In experiments probing for a role of PKCa in human laminin-2-integrin-mediated cell adhesion and spreading of PC12 cells, we observed unexpected enhancements of adhesion, spreading and stress fiber formation to 1 mM Go¨6976 with concomitant increase in membrane translocation of PKCd and autophosphorylation of focal adhesion kinase (FAK). (mirnamimic.com)
Go¨6976 also induced laminin-dependent cell adhesion in NIH/3T3 and CV-1 fibroblasts, suggesting of a mechanism that may be common to multiple cell-types. (mirnamimic.com)
A specific inhibitor of PKCd, rottlerin, completely abrogated Go¨6976-dependent increase in PC12 cell adhesion to laminin as well as the activation of small GTPases, Rac1 and Cdc42, that are downstream of PKCd in adhesion receptor signaling. (mirnamimic.com)
Biological activities of laminin are mediated through binding to a subset of integrin family of cell adhesion receptors, a3b1, a6b1, a6b4, and a7b1 [2]. (mirnamimic.com)

The main function of metalloproteinases is to degrade extracellular matrix and basement membrane components. (medscape.com)
Some cytokines act as competence rather than progression factors, some lack secretory signals, and some must be processed and released from the pericellular matrix or basement membranes (eg transforming growth factor beta [TGF-β ] binding to chondroitin or the keratan sulfate of biglycan, decorin and fibromodulin, or basic fibroblast growth factor and platelet derived growth factor binding to the heparin sulfate of glypican, perlecan and syndecan). (biomedcentral.com)
The lens capsule, which is also called the lens basement membrane, is a specialized extracellular matrix produced anteriorly by the lens epithelium and posteriorly by newly differentiated fiber cells. (silverchair.com)
These results underscore the importance of the capsular extracellular matrix in the maintenance of lens transparency and indicate that SPARC participates in the synthesis, assembly and/or stabilization of the lens basement membrane. (silverchair.com)
Laminins are multifunctional basement membrane glycoproteins composed of a, b, and g polypeptide chains. (mirnamimic.com)

Dermal skin is primarily a combination of fibroblasts growing in this matrix. (wikipedia.org)
Fibronectin is the major glycoprotein secreted by fibroblasts during initial synthesis of extracellular matrix proteins. (wikipedia.org)

We observed as much as 6-fold increases in fibronectin synthesis by 24 h as previously reported for fibroblastic cells (Ignotz, R. A., and Massague, J. (1986) J. Biol. (eurekamag.com)
Using a monospecific antibody raised to the human placental fibronectin receptor complex, we found that TGF-.beta.1 stimulated fibronectin receptor synthesis up to 20-40-fold and increase mRNA levels encoding both the .alpha. (eurekamag.com)
mediated increases in fibronectin receptor complex protein synthesis and mRNA levels occur at 8 h, whereas the earliest increases in fibronectin protein synthesis and mRNA levels occur at 12 h. (eurekamag.com)
These results demonstrate that TGF-.beta.1 stimulates fibronectin receptor synthesis, extending the diverse stimulatory activities of this polypeptide to matrix receptors. (eurekamag.com)

the tadpoles showed reduced expression of cα(E)-catenin , small muscle protein, dystrophin , and myosin light chain genes. (biomedcentral.com)
As confirmation that ligand density in these engineered systems impacts neuronal cell behavior, we demonstrate that increasing the density of fibronectin-derived RGD ligands on coated surfaces while maintaining uniform protein surface coverage results in enhanced neurite extension of PC-12 cells. (frontiersin.org)
In order to gain insight into the red coral biomineralization process and cnidarian biomineralization evolution, we studied the protein repertoire forming the organic matrix (OM) of its two biominerals. (biomedcentral.com)
Moreover, myelin-associated proteins, such as myelin basic protein (MBP), myelin proteolipid protein (PLP), and myelin oligodendrocyte glycoprotein (MOG), serve as antigens to induce an adaptive autoimmune response in MS patients [ 22 , 23 ]. (encyclopedia.pub)
Laminin 411 markedly induced the expression of the genes Foxa2 and Sox17 , markers for pancreatic precursor cells, efficiently induced IPC differentiation from MSCs, and up-regulated insulin expression at both mRNA and protein levels. (biomedcentral.com)
Pikachurin is a recently identified, highly conserved, extracellular matrix (ECM) like protein with a molecular weight around 110 kDa and high mRNA abundance in retina. (diff.org)
The gene encodes a 1017 amino acids protein which contains a N-terminal signal sequence, two fibronectin 3 (FN3), three laminin G and two EGF -like domains. (diff.org)
described pikachurin, an extracellular matrix-like retinal protein, and demonstrated his essential role for photoreceptor ribbon synapse formation, apposition of bipolar dendrite and synaptic signal transmission. (diff.org)
Cytotactin, an extracellular matrix protein of neural and non-neural tissues that mediates glia-neuron interaction. (academicinfluence.com)

