AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth CareGeographicals
InsulinIslets of LangerhansInsulin-Secreting CellsGlycemic IndexGlucoseHemoglobin A, GlycosylatedBlood GlucoseHypoglycemic AgentsDiabetes Mellitus, Type 2Receptor, InsulinHyperglycemiaDiabetes Mellitus, Type 1Blood Glucose Self-MonitoringHypoglycemiaInsulin ResistanceInsulin, Long-ActingInsulin Infusion SystemsDiabetic DietDiabetes MellitusMetforminDietary CarbohydratesSulfonylurea CompoundsInsulin LisproInsulin, IsophaneGlucose Tolerance TestPostprandial PeriodFructosamineC-PeptideDiabetes ComplicationsInsulin Receptor Substrate ProteinsGlucagon-Like Peptide 1Insulin AspartFastingObesityInfusions, SubcutaneousDipeptidyl-Peptidase IV InhibitorsDiabetic AngiopathiesInsulin AntibodiesVenomsGlucose Clamp TechniqueDiabetes Mellitus, ExperimentalSelf CareThiazolidinedionesInsulin AntagonistsGlucagonGlipizidePancreas, ArtificialBody Mass IndexDiabetic NephropathiesBody WeightPregnancy in DiabeticsHyperinsulinismLipidsAdipose TissueRisk FactorsTreatment OutcomeDiabetic KetoacidosisInsulin, Short-ActingMonitoring, PhysiologicDiabetic RetinopathyTime FactorsBiphasic InsulinsIncretinsDiagnostic EquipmentBiological MarkersCross-Over StudiesCritical IllnessPatient ComplianceTriglyceridesCritical CareGlycosuriaFatty Acids, NonesterifiedWeight LossInsulin, Regular, PorkGlucose IntoleranceHyperglycemic Hyperosmolar Nonketotic ComaDiabetic NeuropathiesLiverGliclazideCross-Sectional StudiesHomeostasisDietMuscle, SkeletalReceptors, GlucagonInsulinsDeoxyglucoseDrug Therapy, CombinationAcarboseAllylamineAlbuminuriaEpichlorohydrinFollow-Up StudiesProinsulinMonitoring, AmbulatorySodium-Glucose Transporter 2AdamantaneDietary FiberEnergy IntakeDiet, Carbohydrate-RestrictedInsulin, Regular, Human
ResistanceSecretionProposed to improve glycemic controlDiabetes mellitusPoor glycaemic controlDegludecHbA1cGlargineHypoglycemiaSensitivityAdequate glycemic controlLong-Acting InsulinsRegimensImprovesRegulation of glucose metabolismAchieve glycemicTypeDetemirIntensive insulinSubcutaneous injectionHepaticPancreasMetabolicDaily insulinHyperglycemiaAntidiabeticHypoglycaemia20160.05DosesInhibitsConcentrationsAspartClinicalInjectionsLisproDoseBlood glucose and insulinTherapyGlucose levelsPeripheralPancreaticMedicationsMETHODSRegimenT2DM
Resistance34
Secretion12
Proposed to improve glycemic control1
  • Monitoring additional biomarkers alongside glucose has been proposed to improve glycemic control. (elsevierpure.com)
Diabetes mellitus15
  • Background: Currently, glycemic management for individuals with diabetes mellitus involves monitoring glucose only, which is insufficient as glucose metabolism involves other biomarkers such as insulin. (elsevierpure.com)
  • This is the assessment of the relative effectiveness of 'Sotagliflozin indicated as an adjunct to insulin therapy to improve glycaemic control in adults with type 1 diabetes mellitus with a Body Mass Index (BMI) ≥ 27 kg/m 2 , who have failed to achieve adequate glycaemic control despite optimal insulin therapy. (scuba-capsule.fr)
  • Hypoglycaemia is a frequent adverse effect of treatment of diabetes mellitus with insulin and sulphonylureas. (nature.com)
  • Fear of hypoglycaemia alters self-management of diabetes mellitus and prevents optimal glycaemic control. (nature.com)
  • Mild (self-treated) and severe (requiring help) hypoglycaemia episodes are more common in type 1 diabetes mellitus but people with insulin-treated type 2 diabetes mellitus are also exposed to frequent hypoglycaemic events, many of which occur during sleep. (nature.com)
  • Prevention of hypoglycaemia is an important part of diabetes mellitus management and strategies include patient education, glucose monitoring, appropriate adjustment of diet and medications in relation to everyday circumstances including physical exercise, and the application of new technologies such as real-time continuous glucose monitoring, modified insulin pumps and the artificial pancreas. (nature.com)
  • TRESIBA is indicated to improve glycemic control in adults with diabetes mellitus. (globalrph.com)
  • Young people with insulin- dependent diabetes mellitus (IDDM) may have a higher prevalence of eating disorders, such as anorexia nervosa and bulimia, and adults with longstanding diabetes and major medical complications have a higher prevalence of symptoms of depression and anxiety. (cdc.gov)
  • Elderly persons who have non-insulin-dependent diabetes mellitus (NIDDM) and other symptomatic medical conditions may also have a higher risk of developing psychological problems. (cdc.gov)
