HypoglycemiaDiabetesHeart rate variabComplicationsImprove glycemic controlControlLowest variability groupContinuous glucose monitoIndicesOxidative stressCoefficientExcursionsCardiovascularBloodQuartilesAutonomicTriglyceride levelsDiabetic patientsSubclinicalAcuteRiskMmolMeasuresMortalityFingerstickStabilityIndicatorTimeAssessmentLevelsNewlyOutcomesUnclearDataRoleHigh
Hypoglycemia9
- Physical Activity, Glycemic Variability, and Parental Hypoglycemia Fear in Preschoolers With Type 1 Diabetes. (childrensmercy.org)
- Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes. (bvsalud.org)
- CAN was associated with increased glycemic variability with less time in euglycemia attributed to a greater time in hyperglycemia but not hypoglycemia . (bvsalud.org)
- Targeting Hypoglycemia and Glycemic Variability in T2D? (medscape.com)
- The lowest GV and lowest hypoglycemia were observed in patients using the combination of basal insulin with a GLP-1 RA, supporting the complementary glycemic action of these agents in type 2 diabetes. (medtronic.com)
- Lowest glucose variability and hypoglycemia are observed with the combination of a GLP-1 Receptor Agonist and Basal Insulin (VARIATION Study) DOI: 10.2337/dc16-1582. (medtronic.com)
- Glycemic variability (GV) is a measure of glycemic excursions, including hyper and hypoglycemia and is a marker of glucose control and a predictor of diabetic complications in humans. (vin.com)
- This observational study evaluated the association between glycated hemoglobin (A1c) variability and cardiovascular events, emergency admissions, and episodes of severe hypoglycemia among 13,777 patients with type 2 diabetes and newly initiated insulin therapy . (medscape.com)
- The lowest risk for the outcomes of MI, stroke, and severe hypoglycemia was seen with a variability of approximately 0.5% per quarter, with greater risk for patients with both lower and higher variability. (medscape.com)
Diabetes43
- The researchers concluded that "there were clear associations of [fasting glucose plasma] variability with increased risk [for] type 2 diabetes" independent of other confounding variables. (endocrinologyadvisor.com)
- Impact of visit-to-visit fasting plasma glucose variability on the development of type 2 diabetes: a nationwide population-based cohort study [published online Sept. 25, 2018]. (endocrinologyadvisor.com)
- Methods: To explore the relationship between glycemic control and neuroretinal characteristics, 37 persons with Type 1 diabetes mellitus (Type 1 DM) divided into two groups with no signs (noRD) and with mild non-proliferative diabetic retinopathy (NPDR) compared to 13 healthy control participants (C) were recruited. (uniroma1.it)
- We have assessed the relationship between CAN and extensive measures of glucose variability (GV) in patients with type 1 and type 2 diabetes . (bvsalud.org)
- A Swedish study divided 325 people with diabetes on PD into seven groups based on glycemic variability. (homedialysis.org)
- Objective: Assess in a sample of people with type 1 diabetes mellitus whether mood andstress influence blood glucose levels and variability.Material and Methods: Continuous glucosemonitoring was performed on 10 patients with type 1 diabetes mellitus, where interstitial glucosevalues were recorded every 15 min. (udima.es)
- However, the patient's average glucosedecreases as the mood improves.Conclusions: Variations in mood and stress significantly influenceblood glucose levels, and glycemic variability in the patients analyzed with type 1 diabetes mellitus.Therefore, they are factors to consider for improving glycemic control. (udima.es)
- Objective: To compare the acute and chronic effects of low-volume high-intensity interval training (HIIT) to moderate-intensity continuous training (MICT) on glycemic control, body composition and continuous glucose monitoring (CGM) in older women with type 2 diabetes (T2D). (mdpi.com)
- For the past several years, top diabetes pharmaceutical and biotech companies, clinical research organizations, universities, and research hospitals have used CGM to uncover more glycemic data in their drug development as well as real world trials. (medtronic.com)
- Vildagliptin add-on therapy to insulin has the ability to improve glycemic variations, especially during the nocturnal time period, in patients with uncontrolled type 2 diabetes. (medtronic.com)
- The Aim of the present study was to examine whether there is a relationship between autonomic nervous system function and glycemic variability (GV) in patients with type 2 diabetes (T2D). (hindawi.com)
