• Glutathione S-transferases (GSTs), previously known as ligandins, are a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification. (wikipedia.org)
  • The glutathione binding site, or "G-site", is located in the thioredoxin-like domain of both cytosolic and mitochondrial GSTs. (wikipedia.org)
  • Two subgroups of cytosolic GSTs have been characterized based upon their interaction with glutathione: the Y-GST group, which uses a tyrosine residue to activate glutathione, and the S/C-GST, which instead uses serine or cysteine residues. (wikipedia.org)
  • The activity of GSTs is dependent upon a steady supply of GSH from the synthetic enzymes gamma-glutamylcysteine synthetase and glutathione synthetase, as well as the action of specific transporters to remove conjugates of GSH from the cell. (wikipedia.org)
  • The super family of glutathione S -transferases (GSTs) is composed of multiple isozymes with significant evidence of functional polymorphic variation. (nature.com)
  • Glutathione S-transferases (GSTs), a superfamily of multifunctional enzymes, play an important role in the onset and progression of renal cell carcinoma (RCC). (cancerindex.org)
  • Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. (thermofisher.com)
  • Karaman, "Effects of novel retinoids on human erythrocyte glutathione s-transferases and human lymphocyte DNA," Middle East Technical University, 2000. (metu.edu.tr)
  • Human erythrocyte glutathione S-transferase: a possible marker of chemical exposure. (cdc.gov)
  • To determine the effects of genetic polymorphisms of glutathione S transferase (GST)M1 and GSTT1 on the risk of POAG in a Turkish population. (nih.gov)
  • To investigate whether genetic polymorphisms of glutathione S-transferases ( GSTM1 , GSTT1 , and GSTO2 ) in relation to the work place contribute to the development of cataract. (molvis.org)
  • Concomitance of Polymorphisms in Glutathione Transferase Omega Genes Is Associated with Risk of Clear Cell Renal Cell Carcinoma. (cancerindex.org)
  • Glutathione S-transferases GSTM1 and GSTT1 polymorphisms and asbestosis. (cdc.gov)
  • The role of polymorphisms in glutathione-related genes in asbestos-related diseases. (cdc.gov)
  • In the present study, the oxidative bioactivation of MFA was studied using human liver microsomes (HLM) and recombinant human P450 enzymes. (unboundmedicine.com)
  • Glutathione S-transferase P1 (GSTP1) is one of the xenobiotic-metabolizing and antioxidant enzymes, identified in the peripheral lungs. (thestemcellfoundation.com)
  • Molecular docking analysis for different enzymes involved in aging (collagenase, elastase and hyaluronidase), antioxidant enzymes (superoxide dismutase, glutathione-s-transferase, glutathione peroxidase and catalase) and mitochondrial enzymes (nicotinamide adenine dinucleotide (NAD)+hydrogen (H) dehydrogenase, succinate dehydrogenase, cytochrome c oxidase and adenosine triphosphate synthase) was carried out for epigallocatechin gallate alone (1), withaferin A alone (2), epigallocatechin gallate and withaferin A in combination (3) and a reference molecule. (ijpsonline.com)
  • This ELISA kit applies to the in vitro quantitative determination of Human GSTα1 concentrations in Serum, plasma and other biological fluids. (caslab.com)
  • Description: A sandwich ELISA kit for detection of Glutathione S Transferase Alpha 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (envite.org)
  • AI-based algorithms have been used to analyze large amounts of protein sequence data including the human proteome, complementing experimental structure data found in resources such as the Protein Data Bank. (edu.au)
  • In addition to the well-characterized catalytic activity, recent evidence has shown that certain GST isozymes can regulate mitogen-activated protein kinases or can facilitate the addition of glutathione to cysteine residues in target proteins ( S -glutathionylation). (nature.com)
  • The human multidrug resistance protein 1 (MRP1) is a primary active transporter of reduced (GSH) and oxidized glutathione, as well as GSH-, glucuronate-, and sulfate-conjugated organic anions. (aspetjournals.org)
  • 2002. Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein. . (oregonstate.edu)