  • Complications of Diabetes Mellitus In patients with diabetes mellitus, years of poorly controlled hyperglycemia lead to multiple, primarily vascular, complications that affect small vessels (microvascular), large vessels (macrovascular). (msdmanuals.com)
  • By studying diabetic dyslipid- in diabetes mellitus because insulin resist- aemia among a group of our patients we ance or deficiency affects key enzymes hoped to draw attention of the medical com- and pathways in lipid metabolism [ 1 ]. (who.int)
  • To determine the clinical changes occurred in chronic periodontitis patients presenting uncontrolled type 2 diabetes mellitus after a supragingival plaque control period. (bvsalud.org)
  • It may be concluded that uncontrolled diabetes mellitus reduces periodontal changes in the supragingival plaque control regimen of subjects presenting with chronic periodontitis. (bvsalud.org)
  • diabetes mellitus, plaque control, chronic periodontitis. (bvsalud.org)
  • Chronic periodontitis results from the presence of complex microbial communities in the subgingival sulcus 1 , and diabetes mellitus, especially if poorly controlled, increases significantly risk for development of extensive and severe diseases 2 . (bvsalud.org)
Poor glycaemic control4
  • Poor glycaemic control, dyslipidaemia and HT are common in diabetic children, putting them at risk of cardiovascular complications in adulthood. (who.int)
  • EDIC) has shown that poor glycaemic control is associated measured annual y in all children older than 11 years who have had with a potential y more atherogenic profile in adults. (who.int)
  • The mean duration of diabetes was 9.4 years and 46.0% of patients had poor glycaemic control. (who.int)
  • There was a statistically significant association of triglycerides and HDL-C with increasing age, female sex, obesity, physical inactivity and poor glycaemic control of diabetes. (who.int)
Degludec10
  • The patient's blood glucose level was ultimately controlled by intensive insulin therapy (degludec 9 U before dinner and lispro 24 U before breakfast, 5 U before lunch, and 15 U before dinner). (cdc.gov)
  • TRESIBA forms multi-hexamers when injected into the subcutaneous tissue resulting in a subcutaneous insulin degludec depot. (globalrph.com)
  • The protracted time action profile of TRESIBA is predominantly due to delayed absorption of insulin degludec from the subcutaneous tissue to the systemic circulation and to a lesser extent due to binding of insulin-degludec to circulating albumin. (globalrph.com)
  • I think that basal insulin analogues 20 years ago, 22 years ago, were transformational on how to treat type 2 diabetes with once-daily glargine or degludec, and so on. (medpagetoday.com)
  • Here, similar findings were seen among a 588-participant group comparing once-weekly icodec to once-daily insulin degludec in insulin-naïve patients with type 2 diabetes. (medpagetoday.com)
  • Less Hypoglycemia With Insulin Degludec? (medscape.com)
  • Today we reported on the SWITCH 2 study , [ 1 ] which looks at insulin degludec . (medscape.com)
  • Patients with type 2 diabetes were randomized to receive either insulin glargine or insulin degludec and were titrated weekly to attempt to get the fasting glucose down to less than 90 mg/dL. (medscape.com)
  • Overall, hypoglycemia was reduced by 30% with insulin degludec compared with insulin glargine. (medscape.com)
  • Nocturnal hypoglycemia was reduced by 42%, and severe hypoglycemia, although it did not reach statistical significance, was 50% lower with insulin degludec. (medscape.com)
HbA1c9
  • A literature search was conducted through PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science, to identify Randomized Control Trials (RCTs) that evaluated the effect of milled or ground flaxseed supplementation on fasting blood glucose, HbA1c, insulin concentrations, or HOMA-IR. (unboundmedicine.com)
  • We studied the association between glycosylated hemoglobin (HbA1c) and the risk of a motor vehicle crash using a population-based case control analysis. (plos.org)
  • The mean HbA1c was lower for those in a crash than controls (7.4% versus 7.9%, unpaired t -test, p = 0.019), equal to a 26% increase in the relative risk of a crash for each 1% reduction in HbA1c (odds ratio = 1.26, 95% confidence interval 1.03-1.54). (plos.org)
  • In this selected population, tighter glycemic control, as measured by the HbA1c, is associated with an increased risk of a motor vehicle crash. (plos.org)
