• Phosphinothricin is a glutamine synthetase inhibitor that binds to the glutamate site. (wikipedia.org)
  • The key strategy for coping with elevated brain ammonia levels in vertebrates is the synthesis of glutamine from ammonia and glutamate,catalyzed by glutamine synthetase (GSase). (silverchair.com)
  • Background/Aims: Glutamine synthetase is a key enzyme necessary for ammonia detoxification in the brain, but excessive activation of this enzyme can be cytotoxic to neural cells as a consequence of excessive consumption of ATP and glutamate. (elsevierpure.com)
  • The compound irreversibly inhibits glutamine synthetase, an enzyme necessary for the production of glutamine and for ammonia detoxification, giving it antibacterial, antifungal and herbicidal properties. (wikipedia.org)
  • The F-IO2 and end-tidal CO2 selleck kinase inhibitor concentration were determined and compared among sample groups. (mglursignaling.com)
  • 90 They determined that phosphinothricin irreversibly inhibits glutamine synthetase. (wikipedia.org)
  • The organic product acivicin inhibits the glutaminase activity of cytidine triphosphate (CTP) synthetase and it is a potent lead compound for medication discovery in the region of neglected tropical diseases, specifically trypanosomaisis. (gasyblog.com)
  • Acivicin (Amount?1), a fermentation item of inhibits enzymes like CTP synthetase that catalyze amido exchanges from l\glutamine. (gasyblog.com)
  • In 1990 whilst at the University of Manitoba I created a classification system based on numbers to assist growers in rotating herbicides, and published it in a fact sheet in 1991 - Group 1 = ACCase inhibitors, Group 2 = ALS inhibitors etc. (weedscience.org)
  • Benzofuranes (WSSA Group 16), chlorocarbonic acids (Group 26), phosphorodithioates (Group 8), and thiocarbamates (Group 8) are examples of herbicides that are known inhibitors of several plant processes including: 1) biosynthesis of fatty acids and lipids which may account for reported reductions in cuticular wax deposition, 2) biosynthesis of proteins, isoprenoids (including gibberellins), and flavonoids (including anthocyanins), and 3) gibberellin synthesis inhibition which may result from the inhibition of kaurene synthesis. (weedscience.org)
  • Seedling root growth inhibitors (Group 3) (examples: pendimethalin, trifluralin): Injury from these herbicides can cause swelling of the hypocotyl, reduced root growth, and delayed emergence. (lewishybrids.com)
  • Application of glufosinate to plants leads to reduced glutamine and elevated ammonia levels in tissues, halting photosynthesis and resulting in plant death. (wikipedia.org)
  • An increase in the content of ammonium in the medium changed the activity of glutamine synthetase (GS) (EC 6.3.1.2) and glutamine dehydrogenase (GD) (EC 1.4.1.4), the enzymes of ammonium assimilation, as well as the activities of enzymes responsible for nitrile utilization: nitrile hydratase (EC 4.2.1.84) and amidase (EC 3.5.1.4). (genetika.ru)
  • To restore male fertility, the canola expresses Bacillus amyloliquefaciens barstar, which is an inhibitor of the ribonuclease barnase. (cbd.int)
  • The stomach also expresses high levels of glutamine synthetase and this study aimed to investigate a possible pathophysiological role of glutamine synthetase in ammonia-induced gastric mucosal injury. (elsevierpure.com)
  • Transgenic plants expressing an artificial target mimic directed against miR396 (MIM396) with a decrease in the endogenous microRNA GANT61 Stem Cells & Wnt inhibitor activity or plants expressing miR396-resistant copies of several GRFs are less sensitive to this inhibition. (hsp70inhibitor.com)
  • rhodichrous resistant to phosphotricine, an inhibitor of GS. (genetika.ru)
  • The molecule, acting as an inhibitor of glutamine synthetase activity, was recently used in soil incubation assays for the determination of gross rates of N mineralization. (unifi.it)
  • On the other hand, pretreatment with various concentrations of methionine sulfoximine reduced the glutamine synthetase activity in ammonia-treated RGM-1 cells, and prevented the induction of apoptosis and the reduction in intracellular ATP levels in a dose-dependent manner. (elsevierpure.com)
  • This organic product shows potent anticancer actions, however, it 111025-46-8 supplier hasn't progressed beyond stage?1 scientific trials because of neurotoxicity.6 Nevertheless, the substance shows antitrypanosomatid activity and therefore the structure of the CTP synthetase organic using a lead substance is potentially dear. (gasyblog.com)
  • Some herbicide active ingredients, such as PPO inhibitors, along with the additives, may cause some level of injury to soybean, but injury resulting from an application made according to the label instructions usually does not cause a reduction in yield. (lewishybrids.com)
