AlanineArginineSubunitSpecific residuesGlutamateSerineMerrAromaticProteinHistidineElectrostaticPeptideReceptorsInhibitoryPesticideSequenceEscherichiaMutationMutagenesisSubstitutionCompoundRegulatesCrucialPropertiesSoilContinuousTypeLossesStructuralImportantDetermineResultsSide chainPositionCreateChannelPresenceBlock
Alanine4
- Silks are composed principally of proteins with a predominance of alanine, serine and glycine and silk proteins are able to undergo irreversible transformations from soluble protein to insoluble fibres. (bioone.org)
- The molecular mass distribution of the hydrolysates ranged from 5 to 25 kDa, and they were rich in glycine, alanine, glutamate, proline and hydroxyproline residues. (nih.gov)
- The stability between helical conformations of homopeptides of alanine, glycine, and aminoisobutyric acid has been studied by means of quantum-mechanical methods. (ub.edu)
- THe OTCase lost most of its homotropic cooperativity and gained anabolic activity when residue glutamic acid (Glu) 106, near the CP binding site, was replaced by alanine (Ala) or glycine (Gly). (europa.eu)
Arginine5
- The logo represents the relative frequency of amino acids in each position surrounding the central methylated arginine residue. (cellsignal.com)
- Glycine residues are enriched, especially at the +1 position, in the context of mono-methylated arginine when compared to the overall expected frequency in the human proteome. (cellsignal.com)
- The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. (nih.gov)
- The presence of the charged residues lysine (K) 365, arginine (R) 368 or aspartate (D) 371 with the remaining residues between 365-372 substituted by alanines produced GlyRs with a 2-4-fold increase in the potency of glycine compared to that at the GlyR α3L. (ucl.ac.uk)
- Both cleavages take place at the C-terminal of an Arginine residue. (lu.se)
Subunit5
- Site-directed mutagenesis of the γ-aminobutyric acid type A (GABA A ) receptor β 2 subunit has demonstrated that conversion of a conserved glycine residue located at the entrance to the first transmembrane domain into the homologous ρ 1 residue phenylalanine alters the modulating effects of four different i.v. anesthetics: pentobarbital, alphaxalone, etomidate, and propofol. (aspetjournals.org)
- These results suggest that the first transmembrane glycine residue on the β 2 subunit may be important for conformational or allosteric interactions of channel gating by both GABA and anesthetics. (aspetjournals.org)
- Strickland M, Juárez O, Neehaul Y, Cook DA, Barquera B, Hellwig P. (2014) The conformational changes induced by ubiquinone binding in the Na+-pumping NADH:ubiquinone oxidoreductase (Na+-NQR) are kinetically controlled by conserved glycines 140 and 141 of the NqrB subunit. (iit.edu)
- Juárez O, Neehaul Y, Turk E, Chaubon N, Hellwig P and Barquera B. (2012) The role of Glycine residues 140 and 141 of NqrB subunit in the ubiquinone binding site of the sodium -dependent NADH dehydrogenase. (iit.edu)
- Alternative splicing results in 2 isoforms of the GlyR α3 subunit denoted as short (S) and long (L), which differ by 15 amino acids in the second intracellular loop (residues 358-372). (ucl.ac.uk)
Specific residues1
- however, a detailed understanding of effects of specific residues upon beta-turn stability and conformation is lacking. (rcsb.org)
Glutamate1
Serine1
- It was found that the G/SxS selectivity filter (glycine/serine, non-conserved residue, serine) and other well conserved residues play a crucial role in ion selectivity. (surrey.ac.uk)
Merr2
Aromatic1
- For lithium against sodium, aromatic residues upstream of the selectivity filter seem to be important, whereas for sodium against potassium, negatively charged residues downstream of the selectivity filter seem to be important. (surrey.ac.uk)
Protein5
- TDP-43 is a highly conserved, ubiquitously expressed, multifunctional nucleic acid-binding protein composed of two RNA recognition motifs (RRM), nuclear localization (NLS) and export signals (NES), and a carboxy-terminal glycine rich region. (nature.com)
- A protein modification that effectively removes or replaces an glycine. (reactome.org)
- A protein modification that effectively converts a source amino acid residue to an L-aspartic acid. (reactome.org)
- The information within the KdpD protein that confers SRP interaction was found in the amino-terminal cytoplasmic domain of KdpD, particularly at residues 22-48. (nature.com)