  • ABSTRACT A study of 1000 patients attending a diabetes referral centre in Amman, Jordan, identified factors associated with good glycaemic control, as measured by glycosylated haemoglobin (HbA1c) levels. (who.int)
  • RÉSUMÉ Une étude sur 1 000 patients consultant dans un centre d'orientation-recours spécialisé dans le traitement du diabète à Amman (Jordanie) a mis en évidence les facteurs associés à un bon contrôle de la glycémie, mesuré par les taux d'hémoglobine glycosylée (HbA1c). (who.int)
  • La régression multivariée a mis en évidence qu'un faible indice de masse corporelle, un diabète de plus courte durée et une ligne de base du taux de HbA1c plus élevée étaient associés à une baisse du taux de HbA1c entre la première consultation et celle réalisée 12 mois après. (who.int)
  • This could be partly due to insulin index and baseline HbA1c levels. (medicalnewstoday.com)
  • The 143-site open-label trial include 492 participants in both groups, all of whom had type 2 diabetes (baseline HbA1c between 7-11%) and were never previously treated with insulin. (medpagetoday.com)
Glargine3
  • Initiation of insulin glargine in patients with Type 2 diabetes in suboptimal glycaemic control positively impacts health-related quality of life. (tilburguniversity.edu)
  • SAN DIEGO -- Investigational once-weekly insulin icodec outperformed once-daily insulin glargine U100 when it came to glycemic control in type 2 diabetes, the phase IIIa ONWARDS 1 trial found. (medpagetoday.com)
  • The average weekly insulin dose was 214 U per week (about 31 U per day) in the icodec group and 222 U per week (about 32 U per day) in the glargine U100 group during the main phase of the trial. (medpagetoday.com)
Hypoglycemia7
  • A lower reading is considered an indicator of good diabetic control, but conversely, a blood glucose level that is too low can cause hypoglycemia. (plos.org)
  • The Diabetes Control and Complications Trial (DCCT) identified an inverse relationship between HbA 1c and severe hypoglycemia. (diabetesjournals.org)
  • We investigated the relationship between hypoglycemia and HbA 1c in a large type 1 diabetes cohort on multiple daily injection or insulin pump therapy using blinded continuous glucose monitoring (CGM) data. (diabetesjournals.org)
  • When we use insulin, there always will be hypoglycemia, but we only had less than one event per year. (medpagetoday.com)
  • When our patients with type 2 diabetes are ready to start insulin, there is great concern on the part of the provider as well as the patient as to the risk that this medication will pose for hypoglycemia . (medscape.com)
  • It turns out that these concerns about hypoglycemia not only prevent or postpone the initiation of insulin, but they also often prevent us from being able to titrate basal insulin up to help patients reach their glycemic targets. (medscape.com)
  • The lower hypoglycemia rate shown with ultra-long-acting insulins is important information for providers so that they may have more confidence in starting insulin in their patients. (medscape.com)
Sensitivity7
  • and hepatic and peripheral insulin sensitivity was measured with a two-step euglycemic insulin (40 and 160 mU · min − 1 · m -2 ) clamp performed with 3-[ 3 H]glucose and indirect calorimetry. (diabetesjournals.org)
  • CONCLUSIONS -These results suggest that pioglitazone therapy in type 2 diabetic patients decreases fasting and postprandial plasma glucose levels by improving hepatic and peripheral (muscle) tissue sensitivity to insulin. (diabetesjournals.org)
  • In this work, the development of a rapid and label-free insulin biosensor with high sensitivity and accuracy is presented. (elsevierpure.com)
  • Results: The optimal frequency of insulin is 810.5 Hz, which is characterized by having the highest sensitivity and sufficient specificity. (elsevierpure.com)
  • D+I and D+I+M rats decreased the glycemia and D+I+M rats increased the insulin sensitivity compared to D rats. (hindawi.com)
  • Improves insulin sensitivity and efficiency. (fatfreekitchen.com)
  • Rosiglitazone is an antidiabetic agent (thiazolidinedione derivative) that improves glycemic control by improving insulin sensitivity. (medscape.com)
Adequate glycemic control1
  • I would love to be able to say that if a person were to add insulin to their treatment regimen, that they would be able to easily achieve adequate glycemic control, but we know that's not true. (managedhealthcareexecutive.com)
Long-Acting Insulins1
