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  • synthesis
  • This invention relates to glycolipids and, more specifically, to glycosphingolipids and the synthesis of glycosphingolipids in substantially pure stereochemical form. (google.com.au)
  • May facilitate the transport of diglucosyl-diacylglycerol (Glc2-DAG) from the inner to the outer leaflet of the cytoplasmic membrane, delivering Glc2-DAG as a substrate for LTA synthesis, thereby generating glycolipid-anchored LTA. (uniprot.org)
  • We present here the synthesis and analysis of vaccines based on conjugation of MHC-binding peptide epitopes to α-galactosylceramide, a glycolipid presented by the nonpolymorphic antigen-presenting molecule CD1d to provoke the stimulatory activity of type I natural killer T (NKT) cells. (rsc.org)
  • Nevertheless, these remarkable advances are being counteracted for striking effects on anti-tumor immunity exerted by particular molecular species of tumor-secreted glycolipids and, hence, strategies involving the use of glycolipid synthesis inhibitors are being considered. (frontiersin.org)
  • Inhibition
  • Inhibition of glycolipid shedding in L5178Y-R cells with d -1-phenyl-2-hexadecanoylamino-3-morpholino-1-propanol resulted in the rescue of CD1d1 recognition by canonical (but not noncanonical) NKT cells. (pnas.org)
  • GSLs
  • Marine glycolipids, as well as those from terrestrial organisms, are amphiphylic compounds which are currently divided into two main groups: glycoglycerolipids (GGLs) and glycosphingolipids (GSLs). (springer.com)
  • carbohydrate residues
  • Novel, optically active azido alcohols are synthesized from N-haloacetyl oxazolidinone and are coupled with protected, activated carbohydrate residues in stereoselective glycosidic fashion to provide glycolipids in substantially pure stereochemical form. (google.com.au)
  • peptides
  • In Torpedo and mammals, alternative exons encode H peptides, which contain a C-terminal signal for glypiation, i. e. cleavage and addition of a glycolipid (GPI) anchor. (springer.com)
  • modulation
  • The immunosuppressive function of glycolipids in vivo is thought to be related to direct inhibitory effects by means of the modulation of T lymphocyte signal transduction and effector cell differentiation or development ( 19 , 20 ). (pnas.org)
  • synthetic
  • The enantiomerically pure glycolipids were obtained after careful consideration of the synthetic sequence and by performing the coupling reactions in the absence of base. (mdpi.com)
  • Glycolipid mimetics [ 6 ], in particular synthetic derivatives of biologically relevant ceramides (such as galactosyl ceramides, shown in Figure 1 a), have attracted the attention of many carbohydrate chemists over recent years [ 7 ]. (mdpi.com)
  • NKT cells can also be activated in a CD1d-restricted manner by the synthetic glycolipid, α-galactosylceramide ( 1 ). (pnas.org)
  • sugar
  • 1. Sugar Sequences in Glycolipids and Glycoproteins Richard Kulzn (Heidelberg, Germany) reported on the isolation of a chromatographically pure glycoliposialoprotein (mucolipid A) which gave a uniform sedimentation pattern in the analytical ultracentrifuge and exhibited high acetylcholine esterase activity. (docme.ru)
  • A glycolipid contains a sugar group and a lipid group. (enotes.com)
  • Novel
  • Monohexoside Derivatives of Long-Chain Polyhydroxy Alcohols: a Novel Class of Glycolipid Specific to Heterocystous Algae. (springer.com)
  • class
  • The systematic name of this enzyme class is GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase. (wikipedia.org)
  • The systematic name of this enzyme class is dolichyl-phosphate-D-mannose:glycolipid alpha-D-mannosyltransferase. (wikipedia.org)
  • Rhamnolipids are a class of glycolipid produced by Pseudomonas aeruginosa, amongst other organisms, frequently cited as the best characterised of the bacterial surfactants. (wikipedia.org)