• The oligosaccharide chains of glycoprotein and glycolipid are often terminated by sialic acids, which play intensely important role in regulating physiologically and pathologically interactions with ligands [ 9 ]. (biomedcentral.com)
  • 2011). We report the successful modification with Leg5Ac7Ac of a glycolipid, GM1a, and two glycoproteins, interferon-α2b and α1-antitrypsin, by means of two mammalian sialyltransferases, namely porcine ST3Gal1 and human ST6Gal1. (canada.ca)
  • They catalyze the transfer of N-ACETYLNEURAMINIC ACID from CMP-N-ACETYLNEURAMINIC ACID to an acceptor, which is usually the terminal sugar residue of an oligosaccharide, a glycoprotein, or a glycolipid. (bvsalud.org)
  • While these differences greatly reduce the susceptibility of Leg compounds to sialidases, several sialyltransferases have been identified that can use CMP-Leg5Ac7Ac as a donor (Watson et al. (canada.ca)
  • The ternary complex of ST8SiaIII with a donor sugar analog and a sulfated glycan acceptor identified with a sialyltransferase glycan array provides insight into the residues involved in substrate binding, specificity and sialyl transfer. (rcsb.org)
  • β-galactoside α-2,3-sialyltransferase 1 (ST3GAL-1), which catalyzes the addition of sialic acid in an α-2,3 linkage to Gal β1,3 GalNAc, preforms important role in modulating cellular behavior. (biomedcentral.com)
  • The previous application was concerned with elucidating the structures of these complex glycolipids and assessing biological activities. (grantome.com)
  • 11. Selectin ligands and tumor-associated carbohydrate structures: specificities of alpha 2,3-sialyltransferases in the assembly of 3'-sialyl-6-sialyl/sulfo Lewis a and x, 3'-sialyl-6'-sulfo Lewis x, and 3'-sialyl-6-sialyl/sulfo blood group T-hapten. (nih.gov)
  • 4. Analysis of the specificity of sialyltransferases toward mucin core 2, globo, and related structures. (nih.gov)
  • 6. Probing the CMP-Sialic Acid Donor Specificity of Two Human β-d-Galactoside Sialyltransferases (ST3Gal I and ST6Gal I) Selectively Acting on O- and N-Glycosylproteins. (nih.gov)
  • 7. Specificity of porcine liver gal beta (1 leads to 3)galnac-r alpha(2 leads to 3) sialyltransferase sialylation of mucin-type acceptors and ganglioside GM1 in vitro. (nih.gov)
  • 6. The presence of another sialyltransferase with differing substrate specificity was noted. (nih.gov)
  • Comparison with several glycolipid substrates showed high specificity of G(M3)-synthase for lactosylceramide. (elsevierpure.com)
  • 14. A novel viral alpha2,3-sialyltransferase (v-ST3Gal I): transfer of sialic acid to fucosylated acceptors. (nih.gov)
  • 11. The evolution of galactose alpha2,3-sialyltransferase: Ciona intestinalis ST3GAL I/II and Takifugu rubripes ST3GAL II sialylate Galbeta1,3GalNAc structures on glycoproteins but not glycolipids. (nih.gov)
  • identification of the sialylation sequence and the effects of sulfate, fucose, methyl, and fluoro substituents of the carbohydrate chain in the biosynthesis of selectin and siglec ligands, and novel sialylation by cloned alpha2,3(O)sialyltransferase. (nih.gov)
  • 9. Reversible sialylation: synthesis of cytidine 5'-monophospho-N-acetylneuraminic acid from cytidine 5'-monophosphate with alpha2,3-sialyl O-glycan-, glycolipid-, and macromolecule-based donors yields diverse sialylated products. (nih.gov)
  • 10. Enzymatic basis for N-glycan sialylation: structure of rat α2,6-sialyltransferase (ST6GAL1) reveals conserved and unique features for glycan sialylation. (nih.gov)
  • Impact of sialyltransferase ST6GAL1 overexpression on different colon cancer cell types. (shengsci.com)
  • Glycolipid analysis confirmed a complete lack of GM3 ganglioside in patient fibroblasts, while microarray analysis of glycosyltransferase mRNAs detected modestly increased expression of ST3GAL5 and greater changes in transcripts encoding enzymes that lie downstream of ST3GAL5 and in other GSL biosynthetic pathways. (nih.gov)
  • 7. Overexpression of sialyltransferase CMP-sialic acid:Galbeta1,3GalNAc-R alpha6-Sialyltransferase is related to poor patient survival in human colorectal carcinomas. (nih.gov)
  • 8. Genetically altered mice with different sialyltransferase deficiencies show tissue-specific alterations in sialylation and sialic acid 9-O-acetylation. (nih.gov)
  • 1. Mammalian sialyltransferase ST3Gal-II: its exchange sialylation catalytic properties allow labeling of sialyl residues in mucin-type sialylated glycoproteins and specific gangliosides. (nih.gov)
  • 4. Characterization of cancer associated mucin type O-glycans using the exchange sialylation properties of mammalian sialyltransferase ST3Gal-II. (nih.gov)
  • Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. (nih.gov)
  • A transition (p.E332K) in the ST3GAL5 gene, which encodes for a sialyltransferase also known as GM3 synthase. (nih.gov)
  • CMP-N-acetylneuraminic acid:lactosylceramide (α2-3) sialyltransferase (G(M3)-synthase) was purified to homogeneity from a Triton CF-54 extract of young rat brain. (elsevierpure.com)
  • 14. Purification and enzymatic characterization of CMP-sialic acid: beta-galactosyl1----3-N-acetylgalactosaminide alpha 2----3-sialyltransferase from human placenta. (nih.gov)
  • They catalyze the transfer of N-ACETYLNEURAMINIC ACID from CMP-N-ACETYLNEURAMINIC ACID to an acceptor, which is usually the terminal sugar residue of an oligosaccharide, a glycoprotein, or a glycolipid. (bvsalud.org)
  • 8. Donor substrate specificities of Gal beta 1,4GlcNAc alpha 2,6-sialyltransferase and Gal beta 1,3GalNAc alpha 2,3-sialyltransferase: comparison of N-acetyl and N-glycolylneuraminic acids. (nih.gov)
  • 5. The alpha 2----3sialyltransferase characterized was found to be primarily specific for lactosylceramide though minor activity with other glycolipid acceptors was observed. (nih.gov)
  • The protein encoded by this gene is a member of the sialyltransferase family. (nih.gov)
  • 5. Genetic engineering of CHO cells producing human interferon-gamma by transfection of sialyltransferases. (nih.gov)
  • 13. MUC1 in human and murine mammary carcinoma cells decreases the expression of core 2 β1,6-N-acetylglucosaminyltransferase and β-galactoside α2,3-sialyltransferase. (nih.gov)
  • Oligosaccharides of the glycolipids and glycoproteins at the outer membranes of human cells carry terminal neuraminic acids, which are responsible for recognition events and adhesion of cells, bacteria, and virus particles. (sfb765.de)