Glycogen binding enzymes. Medical search. Frequent questions

Since glycogen is a readily mobilized storage form of glucose, the extended glycogen polymer is branched by glycogen branching enzyme to provide glycogen breakdown enzymes, such as glycogen phosphorylase, with many terminal residues for rapid degradation. (wikipedia.org)
Of note, PLP also functions as a coenzyme for glycogen phosphorylase, an enzyme that catalyzes the release of glucose from stored glycogen. (oregonstate.edu)
Much of the PLP in the human body is found in muscle bound to glycogen phosphorylase. (oregonstate.edu)
Together with phosphorylase , glycogen debranching enzymes function in glycogen breakdown and glucose mobilization. (wikidoc.org)
When phosphorylase has digested a glycogen branch down to four glucose residues, it will not remove further residues. (wikidoc.org)
Glycogen debranching enzymes assist phosphorylase, the primary enzyme involved in glycogen breakdown , mobilize glycogen stores. (wikidoc.org)
Phosphorylase can only cleave α-1,4- glycosidic bond between adjacent glucose molecules in glycogen but branches exist as α-1,6 linkages. (wikidoc.org)
because 1 in 10 residues is branched, cleavage by phosphorylase alone would not be sufficient in mobilizing glycogen stores. (wikidoc.org)
Thus the debranching enzymes, transferase and α-1,6- glucosidase converts the branched glycogen structure into a linear one, paving the way for further cleavage by phosphorylase. (wikidoc.org)
Glucose binds to glycogen phosphorylase and competitively inhibits the enzyme. (cappartnersfund.com)
CP320626, a potential antidiabetic drug, inhibits glycogen phosphorylase in synergism with glucose. (ucy.ac.cy)
Glycogen phosphorylase (GP) is currently exploited as a target for inhibition of hepatic glycogenolysis under high glucose conditions. (ucy.ac.cy)
Structure based inhibitor design targeting glycogen phosphorylase b. (ucy.ac.cy)
Glycogen phosphorylase (GP) is a validated target for the development of new type 2 diabetes treatments. (ucy.ac.cy)
The extract showed good inhibition toward rat intestinal maltase and rabbit glycogen phosphorylase (GP) b, with IC 50 values of 45 and 7.4 μg/ml, respectively. (breakawaymatcha.com)

The activated glucosyl unit of UDP-glucose is then transferred to the hydroxyl group at the C-4 of a terminal residue of glycogen to form an α-1,4-glycosidic linkage, a reaction catalyzed by glycogen synthase. (wikipedia.org)
Importantly, glycogen synthase can only catalyze the synthesis of α-1,4-glycosidic linkages. (wikipedia.org)
Glycogen synthase kinase-3 (GSK-3) a magic enzyme: it's role in diabetes mellitus and glucose homeostasis, interactions with fluroquionlones. (scielo.br)
This disease is mainly regulated by various enzymes and hormones among which Glycogen synthase kinase-3 (GSK-3) is a principle enzyme and insulin is the key hormone regulating it. (scielo.br)
Therefore, it is the need of the day to properly understand functions and mechanisms of GSK-3, especially its role in glucose homeostasis via effects on glycogen synthase. (scielo.br)
In a previous report, we identified the role of glycogen synthase kinase-3β (GSK-3β) in NF-κB activation by regulating IKKγ/NEMO. (mdpi.com)
The action of antidiabetic plants of the Canadian James Bay Cree traditional pharmacopeia on key enzymes of hepatic glucose homeostasis ") report the antidiabetic action of seven Canadian plants as evidenced by glucose-6-phosphatase and glycogen synthase, two key enzymes, respectively, involved in gluconeogenesis and glycogenesis in hepatocytes. (hindawi.com)
In contrast, Larix laricina and A. balsamifera increased glycogen synthase activity. (hindawi.com)
It also stimulates glycogen synthesis by inhibiting glycogen synthase kinase 3 (GSK3) and activating glycogen synthase. (alliedacademies.org)
Furthermore, the calcium- and calcineurin-dependent TF CrzA binds to and regulates the expression of specific chitin synthase genes during the CPE. (bvsalud.org)
[2] These proteins bind with the Low-Density Lipoprotein-Related Protein (LRP), which, in turn, deactivates glycogen synthase kinase-3β (GSK-3β). (biotechpeptides.com)
This domain is also a member of the CBM48 (Carbohydrate Binding Module 48) family whose members include maltooligosyl trehalose synthase, starch branching enzyme, glycogen branching enzyme, glycogen debranching enzyme, isoamylase, and the beta subunit of AMP-activated protein kinase. (unl.edu)