  • Photosystem II inhibitors (Group 5) (example: metribuzin): Injury symptoms include interveinal chlorosis and necrosis on emerged leaves. (lewishybrids.com)
  • Horizon's Glutamine Synthetase system enables the use of a metabolic selection process without the need for chemical inhibitors, the company claims. (biopharma-reporter.com)
  • Certainly, the SGC model continues to be employed for docking computations which formed the foundation for research reported in where research workers sought to create acivicin analogues as stronger CTP synthetase inhibitors.7 Open up in another window Amount 1 The structure and numbering system of acivicin, (2CTP synthetase, (residues 319C589), pursuing incubation with acivicin, crystallized in space group CTP synthetase. (gasyblog.com)
  • Benefits confirmed the need for K-RAS like a predictive biomarker in the establishing of first-line mCRC treatment with EGFR inhibitors.21 The next research, performed by Peeters et al was a randomized, stage III research that evaluated the safety and effectiveness of SRSF2 panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) versus FOLFIRI alone as second-line treatment for mCRC. (smartrailexpo-europe.com)
  • Despite, the predictive part of K-RAS mutational position was confirmed.40 Upon this basis, we've zero particular data about these EGFR findings actually, thus further investigations have to better define their exact part in EGFR inhibitors response. (smartrailexpo-europe.com)
  • independent chloroplast enzymes such as glutamate of this enzyme also against heat and denaturing reagents synthase and glutamine synthetase. (123dok.net)
  • Expression of the M?ller glial cell marker glutamine synthase was also affected in knockdown morphants. (molcells.org)
  • Inhibition of glutamine synthetase prevents ammonia-induced swelling of isolated astrocytes [ 59 ] as well as brain edema in vivo. (medscape.com)
  • We propose that inhibition, dysfunction or loss of astrocytic glutamine synthetase is an important causative factor for some epilepsies, particularly mesial temporal lobe epilepsy and glioblastoma-associated epilepsy. (nih.gov)
  • [ 60 , 61 ] The increase in brain glutamine can be fourfold to sixfold, although the limited capacity of astrocytic glutamine synthetase results in a steady high level of glutamine throughout the course of the neurological disturbance. (medscape.com)
  • encodes a glutamine-dependent asparagine synthetase, the predicted ASN1 peptide contains a purF-type glutamine-binding domain, and is expressed predominantly in shoot tissues, where light has a negative effect on its mRNA accumulation. (or.jp)
  • Other genes which exhibited increase in transcript abundance of more than 2 fold in salt treated ABR17 transgenic but showed less abundance in treated WT included pathogenesis related protein, and glutamine dependent asparagine synthetase. (micrornaassay.com)
  • 7. Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function. (nih.gov)
  • For example, Inhibitors,Modulators,Libraries the Hsp family con tains chaperones, which have important roles in protein folding, assembly and in the disposal of unwanted non functional proteins. (micrornaassay.com)
  • One drawback to this approach is that the LMB has not yet been examined for its potential to act as a competitive inhibitor to the enzyme (2) (Figures 4 and 5). (heyfellas.co)
  • Both the absence of external nitrogen and the presence of L- norvaline, an inhibitor of Arg synthesis, prevented the synthesis of Arg in the ERM and resulted in decreased activity of arginase and urease in the AM root. (dtu.dk)
  • buthionine sulfoximine (BSO) a potent inhibitor of glutathione (GSH) synthesis is capable of sensitizing antihormone resistant MCF-7:2A cells to estradiol-induced apoptosis. (bioinbrief.com)
  • The researchers fed glutamine into the tricarboxylic acid cycle using methionine sulfoximine (MSO), a pharmacologic inhibitor of glutamine synthetase (GLUL). (medpagetoday.com)
  • Through stable isotope tracing, results show that genetic or pharmacological inhibition of CII truncates the tricarboxylic acid cycle (TCA) and leads to anaplerotic glutamine metabolism to reestablish the truncated cycle. (biomed.news)
  • Application of glufosinate to plants leads to reduced glutamine and elevated ammonia levels in tissues, halting photosynthesis and resulting in plant death. (wikipedia.org)
  • Expression is induced within 3 hours of dark treatment, in senescing leaves and treatment with exogenous photosynthesis inhibitor. (or.jp)
  • Here we review the role of astrocytes in epilepsy development (a.k.a. epileptogenesis), particularly astrocyte pathologies related to: aquaporin 4, the inwardly rectifying potassium channel Kir4.1, monocarboxylate transporters MCT1 and MCT2, excitatory amino acid transporters EAAT1 and EAAT2, and glutamine synthetase. (nih.gov)