  • If all things were equal and this were available to our patients, I would recommend that we start one of the ultra-long-acting insulins as the basal insulin of choice. (medscape.com)
Regimens2
  • Aims: Carbohydrate (CHO) quantification is used to adjust pre-meal insulin in intensive insulin regimens. (edu.au)
  • Dr Jennifer Brigitte Green addresses clinical considerations for patients with type 2 diabetes who are not responding to their oral antidiabetic agents and discusses her strategy for insufficient target glycemic control with insulin regimens. (managedhealthcareexecutive.com)
Improves1
  • The present meta-analysis provides evidence that MSD improves outcomes of glycemic control, body weight and cardiovascular risk factors in T2D patients. (nature.com)
Regulation of glucose metabolism1
Achieve glycemic1
  • Only half of the many patients with type 2 diabetes in the US achieve glycemic control with current medical treatment, Schauer noted. (medscape.com)
Type27
  • Insulin is released when eating any meal that contains carbohydrates or protein, however, in larger amounts based on the type of food you eat. (cancerproofkitchen.com)
  • Aims To evaluate short‐ and long‐term glycaemic control and hypoglycaemia incidence in insulin‐naïve patients ≥30 years of age with type 2 diabetes (T2DM) initiating basal insulin (BI) with or without oral anti‐hyperglycaemic drugs (OADs). (le.ac.uk)
  • Yamaoka K, Tango T . Efficacy of lifestyle education to prevent type 2 diabetes: a meta-analysis of randomized controlled trials. (nature.com)
  • Type 1 diabetes occurs when the body's immune system prevents the production of insulin, the hormone that controls blood glucose. (plos.org)
  • Patients with type 1 diabetes need to inject insulin to survive. (plos.org)
  • The other , from Maria Vamvini, MD, of the Joslin Diabetes Center, Boston, Massachusetts, and colleagues, showed that age and glycemic control didn't differ significantly between adults with type 1 diabetes hospitalized for COVID-19 and those hospitalized for other reasons. (medscape.com)
  • Indeed, in pivotal phase 3 trials, URLi was superior to Lispro for PPG control both at 1 and 2 hours after a meal in type 1 and type 2 diabetes with multiple daily injections, and in type 1 diabetes with continuous subcutaneous insulin infusion. (nih.gov)
  • Fifty-four patients with type 2 diabetes participated in this randomized, double-blind, placebo controlled study. (magiran.com)
  • Despite metformin being widely used in T2D treatment [ 7 , 19 ], recent clinical studies evaluated dual therapy with insulin and metformin for type 1 diabetic (T1D) patients [ 20 , 21 ]. (hindawi.com)
  • Schauer replied that the trial was not powered to detect this, but "if [patients] have type 2 diabetes and are not well controlled, we generally encourage them to go with the gastric-bypass procedure. (medscape.com)
  • The review question is: Are metabolic outcomes improved in outpatient adolescents (aged 13 to 19 years) with type 1 diabetes on a Continuous Subcutaneous Insulin Infusion (CSII) when continuous glucose monitoring is used, compared to self-glucose monitoring alone? (nih.gov)
  • Type 1 diabetes is the most common childhood paediatric disease, characterised by impairment of insulin producing βeta-cells in the pancreas. (nih.gov)
  • The Diabetes Control and Complications Trial (DCCT) study in 1993 ( 1 ) demonstrated a substantial reduction in microvascular complication risk in an intensely treated group of adults with type 1 diabetes, and later analysis confirmed a reduction in macrovascular risk ( 2 ). (diabetesjournals.org)
  • Individualize dose based on type of diabetes, metabolic needs, blood glucose monitoring results and glycemic control goal. (globalrph.com)
  • Many people on oral medications for the management of hyperglycemia and type 2 diabetes will not be meeting their glycemic goals, but they still might be responding to the oral medications. (managedhealthcareexecutive.com)
  • The other thing to keep in mind is that there will be the occasional cases where an adult with newly or recently diagnosed diabetes actually has a kind of diabetes that is autoimmune, or type 1, or related to very significant inability to product insulin. (managedhealthcareexecutive.com)
  • For many people with type 2 diabetes, they do progress to insulin therapy. (managedhealthcareexecutive.com)
  • And in fact, if you look across the landscape of people with type 2 diabetes in this country, unfortunately, people who are on insulin tend to have poorer glycemic control than individuals who aren't using insulin. (managedhealthcareexecutive.com)