Glycogen branching enzyme is an enzyme that adds branches to the growing glycogen molecule during the synthesis of glycogen, a storage form of glucose. (wikipedia.org)
More specifically, during glycogen synthesis, a glucose 1-phosphate molecule reacts with uridine triphosphate (UTP) to become UDP-glucose, an activated form of glucose. (wikipedia.org)
When activated, AMPK phosphorylates and inhibits enzymes involved in ATP-consuming processes, such as fatty acid synthesis (e.g., acetyl-CoA carboxylase, ACC) and protein synthesis (e.g., mammalian target of rapamycin, mTOR). (alliedacademies.org)
Definition, foods, and health effects of the Mediterranean Diet, Mediterranean Diet and greenhouse gas emissions, Structure, classification and functions of carbohydrates, Chemical structure and classification of starch, Glycogen synthesis pathway in the liver and muscle. (imingo.net)
a key enzyme for the synthesis of DHA and sapienic acid. (ocl-journal.org)

Shown by x-ray crystallography, glycogen branching enzyme has four marginally asymmetric units each that are organized into three domains: an amino-terminal domain, involved in determining the length of the chain transfer, a carboxyl-terminal domain, involved in substrate preference and catalytic capacity, and a central (α/β) barrel catalytic domain. (wikipedia.org)
In comparison to the other family members, glycogen binding enzyme has shorter loops, which result in a more open cavity, favorable to the binding of a bulkier substrate such as branched sugar. (wikipedia.org)
These residues are implicated in catalysis and substrate binding. (wikipedia.org)
PFK has two binding sites and inhibitor and substrate site. (flashcardmachine.com)
When the enzyme was applied to the other sugars, there was no absorbance at all because the enzyme is specific to one substrate thus it didnt catalyse the reaction of other sugars and GODPOD. (cappartnersfund.com)

This enzyme participates in starch and sucrose metabolism. (wikipedia.org)
Here we show that c-di-GMP also binds the glycogen-debranching-enzyme, GlgX, uncovering a direct link between c-di-GMP and glycogen metabolism in bacteria. (nih.gov)
Vitamin B 6 and its derivative pyridoxal 5'-phosphate (PLP) are essential to over 100 enzymes mostly involved in protein metabolism . (oregonstate.edu)
The many biochemical reactions catalyzed by PLP-dependent enzymes are involved in essential biological processes, such as hemoglobin and amino acid biosynthesis, as well as fatty acid metabolism . (oregonstate.edu)
Alpha-amylase is an essential enzyme in alpha-glucan metabolism, acting to catalyse the hydrolysis of alpha-1,4-glucosidic bonds of glycogen, starch and related polysaccharides. (embl.de)
They modulate energy metabolism through the deacetylation of various substrates, including transcription factors, metabolic enzymes, and histones. (alliedacademies.org)
Luis Leloir was born in the shadow of the Arc de Triomphe in Paris and went on to achieve greatness and crucial insights in sugar metabolism and glycogen biosynthesis. (novapublishers.com)
CBM20 is also present in proteins that have a regulatory role in starch metabolism in plants (e.g. alpha-amylase) or glycogen metabolism in mammals (e.g. laforin). (unl.edu)

[1] When glycogen breakdown is compromised by mutations in the glycogen debranching enzyme, metabolic diseases such as Glycogen storage disease type III can result. (wikidoc.org)

Libtayo (cemiplimab-rwlc) is a recombinant human IgG4 monoclonal antibody that inhibits programmed death-1 (PD-1) activity by binding to PD-1 and blocking the interactions with the ligands PD-L1 and PD-L2, releasing PD-1 pathway-mediated inhibition of immune response, including anti-tumor response. (geisinger.org)
Ranibizumab is a recombinant humanized monoclonal antibody fragment which binds to and inhibits human vascular endothelial growth factor A (VEGF-A). Ranibizumab inhibits VEGF from binding to its receptors and thereby suppressing neovascularization and slowing vision loss. (geisinger.org)