Reductive amination dramatically improved the peptide grafting efficiency, with yields of 50 % vs. 20 %, allowing 1.5 to 3-fold higher incorporation of cell-adhesive and matrix-metalloproteinases (MMP)-sensitive peptides, respectively. (bvsalud.org)
In addition, because fibronectin matrix assembly may assembly may involve the fibronectin cell adhesive receptor complex, increased receptor expression may help drive deposition into matrix. (eurekamag.com)

The alphaM subunit of integrin Mac-1 contains several distinct regions in its extracellular segment. (embl.de)
Extracellular factors that influence integrin activation are ligand binding, divalent cation concentration, chemokine signaling and mechanical stress. (thno.org)
Integrin ligation via cell-to-cell and cell-to-matrix contacts transduces intracellular signaling events in a process called 'outside-in' signaling (Fig. 2 ). (thno.org)
In PC12 cells, we recently showed that the engagement of integrin a3b1 to a binding sequence within the human laminin a2 chain was sufficient to recruit PKCa and PKCd to the integrin receptor [6]. (mirnamimic.com)

The TGF-β family forms an important group of growth factors, consisting of three isoforms in man, and is important for matrix deposition because it modulates fibroblast recruitment and proliferation. (biomedcentral.com)
WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)

Degradation of matrix is a key event in progression, invasion and metastasis of potentially malignant and malignant lesions of the head and neck. (biomedcentral.com)
Some cancer cells form highly regulated structures, termed invadopodia, which mediate local, enzymatic degradation of extracellular matrix and facilitate cancer cell invasion and migration during metastatic progression. (bvsalud.org)
In addition, we extended our base model to account for matrix sensing and degradation, crucial aspects of angiogenesis. (ibecbarcelona.eu)

Thrombospondin-4 (TSP-4) belongs to the extracellular matrix glycoprotein family of thrombospondins (TSPs). (bvsalud.org)

Their localisation in relation to extracellular matrix components was shown by immunohistochemical double labelling. (bmj.com)
This study aims to investigate the effects of oral administration of sodium nitrite on expression of laminin α5 in extracellular matrix of mice testicular interestitium using an Immunohistochemical (IHC) assessment. (biomedres.info)

Matrix metalloproteinases (MMPs) are a group of structurally related endopeptidases that require a metal cofactor. (medscape.com)
Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix (ECM) substrates. (biomedcentral.com)
The matrix metalloproteinases (MMPs) are a family of structurally and functionally related endoproteinases that are collectively capable of degrading most of the components of the extracellular matrix (ECM) 1, 2 . (periobasics.com)
The generic structure of matrix metalloproteinases (MMPs). (periobasics.com)
Another type of MMPs are called as the MT-MMPs (Membrane Type Matrix Metalloproteinases) that are localized to the cell surface. (periobasics.com)
It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). (affbiotech.cn)

Although still not fully understood, an acidic microenvironment with an inverted pH gradient of extracellular pH (pH e ) lower than intracellular pH (pH i ) appears to impose selective pressures whereby tumor cells must adapt or die [ 10 , 11 ]. (biomedcentral.com)
Such biological functions depend on their lectinic properties (recognition of N-acetyllactosamine sequences displayed on the cell surface, in the extracellular matrix, or intracellular glycoconjugates) ( Table 1 ). (encyclopedia.pub)

Our results demonstrate that laminin 411 acts as a potent differentiation inducer of IPCs from UC-MSCs via the Pdx1 and Ngn3 signaling pathways. (biomedcentral.com)

The higher expression of gremlin 1 and HIF1a genes after exposure to dragonfly larvae indicated an in vivo hypoxic reaction, while down-regulation of syndecan-2 may indicate impairment of angiogenesis. (biomedcentral.com)