  • Insulin though is a really powerful tool, and I don't want to downplay its role in the management of type 2 diabetes. (managedhealthcareexecutive.com)
  • But insulin only addresses 1 of the physiologic abnormalities that contributes to hyperglycemia and type 2 diabetes. (managedhealthcareexecutive.com)
  • Studies in nondiabetic subjects and patients with type 1 (insulin-dependent) diabetes demonstrated that Humalog, the rapid-acting component of Humalog Mix75/25, is absorbed faster than Regular human insulin (U-100). (nih.gov)
  • I feel that weekly insulins have the potential to become transformational as preferred options for basal insulin replacement in people with type 2 diabetes in need of initiation of insulin therapy," Rosenstock said during an ADA presentation. (medpagetoday.com)
  • AIM: We aimed to examine the effect of Ramadan fasting on interstitial glucose control and variability before, during, and after Ramadan in type 2 diabetes patients receiving insulin therapy. (lu.se)
  • CONCLUSIONS: Ramadan fasting in patients with insulin-treated type 2 diabetes is associated with an initial increase in glucose variability that quickly returned to pre-Ramadan levels. (lu.se)
  • Terms that describe the age of onset (juvenile or adult) or type of treatment ( insulin -dependent or non- insulin -dependent) are no longer used because of overlap in age groups and treatments between disease types. (msdmanuals.com)
  • ABSTRACT This study investigated the patterns and determinants of lipid disorders among a group of 250 type 2 adult diabetic patients and 60 age- and sex-matched healthy controls in Sudan. (who.int)
  • Thus, the aim of the present study was to determine clinical changes in type 2 diabetic patients after 28 days of strict supragingival plaque control compared with non-diabetic patients. (bvsalud.org)
Detemir10
  • Insulin detemir differs from human insulin in that the amino acid threonine in position B30 has been omitted, and a C14 fatty acid chain has been attached to the amino acid B29. (globalrph.com)
  • Each milliliter of LEVEMIR contains 100 U (14.2 mg/mL) insulin detemir, 65.4 mcg zinc, 2.06 mg m-cresol, 16.0 mg glycerol, 1.80 mg phenol, 0.89 mg disodium phosphate dihydrate, 1.17 mg sodium chloride, and water for injection. (globalrph.com)
  • Insulin Detemir must NOT be diluted or mixed with any other insulin or solution. (globalrph.com)
  • Insulins, including insulin detemir, exert their specific action through binding to insulin receptors. (globalrph.com)
  • Insulin detemir is a soluble, long-acting basal human insulin analog with a relatively flat action profile. (globalrph.com)
  • The prolonged action of LEVEMIR is mediated by the slow systemic absorption of insulin detemir molecules from the injection site due to strong self-association of the drug molecules and albumin binding. (globalrph.com)
  • Insulin detemir is distributed more slowly to peripheral target tissues since insulin detemir in the bloodstream is highly bound to albumin. (globalrph.com)
  • After subcutaneous injection of insulin detemir in healthy subjects and in patients with diabetes, insulin detemir serum concentrations indicated a slower, more prolonged absorption over 24 hours in comparison to NPH human insulin. (globalrph.com)
  • insulin detemir, pramlintide. (medscape.com)
  • ethanol, insulin detemir. (medscape.com)
Intensive insulin1
  • Conclusions: In patients using intensive insulin therapy, an individually calculated insulin dose for 60 g of carbohydrate maintains postprandial BGLs for meals containing between 50 and 70 g of carbohydrate. (edu.au)
Subcutaneous injection2
  • On the second day of hospitalization, we switched from intravenous to subcutaneous injection of insulin. (cdc.gov)
  • Figure 1: Serum Immunoreactive Insulin (IRI) Concentrations, After Subcutaneous Injection of Humalog Mix75/25 or Humulin 70/30 in Healthy Nondiabetic Subjects. (nih.gov)
Hepatic2
  • This agent increases hepatic glucose output by inhibiting pancreatic insulin release and, possibly, through an extrapancreatic effect, as well as decreases cellular glucose uptake. (medscape.com)
  • Insulin and its analogs lower blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. (globalrph.com)
Pancreas4
  • This means much better control over the release of insulin - an important fat storage hormone secreted by the pancreas. (cancerproofkitchen.com)
  • But when blood sugar levels are chronically elevated, the pancreas becomes stressed and progressively more dysfunctional, unable to produce enough insulin to deal with the spikes. (vitalitymagazine.com)