Disturbances in the action of GSK-3 enzyme may leads to various disease conditions that include insulin resistance leading to diabetes, neurological disease like Alzheimer's disease and cancer. (scielo.br)
Glycogen breakdown is highly regulated in the body, especially in the liver , by various hormones including insulin and glucagon , to maintain a homeostatic balance of blood-glucose levels. (wikidoc.org)
Curcumin modulates blood sugar and improves insulin receptor function by improving its binding capacity to sugar. (supervits.com)
It produces enzymes that are vital for digestion as well as insulin. (dogzone.com)
After the process of insulin release has been stimulated insulin binds to receptors on the surface of cells and this allows them to take in glucose and store it either as glycogen or fat which can be used as a future energy source. (dogzone.com)
Any interruption to the process of insulin release or cell binding can produce diabetes mellitus. (dogzone.com)
Upon binding to its receptor, insulin activates a cascade of intracellular signaling events. (alliedacademies.org)
Vanadium is a critical trace mineral that enhances insulin signaling and blood sugar balance by inhibiting the tyrosine phosphatase enzyme. (naturalnews.com)

During the final stage of glycogen breakdown, lactate dehydrogenase converts a molecule called pyruvate to a similar molecule called lactate. (medlineplus.gov)
A debranching enzyme is a molecule that helps facilitate the breakdown of glycogen , which serves as a store of glucose in the body, through glucosyltransferase and glucosidase activity. (wikidoc.org)

Proteins that catalyze both functions are referred to as glycogen debranching enzymes (GDEs). (wikidoc.org)
Elevated blood sugar creates hazardous glucose cross-links with proteins, causing Advanced Glycolytic Enzymes (AGEs) to form. (supervits.com)
2. Activation of transporter proteins: After CAROL Bike sprints, muscle glycogen stores need to be replenished. (carolbike.com)
More recently, the concept of lysosomal storage disease has been expanded to include deficiencies or defects in proteins necessary for the normal post-translational modification of lysosomal enzymes (which themselves are often glycoproteins), activator proteins, or proteins important for proper intracellular trafficking between the lysosome and other intracellular compartments. (medscape.com)

Branching of the chains is essential to increase the solubility of the glycogen molecule and, consequently, in reducing the osmotic pressure within cells. (wikipedia.org)
Both pyridoxal and PLP are able to bind to the hemoglobin molecule and affect its ability to pick up and release oxygen. (oregonstate.edu)

Fermentation of cellulosic biomass goes through an atypical glycolytic pathway in this thermophilic bacterium, with various glycolytic enzymes capable of utilizing different phosphate donors, including GTP and inorganic pyrophosphate (PP i ), in addition to or in place of the usual ATP. (biomedcentral.com)

The protein encoded by this gene is a glycogen branching enzyme that catalyzes the transfer of alpha-1,4-linked glucosyl units from the outer end of a glycogen chain to an alpha-1,6 position on the same or a neighboring glycogen chain. (wikipedia.org)
The GSK-3, that is the key enzyme is normally showing its actions by various mechanisms that include its phosphorylation, formation of protein complexes, and other cellular distribution and thus it control and directly affects cellular morphology, its growth, mobility and apoptosis of the cell. (scielo.br)
Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)
There are five different forms of this enzyme, each made up of four protein subunits. (medlineplus.gov)
[9] A second protein, referred to as debranching enzyme, performs α-1,6-glucose cleavage. (wikidoc.org)
We also determined FLB-3 DNA-binding preferences via protein-binding microarrays (PBMs) and demonstrated by chromatin immunoprecipitation (ChIP) that FLB-3 binds the aba-1, wet-1 and vos-1 promoters. (bvsalud.org)
PTD-DBM stands for Protein Transduction Domain-fused Disheveled Binding Motif. (biotechpeptides.com)
[3] CXXC5 works by binding with another type of protein called Dvl protein. (biotechpeptides.com)
The mode of action of enzymes and macromolecular complexes as protein machines will be investigated. (manchester.ac.uk)

it cleaves 1,6-alpha-glucosidic linkages in pullulan, amylopectin, and glycogen, and in alpha-and beta-amylase limit-dextrins of amylopectin and glycogen. (unl.edu)

4-α-D-glucanotransferase ( EC 2.4.1.25 ), or glucosyltransferase , transfers three glucose residues from the four-residue glycogen branch to a nearby branch. (wikidoc.org)

