• Based on that published data on the association of prostate cancer susceptibility with polymorphisms in genes encoding Glutathione S-transferases (GSTs) were inconclusive, the aim of this study was to more precisely address the role of GSTs polymorphisms (especially, GSTT1 and GSTM1 deletions) on prostate cancer risk in Asian descent. (oncotarget.com)
  • Glutathione S-transferase polymorphisms and survival in primary malignant glioma. (cdc.gov)
  • This study examined the association between overall survival and Glutathione S-transferase Pi (GST Pi) expression and genetic polymorphism in stage C colon cancer patients after resection alone versus resection plus 5-fluourouracil-based adjuvant chemotherapy. (biomedcentral.com)
  • Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia. (qxmd.com)
  • MGST1 has both glutathione transferase and peroxidase activities. (nih.gov)
  • Owing to the presence of a cysteine with a pK a value around 5 in their active site, GSTF3, F7, and F8 displayed a thiol transferase activity in addition to the usual glutathione transferase and peroxidase activities. (rcsb.org)
  • Description: A sandwich ELISA kit for detection of Glutathione S Transferase Alpha 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (envite.org)
  • The primary role of GSTs is to catalyze the conjugation of glutathione (GSH) with the electrophilic centers of a wide variety of molecules. (wikipedia.org)
  • There are also classes of GSTs that utilize glutathione as a cofactor rather than a substrate. (wikipedia.org)
  • In bacteria, the theta class GSTs includes all of the currently known bacterial glutathione transferases. (wikipedia.org)
  • The considerable amount of protein sequence variation has led to the general belief that GSTs carry out a very wide variety of glutathione-dependent conjugation functions. (wikipedia.org)
  • The regulation of levels of ROS, levels of oxidized and reduced glutathione and other thiols, and antioxidant enzymes (such as GSTs and glutathione reductase) are important in determination of the most stable conditions for redox control, or for activation of apoptosis. (wikipedia.org)
  • The N-terminal domain contains the glutathione-binding site and is a highly conserved region among all GSTs. (wikipedia.org)
  • The super family of glutathione S -transferases (GSTs) is composed of multiple isozymes with significant evidence of functional polymorphic variation. (nature.com)
  • Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some of which are suspected human carcinogens. (qxmd.com)
  • In this report, we describe the glutathione transferase (GST) gene family in the dengue vector Aedes aegypti and suggest a novel role for a new class of mosquito GSTs. (lstmed.ac.uk)
  • These antioxidant enzymes are a part of the glutathione biosynthetic pathway, which is present in cyanobacteria, proteobacteria, and certain Gram-negative bacteria. (wikipedia.org)
  • Bacterial glutathione transferases of all classes are homodimeric enzymes (although heterodimeric isozymes of certain classes are also known). (wikipedia.org)
  • Glutathione level and activity of studied glutathione enzymes were determined in the supernatants. (nih.gov)
  • Genetic susceptibility to the development of chronic obstructive pulmonary disease (COPD) might depend on variation in the activities of enzymes that detoxify cigarette smoke products, such as microsomal epoxide hydrolase (mEPHX) and glutathione S-transferase (GST). (ntu.edu.tw)
  • Glutathione S-transferase P1 (GSTP1) is one of the xenobiotic-metabolizing and antioxidant enzymes, identified in the peripheral lungs. (thestemcellfoundation.com)
  • Glutathione-S-transferase also referred as GST is one of the major detoxification enzymes in parasitic helminths. (cellmolbiol.org)
  • In this study, these data have been analyzed to find all human proteins containing (or predicted to contain) the cytosolic glutathione transferase (cGST) fold. (edu.au)
  • The study aimed at identifying and purifying cytosolic glutathione transferase isoforms expressed in Pseudomonas sp. (mabjournal.com)
  • The defluorinating activity is cytosolic and has an absolute requirement for glutathione. (wgtn.ac.nz)
  • In addition to the well-characterized catalytic activity, recent evidence has shown that certain GST isozymes can regulate mitogen-activated protein kinases or can facilitate the addition of glutathione to cysteine residues in target proteins ( S -glutathionylation). (nature.com)
  • Microsomal glutathione transferase 1 (MGST1) is a member of the MAPEG family (membrane associated proteins in eicosanoid and glutathione metabolism), defined according to enzymatic activities, sequence motifs, and structural properties. (nih.gov)
  • The glutathione transferase (GST) gene family is divided into 14 classes in photosynthetic organisms. (rcsb.org)