  • Western blot: Recognizes a diffuse band at approximately 70-85 kDa on western blots of extracts (20 ug total protein) from human caudate, putamen, and nucleus accumbens. (sigmaaldrich.com)
  • The protein encoded by this gene is an omega class glutathione S-transferase (GST). (cancerindex.org)
  • Full length human recombinant protein of human GSTP1 produced in E.coli. (thermofisher.com)
  • Three years after the initial discovery, they found that another protein structurally related to glutathione transferases, a chloride intracellular ion channel, CLIC-2, could also dampen the activity of the ryanodine receptor in the heart. (the-scientist.com)
  • In this study, these data have been analyzed to find all human proteins containing (or predicted to contain) the cytosolic glutathione transferase (cGST) fold. (edu.au)
  • ECSA Scientific Day 2023 (23 November 2023): Antibodies against high-risk human papillomavirus proteins as markers for noncervical HPV-related cancers in a black South African population, according to HIV status. (who.int)
  • Human papillomavirus (HPV) proteins may elicit antibody responses in the process towards HPV-related malignancy. (who.int)
  • Glutathione S-transferase (GST) is a search Centre (NRC), Cairo, Egypt from detoxification enzyme that catalyses the 2001 to 2004, in accordance with the ethical addition of glutathione to various xeno- principles of the NRC, in collaboration with biotics [ 4 ]. (who.int)
  • Quantification evaluation of bromodichloromethane metabolism by recombinant rat and human cytochrome P450s. (cdc.gov)
  • The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human GSTα1. (caslab.com)
  • Then a biotinylated detection antibody specific for Human GSTα1 and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. (caslab.com)
  • Only those wells that contain Human GSTα1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. (caslab.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Glutathione S Transferase Alpha 4 (GSTa4) in serum, plasma and other biological fluids. (envite.org)
  • Antibody response was evaluated using a glutathione S-transferase-based multiplex serology assay. (who.int)
  • In this study, the authors investigated that depletion of GSTP1 by itself could induce cell death, including apoptosis, in human lung fibroblast-derived HFL-1 cells. (thestemcellfoundation.com)
  • Finally, the nasal lesions associated with exposure to high concentrations of MeI in rats are best supported by a mode of action that involves glutathione (GSH) depletion in the nasal epithelial tissue. (cdc.gov)
  • The region containing the greatest amount of variability between the assorted classes is that of helix α2, where one of three different amino acid residues interacts with the glycine residue of glutathione. (wikipedia.org)
  • Glutathione transferase Omega 1-1 (GSTO1-1) modulates Akt and MEK1/2 signaling in human neuroblastoma cell SH-SY5Y. (expasy.org)
  • Within a few months, Dulhunty and her colleagues published their first paper on the role of the omega class glutathione S-transferase, GSTO1-1, in inhibiting the ryanodine receptor in cardiac muscle and in increasing the activity of the skeletal muscle ryanodine receptor. (the-scientist.com)
  • Both glutathione S-transferase pi ( GSTpi ) (80%, 24/30 in tumor and 56.7%, 17/30 in the paired non-cancerous tissues) and cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) ( CFTR ) (77%, 23/30 in tumor and 50%, 15/30 in the paired non-cancerous tissues) genes were prevalently hypermethylated in HCC as well as their neighboring non-cancerous tissues. (wjgnet.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Glutathione S Transferase Alpha 4 (GSTa4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (envite.org)
  • We defined the seropositivity rate of STLpolyomavirus(STLPyV)wasrecentlyidentifiedin STLPyV in humans using serum from 2 independent US humanspecimens.TodetermineseropositivityforSTLPyV, sites (Denver, Colorado, and St. Louis, Missouri). (cdc.gov)