The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). (unl.edu)

From multiple inhibition studies by Dixon plots, GCG appears to bind a new allostelic site, the indole inhibitor site. (breakawaymatcha.com)

MYOZYME ® (alglucosidase alfa) is a lysosomal glycogen-specific enzyme indicated for use in patients with Pompe disease (GAA deficiency). (nih.gov)
Classically, lysosomal storage diseases encompassed only enzyme deficiencies of the lysosomal hydrolases. (medscape.com)
This has led to active clinical trials evaluating the safety and efficacy of intrathecal enzyme delivery in several lysosomal storage diseases (see www.ClinicalTrials.gov ). (medscape.com)

Mutations in this gene are associated with glycogen storage disease type IV (also known as Andersen's disease). (wikipedia.org)
Mutations in the LDHA gene result in the production of an abnormal lactate dehydrogenase-A subunit that cannot attach (bind) to other subunits to form the lactate dehydrogenase enzyme. (medlineplus.gov)
LDHB gene mutations lead to the production of an abnormal lactate dehydrogenase-B subunit that cannot form the lactate dehydrogenase enzyme. (medlineplus.gov)
Un facteur stimulant : les mutations sur le gène FADS2 de la Δ6-désaturase, enzyme clé de la synthèse du DHA et de l'acide sapiénique. (ocl-journal.org)
Avec l'apport de la cuisson et de nouvelles mutations plus productives de FADS2, le volume cérébral a trouvé son apogée chez Homo neanderthalensis dans un écosystème alimentaire favorable en acide α-linolénique et DHA. (ocl-journal.org)

Glycogen branching enzyme belongs to the α-amylase family of enzymes, which include α-amylases, pullulanas/isoamylase, cyclodextrin glucanotransferase (CGT), and branching enzyme. (wikipedia.org)

Research shows that this number and duration of sprints is enough to deplete glycogen stores to a level that triggers, and saturates, the signaling response pathway telling your body to get fitter and stronger ( Vollaard et al. ). (carolbike.com)
We now demonstrate that this enzyme can also phosphorylate sedoheptulose-7-phosphate (an intermediate in the pentose phosphate pathway), with the V max and K m of F6P being approximately 15 folds higher and 43 folds lower, respectively, in comparison to sedoheptulose-7-phosphate. (biomedcentral.com)

1. Activation of signaling pathways: Glycogen depletion triggers the release of a glycogen-bound enzyme called AMPK. (carolbike.com)

We investigated in vitro inhibition of mammalian carbohydrate-degrading enzymes by green tea extract and the component catechins, and further evaluated their inhibitory activities in cell cultures. (breakawaymatcha.com)

undergoes proteolytic cleavage that results in increased enzymatic activity and ability to cleave glycogen. (medscape.com)

Together with phosphorylases , debranching enzymes mobilize glucose reserves from glycogen deposits in the muscles and liver. (wikidoc.org)
Just like in a 'fight or flight" situation, your muscles are forced to mobilize about 25-30% of muscular glycogen-depleting your emergency energy reserves substantially. (carolbike.com)

Recombinant human enzyme alpha-glucosidase (rhGAA) is indicated as an orphan drug for treatment of Pompe disease. (medscape.com)
Recombinant human enzyme alpha-glucosidase has recently been designated an orphan drug. (medscape.com)
Recombinant human enzyme alpha-glucosidase (rhGAA) is indicated for treatment of Pompe disease in all age groups. (medscape.com)

Lutathera (lutetium Lu 177 dotatate) is a beta- and gamma-emitting radionuclide which binds to somatostatin receptors with highest affinity to subtype 2 receptors (SSRT2). (geisinger.org)

His research focus is to apply kinetic and biophysical techniques to understand enzyme structure and function, as well as applying High-Throughput screening approaches to discover and develop inhibitors for enzyme targets relevant to human disease. (proquest.com)

Ecdysone-regulated genes are bound by a heterodimer of Ecdysone receptor (EcR) and Ultraspiracle . (sdbonline.org)
Lunsumio (mosunetuzumab-axgb) is a T-cell engaging bispecific humanized monoclonal antibody that binds to the CD3 receptor expressed on the surface of T-cells and CD20 expressed on the surface of lymphoma cells and some healthy B-lineage cells. (geisinger.org)
Upon binding to somatostatin receptor expressing cells, including malignant somatostatin receptor-positive tumors, the compound is internalized. (geisinger.org)