The elevated glucose consumption-coupled with increased excretion of lactate and protons from glycolytic cells to the poorly perfused extracellular spaces-leads to an acidification of the tumor microenvironment [ 7 , 8 ]. (biomedcentral.com)
A gelatin-methacrylate/fibrin-based matrix containing multiple cell types mimics the tumor-microenvironment that promotes spontaneous micro-vessel formation by embedded endothelial cells. (regenhu.com)

citation needed] Extra cellular matrix (or "ECM") is the external structural framework that cells attach to in multicellular organisms. (wikipedia.org)
The process is activated, though perhaps not exclusively, by cells responding to fragments of damaged ECM, and the repairs are made by reassembling the matrix by cells growing on and through it. (wikipedia.org)
Epithelial cells adjacent to the area of the defect flatten, lose their hemidesmosome attachments, and migrate on transient focal contact zones that are formed between cytoplasmic actin filaments and extracellular matrix proteins. (medscape.com)
The expression patterns of two genes only expressed in ESCd >40 and ESCd >70 cells (GABRP and VTCN1), one gene expressed strongly in PHTd cells (PSG4), and a fourth (KRT7) expressed more generally in trophoblast were confirmed by quantitative PCR (qPCR) (SI Appendix, Fig. S8). (ack1inhibitor.com)
Representative PDAC cells were exposed to various biologically relevant periods of extracellular acidity. (biomedcentral.com)
Our study offers a novel mechanism of early rapid response and late reversible adaptation of PDAC cells to the stress of extracellular acidosis. (biomedcentral.com)
Cells are known to bind to individual extracellular matrix glycoproteins in a complex and poorly understood way. (silverchair.com)
The expression of biomarkers can be detected intracellularly or on the cell membrane of melanoma cells or noncancer cells in association with the melanoma. (hindawi.com)
The aim of this study was to investigate whether mast cells accumulate in these tissues and whether their localisation is associated with extracellular matrix components. (bmj.com)
All mast cells in the muscularis propria were colocalised with patches of laminin. (bmj.com)
In contrast, in the submucosa, laminin was exclusively found in the basal lamina of blood vessels where many adherent mast cells were seen. (bmj.com)
The colocalisation with laminin indicates a mechanism of interaction between smooth muscle cells and mast cells that may be important in the role of mast cells in the process of fibrosis. (bmj.com)
Because cells communicate with several extracellular matrix components via specific cell membrane receptors, we hypothesized that TGFs-.beta. (eurekamag.com)
Hence, altering expression of CS and heparan sulfate (HS) on surface of tumor cells is a potential molecular strategy to prevent malignant transformation and tumor metastasis [ 2 ]. (biomedcentral.com)
This study presents an in-silico model replicating a microfluidic assay where endothelial cells sprout into a biomimetic extracellular matrix, specifically, a large-pore, low-concentration fibrin-based porous hydrogel, influenced by chemotactic factors. (ibecbarcelona.eu)
Expression is repressed in neuroblastoma cells. (affbiotech.cn)
The resultant matrices can be sectioned as uniform slices within which cells were cultured. (atsjournals.org)
By using human lungs and cells, this new system provides a novel way to culture cells in vitro to investigate matrix contributions to lung pathology in a disease-specific manner. (atsjournals.org)
Importantly, enhanced cellular behavior and membrane translocation of PKCd induced by Go¨6976 was retained in siRNA-transfected PC12 cells to knockdown PKCa expression. (mirnamimic.com)
siRNA knockdown of Rac1 and Cdc42 expression inhibited cell spreading and lamellipodia formation in PC12 cells. (mirnamimic.com)

may also regulate the expression of such receptors. (eurekamag.com)

The structural organization of all MMPs presents a prepeptide sequence that directs their secretion in the extracellular environment and a propeptide domain that maintains them in their zymogenic form. (periobasics.com)

Matrix metalloproteinase are a family of zinc dependent endopeptidases that are capable of degrading most components of the extra cellular matrix (ECM) [ 7 - 9 ]. (biomedcentral.com)
Extracellular matrix is important in driving cellular phenotypic responses in fibrotic and other lung disorders. (atsjournals.org)

