The protein encoded by this gene serves as a receptor for thrombospondin in platelets and various cell lines, and is the fourth major glycoprotein of the platelet surface. (thermofisher.com)
CD14 is a 53-55 kD glycosylphosphatidylinositol (GPI)-linked membrane glycoprotein that is also known as the LPS receptor. (biolegend.com)
ACKR1 is the approved gene symbol for DARC, the Duffy Antigen Receptor for Chemokines. (snpedia.com)
Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
The most active T cell endogenous inhibitory pathway is the immunoglobulin superfamily such as CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4): B7-1/B7-2 receptor/ligand grouping, which plays a central role in coordinating immune responses [ 7 , 8 ]. (hindawi.com)
1989) demonstrated that the lymphocyte homing receptor is identical to the human leukocyte surface glycoprotein called CDw44, on the basis of studies at the Third International Workshop on Human Leukocyte Differentiation Antigens. (wdv.com)
the lymphocyte homing receptor' 'also appears to be identical'' to the Pgp-1 glycoprotein of Omary et al. (wdv.com)
CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. (biolegend.com)
CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. (exbio.cz)
Multifunctional glycoprotein that acts as receptor for a broad range of ligands. (creative-biolabs.com)
Mature M cells use the receptor glycoprotein 2 (GP2) to aid in transcytosis. (bvsalud.org)
Antibodies10
Both the TRA-1-60 and TRA-1-81 monoclonal antibodies (MAB4381) recognize antigens that are associated with a pericellular matrix proteoglycan. (sigmaaldrich.com)
Monoclonal antibodies against a glycoprotein presumably involved in adhesion of aggregating Dictyostelium discoideum cells have been used for labeling of the antigen at the cell surface. (uni-regensburg.de)
Another antigen strongly reacting with the same monoclonal antibodies has an apparent molecular weight of 106 000 and is not detectable before slugs are formed. (uni-regensburg.de)
1983) showed that the antigens defined by monoclonal antibodies A3D8 and A1G3 are determined by genes on 11p. (wdv.com)
Dengue Duo Panel is a qualitative immunochromatographic assay for the rapid detection of Dengue NS1 antigens and anti-dengue IgG/IgM antibodies in human blood, serum, and plasma specimens simultaneously. (rapidtest.com)
The detection of both NS1 antigen and anti-Dengue antibodies provides the tool for the diagnosis of dengue infection from the early infection to the stage after the onset of the illness. (rapidtest.com)
As the test sample flows through the membrane within the test device, the colored-Dengue specific recombinant antigen-colloidal gold conjugate complexes with specific antibodies (IgM and/or IgG) of Dengue virus if present in the sample. (rapidtest.com)
The solution has identified and patented B cell epitopes of filovirus glycoprotein and has validated the ability of synthetic epitopes and their antibodies to capture host specific IgG responses in survivor serum and recombinant GP, respectively. (who.int)
In addition, the licensed screening tests, which use HTLV-I antigens, vary in their sensitivity to detect antibodies to HTLV-II (4,5). (cdc.gov)
Membrane8
Disposition of T200 glycoprotein in the plasma membrane of a murine lymphoma cell line. (wikidata.org)
Isolation and sequencing of a cDNA clone encoding lysosomal membrane glycoprotein mouse LAMP-1. (bdbiosciences.com)
Sawada R, Lowe JB, Fukuda M. E-selectin-dependent adhesion efficiency of colonic carcinoma cells is increased by genetic manipulation of their cell surface lysosomal membrane glycoprotein-1 expression levels. (bdbiosciences.com)
CD45 is a 180-240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. (biolegend.com)
Glycoprotein antigens on the extracellular surface of the RBC membrane determine an individual's blood group. (cap.org)
Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)
Cluster6
CD34 derives its name from the cluster of differentiation protocol that identifies cell surface antigens. (wikipedia.org)
Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. (peprotech.com)
ACKR1 encodes for the Duffy blood group antigen, also called Fy glycoprotein (FY) or CD234 (Cluster of Differentiation 234). (snpedia.com)
Magnetic Luminex Assay Kit for Cluster Of Differentiation 36 (CD36) ,etc. (uscnk.com)
Cluster of differentiation 1 (CD1) is a family of cell-surface glycoproteins that present lipid antigens to T cells. (korea.ac.kr)
CD1d is a member of the CD1 (cluster of differentiation 1) group of glycoproteins on the surface of human antigen-presenting cells. (msdmanuals.com)
CD361
Diseases associated with CD36 include Platelet Glycoprotein IV Deficiency and Coronary Heart Disease 7. (thermofisher.com)
Lipid3
CD1c is involved in the presentation of lipid antigens such as microbial fatty acids to effector T cells during the adaptive immune response. (fishersci.com)
