Glyceraldehyde 3 phosphate dehydrogenase nadp phosphorylating. Medical search. Frequent questions

The systematic name of this enzyme class is D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating). (wikipedia.org)

Other names in common use include: dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating) GAPDH glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating) glyceraldehyde-3-phosphate dehydrogenase (NADP) (phosphorylating) NADP-dependent glyceraldehyde phosphate dehydrogenase NADP-glyceraldehyde phosphate dehydrogenase NADP-glyceraldehyde-3-phosphate dehydrogenase NADP-triose phosphate dehydrogenase triosephosphate dehydrogenase (NADP) Brenneman FN, Volk WA (1959). (wikipedia.org)
GAPDH catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). (avivasysbio.com)
The compound is a dinucleotide, since it consists of two nucleotides joined through their phosphate groups: with one nucleotide containing an adenosine ring, and the other containing nicotinamide . (wikidoc.org)
Nicotinamide adenine dinucleotide is a dinucleotide since it consists of two nucleotides joined by a pair of bridging phosphate groups. (wikidoc.org)

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays an important role in glycolysis and gluconeogenesis [ ( PUBMED:2716055 ) ] by reversibly catalysing the oxidation and phosphorylation of D-glyceraldehyde-3-phosphate to 1,3-diphospho-glycerate. (embl.de)
The structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase(GAPDH) from the trypanosomatid parasite Leishmania mexicana has beendetermined by X-ray crystallography. (embl.de)
This unusual loop conformation in L. mexicanaGAPDH occludes the inorganic phosphate binding site which has been seen inprevious GAPDH structures. (embl.de)

In addition, we demonstrated that 14-3-3 proteins interacted with one isocitrate dehydrogenase and two malate dehydrogenases. (biomedcentral.com)

We now demonstrate that this enzyme can also phosphorylate sedoheptulose-7-phosphate (an intermediate in the pentose phosphate pathway), with the V max and K m of F6P being approximately 15 folds higher and 43 folds lower, respectively, in comparison to sedoheptulose-7-phosphate. (biomedcentral.com)
These findings along with previous proteomic data suggest that Pfp, plays a role in both glycolysis and the pentose phosphate pathway, while PfkA and PfkB may phosphorylate sugars in glycolysis but is responsible for sugar metabolism elsewhere under conditions outside of growth on sufficient cellobiose. (biomedcentral.com)
The pentose phosphate pathway (PPP) is divided into an oxidative branch that makes pentose phosphates and a non-oxidative branch that consumes pentose phosphates, though the non-oxidative branch is considered reversible. (mdpi.com)

In enzymology, a glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) (EC 1.2.1.13) is an enzyme that catalyzes the chemical reaction D-glyceraldehyde 3-phosphate + phosphate + NADP+ ⇌ {\displaystyle \rightleftharpoons } 3-phospho-D-glyceroyl phosphate + NADPH + H+ The 3 substrates of this enzyme are D-glyceraldehyde 3-phosphate, phosphate, and NADP+, whereas its 3 products are 3-phospho-D-glyceroyl phosphate, NADPH, and H+. (wikipedia.org)

Crystal structure of glycosomal glyceraldehyde-3-phosphate dehydrogenasefrom Leishmania mexicana: implications for structure-based drug design anda new position for the inorganic phosphate binding site. (embl.de)
Fermentation of cellulosic biomass goes through an atypical glycolytic pathway in this thermophilic bacterium, with various glycolytic enzymes capable of utilizing different phosphate donors, including GTP and inorganic pyrophosphate (PP i ), in addition to or in place of the usual ATP. (biomedcentral.com)

The most intensively characterized 14-3-3 target proteins are nitrate reductase and H + -ATPase. (biomedcentral.com)
Nitrate reductase is phosphorylated in the dark by the calcium-dependent protein kinase (CDPK) and the sucrose non-fermenting related kinase 1 (SnRK1) that initiates the interaction of the enzyme with the 14-3-3 proteins and its inactivation. (biomedcentral.com)

The reaction sequence in the Calvin-Benson cycle is from triose phosphates to pentose phosphates, the opposite of the typical direction of the non-oxidative PPP. (mdpi.com)