- Cardiac autonomic neuropathy (CAN) in diabetes results from damage to the autonomic nerve fibers (parasympathetic and sympathetic) that innervate the heart and blood vessels, with resultant abnormalities in heart rate control and vascular dynamics [ 1 ], ultimately leading to diminished heart rate variability (HRV) [ 2 ]. (hindawi.com)
- The concept of glycemic variability (GV) in type 2 diabetes (T2D) has recently attracted great interest for several reasons, including association with higher levels of markers of oxidative stress [ 9 ] and increased mortality in certain circumstances, such as sepsis and critical illness [ 10 ]. (hindawi.com)
- Aims: We investigated the interrelationship between HbA1c, fructosamine, glycoalbumin (GA), 1,5-anhydroglucitol (1,5-AG) with glycemic variability data from continuous glucose monitoring system (CGMS).Methods: Seventy diabetic patients (mean age of 54 years including seven type 1 diabetes mellitus subjects) were enrolled, and all wore a CGMS for 72 hours. (endocrine-abstracts.org)
- This study is to determine whether an internet based mentoring program can improve glycemic control in type 1 diabetes (T1DM) patients with inadequate glycemic control.Methods: Patients with T1DM on intensive insulin therapy and with HbA1c . (endocrine-abstracts.org)
- En el tratamiento de los pacientes con diabetes o hiperglucemia de estrés y la nutrición artificial existen muchas áreas de incertidumbre, sobre todo en pacientes no críticos. (isciii.es)
- Las indicaciones y las rutas de acceso a la nutrición artificial no difieren en los pacientes con hiperglucemia de estrés o diabetes respecto a los no diabéticos. (isciii.es)
- Recomendamos el uso de fórmulas enterales diseñadas para pacientes con diabetes (alto contenido en grasas monoinsaturadas) para facilitar el control metabólico. (isciii.es)
- El mejor tratamiento farmacológico para tratar la hiperglucemia/diabetes en pacientes hospitalizados es la insulina, aconsejando adaptar la acción teórica de la insulina al régimen de infusión de la nutrición. (isciii.es)
- AIM: We aimed to examine the effect of Ramadan fasting on interstitial glucose control and variability before, during, and after Ramadan in type 2 diabetes patients receiving insulin therapy. (lu.se)
- CONCLUSIONS: Ramadan fasting in patients with insulin-treated type 2 diabetes is associated with an initial increase in glucose variability that quickly returned to pre-Ramadan levels. (lu.se)
- For hospitalised patients with diabetes, poor glycaemic control is common. (isdi.org)
- The American Diabetes Association has defined two key goals for nutrition therapy of hospitalised patients: to optimise glycaemic control and provide adequate nutrients to meet metabolic demands. (isdi.org)
- Diabetes-specific formulas (DSFs) are a category of foods for special medical purposes designed to meet these objectives by not only supporting the metabolic nutritional requirements of a standard formula, but also minimising glycaemic response. (isdi.org)
- Glycaemic variability and other metrics are not well characterised in subjects without diabetes. (jefferson.edu)
- Our goal is to investigate the glycaemic system as it shifts from health to pre-disease in adult patients without diabetes using CGM metrics. (jefferson.edu)
- In insulin-treated diabetes, disordered gastric emptying may predispose an individual to hypoglycaemia/increased blood glucose variability. (diabetologia-journal.org)
- Is A1c Variability a Useful Measure in Diabetes? (medscape.com)
- Gorst and colleagues conducted a systematic review and meta-analysis to evaluate the association between A1c variability and micro- and macrovascular complications and mortality among patients with type 1 and type 2 diabetes. (medscape.com)
- Seven studies of patients with type 1 diabetes showed an association of A1c variability with renal disease, cardiovascular events, and retinopathy. (medscape.com)
- Thirteen studies evaluated A1c variability among patients with type 2 diabetes. (medscape.com)
- Moreover, eight studies (three in type 1 diabetes and five in type 2 diabetes) indicated that A1c variability was statistically significantly associated with risk for diabetes-related complications after controlling for mean A1c. (medscape.com)
- Cite this: Is A1c Variability a Useful Measure in Diabetes? (medscape.com)
- Suggested citation for this article: Juarez DT, Sentell T, Tokumaru S, Goo R, Davis JW, Mau MM. Factors Associated With Poor Glycemic Control or Wide Glycemic Variability Among Diabetes Patients in Hawaii, 2006-2009. (cdc.gov)
- Although glycemic control is known to reduce complications associated with diabetes, it is an elusive goal for many patients with diabetes. (cdc.gov)