There are three modes by which the T-cell receptors of CD1a-restricted T cells interact with the CD1a:lipid complex: they bind to both the CD1a surface and the antigen or to only CD1a itself, which activates the T cell, or they are unable to bind because of bulky motifs protruding from the antigen-binding groove, which might inhibit autoreactive T-cell activation. (korea.ac.kr)
Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid antigens. (msdmanuals.com)
Monocytes2
CD14 is a 55 kDa GPI-anchored glycoprotein that is constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils. (thermofisher.com)
Description: The 61D3 monoclonal antibody reacts with human CD14, a 53-55 kDa GPI-linked glycoprotein. (thermofisher.com)
Leukocyte surface2
Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1. (wikidata.org)
1989)' 'demonstrated' 'sameness' 'the human leukocyte surface glycoprotein' 'is called' 'CDw44' 'studies' 'were conducted at' 'the Third International Workshop on Human Leukocyte Differentiation Antigens. (wdv.com)
Receptors2
Ly6C high MC presented downregulated co-stimulatory receptors (CD2, GITR, and TIM1) which direct immune cell proliferation, and upregulated co-stimulatory ligands (LIGHT and SEMA4A) which trigger antigen priming and differentiation. (frontiersin.org)
In contrast to CTLs, NK cells lack receptors for antigen detection but can still recognize normal cells infected with viruses and cancer cells. (msdmanuals.com)
Transmembrane3
Herein, we report a potential leukocyte differentiation antigen gene VSTM1 ( V-set and transmembrane domain-containing 1 ) that was downregulated in bone marrow cells from leukemia patients and exhibited a higher degree of promoter methylation. (biomedcentral.com)
VSTM1 ( V-set and transmembrane domain-containing 1 ) encodes a potential leukocyte differentiation antigen that is highly expressed in myeloid cells, but silenced in multiple leukemia cell lines [ 1 ]. (biomedcentral.com)
CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). (exbio.cz)
Recognize antigens1
Cytotoxic T lymphocytes (CTLs) recognize antigens on target cells and lyse these cells. (msdmanuals.com)
Surface13
Cell surface molecules of Friend erythroleukemias: decrease in T200 glycoprotein expression after induction. (wikidata.org)
as a cell surface glycoprotein and functions as a cell-cell adhesion factor. (wikipedia.org)
This antibody reacts with TRA-1-60 antigen that is expressed upon the surface of human tetracarcinoma stem cells (EC), human embryonic germ cells (EG) and human embryonic stem cells (ES). (sigmaaldrich.com)
The antigen is distributed over the whole surface of the cells, apparently in form of small clusters. (uni-regensburg.de)
Identification and characterization of LAMP-1 as an activation-dependent platelet surface glycoprotein. (bdbiosciences.com)
Murine MC are divided into three subsets based on surface expression of lymphocyte antigen 6 complex, locus C (Ly6C) ( 3 , 4 ). (frontiersin.org)
CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. (biolegend.com)
CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. (exbio.cz)
Results We identified 696 MM cell surface N -glycoproteins by CSC, and developed 73 targeted MS detection assays. (bmj.com)
1 2 Cell surface antigens CD38 and CD138 can be used to distinguish normal cells from clonal plasma cells, but more extensive use of immunophenotyping has been limited by a lack of universally accepted markers of MM. 3-5 Once diagnosed, the current standard-of-care for MM includes immunomodulatory drugs, proteasome inhibitors, steroids, and antibody therapies. (bmj.com)
Tumor Antigens Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)
These antigens may be cell surface proteins or may be intracellular proteins (eg, TAAs) that are expressed on the surface in combination with class I major histocompatibility complex (MHC) molecules. (msdmanuals.com)
The epidermis is derived primarily from surface ectoderm but is colonized by pigment-containing melanocytes of neural crest origin, antigen-processing Langerhans cells of bone marrow origin, and pressure-sensing Merkel cells of neural crest origin. (medscape.com)
Leukocyte differentiation antigens often represent important markers for the diagnosis, classification, prognosis, and therapeutic targeting of myeloid leukemia. (biomedcentral.com)
Therefore, VSTM1-v1 might represent an important myeloid leukocyte differentiation antigen and provide a potential target for the diagnosis and treatment of leukemia. (biomedcentral.com)
Molecule3
This study aims to explore molecule signaling mediating MC subset differentiation in HHcy and control mice. (frontiersin.org)
CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. (biolegend.com)
Any molecule capable of being recognized by the immune system is considered an antigen. (msdmanuals.com)