  • Excess body fat blocks cell receptor because of which insulin can't function properly causing pancreas to secret even more insulin to its regular capacity making body resistant to insulin and further resulting in a lot of other associated complications. (indiatimes.com)
  • Repaglinide is a meglitinide analogue, a secretagogue that acts on the pancreas to stimulate the release of insulin. (medscape.com)
Metabolic3
  • The bottom line is that a low-glycemic diet with plenty of fiber-rich vegetables seems to offer huge benefits for those wishing to lose weight and address illnesses like metabolic syndrome, prediabetes, and diabetes. (cancerproofkitchen.com)
  • This would be consistent with possible beneficial metabolic effects as a consequence of the lower and prolonged glycaemic response and lower insulinaemic burden. (cambridge.org)
  • However, despite the positive association between parents' well-being and children's metabolic control (35), little research has investigated changes in parents' diabetes treatment-related burden or in parents' feeling and stress around managing a chronic illness after their children attended the camp (10, 22, 36). (researchgate.net)
Daily insulin1
  • Five months after discharge, the patient still requires multiple daily insulin injections for glycemic control. (cdc.gov)
Hyperglycemia2
  • Development of advanced glycation end products (AGEs), i.e. the cross-linking of proteins and glucose caused by chronically elevated levels of glucose and insulin in the blood causing hyperglycemia and hyperinsulinemia. (vitalitymagazine.com)
  • Insulin administration, carbohydrate counting, and correction of hyperglycemia are necessary for maintaining glycemic control. (nih.gov)
Antidiabetic2
  • about half were taking at least three antidiabetic medications, and about half were taking insulin. (medscape.com)
  • The patients in the surgery groups attained this glycemic control with fewer antidiabetic medications (often none), including less use of insulin. (medscape.com)
Hypoglycaemia4
  • A multivariable logistic regression model assessed baseline and short‐term (0‐3 months post BI initiation) factors associated with long‐term (3‐24 months) glycaemic control and hypoglycaemia. (le.ac.uk)
  • Treatment response and hypoglycaemia incidence by 3 months post BI initiation are associated with longer‐term glycaemic control and hypoglycaemic risk, respectively. (le.ac.uk)
  • These results support the need for early anti‐hyperglycaemic interventions that more effectively control blood glucose levels without increasing the risk of hypoglycaemia. (le.ac.uk)
  • Increased demand for faster acting insulins, which can quickly control PPG excursions without increasing the risk of late hypoglycaemia, led to the development of ultra-rapid-acting insulins, including ultra-rapid lispro (URLi). (nih.gov)
20161
  • Differential changes in clinical outcomes comparing propensity-score matched members who switched from analog to human insulin versus members who did not switch (i.e. remained on analog insulin) in the subgroup of patients who had continuous enrollment between 2014 and 2016, excluding those who died. (jamanetwork.com)
0.051
  • 0.05 for all glycaemic variables) at improving glycaemic control. (edu.au)
Doses2
  • The groups didn't differ in outpatient insulin doses corrected for weight or in glycemic control in the months preceding admission. (medscape.com)
  • When nondiabetic subjects received equivalent doses of Regular human insulin, peak insulin concentrations occurred between 50 to 120 minutes after dosing. (nih.gov)
Inhibits5
  • Insulin inhibits the use of fat as an energy source by stopping the release of glucagon - another peptide hormone that helps in the release of glucose. (cancerproofkitchen.com)
  • Insulin also inhibits lipolysis and proteolysis, and enhances protein synthesis. (globalrph.com)
  • Insulin inhibits lipolysis in the adipocyte, inhibits proteolysis, and enhances protein synthesis. (globalrph.com)
  • In muscle and other tissues (except the brain), insulin causes rapid transport of glucose and amino acids intracellularly, promotes anabolism, and inhibits protein catabolism. (nih.gov)
  • In the liver, insulin promotes the uptake and storage of glucose in the form of glycogen, inhibits gluconeogenesis, and promotes the conversion of excess glucose into fat. (nih.gov)
Concentrations2
  • 0.01) decreased significantly without change in fasting or glucose-stimulated insulin/C-peptide concentrations. (diabetesjournals.org)