- The objective of this study was to identify factors associated with sustained poor glycemic control, some glycemic variability, and wide glycemic variability among diabetes patients over 3 years. (cdc.gov)
- Longer duration of diabetes, being under age 35, and taking 15 or more medications were significantly associated with sustained poor glycemic control. (cdc.gov)
- Wide glycemic variability was significantly related to being younger than age 50, longer duration of diabetes, having coronary artery disease, and taking 5 to 9 medications per year. (cdc.gov)
- Results indicate that duration of diabetes, age, number of medications, morbidity, and type of insurance coverage are risk factors for sustained poor glycemic control. (cdc.gov)
- evaluar los factores de riesgo del diagnóstico de enfermería Riesgo de glucemia inestable en ancianos con diabetes mellitus tipo 2. (bvsalud.org)
- Poor long-term glycemic control (AUC HbA1c), high blood pressure, and elevated triglyceride levels were correlates of CAN in subjects with type 1 diabetes. (cdc.gov)
- Improved glycemic control, measured by lower A1C levels, reduced the risk for onset and progression of long-term diabetes microvascular and macrovascular complications ( 2 ). (cdc.gov)
- There are opportunities to improve type 2 diabetes mellitus self-management practices in Saudi Arabia and increase the proportion of patients who achieve good glycaemic control. (who.int)
Heart rate variab5
- Assessment of heart rate variability (HRV), orthostatic hypotension, and 24 h blood pressure profiles provide indices of both parasympathetic and sympathetic autonomic function and can be used in clinical settings. (hindawi.com)
- Psychophysiological research integrating heart rate variability (HRV) has increased during the last two decades, particularly given the fact that HRV is able to index cardiac vagal tone. (frontiersin.org)
- heart rate variability (HRV), representing the change in the time interval between successive heartbeats (see Figure 1 ), became a strong focus of psychophysiological research. (frontiersin.org)
- Heart rate variability (HRV). (frontiersin.org)
- CAN was assessed by time and frequency domain indices of heart rate variability (HRV). (cdc.gov)
Complications6
- To prevent complications, it is crucial to understand the role of glycemic variability, particularly the fluctuations between peak and nadir. (klehospital.org)
- High levels of glucose variability can activate oxidative stress, leading to complications. (klehospital.org)
- The contribution of glycemic variability to macrovascular complications remains unclear. (biomedcentral.com)
- Your diabetic complications depend upon how much variations you have in your blood glucose on a daily basis and this is called glycemic variability. (sugarfreepak.com)
- Background: Increased glycaemic variability (GV) (short-term fluctuations in blood glucose level) is associated with increased oxidative stress, vascular complications and mortality in diabetic and prediabetic patients. (eurospe.org)
- Poor glycaemic control, dyslipidaemia and HT are common in diabetic children, putting them at risk of cardiovascular complications in adulthood. (who.int)
Improve glycemic control1
- Patients with these characteristics may need additional therapies and targeted interventions to improve glycemic control. (cdc.gov)
Control14
- Data suggest that intermittent bolus nutrition is better for glycemic control than continuous nutrition. (unige.it)
- Objective: Craving of sweet foods and sucrose may be a big obstacle for glycemic control of diabetic patients. (endocrine-abstracts.org)
- Stability in glycemic control (hourly change in the median) for NGT subjects averaged 3 +/- 1 mg/dL/h. (healthpartners.com)
- Ramadan fasting was not associated with any significant changes in glycemic control measures. (lu.se)
- With this data and knowledge in hand, you can better understand what dietary and lifestyle habits may be contributing to your poor glycemic control. (nutrisense.io)
- The once-weekly SQ administration of EER in cats has been investigated and shown to be safe, with potential beneficial effects on glycemic control and diabetic remission. (vin.com)
- Factors Associated With Poor Glycemic Control or Wide Gl. (cdc.gov)
- continuing medical education (CME) for this journal article, allowing clinicians the Analyze risk factors for poor glycemic control among patients opportunity to earn CME credit. (cdc.gov)