- The duMRE11 gene encoded a protein of 703 amino acid residues and showed the highest sequence similarity to goose MRE11. (bvsalud.org)
Histidine2
- All copper-transporting ATPases have a histidine residue in the large cytoplasmic loop adjacent to the ATP-binding domain. (medscape.com)
- The histidine residue is the most common mutation site in Wilson disease, and this histidine residue is essential for the function of the Menkes ATPase, ATP7A. (medscape.com)
Electrostatic2
- Furthermore, it is suggested that the binding of SRP to the signal sequence is promoted by the presence of basic amino acid residues through electrostatic interactions 18 . (nature.com)
- Since this region confers myosin electrostatic property to initiate staggered dimerization, deamidation in this region, which severely affected the electrostatic balance between residues, impaired ordered thick filament growing and elongating, thus promoting the solubilization of MPs in water. (bvsalud.org)
Peptide5
- in humans and most other species, the peptide is 1 residue longer and is not amidated. (wikipedia.org)
- [1] [2] The 26-residue peptide named amidorphin is found in several species including bovine (Bos taurus), sheep (Ovis aries), and pig (Sus scrofa). (wikipedia.org)
- The properties of the 27-residue peptide are presumably similar to those of amidorphin, although this has not been adequately tested. (wikipedia.org)
- The influence of peptide length on the relative stability between helical conformations has also been analyzed by means of systematic studies for peptides of size up to 11 residues. (ub.edu)
- The enzyme acts on the product of the reaction catalysed by EC 1.14.17.3 peptidylglycine monooxygenase, thus removing a terminal glycine residue and leaving a des-glycine peptide amide. (genome.jp)
Receptors1
- The present results suggest that the α9 nAChR must conserve in its primary structure some residues responsible for ligand binding common to other Cys-loop receptors. (aspetjournals.org)
Inhibitory2
- His interests and those of his research groups have included exploring the mechanisms of ion permeation and selectivity in ion channels, the relationship between the molecular structure and the physiological function of channels, such as those of the inhibitory neurotransmitter receptor glycine channel and the olfactory cyclic nucleotide-gated channel, and investigating the factors that determine their ion permeation, selectivity and conductance. (edu.au)
- The glycine receptor (GlyR) is an inhibitory neurotransmitter-gated ion channel found mainly in the brainstem and spinal cord. (ucl.ac.uk)
Pesticide2
- 1999. Determination of organochlorine and organophosphate pesticide residues in fruits, vegetables and sediments. (cdc.gov)
- Solid-phase extraction for cleanup of pesticide residues suspected as endocrine disruptors in foods. (cdc.gov)
Sequence4
- Two turns related by the threefold structural symmetry, the beta4/beta5 and beta8/beta9 turns, were subjected to both sequence-swapping and poly-glycine substitution mutations, and the effects upon stability, folding, and structure were investigated. (rcsb.org)
- These conformations were observed to be retained during sequence-swapping and glycine substitution mutagenesis. (rcsb.org)
- Within this sequence a Walker A motif is present at residues 30-38. (nature.com)
- this is due to the absence of a Gly in the precursor sequence and replacement with Ala, which is not a substrate for the amidating enzyme (Peptidyl-glycine alpha-amidating monooxygenase). (wikipedia.org)
Escherichia2
- When the corresponding Glu NH2 residue of Escherichia coli anabolic OTCase was exchanged for Glu, no cooperativity resulted, however. (europa.eu)
- 5'-monophosphate deaminase from Streptomyces murinus, D-allulose 3-epimerase from Arthrobacter globiformis expressed in Escherichia coli , carbohydrate-derived fulvic acid, jagua (genipin-glycine) blue (Jagua blue), lipase from Mucor javanicus and phosphatidylinositol-specific phospholipase C expressed in Pseudomonas fluorescens ). (who.int)
Mutation1
- The patient has a mutation on exon 15, A504T, which changed an asparagine residue to a valine residue. (medscape.com)
Mutagenesis1