Quantitative PCR Confirmation of Expression of Selected Genes. (ack1inhibitor.com)
Similarly the dominant presence of transcripts for CYP11A1 and CYP19A1, which encode P450 side chain cleavage enzyme and aromatase, respectively, confirms the potential of both types of syncytial cell to synthesize sex steroids from cholesterol (SI Appendix, Fig. S5B).Expression of Genes Encoding Extracellular Matrix Components Distinguish ESCd >70 from STB Generated from PHTd. (ack1inhibitor.com)
ELAV - like1 , methyltransferase like 7A , dolichyl-phosphate mannosyltransferase , laminin subunit beta-1 , gremlin 1 , BCL6 corepressor-like 1 , and three genes of unknown identity. (biomedcentral.com)
A further 80 genes showed greater than 5 fold differences in expression after exposure to dragonfly larvae and 81 genes showed altered expression after exposure to larval salamanders. (biomedcentral.com)
Predation-threat responsive genes were identified by selecting genes that reverted to control levels of expression following removal of the predator. (biomedcentral.com)
Furthermore, the expression of the genes known to govern insulin expression including Pdx1 and Ngn3 was markedly induced by laminin 411, which suggests that Pdx 1 and Ngn 3 signaling pathways are involved in laminin 411 induced-insulin expression machinery. (biomedcentral.com)

MMP-2 and MMP-9 (also known as gelatinases based on their substrate preference) contain fibronectin-like domain repeats which aid in substrate binding. (periobasics.com)

We examine how transdifferentiation protocols are evolving to ever more faithfully recapitulate normal developmental biology using increasingly sophisticated biomimetic techniques and ectopic transcription factor expression. (silverchair.com)

Biofunctionalization of polysaccharides is a widely used strategy for obtaining extracellular matrix (ECM)-mimicking biomaterials. (bvsalud.org)

however, little is known about a role of laminin 411 in the regulation of IPC differentiation from human MSCs. (biomedcentral.com)
UC-MSCs were then cultured in the IPC induction and differentiation medium in the presence of laminin 411. (biomedcentral.com)
in this manner we show that fibrotic matrices clearly promote transforming growth factor-β-independent myofibroblast differentiation compared with normal matrices. (atsjournals.org)

Collagenases degrade triple-helical fibrillar collagens, which are the main components of bone and cartilage. (periobasics.com)
Stromelysins [MMP-3, MMP-10, MMP-11, and MMP-7 (also known as matrilysins)] are small proteases that degrade components of the ECM, although not the triple-helical fibrillar collagens. (periobasics.com)

The differences in gene expression profiles induced by the two predators suggest that there are functional differences between the altered tail tissues of the two groups of tadpoles. (biomedcentral.com)
In vivo anti-cancer effect of dung beetle GAG on solid tumor size, survival time and gene-expression profiles was also assayed using B10F10 melanoma mice model. (biomedcentral.com)
Here, we find that persistent mtDNA stress is not associated with basally activated NF-κB signalling or interferon gene expression typical of an acute antiviral response. (regenerativemedicine.net)

MMPs are able to degrade practically all ECM components and can be classified according to their substrate specificity as collagenases, gelatinases, stromelysins, and matrilysins 6 (Figure 10.2). (periobasics.com)

Complement C3a receptor 1 is the receptor for complement factor C3a, a component of the alternative complement cascade. (guidetomalariapharmacology.org)

Due to the expression of neural markers, PSCs were initially thought to be of neuroectodermal origin. (pancreapedia.org)

demonstrated that a certain steric structure formed by the second and the third laminin globular domains is necessary for the pikachurin-dystroglycan interaction. (diff.org)

The inferred regulatory function of these OM proteins suggests that the difference between the two biominerals is due to the modeling of the matrix network, rather than the presence of specific structural components. (biomedcentral.com)

Flow cytometry, Quantitative realtime PCR, immunofluorescence staining, ELISA, Western blotting and other techniques were applied to determine IPC generation, insulin expression and related mechanisms. (biomedcentral.com)

Degeneration of matrix is a key event in invasion and metastasis of malignant lesions of the head and neck. (biomedcentral.com)

These increases are accompanied by similar increases in fibronectin mRNA levels which are prevented by actinomycin D treatment. (eurekamag.com)

Anatomy22

Organisms5

Diseases3

Chemicals and Drugs74

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes24

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

Collagen12

Proteins fibronectin and laminin1

Elastin2

Vitronectin1

Tissue17

Molecules6

Interactions6

Adhesion6

Basement5

Fibroblasts2

Synthesis4

Protein9

Adhesive2

Integrin4

Proliferation2

Degradation3

Thrombospondin1

Immunohistochemical2

Metalloproteinases6

Intracellular2

Inducer1

Syndecan1

Tumor microenvironment2

Cells20

Receptors1

Secretion1

Cellular2

Genes6

Repeats1

Biomimetic1

Biomaterials1

Differentiation3

Collagens2

Gene expression3

Degrade1

Receptor1

Neural1

Interaction1

Structural1

Quantitative1

Metastasis1

MRNA1