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  • Biology
  • A study in The Journal of Cell Biology reveals how damaged cells normally switch off glycolysis as they shut down and shows that defects in this process may contribute to the early stages of tumor development. (eurekalert.org)
  • cells
  • Glycolysis is a universal pathway in the living cells. (springer.com)
  • Pérez-Rodríguez J, Sánchez-Jiménez F, Márquez FJ, Medina MA, Quesada AR, Núñez de Castro I (1987) Malate-citrate cycle during glycolysis and glutaminolysis in Ehrlich ascites tumor cells. (springer.com)
  • Without oxygen, glycolysis allows cells to make small amounts of ATP. (novapublishers.com)
  • In 2005, Hiroshi Kondoh and colleagues found that cells normally limit glycolysis as they enter senescence and that increasing the levels of the glycolytic enzyme PGAM can prevent cells from exiting the cell cycle. (eurekalert.org)
  • Working at Kyoto University in Japan, Kondoh and colleagues followed up on their previous work and found that, in response to DNA damage or oncogene expression, PGAM was degraded, thereby inhibiting glycolysis as the cells entered senescence. (eurekalert.org)
  • These studies have led to the hypothesis that increased consumption of glucose in metastatic lesions is not used for substantial energy production via Embden-Meyerhoff glycolysis, but rather for production of acid, which gives the cancer cells a competitive advantage for invasion. (springer.com)
  • organisms
  • In the tissues of many organisms, including mammals, glycolysis is a prelude to the complex metabolic machinery that ultimately converts pyruvic acid to carbon dioxide and water with the concomitant production of much ATP and the consumption of oxygen. (thefreedictionary.com)
  • produces
  • The next step in glycolysis, catalyzed by fructose biphosphate aldolase, produces two products: glyceraldehyde 3-phosphate, which continues in the glycolysis pathway, and dihydroxyacetone phosphate, which is converted to glyceraldehyde 3-phosphate by triose phosphate isomerase. (wyzant.com)