  • Activation of PPAR-gamma receptors regulates insulin-responsive gene transcription involved in glucose production, transport, and utilization, thereby reducing blood glucose concentrations and reducing hyperinsulinemia. (medscape.com)
Aspart1
  • In a head-to-head study with Faster aspart, Aspart and Lispro, URLi was absorbed faster, provided earlier insulin action, and more closely matched physiological glucose response than the other insulins tested. (nih.gov)
Clinical9
  • This non-randomized clinical trial was aimed at evaluating the effects of insulin therapy optimization with SAP therapy , combined with a structured educational program, on glycemic control and body composition in individuals with insulin -requiring CFRD. (bvsalud.org)
  • Study participants contributed hypoglycemic or hyperglycemic events only if they had been dispensed insulin during the same month as their clinical event. (jamanetwork.com)
  • The principal research methodologies used within the department are epidemiological, clinical and psychological research, including cross sectional studies, cohort studies and randomised controlled trials. (kcl.ac.uk)
  • There are many glycemic management barriers among patients, such as cost, patient perceptions, and clinical inertia. (ajmc.com)
  • Individual response to glycemic index values vary so much that it may not be useful in indicating blood sugar response, says research published in the American Journal of Clinical Nutrition . (medicalnewstoday.com)
  • All subjects went through 28 days of supragingival plaque control - ST - (including prophylaxis, calculus removal, extraction of hopeless teeth and oral hygiene instructions) and were evaluated at baseline and after 28 days by the following parameters: Full-Mouth Plaque Score (FMPS) and Full-Mouth Bleeding Scores (FMBS), Periodontal Probing Depth (PPD), Gingival Recession (GR) and Clinical Attachment Level (CAL). (bvsalud.org)
  • However, supragingival plaque control appears to have a significant effect on clinical and microbiological characteristics of periodontal pockets, which could be associated with the close relationship between those environments 8 . (bvsalud.org)
  • Previous studies have evaluated the relationship between supragingival plaque control and clinical and microbiological effects on subgingival areas, reporting a positive effect in systemically healthy subjects with periodontitis, i.e., a reduction in probing depth and some periodontal pathogens and preventing re-colonization 9-11 . (bvsalud.org)
  • However, conflicting results of the impact of supragingival dental biofilm control on clinical features in untreated periodontal sites are found in the literature 12-14 . (bvsalud.org)
Injections1
  • Methods: Thirty-one children and adolescents (age range 9.5-16.8 years), 17 using continuous subcutaneous insulin infusion (CSII) and 14 using multiple daily injections (MDI), participated. (edu.au)
Lispro11
  • URLi is a novel formulation of insulin lispro with accelerated absorption driven by two excipients: treprostinil, which increases local vasodilation, and citrate, which increases local vascular permeability. (nih.gov)
  • Humalog ® Mix75/25™ [75% insulin lispro protamine suspension and 25% insulin lispro injection, (rDNA origin)] is a mixture of insulin lispro solution, a rapid-acting blood glucose-lowering agent and insulin lispro protamine suspension, an intermediate-acting blood glucose-lowering agent. (nih.gov)
  • Chemically, insulin lispro is Lys(B28), Pro(B29) human insulin analog, created when the amino acids at positions 28 and 29 on the insulin B-chain are reversed. (nih.gov)
  • Insulin lispro is synthesized in a special non-pathogenic laboratory strain of Escherichia coli bacteria that has been genetically altered to produce insulin lispro. (nih.gov)
  • Insulin lispro protamine suspension (NPL component) is a suspension of crystals produced from combining insulin lispro and protamine sulfate under appropriate conditions for crystal formation. (nih.gov)
  • Insulin lispro has the empirical formula C 257 H 383 N 65 O 77 S 6 and a molecular weight of 5808, both identical to that of human insulin. (nih.gov)
  • Humalog Mix75/25 vials and Pens contain a sterile suspension of insulin lispro protamine suspension mixed with soluble insulin lispro for use as an injection. (nih.gov)
  • Each milliliter of Humalog Mix75/25 injection contains insulin lispro 100 units, 0.28 mg protamine sulfate, 16 mg glycerin, 3.78 mg dibasic sodium phosphate, 1.76 mg Metacresol, zinc oxide content adjusted to provide 0.025 mg zinc ion, 0.715 mg phenol, and Water for Injection. (nih.gov)