In plants, 14-3-3 proteins have major roles as regulators of nitrogen and carbon metabolism, conclusions based on the studies of a few specific 14-3-3 targets. (biomedcentral.com)
In this study, extensive novel roles of 14-3-3 proteins in plant metabolism were determined through combining the parallel analyses of metabolites and enzyme activities in 14-3-3 overexpression and knockout plants with studies of protein-protein interactions. (biomedcentral.com)
Plant 14-3-3 proteins are mainly thought to be regulators of carbon and nitrogen metabolism [ 2 ]. (biomedcentral.com)
E. coli growing aerobically on glycerol incorporates this molecule into central metabolism as dihydroxyacetone phosphate (DHAP), a metabolite which can participate in both gluconeogenic and glycolytic processes (Figure 1 ) [ 6 ]. (biomedcentral.com)
αKlotho is a transmembrane protein acting as a co-receptor for FGF23, a bone hormone regulating renal phosphate and vitamin D metabolism. (bvsalud.org)

Pfp (Cthe_0347) was previously characterized as pyrophosphate dependent with fructose-6-phosphate (F6P) as its substrate. (biomedcentral.com)

7a-hydroxy-cholestene-3-one then is used in two different chains of reactions. (smpdb.ca)
It is then transported back into intracellular space, where after its used in 3 different reactions, its derivatives interact with intestinal microflora in the extracellular space to become lithocholyltaurine, lithocholic acid glycine conjugate, and lithocholic acid. (smpdb.ca)
Revisiting 7a-hydroxy-cholestene-3-one, the second chain of reactions it is involved in follows a similar path as the first, moving through the mitochondria, endoplasmic reticulum and peroxisome until choloyl-CoA is formed, which then is used in three reactions so that its derivatives may leave the cell to interact with intestinal microflora and become taurodeoxycholic acid, deoxycholic acid glycine conjugate and deoxycholic acid. (smpdb.ca)

The protein crystallizes in spacegroup P2(1)2(1)2(1) with unit cell parameters a = 99.0 A, b = 126.5 A, andc = 138.9 A. There is one 156,000 Da protein tetramer per asymmetric unit.The model of the protein with bound NAD+s and phosphates has been refinedagainst 86% complete data from 10.0 to 2.8 A to a crystallographic Rfactorof 0.198. (embl.de)

Decreases in the levels of sugars and nitrogen-containing-compounds and in the activities of known 14-3-3-interacting-enzymes were observed in 14-3-3 overexpression plants. (biomedcentral.com)
These modifications were related to the reduced activities of isocitrate dehydrogenase and malate dehydrogenase, which are key enzymes of TCA cycle. (biomedcentral.com)

Cytostatic drugs cisplatin, paclitaxel, and doxorubicin as well as apoptosis induction with caspase 3 activator PAC-1 and serum deprivation induced αklotho and PPARG gene expression while decreasing viability and proliferation and inducing apoptosis of MDCK and NRK-52E cells to a variable extent. (bvsalud.org)

Taken together, our findings indicate that 14-3-3 proteins play roles as crucial tuners of multiple primary metabolic processes including TCA cycle and the shikimate pathway. (biomedcentral.com)
construction of a synthetic pathway for bioalcohol production at 70°C by insertion of the gene for alcohol dehydrogenase AdhA into the archaeon Pyrococcus furiosus. (brenda-enzymes.info)

Our study further confirms that 14-3-3 proteins are important regulators of both nitrogen and carbon metabolic processes. (biomedcentral.com)
deletion of the hypoxanthine phosphoribosyltransferase gene in ethanol tolerant strain adhE*(EA), carrrying mutation P704L/H734R in the alcohol dehydrogenase gene, and deletion of lactate dehydrogenase (ldh) to redirect carbon flux towards ethanol reults in a strain producing 30% more ethanol than wild type on minimal medium. (brenda-enzymes.info)

Our previous study suggests that three 14-3-3 isoforms (kappa, chi and psi) also play important roles in nitrogen and sulfur metabolic processes by regulating the activities of phosphoenolpyruvate carboxylase and O-acetylserine lyase [ 13 ]. (biomedcentral.com)

The functional relevance of 14-3-3 proteins in the regulatory mechanism of their targets, however, is still not clear. (biomedcentral.com)

The established qPCR targeting the M. parvum glyceraldehyde-3-phosphate dehydrogenase encoding gene (gap) showed a lower detection limit of 10 gene copies per reaction and no cross-reactivity within the specificity test. (bvsalud.org)