- We conducted multivariable logistic regressions to examine factors related to sustained poor control, some glycemic variability, and wide glycemic variability during the next 3 years. (cdc.gov)
- Preferred provider organization and Medicare (vs health maintenance organization) enrollees and patients with high morbidity were less likely to have sustained poor glycemic control. (cdc.gov)
- If those measures are not sufficient for glycemic control, patients may be prescribed non- insulin antihyperglycemic medications (eg, injectable glucagon -like peptide-1 [GLP-1] receptor agonists), insulin , or a combination of these medications. (msdmanuals.com)
- Suboptimal glycemic control and elevated triglycerides were the modifiable risk factors associated with CAN. (cdc.gov)
- Only 15% of participants had a blood glucose level indicative of good glycaemic control (glycosylated haemoglobin 7 mmol/L). (who.int)
- EDIC) has shown that poor glycaemic control is associated measured annual y in all children older than 11 years who have had with a potential y more atherogenic profile in adults. (who.int)
Lowest variability group2
- Using the lowest variability group as a reference point, survival was significantly better with less variability in blood sugar. (homedialysis.org)
- They further considered whether studies compared the highest vs lowest variability group (eg, quartiles) or evaluated continuous (incremental) increase in variability. (medscape.com)
Continuous glucose monito1
- The standard deviation of blood glucose values (SDBG) and the mean amplitude of glycemic excursion (MAGE) were calculated from continuous glucose monitoring system data for assessing glycemic variability while 24h mean blood glucose (MBG) was calculated for measuring overall blood glucose level. (biomedcentral.com)
Indices1
- Fasting plasma glucose coefficient of variation, standard deviation, and variability independent of the mean were indices used to calculate fasting glucose plasma variability. (endocrinologyadvisor.com)
Oxidative stress1
- It is intriguing to hypothesize that increased glycemic variability may lead to autonomic imbalance through oxidative stress and acute elevation of proinflammatory cytokines [ 13 ]. (hindawi.com)
Coefficient1
- Glycaemic variability coefficient (GVC) was calculated using the standard deviation and the average glucose value obtained by SCGM. (eurospe.org)
Excursions2
- The mean amplitude of glycemic excursions did not differ between the two cohorts statistically. (unige.it)
- Both short- and long-acting glucagon-like peptide-1 receptor agonists slow gastric emptying to diminish postprandial glycaemic excursions. (diabetologia-journal.org)
Cardiovascular2
- Beyond this however, there's also research showing that high glycemic variability is an independent risk factor for cardiovascular disease. (nutrisense.io)
- Area under the curve (AUC) was used to assess the longitudinal glycemic exposure and cardiovascular risk factors. (cdc.gov)
Blood6
- Glycemic variability is the up and down variations in blood glucose level. (drdanenberg.com)
- Individual response to glycemic index values vary so much that it may not be useful in indicating blood sugar response, says research published in the American Journal of Clinical Nutrition . (medicalnewstoday.com)
- The glycemic index (GI) of a food indicates the speed with which blood sugar can be expected to rise after a person eats it. (medicalnewstoday.com)
- A food that is low glycemic index for you one time you eat it could be high the next time, and it may have no impact on blood sugar for me," she adds. (medicalnewstoday.com)
- They also looked at how the biological factors such as sex, body-mass index ( BMI ), blood pressure , and physical activity impact GI variability. (medicalnewstoday.com)
- Another biological correlate of negative mood and lower quality of life is glycemic variability, or constant fluctuation in blood sugar. (alive.com)
Quartiles2
Autonomic1
- So far it is not known whether glycemic variability is associated with cardiac autonomic dysfunction in diabetic patients [ 12 ]. (hindawi.com)
Triglyceride levels2
- Whether triglyceride variability, independent of absolute triglyceride levels, is a predictor of acute pancreatitis is unknown. (lww.com)
- In this multi-institutional cohort study, high triglyceride variability was associated with an increased risk of first attack of acute pancreatitis, independent of baseline and mean triglyceride levels. (lww.com)
Diabetic patients1
- We therefore investigated the association between glycemic variability and cervical and/or intracranial atherosclerosis in Chinese type 2 diabetic patients. (biomedcentral.com)
Subclinical2