Merk T, Wibmer T, Schumann C, Krüger S. Glycogen storage disease type II (Pompe disease)--influence of enzyme replacement therapy in adults. (medscape.com)
Cardiovascular abnormalities in late-onset Pompe disease and response to enzyme replacement therapy. (medscape.com)
Nexviazyme ( avalglucosidase alfa-ngpt) is an enzyme replacement infusion therapy used for the treatment of patients 1 year of age and older with late-onset Pompe disease. (ivxhealth.com)
Patients with late-onset Pompe disease (LOPD) lack or have a deficiency of the enzyme that breaks down glycogen in muscle cells, causing the glycogen to build up and result in muscle damage. (ivxhealth.com)
Enzyme replacement therapy (ERT) appears safe and effective for peripheral manifestations in patients with Gaucher disease types I and III, Fabry disease, mucopolysaccharidosis I (Hurler, Hurler-Scheie, and Scheie syndromes), mucopolysaccharidosis II (Hunter syndrome), mucopolysaccharidosis VI (Maroteaux-Lamy syndrome), and Pompe disease. (medscape.com)

CDDs are slowly metabolized in mammalian tissues via oxidation and reductive dechlorination reactions catalyzed by cytochrome P450 enzymes, followed by conjugation to more polar molecules such as glutathione and glucuronic acid (ATSDR 1998). (cdc.gov)

Glycogen binding enzymes in other organisms have also been crystallized and structurally determined, demonstrating both similarity and variation to GBE found in Escherichia coli. (wikipedia.org)

Phosphoenolpyruvate and PP i were the only inhibitors for PfkA determined from the study, which corroborates what is known about enzymes from this subfamily. (biomedcentral.com)

in particular, PLP is the cofactor for the enzyme kynureninase, which catalyzes the conversion of 3-hydroxykynurenine to 3-hydroxyanthranilic acid. (oregonstate.edu)

Saliva contains ptyalin (salivary amylase) enzyme which acts on starch, glycogen and other carbohydrates to form maltose. (psebsolutions.com)
Since noroviruses attach to carbohydrates of the histo-blood group family, tests using immunohistochemical analysis were performed to evaluate specific binding of virus or viruslike particles to oyster tissues through these ligands. (cdc.gov)
Since noroviruses can attach to carbohydrates of the ABH and Lewis histo-blood group family in humans, we also examined the possibility of a similar specific binding to oyster tissues through related carbohydrates ( 17 , 18 ). (cdc.gov)

Instead of being cleaved in twain by our enzymes and absorbed as glucose, resistant starch (RS) travels unscathed through the small intestine into the colon, where colonic gut flora metabolize it into short chain fatty acids. (marksdailyapple.com)
Conversely, it activates enzymes involved in ATP-generating processes, such as fatty acid oxidation (e.g., carnitine palmitoyltransferase 1, CPT1) and glucose uptake (e.g., translocation of GLUT4). (alliedacademies.org)
SCIRP: Food and Nutrition Sciences, Vol. In this process, both in vivoand in cultur… This binding will likewise lead to the cAMP/PKA-led phosphorylation of hormone sensitive lipase, that will ultimately drive the release of free fatty acids and glycerol. (imingo.net)
The three main categories of disease include the mitochondrial myopathies, fatty acid oxidation defects (FAODs), and glycogen storage diseases (GSDs). (essayempire.com)

High glucose affected the expression level of cell-bound perlecan, angiogenesis-associated cytokines, and the matrix degradation on the cells, implying that hyperglycemia influences vessel formation during placentation. (hindawi.com)

Glucosyltransferase and glucosidase are performed by a single enzyme in mammals, yeast, and some bacteria, but by two distinct enzymes in E. coli and other bacteria, complicating nomenclature. (wikidoc.org)
In E. coli and other bacteria, glucosyltransferase and glucosidase functions are performed by two distinct enzymes. (wikidoc.org)

Conversely, the C-terminal half has primarily a regulatory function, and also includes the hydrophobic region responsible for the binding of lipid droplets, essential for in vivo enzyme activity. (imingo.net)

The first and rate-limiting step of lipolysis involves the enzyme, adipose triglyceride lipase (or ATGL), which is sensitive to hormones. (imingo.net)

