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  • phenotype
  • In this study, we found that CD44, a cell surface marker for cancer stem cells, interacts with pyruvate kinase M2 (PKM2) and thereby enhances the glycolytic phenotype of cancer cells that are either deficient in p53 or exposed to hypoxia. (aacrjournals.org)
  • oxidation
  • Tight coupling of glucose uptake and oxidation and improved cardiac efficiency were associated with a reduction in glucose 6-phosphate and oleoyl-CoA levels, as well as a reduction in the content of uncoupling protein 3. (nih.gov)
  • Activity
  • Pugliese G, Tilton RG, Speedy A, Chang K, Province MA, Kilo C, Williamson JR (1990) Vascular filtration function in galactose-fed versus diabetic rats: the role of polyol pathway activity. (springer.com)
  • reduction
  • The common pathway in life-threatening acute anemia is a sudden reduction in the oxygen-carrying capacity of the blood. (medscape.com)
  • activation
  • In M(LPS) macrophages, LPS engages TLR4 to trigger a signaling pathway that culminates in the activation of transcription factors such as NF-κB and IRFs. (frontiersin.org)
  • cell
  • Understanding of the different signalling pathways and transcriptional patterns which characterize particular immune cell subsets led to the identification of novel targets for the improved monitoring and treatment of transplanted patients. (lww.com)
  • The glycolytic pathway breaks down energy-containing glucose to pyruvate, in the process extracting chemical energy in the form of the molecule ATP to power the cell. (utsouthwestern.edu)