Although metabotropic glutamate receptor (mGluR) modulation has been studied extensively in neurons, it has not been investigated in astrocytes. (jneurosci.org)
These data suggest that glutamate, acting at several metabotropic receptors expressed by astrocytes, could modulate glial activity evoked by neurotransmitters and thereby influence the ongoing modulation of neurons by astrocytes. (jneurosci.org)
Isoflurane acts as a positive allosteric modulator of the GABA A receptor in electrophysiology studies of neurons and recombinant receptors. (mdwiki.org)
Most convulsants are antagonists (or inverse agonists) at either the GABAA or glycine receptors, or ionotropic glutamate receptor agonists. (wikipedia.org)
Bicuculline Brucine Colubrine Diaboline Gelsemine Hyenandrine Laudanosine Oripavine RU-5135 (also GABA antagonist) Sinomenine Strychnine Thebaine Tutin Ionotropic glutamate receptor agonists are drugs that activate the ionotropic glutamate receptors in the brain. (wikipedia.org)
The glutamate receptor agonist kainic acid [21] and the cholinergic agonist pilocarpine [22] are commonly used in SE models. (jle.com)
[17] It inhibits receptor activity in the NMDA glutamate receptor subtypes. (mdwiki.org)
Neurotransmitter5
Once released, the neurotransmitter diffuses across the cleft and binds to receptors on the postsynaptic cell, allowing the signal to propagate. (org.es)
2) Specific neurotransmitter receptors are localized on the postsynaptic cells, and (3) there exists a mechanism to stop neurotransmitter release and clear molecules from the cleft. (org.es)
Neurotransmitter compounds can be small molecules, such as glutamate and glycine, or large peptides, such as vasoactive intestinal peptide (VIP). (org.es)
It is a cyclic derivative of the neurotransmitter GABA [9] and shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid . (cloudfront.net)
A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. (lookformedical.com)
GABA3
GABAA receptor antagonists are drugs that bind to GABAA receptors but do not activate them and inhibit the action of GABA. (wikipedia.org)
Title: Neurosteroid Binding Sites on the GABA(A) Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence. (aablocks.com)
Isoflurane likely binds to GABA , glutamate and glycine receptors, but has different effects on each receptor. (mdwiki.org)
Family of receptors2
A family of receptors that modulate the activation of T-LYMPHOCYTES by the T-CELL ANTIGEN RECEPTOR. (edu.au)
A family of receptors (RECEPTORS, DOPAMINE) mediate its action. (lookformedical.com)
Agonist3
For example, kainic acid can lead to status epilepticus in animals as it is a cyclic analog of l-glutamate and an agonist for kainate receptors in the brain which makes it a potent neurotoxin and excitant. (wikipedia.org)
A selective D1 dopamine receptor agonist used primarily as a research tool. (lookformedical.com)
When apomorphine interacts with where to purchase zaleplon canada the dopamine receptor, or the ATP on the receptor, the catechol and where to purchase zaleplon canada nitrogen are important to stabilize the structure with hydrogen bonding. (pariuri-ponturi.com)
Modulate1
The receptors are responsive to one or more B7 ANTIGENS found on ANTIGEN-PRESENTING CELLS and, depending upon the specific ligand-receptor combination, modulate a variety of T-cell functions such as the rate of clonal expansion, CELL SURVIVAL and cytokine production. (edu.au)
Excitatory amin2
Neuroactive glutamate is classified as an excitatory amino acid (EAA) because glutamate binding onto postsynaptic receptors typically stimulates, or depolarizes, the postsynaptic cells. (org.es)
The main mechanism involved in early tolerance is adaptation of membrane receptors, whereas gene activation with subsequent de novo protein synthesis dominates delayed tolerance. (biomedcentral.com)
Quinolinic1
Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS. (lookformedical.com)
Proteins1
Included under this heading are signaling receptors, non-signaling receptors and accessory proteins required for receptor signaling. (edu.au)
Agonists1
Thus it blocks both the endogenous and exogenous actions of GABAA receptor agonists. (wikipedia.org)
Inhibit1
D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES. (lookformedical.com)
Amino acid2
In the course of study, every non-polar amino acid in the model is replaced by glycine, whereupon the biochemical characteristics of polar amino acids should become more distinguished. (go.jp)
Biophysical studies using NMR spectroscopy has provided molecular details of how inhaled anesthetics interact with three amino acid residues (G29, A30 and I31) of amyloid beta peptide and induce aggregation. (mdwiki.org)
Bind1
Cell surface receptors that bind to ACETYLGLUCOSAMINE. (lookformedical.com)
Nervous1
Dynorphins prefer kappa-opioid receptors (RECEPTORS, OPIOID, KAPPA) and have been shown to play a role as central nervous system transmitters. (lookformedical.com)
Endogenous1
Kynurenic acid (KYNA) is an endogenous tryptophan (Trp) metabolite known to possess neuroprotective property. (mdpi.com)
Brain1
The results suggest that exposure to GLA, even in low doses, during infantile period in the rat induces alterations in the kainic acid receptor in the brain. (go.jp)
Studies1
Single-channel studies of glutamate receptors. (ox.ac.uk)
Cell4
Some neuroactive compounds are amino acids, which also have metabolic functions in the presynaptic cell. (org.es)
Cell surface receptors that are specific for INTERLEUKIN-1. (edu.au)
Immunobiology of natural killer cell receptors / E. Vivier and M. Colonna (eds. (edu.au)
Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. (edu.au)
Response2
Because of the structural analogy between GLA and glutamate, GLA-exposed rats were examined for the wet-dog shakes response to kainic acid. (go.jp)
They were weaned at 3 weeks of age and tested for the response to 9mg/kg kainic acid at 5 or 6 weeks of age. (go.jp)
Models1
The DEV analyses of the models select four amino acids ( H, D, S and C ) as the essential members of the functional system. (go.jp)
Specific1
Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. (edu.au)
Combination1
The first three amino acids are coincide with the active sites of trypsin (40- H , 84- D and 177- S ). When the area of triangle made up of a combination of three amino acids out of the above four is measured, the triangle of HDS is found to be the minimum among those made of other combinations investigated, suggesting that they are closely located each other. (go.jp)
Positive1
Drug responses in synchronized Ca2+ oscillations were recorded in both 2D and 3D hiPSC-derived neuron/primary astrocyte co-cultures using positive controls (4-aminopyridine and kainic acid) and negative control (acetaminophen). (bvsalud.org)
Drugs1
3-Mercaptopropionic acid Allylglycine Glycine receptor antagonists are drugs which inactivates the glycine receptors. (wikipedia.org)
High1
Title: High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach. (aablocks.com)