• Objective: In this study, we plan to measure plasma Catalase (CAT), Antioxidant Activity (AOA) and Glu- tathione-S-Transferase (GST) levels to understand whether oxidative stress develops or not and whether or not the detoxification mechanism properly functions in children with Attention Deficit and Hyperactivity Disorder (ADHD) with unknown etiology and pathogenesis. (scirp.org)
  • The results indicate that a GSH S-transferase is involved in the metabolism of isoprene and that the enzyme can detoxify reactive epoxides produced by monooxygenation of chlorinated ethenes. (tudelft.nl)
  • Glutathione transferase genes ( GST ) are candidate genes for Parkinson's disease because they are involved with the metabolism of pesticides, dopamine, and glutathione. (bmj.com)
  • We will also discuss glutathione transferase omega 1, a deglutathionylating enzyme recently shown to play a role in many aspects of macrophage activity, including metabolism, NF-κB activation, and cell survival pathways. (asmscience.org)
  • The genetic polymorphism of the subunits mu and psi was confirmed by h.p.l.c. analysis, and correlated with the enzymic glutathione conjugation of trans-stilbene oxide and with Western blotting of cytosols, using a monoclonal anti-(Class Mu GST) antibody. (biochemj.org)
  • The glutathione transferase activity towards trans-stilbene oxide (GST-tSBO) can be separated in blood in GST-positive and GST-negative phenotypes. (lu.se)
  • Alkylating agents can be detoxified by conjugation with glutathione (GSH). (tudelft.nl)
  • Cytotoxic drugs and their by-products are metabolized in vivo by enzymatic reactions that are classically divided into two categories: the phase I enzymes, mediating oxidation and activation, which are almost exclusively cytochrome P450 enzymes, and the phase II enzymes, mediating glucorinidation, acetylation, or conjugation with glutathione producing more water-soluble conjugates that are less toxic and readily excretable (7) . (aacrjournals.org)
  • Glutathione S-transferase A1-1 (40 μM) also increased the conjugation of phosphoramide mustard and GSH (both 1 mM) 2- fold, while the other major human isoenzymes, A2-2, M1a-1a, and P1-1, did not influence the formation of monochloromonoglutathionylphosphoramide mustard. (tudelft.nl)
  • We previously reported that high expression of glutathione S -transferase M4 (GSTM4) in primary tumors correlates with poor patient outcomes. (frontiersin.org)
  • The effect of the dinoflagellate, Alexandrium fundyense , on relative expression of glutathione S-transferase (GST) transcripts was examined in the copepod Calanus finmarchicus . (plos.org)
  • The insect GST (glutathione transferase) supergene family encodes a varied group of proteins belonging to at least six individual classes. (rcsb.org)
  • 1. Four different rat glutathione S-transferase (GST) isoenzymes, belonging to three different classes, were examined for their GSH conjugating capacity towards 11 2-substituted 1-chloro-4-nitrobenzene derivatives. (tudelft.nl)