Macrophages1
Glycoproteins with a wide distribution on hematopoietic and non-hematopoietic cells and strongly expressed on MACROPHAGES. (bvsalud.org)
Lymphocyte3
Identification with a monoclonal antibody of a predominantly B lymphocyte-specific determinant of the human leukocyte common antigen. (wikidata.org)
Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. (peprotech.com)
Finally, we established 3 groups of transcriptional models to describe Ly6C high to Ly6C low MC subset differentiation, immune checkpoint regulation, Ly6C high MC to MΦ subset differentiation and Ly6C low MC to lymphocyte functional adaptation. (frontiersin.org)
Cellular Differentiation1
It is implicated in regulation of cellular differentiation, growth and apoptosis. (exbio.cz)
Assay3
Dengue NS1 Antigen Test is a sandwich solid phase immunochromatographic assay. (rapidtest.com)
Enzyme-linked immunosorbent assay for Antigen Detection. (uscnk.com)
Magnetic Luminex Assay for Antigen Detection. (uscnk.com)
Thymocytes1
This L161 monoclonal antibody detects CD1c, a glycoprotein that is noncovalently linked to beta-2 microglobulin on thymocytes and antigen presenting cells such as dendritic and Langerhans cells. (fishersci.com)
T2001
Human homologue of murine T200 glycoprotein. (wikidata.org)
Cognate1
It is suggested that CD8 + T-lymphocytes remain in the brain and spinal cord as tissue resident cells, which may focally propagate neuroinflammation, when they re-encounter their cognate antigen. (frontiersin.org)
Cells8
The antigen appears concomitantly with the acquisition of EDTA-stable adhesiveness typical of aggregation competent cells. (uni-regensburg.de)
The 80 kilodalton glycoprotein typical of aggregation competent cells has been purified by affinity chromatography on a monoclonal antibody column. (uni-regensburg.de)
Differentiation of naïve CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-β1. (peprotech.com)
Due to the rarity of these cells in the intestine, their development and differentiation remain yet to be fully understood. (bvsalud.org)
BACKGROUND & AIMS: Microfold cells (M cells) are immunosurveillance epithelial cells located in the Peyer's patches (PPs) in the intestine and are responsible for monitoring and transcytosis of antigens, microorganisms, and pathogens. (bvsalud.org)
CD1a is distinguished by the small volume of its antigen-binding groove and its stunted A′ pocket, its high and exclusive expression on Langerhans cells, and its localization in the early endosomal and recycling intracellular trafficking compartments. (korea.ac.kr)
Key open questions in MS research are the identification of the target antigen recognized by tissue resident CD8 + T-cells and B-cells and the molecular nature of the soluble inflammatory mediators, which may trigger tissue damage. (frontiersin.org)
Hypersensitivity2
Hypersensitivity to tobacco glycoprotein in human peripheral vascular disease. (mcmaster.ca)
The earliest forms of hypersensitivity pneumonitis were related to farming and, each year, new antigens causing occupational disease are described. (cdc.gov)
One of these antigens, defined by monoclonal antibody TRA-1-60, can be detected in the serum of GCT patients and provides a useful complement to the established serum markers human chorionic gonadotropin and α-fetoprotein, especially in those patients without elevated serum human chorionic gonadotropin or α-fetoprotein. (sigmaaldrich.com)
World Health Organization differentiation markers and criteria for AMLs defined by differentiation. (medscape.com)
Gene3
Mutations in this gene cause platelet glycoprotein deficiency. (thermofisher.com)
In the promoter region of the ACKR1 gene, at rs2814778 , a variant exists that abolishes all Duffy antigen. (snpedia.com)
1983) used a murine monoclonal antibody (A3D8) to identify an erythrocyte antigen inhibited by the In(Lu) gene. (wdv.com)
Extracellular1
PeproTech's CHO cell-derived Recombinant Human sCD8α is a monomeric glycoprotein of 161 amino acid residues, which corresponds to the extracellular domain of CD8α. (peprotech.com)
Human2
After the anti-NS1 antibody elevate in human body, the detectable NS1 antigens decline quickly. (rapidtest.com)
This report describes generation of a recombinant Sudan virus and demonstrates its utility by quantifying antibody cross-reactivity between Ebola and Sudan virus glycoproteins after human infection or vaccination with a licensed Ebola virus vaccine. (cdc.gov)
Pathogens1
They are responsible for the uptake and transcytosis of microorganisms, pathogens, and other antigens in the gastrointestinal tract. (bvsalud.org)
Tumors1
Our data demonstrated that fucosylated PSA has a better predictive power to differentiate aggressive tumors from non-aggressive tumors, than that of native PSA and two other glycoproteins. (nih.gov)