14-3-3 proteins are known to regulate diverse processes via binding phosphorylated target proteins in all eukaryotes [ 1 - 5 ]. (biomedcentral.com)

Other names in common use include: dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating) GAPDH glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating) glyceraldehyde-3-phosphate dehydrogenase (NADP) (phosphorylating) NADP-dependent glyceraldehyde phosphate dehydrogenase NADP-glyceraldehyde phosphate dehydrogenase NADP-glyceraldehyde-3-phosphate dehydrogenase NADP-triose phosphate dehydrogenase triosephosphate dehydrogenase (NADP) Brenneman FN, Volk WA (1959). (wikipedia.org)

Five proteins were included in more than two pathways: pyruvate dehydrogenase (PDH) E1 component subunit-α (PDHA), dihydrolipoamide S-acetyltransferase (DLAT), PDH E1 component subunit-β (PDHB), dihydrolipoamide dehydrogenase (DLD) and aldehyde dehydrogenase, mitochondrial precursor (ALDH2). (medscape.com)
3-chloroallyl aldehyde dehydrogenase/ glyceraldehyde-3-p. (cornell.edu)

[ 92 ] PDH activity was regulated by the relative ratios of ATP/ADP, NADH/NAD + and acetyl-CoA/CoA via pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase. (medscape.com)

This was accompanied by an increase in promoter methylation of the gene Sdh1-2 encoding the flavoprotein subunit A, while methylation was low for Sdh2-3 encoding the iron-sulfur subunit B under all conditions. (bvsalud.org)
It is concluded that the dicarboxylic branch of the tricarboxylic acid cycle is regulated by light via the phytochrome mechanism, and promoter methylation is involved with the flavoprotein subunit of succinate dehydrogenase and the mitochondrial fumarase. (bvsalud.org)
Two classes of mutants were defective in production of the a subunit of methanol dehydrogenase, another two classes in the production of both the a subunit and cytochrome c L , while the fifth class produced the a subunit, but did not contain an active methanol dehydrogenase, nor cytochrome c L . The genes defective in these mutants were linked. (microbiologyresearch.org)

Only one gene encoding the mitochondrial NAD-malate dehydrogenase gene (mMdh1) was regulated by red and far-red light, while the second gene (mMdh2) did not respond to irradiation, and neither gene was controlled by promoter methylation. (bvsalud.org)

Malate dehydrogenase (MDH) as an essential metabolic enzyme is widely involved in plant developmental processes. (bvsalud.org)

Pyruvate replaced acetate as the major excreted product, and the following intermediates of glycolysis were excreted in significant amounts: glucose-6-phosphate, fructose-1 ,6-diphos- phate, dihydroxyacetone phosphate, and 3-phosphoglycerate. (nih.gov)

The genes encoding the catalytic subunits of succinate dehydrogenase showed suppression of expression upon irradiation by red light, which was abolished by far-red light. (bvsalud.org)

The expression and methylation of promoters of the genes encoding succinate dehydrogenase, fumarase, and NAD-malate dehydrogenase in maize (Zea mays L.) leaves depending on the light regime were studied. (bvsalud.org)

Total "C-glucose uptake was measured by filtering a chilled sample and wash- ing it with phosphate buffer containing cold glucose (20 pg/ml). (nih.gov)

part of family of 3'-to5' exonucleases. (lbl.gov)

A direct evidence to this is the elicitation of defense response in Arabidopsis that leads to accumulation of defense molecules upon treatment with vibrations caused by churning sound of caterpillar 3 . (nature.com)

Anatomy12

Organisms10

Diseases3

Chemicals and Drugs165

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes42

Disciplines and Occupations1

Information Science3

Health Care1

Oxidoreductase1

Nicotinamide4

GAPDH3

Malate dehydrogenases1

Pentose phospha3

NADPH1

Inorganic2

Reductase2

Oxidative1

Metabolism5

Substrate1

Reactions3

Protein1

Enzymes2

Deprivation1

Pathway2

Carbon2

Important1

Regulatory1

Reaction1

Target1

Triosephosphate1

Aldehyde dehydrogenase2

Pyruvate dehydrogenase1

Subunit3

Mitochondrial1

Enzyme1

Glycolysis1

Catalytic1

Genes1

Glucose1

Family1

Treatment1