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  • AQP3
  • We have developed a unique system applying the strain of the yeast Pichia pastoris , where the endogenous aquaporins/aquaglyceroporins have been removed and human aquaglyceroporins AQP3, AQP7, and AQP9 are recombinantly expressed enabling comparative permeability measurements between the expressed proteins. (springer.com)
  • In this approach, human AQP3, AQP7, and AQP9 are highly expressed in an AQP deletion strain of P. pastoris , where both endogenous aquaporins (Aqy1 and Agp1) have been removed by standard cloning strategies. (springer.com)
  • They have shown that HDAC3 inhibitors are particularly adept at increasing expression of aquaporin-3, or AQP3, a channel that transports glycerin, a natural alcohol and water attractor, which helps skin look better and aids healthy production and maturation of high-turnover skin cells. (medicaldialogues.in)
  • Indeed, the protein abundance of Aqp1 recovered partially, with complete recovery of mRNA expression level and protein abundance of Aqp3, in the gills of P. annectens after 3 days of arousal. (frontiersin.org)
  • Aquaporin 1 (AQP1), aquaporin 2 (AQP2) and the mercury-insensitive water channel (MIWC) are water-selective channel proteins, whereas the fourth, referred to as aquaporin 3 (AQP3), permits transport of urea and glycerol as well. (springer.com)
  • Aquaporin 3 antibody LS-C3804 is an unconjugated rabbit polyclonal antibody to rat Aquaporin 3 (AQP3). (lsbio.com)
  • In a recent study of mice deficient in the epidermal water/glycerol transporter aquaporin-3 (AQP3), glycerol replacement ameliorated several defects, including diminished SC hydration and skin elasticity, as well as poor barrier recovery after SC removal. (skintypesolutions.com)
  • Notably, SC water content, which was measured as threefold lower in the AQP3-null mice than in wild-type mice, was restored by administration of topical or systemic glycerol, but administration of glycerol-like osmolytes, such as xylitol, erythritol, and propanediol, was unsuccessful. (skintypesolutions.com)
  • HT-29 human colonic epithelial cells were treated with IFNγ to assess AQP3 mRNA expression by real-time RT-PCR and functional protein expression through the uptake of radiolabelled glycerol. (springer.com)
  • IFNγ decreased AQP3 mRNA expression in HT-29 cells in a time- and concentration-dependent manner and reduced functional AQP3 protein expression (decreased 3 H-labelled glycerol uptake). (springer.com)
  • AQP1
  • Expression of aquaporin 1 (AQP1) in chorioallantoic membranes of near term ovine foetuses with induced hypoxia. (prolekare.cz)
  • The human genes encoding AQP1 and AQP2 have been cloned, permitting deduction of their amino acid sequence, prediction of their two-dimensional structure by hydropathy analysis, speculations on their way of functioning and DNA analysis in patients with diseases possibly caused by mutant aquaporins. (springer.com)
  • high glycerol
  • This is distinctly different from glycerol and arsenic trioxide, where high glycerol transport efficiency was recorded. (springer.com)
  • In a 5-year study comparing two high-glycerol moisturizers with 16 other popular moisturizers in 394 patients with severe xerosis, the high-glycerol products outperformed the rest by more rapidly restoring normal hydration and preventing the resumption of dryness for a longer period-longer even than petrolatum. (skintypesolutions.com)
  • Ultrastructural analysis of skin treated with high-glycerol formulations has shown that glycerol expands not only corneocytes but also the space between layers of corneocytes, which results in expansion of the SC (Poster presentation, 53rd Annual Meeting of the American Academy of Dermatology, February 1995). (skintypesolutions.com)
  • transmembrane
  • with six transmembrane helices (1-6) and five connecting loops (A-E). Two highly conserved loops (B and E) each contain the signature motif present in every aquaporin, asparagine-proline-alanine (NPA), which forms one wall of the water pore. (rupress.org)
  • Verkman
  • They are involved in (1) nephrogenic diabetes insipidus, (2) brain water balance and hearing and (3) salivary secretion ( Li and Verkman, 2001 ). (tcdb.org)
  • Dryness
  • Ingredients that stimulate aquaporin activity in skin may or may not be helpful, but what's certain is you don't need to tolerate a product with irritating ingredients to see improvement in dryness or signs of aging! (beautypedia.com)
  • Indeed, diglycerol and triglycerol, with higher humectant activity, have demonstrated low improvements in skin dryness, compared with glycerol. (cosmeticsandtoiletries.com)
  • functional
  • Glucagon induces the plasma membrane insertion of functional aquaporin-8 water channels in isolated rat hepatocytes. (prolekare.cz)
  • Aqy1p has been shown to be a functional aquaporin in some strains, such as Sigma1278b. (jhu.edu)
  • AQP-3 may play an important functional role in osmoregulation the teleostean gill but is unlikely to be responsible for the increases in intestinal water absorption that occur following SW acclimation. (antibodybeyond.com)
  • Regulation
  • pH regulation was also found in two other members of the aquaporin family. (rupress.org)
  • The purpose of this study was to focuse on aquaporins and their role in the regulation of amniotic fluid circulation. (prolekare.cz)
  • The present review summarizes the results of clinical and experimental research on aquaporins and the regulation of amniotic fluid circulation. (prolekare.cz)
  • vivo
  • In vivo silencing of aquaporin-1 by RNA interference inhibits angiogenesis in the chicken embryo chorioallantoic membrane assai. (prolekare.cz)
  • Also, one in vivo attempt has been made to characterize the effects of low glycerol doses, e.g. from 1% up to 10%, on water transport through the skin after acute chemical irritation by sodium lauryl sulfate (SLS). (cosmeticsandtoiletries.com)
  • renal
  • Expression of aquaporins in the renal connecting tubule. (prolekare.cz)
  • Future research on renal water transport will focus on the search for other aquaporins, structure-function relationship of aquaporins, the development of aquaporin inhibitors and their possible use as diuretics, and further elucidation of the renal vasopressin pathway. (springer.com)
  • kidney
  • Aquaporin-2 function is to reabsorb water from urine in the kidney. (proteopedia.org)
  • Frindt, G. Cloning and expression of AQP 3, a water channel from the medullary collecting duct of rat kidney. (prolekare.cz)
  • arsenic
  • Aquaglyceroporins play important roles in human physiology, in particular for glycerol metabolism and arsenic detoxification. (springer.com)
  • humectant
  • Glycerol is one humectant commonly employed due to its high hygroscopic and hyperosmotic properties. (cosmeticsandtoiletries.com)
  • Derived from the saponification of fats, glycerin (also spelled glycerine and usually referred to in the literature as glycerol) is a strong, nonvolatile trihydroxylated humectant that exhibits hygroscopic ability very similar to that associated with natural moisturizing factor (J. Soc. (skintypesolutions.com)
  • Glycerol is considered to be the most effective humectant (Skin Therapy Lett. (skintypesolutions.com)
  • yeast
  • Upon high osmolarity conditions, yeast accumulate glycerol by increased production of the osmolyte and by restricting glycerol efflux through Fps1. (tcdb.org)
  • Function
  • Although the physiological role of glycerol in the normal function of erythrocytes is not clear, plasma glycerol is an important substrate for lipid biosynthesis of intraerythrocytic malarial parasites. (jhu.edu)