  • Analysis of the glutathione S-transferase (GST) gene family. (mabjournal.com)
  • Glutathione reductase is another enzyme that helps maintain cellular redox homeostasis by maintaining the supply of reduced glutathione. (wikipedia.org)
  • This allows positioning of several active site residues at proximity of the glutathione molecule, which itself remains unchanged in GSTF three-dimensional structures. (rcsb.org)
  • The crystal structures of glutathione S-transferases isozymes 1-3 and 1-4 from Anopheles dirus species B. Protein Science : A Publication of the Protein Society, 10(11): 2176-2185. (mabjournal.com)
  • This has proven that putative GST possessed peroxidase activity and proposed to be similar to PputUW4_00801 (putative glutathione S-transferase) of Pseudomonas sp. (mabjournal.com)
  • Glutathione contains a significant amount of cysteine residues, which contributes to its nature of being readily oxidized. (wikipedia.org)
  • The -SH groups on these residues act as strong nucleophiles, which can conjugate with a variety of molecules, including other glutathione molecules. (wikipedia.org)
  • Conjugation with glutathione receptors renders toxic substances more soluble, and therefore more readily exocytosed from the cell. (wikipedia.org)
  • Additionally, the ability of seven human glutathione S-transferases (hGSTs) to catalyze the GSH conjugation of the quinoneimines formed by P450s was also investigated. (unboundmedicine.com)
  • Fluoroacetate(Compound 1080) was the only substrate tested that showed appreciable catalysed conjugation with glutathione. (wgtn.ac.nz)
  • A recent clinical study has focused on: 1- the interaction between genetic variants of glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) and smoking on the risk of cardiovascular diseases, 2- the potential capacity of GSTM1 and T1 genotypes in modifying the effect of smoking on inflammation and endothelial function. (tu-dortmund.de)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Glutathione S Transferase Alpha 4 (GSTa4) in serum, plasma and other biological fluids. (envite.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Glutathione S Transferase Alpha 4 (GSTa4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (envite.org)
  • In recent years, the importance of the endogenous plant tripeptide glutathione (GSH) has been increasingly recognized in plant-pathogen interactions due to its contribution to various signaling and defense mechanisms. (mtak.hu)
  • Glutathione S-transferase (GST) is a search Centre (NRC), Cairo, Egypt from detoxification enzyme that catalyses the 2001 to 2004, in accordance with the ethical addition of glutathione to various xeno- principles of the NRC, in collaboration with biotics [ 4 ]. (who.int)
  • The changes in reduced glutathione (GSH), activity of glutathione transferase (GST) and glutathione peroxidase (GSPx) after administration of exogenous melatonin (N-acetyl-5-methoxy-tryptamine) at a dose 20 mg/kg b.w. were investigated for five and ten days in the liver and kidney of male and female mice. (nih.gov)
  • Detection principle Glutathione S-transferase is a kind of enzyme related to liver detoxification, which is often used as an indicator of liver injury. (agtcbioproducts.com)
  • whether a decoction of Nigella sativa, Hemidesmus indicus and Smilax glabra ubhibits glutathione S-transferase (GST-P) expression in rat liver. (who.int)
  • Biophysical methods were used to elucidate the mechanism and molecular consequences of S-nitrosation of glutathione transferase (GST) P1-1, a ubiquitous homodimeric detoxification enzyme and important target for cancer therapeutics. (wits.ac.za)
  • The glutathione-requiring dehalogenating activity bound only to the GSH-BSP conjugate ligand attached to epichlorhydrin-activated Sepharose. (wgtn.ac.nz)
  • Functions of His107 in the catalytic mechanism of human glutathione S-transferase hGSTM1a-1a. (expasy.org)
  • An electron-sharing network involved in the catalytic mechanisms is functionally conserved in different glutathione transferase classes. (mabjournal.com)
  • As the key substrate in GST-mediated reactions, glutathione is one of the most conserved reducing agents in bacterial cells. (wikipedia.org)
  • Without glutathione in its reduced form, glutathione transferases are not able to utilize it as a substrate in redox reactions. (wikipedia.org)
  • The Ligandin (Non-Substrate) Binding Site of Human Pi Class Glutathione Transferase is Located in the Electrophile Binding Site (H-Site). (expasy.org)
  • In addition to base assisted deprotonation of glutathione, it is proposed that a positively charged group in the GST active site assists in the leaving of the chloride ion from CDNB. (wgtn.ac.nz)
  • Glutathione may be useful for monitoring melatonin's protective role on cell damage. (nih.gov)