This subfamily also includes bacterial alpha amylases and 1,4-alpha-glucan branching enzymes which are highly similar to MTHase. (unl.edu)

There are two types of this condition: lactate dehydrogenase-A deficiency (sometimes called glycogen storage disease XI) and lactate dehydrogenase-B deficiency. (medlineplus.gov)
It is unclear why this type of enzyme deficiency does not cause any health problems. (medlineplus.gov)

Viral particles bind specifically to digestive ducts (midgut, main and secondary ducts, and tubules) by carbohydrate structures with a terminal N-acetylgalactosamine residue in an α linkage (same binding site used for recognition of human histo-blood group antigens). (cdc.gov)

The highest levels of this enzyme are found in liver and muscle cells. (wikipedia.org)
As a result, glycogen is not broken down efficiently, leading to decreased energy in muscle cells. (medlineplus.gov)
What is muscle glycogen? (carolbike.com)
Muscular glycogen is a stored form of sugar found in skeletal muscle. (carolbike.com)
Lumizyme (alglucosidase alfa) provides an exogenous source of GAA allowing conversion of glycogen to energy in heart and muscle cells. (geisinger.org)
Nexiazyme works by replacing the missing or deficient enzyme to bind to muscle cells and then enter the cells to help break down glycogen. (ivxhealth.com)
This process also reduces glucose formation and enhances the body's ability to store sugar in the form of muscle and liver glycogen. (naturalnews.com)

A lack of functional subunit reduces the amount of enzyme that is formed, mostly affecting skeletal muscles. (medlineplus.gov)

Also, advances in therapy and therapeutical trials are presented in Duchenne and other muscular dystrophies, and some novel treatments in glycogen storage disease by enzyme replacement are proposed. (novapublishers.com)
It is then forced to use muscular glycogen to create ATP. (carolbike.com)

Curcumin also reduces the activity of specific liver enzymes that release sugar into the bloodstream while activating enzymes that store sugar as glycogen. (supervits.com)

These sulfated polysaccharides have also been shown to block the typical binding sites for many viruses such as Herpes. (naturalnews.com)

1,4-alpha-glucan-branching enzyme, also known as brancher enzyme or glycogen-branching enzyme is an enzyme that in humans is encoded by the GBE1 gene. (wikipedia.org)
This enzyme has a molecular mass of 73.6 kDa, and is coded for by the gene glgX. (wikidoc.org)
Galehdari H, Emami M, Mohammadian G, Khodadadi A, Azmoon S, Baradaran M. Detection of a novel mutation in the GAA gene in an Iranian child with glycogen storage disease type II. (medscape.com)

Other neurotransmitters, including glycine, D-serine, glutamate, histamine, and γ-aminobutyric acid (GABA), are also synthesized in reactions catalyzed by PLP-dependent enzymes (7) . (oregonstate.edu)
These acids and bases are amino acid side chains in the active site of the enzyme. (wikidoc.org)

It turned out that the "carbs" in the article were resistant starch, a type of carbohydrate that our digestive enzymes cannot break down. (marksdailyapple.com)

In short, you only need really short sprints to achieve sufficient glycogen depletion. (carolbike.com)

The brains of adults who live on a high-carbohydrate diet lose the ability to synthesize the key enzymes needed to metabolize ketones. (medscape.com)

Further, we show c-di-GMP binding is required for GlgX activity. (nih.gov)
[10] Activity of the two enzymes is not always necessarily coupled. (wikidoc.org)
The complex binds to dsDNA fragments and exhibits ATPase activity, which is strongly enhanced in the presence of DNA. (bvsalud.org)

This enzyme is associated NAD + , which suggests that the reaction involves the sequential oxidation and reduction of the hexose C4 atom. (flashcardmachine.com)

Frequency of glycogen storage disease type II in The Netherlands: implications for diagnosis and genetic counselling. (medscape.com)
A diagnostic protocol for adult-onset glycogen storage disease type II. (medscape.com)

Anatomy4

Organisms3

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Chemicals and Drugs65

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Psychiatry and Psychology1

Phenomena and Processes14

Anthropology, Education, Sociology and Social Phenomena1

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Synthase12

Synthesis5

Substrate5

Metabolism8

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Glycolytic Enzymes1

Protein9

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Receptors1

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