  • Direct measurements in experimental animals [ 57 ] and nuclear magnetic resonance (NMR) spectroscopic findings in humans [ 58 ] have repeatedly shown a marked increase in brain glutamine, the product of ammonia detoxification in astrocytes. (medscape.com)
  • Journal Article] Glutamine triggers acetylation-dependent degradation of glutamine synthetase via the thalidomide receptor cereblon. (nii.ac.jp)
  • Time courses of specific enzyme activity were obtained for glutamine synthetase, argininosuccinate synthetase, arginase, and urease in the ERM and AM roots. (dtu.dk)
  • induction in the transgenic seedlings versus the repression in the WT may have important Inhibitors,Modulators,Libraries conse quences with respect to the ability to tolerate salinity stress. (micrornaassay.com)
  • We postulate that the regulatory mechanisms of glutamine synthetase as well as the downstream effects of glutamine synthetase dysfunction, represent attractive, new targets for antiepileptogenic interventions. (nih.gov)
  • 2017). Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. (deshaieslab.com)
  • The volume of tumors that were positive for glutamine synthetase (GS), which is indicative of mutations in the beta-catenin gene, was increased in both wild-type and p50-/- mice administered PCB-153 compared to vehicle controls, and inhibited in p50-/- mice compared to wild-type mice (in both PCB- and vehicle-treated mice). (nih.gov)
  • FOXO1 activates glutamine synthetase gene in mouse. (cancertreatmentsresearch.com)
  • Metabolic rewiring of the cells using a pharmacological inhibitor of glutamine synthetase partially restored the phagocytic and inflammatory capacity of in vitro generated- as well as ACLF patient-derived monocytes," wrote Hannelie Korf, PhD, of the Catholic University of Leuven, Belgium, and colleagues in the journal Gut . (medpagetoday.com)
  • Implications: This work highlights the effects of direct CII inhibition in mediating selective AML cell death and provides insights into glutamine anaplerosis as a metabolic adaptation that can be therapeutically targeted. (biomed.news)
  • To characterize metabolic pathway markers, we investigated the expression of phosphofructokinase (PFK), lactate dehydrogenase-A (LDHA), β-F1-ATPase (ATPB), glucose-6-phosphate dehydrogenase (G6PDH), glutaminase (GLS), fatty acid synthetase (FASN), and carnitin-O-palmitoyltransferase-1 (CPT1A). (por-journal.com)
  • PMID- 5428627 TI - The extraction and separation of activators and inhibitors of fibrinolysis from bovine endothelium and mesothelium. (nih.gov)
  • Their function, structure, possible catalytic mechanisms, and current inhibition strategies and inhibitors are reviewed and discussed. (currentmedicinalchemistry.com)
  • L-Buthionine sulfoximine (BSO) is a specific γ-glutamylcysteine synthetase inhibitor that blocks the Tropisetron (ICS 205930) rate-limiting step of glutathionine (GSH) biosynthesis and in doing so depletes the intracellular GSH pool in both cultured cells and in whole animals [10]. (bioinbrief.com)
  • Inhibitors,Modulators,Libraries However, no isolates with high level resistance to azithromycin (MIC 256 mg L which have been described from several other countries, have yet been identified in Russia. (micrornaassay.com)
  • Our findings suggest the importance of the Warburg-effect, pentose-phosphate pathway, glutamine demand, and fatty-acid beta oxidation in osteosarcoma cells. (por-journal.com)
  • LMBs are known to be expressed in the brain and are well-known inhibitors of glutamine synthetase (3, 4). (heyfellas.co)
  • Administration of a xanthine oxidoreductase inhibitor to a mouse model of radiation dermatitis resulted in increased blood Hx levels that inhibited severe dermatitis and accelerated recovery. (bvsalud.org)
  • Figure 3 Rate of lipid Inhibitors,research,lifescience,medical peroxidation (LPO) in different groups. (gsk-3inhibitors.com)
  • In case the reporter had used a report card, the additional information requested on the elaborate report form was also obtained during this Inhibitors,research,lifescience,medical interview. (gsk-3inhibitors.com)
  • PRISMA examines the relative contributions of latent factors Inhibitors,research,lifescience,medical (technical and organisational), active failures (human) and other factors (patient related and other). (gsk-3inhibitors.com)
  • By continuing to ask "why" for each event or action, beginning with the top event, Inhibitors,research,lifescience,medical all relevant causes are revealed. (gsk-3inhibitors.com)
  • His Internal medicine research is multidisciplinary, incorporating elements of Glutamine and Cardiology. (research.com)
  • We suggest performing a detailed investigation of the mTOR profile before considering mTORC1 inhibitor therapy. (por-journal.com)