- Site directed mutagenesis was used to check the catalytic role of residue C his 134, which is in a position to interact with the carbonyl group of CP, and was a candidate for bearing a group whose deprotonation is involved in catalytic efficiency. (europa.eu)
Substitution1
Compound2
- Another polar component was an acidic compound with similar chromatographic properties to glycine. (inchem.org)
- A deuterated compound that is is an isotopologue of glycine in which all five hydrogen atoms have been replaced by deuterium. (mcw.edu)
Regulates1
- A multisubunit enzyme complex that regulates GENETIC TRANSCRIPTION by deacetylating the HISTONE residues of NUCLEOSOMES. (bvsalud.org)
Crucial1
- In its capacity to assure the sound scientific basis for international standards and recommendations on food additives, contaminants in food and veterinary drug residues in food, the work of the Committee is crucial to the work of the Codex Alimentarius Commission. (who.int)
Properties2
- Depending on the ion type, residues with different properties are involved in ion permeability. (surrey.ac.uk)
- A combination of charged residues are important determinants for the differing desensitisation properties of the GlyR α3L but are not responsible for lowering the potency of glycine. (ucl.ac.uk)
Soil3
- Enhanced greenhouse gas fluxes during spring freeze-thaw are related to the mineralization of bioavailable substrates, which may be elevated when soil is amended with organic residues (e.g., biobased residues such as compost, digestate, biosolids). (frontiersin.org)
- 2018. Perennialization and cover cropping mitigate soil carbon loss from residue harvesting. (msu.edu)
- While the US Midwest is expected to serve as a primary feedstock source for cellulosic biofuel production, the impacts of residue harvesting on soil organic carbon ( SOC ) may greatly limit sustainable production capacity. (msu.edu)
Continuous1
- This filter computes the longest continuous stretch of polar residues within a pose or selection. (rosettacommons.org)
Type2
- Set whether glycine is counted as a polar residue type. (rosettacommons.org)
- Given a residue type, determine whether it's one of the types that this filter should count. (rosettacommons.org)
Losses2
- Vegetable crop residues may lead to considerable N losses through leaching during winter and pose a threat to meeting water quality objectives. (mdpi.com)
- However, viable feedstock production could be realized through adoption of management practices and cropping systems that offset residue-harvest-induced SOC losses. (msu.edu)
Structural1
- Structural analysis suggests that residues flanking the turn are a primary structural determinant of the conformation within the turn. (rcsb.org)
Important1
- These residues were also important determinants of the slower desensitisation rate of the GlyR α3L, their deletion increasing the rate of desensitisation 3-fold. (ucl.ac.uk)
Determine1
- The objective of this study was to determine the impact of biobased residues, compared to urea fertilizer, on greenhouse gas emissions during spring freeze-thaw events. (frontiersin.org)
Results1
- The results establish that C his 134 is indeed the residue interacting with the carbonyl group of CP but that it is not directly involved in the catalytic mechanism. (europa.eu)
Side chain1
- Here, we describe the synthesis of a new heptamethine indocyanine dye (NIR-27) modified with a glycine at the end of each N-alkyl side chain, and its biological characterization for in vivo cancer-targeted NIR imaging. (dovepress.com)
Position1
- Vegetable crop residues take a particular position relative to arable crops due to often large amounts of biomass with a N content up to 200 kg N ha −1 left behind on the field. (mdpi.com)
Create2
- A carbodiimide-activation coupling reaction was used to create the lysozyme-amino-glycine-cellulose conjugates using both NCI and NCII in a polar solvent, and giving yields of covalently linked lysozyme at 630mg/gram of cotton nanocrystal. (usda.gov)
- It has been stated that residues of the selectivity filter create an energy barrier that ions have to cross. (surrey.ac.uk)
Channel1
- The motif in the ENaC/DEG Family is (G/S)XS, where X is a non-conserved residue within this ion channel family. (surrey.ac.uk)
Presence1
- The presence of all three charged residues restored slow desensitisation to the GlyR α3L. (ucl.ac.uk)
Block1
- Standard building block for introduction of glycine amino-acid residues by Boc SPPS. (sigmaaldrich.com)