  • Seroepidemiology has played an important role in We screened 500 serum specimens collected from establishing the link between human polyomaviruses and children and adults in Denver for antibodies against STL- disease and in understanding infection dynamics. (cdc.gov)
  • ABSTRACT Serum levels of glutathione reductase (GR), glutathione S-transferase- (GST-) and malondialdehyde (MDA) were determined to evaluate their use in diagnosing hepatocellular damage in 75 children with liver disease. (who.int)
  • There are various ways of detecting the antigenotoxic potential of these substances from short-term genotoxicity assays in vitro to bioassays in humans. (scialert.net)
  • 2006). A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells - 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells. (torvergata.it)
  • Recently, the authors reported the association between GSTP1 gene polymorphism and susceptibility to chronic obstructive pulmonary disease (COPD), and protective effect of GSTP1 against cigarette smoke in human lung fibroblasts in vitro. (thestemcellfoundation.com)
  • Glutathione S-transferases and their implications in the lung diseases asthma and chronic obstructive pulmonary disease: Early life susceptibility? (rug.nl)
  • This result indicates that human polyomavirus 12, have been identified in speci- there was no significant cross-reactivity between STLPyV mens from humans, but their role in disease remains to and MWPyV VP1 capsomeres. (cdc.gov)
  • Non-resolving inflammation is the main mechanism of morbidity and mortality among patients suffering from cystic fibrosis (CF), the most common life-threatening human genetic disease. (frontiersin.org)
  • Although the implementation is currently limited to the browser on the reference genome for the laboratory mouse and human, this software platform agnostic deliberately genome. (symapdb.org)
  • The nuclear factor erythroid-derived two-like 2-antioxidant response element (Nrf2-ARE) pathway and its downstream antioxidant enzyme heme oxygenase-1 (HMOX1 or HO-1) play essential roles in H2 O2 -induced oxidative damage in human melanocytes. (nih.gov)
  • Noni juice has been found to exert an antioxidant effect in human athletes, resulting in increased endurance [ 32 ]. (hindawi.com)
  • This review addresses how differences in the human GST isozyme expression patterns influence cancer susceptibility, prognosis and treatment. (nature.com)
  • Therefore, if a human glutathione S-transferase is a homodimer in the pi-class subfamily 1, its name will be written as "hGSTP1-1. (wikipedia.org)
  • In this study we show that contactin coimmunoprecipitates with Na v 1.3 from postnatal day 0 rat brain where this channel is abundant, and from human embryonic kidney (HEK) 293 cells stably transfected with Na v 1.3 (HEK-Na v 1.3). (jneurosci.org)
  • The new glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol- 4-ylthio)hexanol (NBDHEX) is cytotoxic toward P-glycoprotein-overexpressing tumor cell lines, i.e. (torvergata.it)
  • No significant cross-reactivity or interference between Human GSTα1 and analogues was observed. (caslab.com)
  • However, HPV seroepidemiology in noncervical HPV-related cancers remains poorly understood, particularly in populations with a high prevalence of human immunodeficiency virus (HIV). (who.int)
  • ADH is a dimeric zinc metalloprotein and occurs as five different classes in humans, resulting from gene duplications during vertebrate evolution, the first one traced to ~500. (researchgate.net)
  • 2009. Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K. . (oregonstate.edu)
  • Standardized GST nomenclature first proposed in 1992 identifies the species to which the isozyme of interest belongs with a lower-case initial (e.g., "h" for human), which precedes the abbreviation GST. (wikipedia.org)
  • 2007. Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. . (oregonstate.edu)
  • Methods for Detecting DNA Damaging Agents in Humans: Applications in Cancer Epidemiology and Prevention. (cdc.gov)
  • The relation of asbestosis to human 8-oxoguanine DNA glycosidase polymorphism and DNA damage in peripheral lymphocytes]. (cdc.gov)
  • This study was taken up to evaluate the antigenotoxic potential of ginger in human peripheral blood lymphocytes. (scialert.net)