  • Insulin lispro, the rapid-acting component of Humalog Mix75/25, has been shown to be equipotent to Regular human insulin on a molar basis. (nih.gov)
  • The early phase represents insulin lispro and its distinct characteristics of rapid onset. (nih.gov)
  • The late phase represents the prolonged action of insulin lispro protamine suspension. (nih.gov)
Dose5
  • We determined the effect of a ±10-g variation in CHO amount, with an individually calculated insulin dose for 60 g CHO, on postprandial glycaemic control. (edu.au)
  • For each participant, the insulin dose was the same for each meal, based on their usual insulin : CHO ratio for 60 g CHO. (edu.au)
  • A single mealtime insulin dose will cover a range in carbohydrate amounts without deterioration in postprandial control. (edu.au)
  • In healthy volunteers, a single dose intake of iso resulted in lower postprandial blood glucose and insulin responses than did sucrose (suc), while showing prolonged blood glucose delivery over 3 h test. (cambridge.org)
  • The TRESIBA U-100 and U-200 FlexTouch pens dose window shows the number of insulin units to be delivered and NO conversion is needed. (globalrph.com)
Blood glucose and insulin2
  • In the glucosamine group, the means of fasting blood glucose and insulin were 107.31±24.07 mg/dl and 8.75±4.37 μu/ ml, respectively at baseline, which reached 112.38±31.50 and 9.10±4.17 at week 12. (magiran.com)
  • In the placebo group, the mean for fasting blood glucose and insulin were 103.84±24.15 and 9.79±4.02 at the beginning of the study, which reached to 111.40±26.43 and 8.58±3.68 at week 12. (magiran.com)
Therapy7
  • Effects of insulin therapy optimization with sensor augmented pumps on glycemic control and body composition in people with cystic fibrosis-related diabetes. (bvsalud.org)
  • Sensor augmented pump (SAP) therapy may improve glycemic control as compared to multiple daily injection (MDI) therapy . (bvsalud.org)
  • Therapy optimization with SAP led to a significant improvement in glycemic control , which was associated with an increase in fat-free mass. (bvsalud.org)
  • In conclusion, our results reveal that dual therapy with metformin and insulin promotes more benefits to oxidative stress control in muscle of hypoinsulinemic rats than insulinotherapy alone. (hindawi.com)
  • This dual therapy showed that glycemic control was better or similar to insulin therapy alone. (hindawi.com)
  • We do not known studies that verified the role of metformin associated with insulin compared to insulin therapy alone in oxidative stress control in gastrocnemius muscle of streptozotocin-diabetic rats. (hindawi.com)
  • 7%, and BMI 27 to 43 to receive medical therapy alone (50 patients) or Roux-en-Y gastric-bypass surgery (50) or sleeve gastrectomy (50). (medscape.com)
Glucose levels5
Peripheral2
Pancreatic3
  • These cycles accelerate, and eventually pancreatic insulin production collapses and fat is no longer oxidized. (vitalitymagazine.com)
  • Sulfonylureas stimulate insulin release from pancreatic beta cells. (medscape.com)
  • Glipizide is a second-generation sulfonylurea that stimulates the release of insulin from pancreatic beta cells. (medscape.com)
Medications2
  • It's just not enough of an effect from those oral medications to control their blood sugars adequately. (managedhealthcareexecutive.com)
  • Thus, we need to be on the alert for that condition, and one of the signs would be that the oral medications for glycemic control simply don't seem to be working. (managedhealthcareexecutive.com)
METHODS2
  • Methods: Electrochemical impedance spectroscopy was used to identify an optimal frequency specific to insulin detection on a gold disk electrode with insulin antibody immobilized, which was accomplished by conjugating the primary amines of insulin antibody to the carboxylic bond of the self-assembling monolayer on the gold surface. (elsevierpure.com)
  • Methods: We will perform a systematic search for randomised and non-randomised controlled trials. (bcu.ac.uk)
Regimen1
  • Aim: To explore the influence of lifestyle advice, drug regimen and other processes of care on glycaemic control. (bvsalud.org)
T2DM1
  • The logistic regression was adopted to investigate the relationships between various durations of diabetes and the control rates of achieving the control targets for T2DM as well as diabetic vascular complications. (frontiersin.org)