- and (ii) to explore the role of glycemic variability in both the subclinical stage and plaque formation stage of atherosclerosis in this population. (biomedcentral.com)
- The association between triglyceride variability and acute pancreatitis may be partly mediated by subclinical inflammation. (lww.com)
Acute1
- Meanwhile, several lines of evidence have raised the possibility that glycemic variability, which includes both upward and downward acute glucose changes, is another important component of dysglycemia [ 3 ]. (biomedcentral.com)
Risk4
- Various medical papers have shown that the standard deviation of glycemic variability directly correlates with the risk of chronic disease and cancer. (drdanenberg.com)
- High Triglyceride Variability Increases the Risk of First At. (lww.com)
- Emergency admissions produced a more linear relationship, with the lowest risk occurring among those with no variability. (medscape.com)
- Higher A1c variability was associated with higher risk for renal disease, macrovascular events, ulceration/gangrene, CVD, and mortality. (medscape.com)
Mmol1
- Seuls 15 % des participants présentaient un taux glycémique révélateur d'un bon contrôle de leur glycémie (hémoglobine glycosylée 7 mmol/L). La plupart indiquaient avoir pris leur traitement comme prescrit, mais ils étaient nombreux à présenter des taux d'observance faibles pour d'autres pratiques d'auto-prise en charge (moyenne d'observance globale hebdomadaire : 3,7 jours sur sept). (who.int)
Measures1
- One study conducted in 2018, for example, found that many individuals considered non diabetic by standard measures had high glucose variability revealed by the CGM . (nutrisense.io)
Mortality1
- Effect of in-hospital glycemic variability on mortality in. (revclinesp.es)
Fingerstick1
- Are you still only relying on A1C and fingerstick testing to assess glycemic safety, efficacy, and superiority endpoints in your clinical studies? (medtronic.com)
Stability1
- AGP analysis, which graphs CGM data by time without regard to date, was used to characterize glucose exposure, variability, and stability. (healthpartners.com)
Indicator1
- The mean of daily differencesdoes not seem to be a good indicator for variability. (udima.es)
Time3
- These optimized glycemic data sets can be analyzed more efficiently to assess safety, efficacy, and superiority endpoints in the studies in less time. (medtronic.com)
- Glycemic variability is the degree to which your glucose fluctuates over time. (nutrisense.io)
- The investigators calculated variability using differences between A1c measurements scaled according to length of time between measurements, thereby producing a standardized rate of change. (medscape.com)
Assessment1
- With the emergence of continuous glucose monitoring (CGM) technology, the assessment of glycemic variability is now much less cumbersome. (biomedcentral.com)
Levels1
- In fact, a quarter of the participants had severe glucose variability for up to 15 percent of the study duration, with glucose levels reaching the prediabetic range. (nutrisense.io)
Newly1
- Glycemic variability in newly diagnosed diabetic cats treated with the glucagon-like peptide-1 analogue exenatide extended release. (vin.com)
Outcomes1
- Estimated 5-year incidences of all outcomes increased dramatically with greater A1c variability. (medscape.com)
Unclear2
- However, the exact role of glucose variability in the development of atherosclerosis remains unclear. (biomedcentral.com)
- The effect of light to moderate intensity exercise, such as that used as a mode of transport, on glycaemic response (GR) testing is unclear. (brookes.ac.uk)
Data2
- BIG IDEAs Lab Glycemic Variability and Wearable Device Data (version 1.1.1). (physionet.org)
- As always though, glycaemic targets should be individualised and rarely is that more applicable than in the personal use of CGM and the data it provides. (springer.com)
Role3
- To gain insight into the role of glycemic variability in the different stages of atherosclerosis, we used both ultrasonography and MRA to determine preclinical atherosclerosis and plaque formation. (biomedcentral.com)
- Macfarlane, W 2018, ' P32 Glycaemic variability induces beta cell dysfunction: The role of oscillations in glucose concentration ', Diabetic Medicine , vol. 35, pp. 40-41. (brighton.ac.uk)
- However, the role of glycemic variability (GV) on early retinal neurodegeneration is still not clarified. (uniroma1.it)
High1
- In normal individuals the heart rate has a high degree of beat-to-beat variability, fluctuating with respiration, increasing with inspiration and decreasing with expiration. (hindawi.com)