AnatomyDiseasesChemicals and Drugs
Alanine Transaminasebeta-Alanine-Pyruvate TransaminaseDrug-Induced Liver InjuryTransaminasesLiverAspartate AminotransferasesGlutamatesPyruvate Kinase4-Aminobutyrate TransaminasePyruvate Dehydrogenase ComplexReceptors, GlutamateGlutamic AcidPyruvic AcidPyruvatesGlutamate DehydrogenaseD-Alanine TransaminaseReceptors, Metabotropic GlutamatePyruvate DecarboxylasePyruvate OxidasePyruvate Dehydrogenase (Lipoamide)Sodium GlutamateAmino Acid Transport System X-AGGlutamate Synthase
SGPTOxaloacetate transaminaseAlanine transaminaseSGOTAminotransferaseLactateReversible transaminationParticipatesKinaseTriglyceridesEnzyme that catalyzesTransferasesGlutamineHepaticAlkaline phosphataseOxaloacetateEnzymeAspartate-transaminaseTransaminationLiverDehydrogenaseBiosynthesisTumorsGlucoseMalateReactionLesionsOxidationCofactorTissuesAcidHighlyHumanCells
SGPT4
  • ALT (SGPT) TEST KIT is used for the quantitative determination of Serum Glutamate Pyruvate Transaminase (SGPT) or Alanine Aminotransferase (ALT) in human serum or plasma. (quicklab.in)
  • Biochemical parameters in serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP), bilirubin and plasma protein. (phytojournal.com)
  • The enzyme was previously known as serum glutamate pyruvate transaminase (SGPT). (redcliffelabs.com)
  • It was originally referred to as serum glutamic pyruvic transaminase (SGPT). (medscape.com)
Oxaloacetate transaminase1
  • Furthermore, GOT (glutamate oxaloacetate transaminase) activity demonstrated an initial surge following exposure to lower microplastic concentrations, followed by a continuous descent as concentrations increased. (hilarispublisher.com)
Alanine transaminase1
SGOT1
  • It is an enzyme which is previously known as serum glutamate oxalate transaminase (SGOT) The AST enzyme is present in all tissues except bone, with the highest levels in the liver and skeletal muscles. (redcliffelabs.com)
Aminotransferase2
  • The systematic name of this enzyme class is L-glutamine:pyruvate aminotransferase. (wikipedia.org)
  • Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2. (mousephenotype.org)
Lactate3
  • This result suggests that taurine improves pyruvate, lactate, and glutamate metabolism, thus decreasing IUI-caused cerebral damage and relieving motor behavior impairment. (hindawi.com)
  • Glucose is the primary energy source in the brain whose metabolism via the glycolysis pathway leads to pyruvate, which enters the Krebs cycle in the mitochondria or is converted into lactate by LDH [ 10 , 11 ]. (hindawi.com)
  • Confocal studies showed differential cellular and compartmental distribution of isozymes involved in glucose, glutamate, glutamine, lactate, and creatine metabolism. (molvis.org)
Reversible transamination1
  • Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. (biossusa.com)
Participates1
  • This enzyme participates in glutamate metabolism. (wikipedia.org)
Kinase1
  • The combined results indicate that glycolysis is regulated by the compartmental expression of hexokinase 2, pyruvate kinase M1, and pyruvate kinase M2 in photoreceptors, whereas the inner retinal neurons exhibit a lower capacity for glycolysis and aerobic glycolysis. (molvis.org)
Triglycerides1
  • animals were sacrificed at 30, 60, or 90 days for chemical analyses (serum glutamate-oxalacetate-transaminase, lactic-dehydrogenase, blood urea nitrogen, serum glutamate-pyruvate-transaminase, and serum triglycerides). (cdc.gov)
Enzyme that catalyzes2
  • In enzymology, a glutamine-pyruvate transaminase (EC 2.6.1.15) is an enzyme that catalyzes the chemical reaction L-glutamine + pyruvate ⇌ {\displaystyle \rightleftharpoons } 2-oxoglutaramate + L-alanine Thus, the two substrates of this enzyme are L-glutamine and pyruvate, whereas its two products are 2-oxoglutaramate and L-alanine. (wikipedia.org)
  • An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (curehunter.com)
Transferases1
  • This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. (wikipedia.org)
Glutamine2
  • Other names in common use include glutaminase II, L-glutamine transaminase L, and glutamine-oxo-acid transaminase. (wikipedia.org)
  • L-Glutamate and L-glutamine can also act as amino donors. (expasy.org)
Hepatic1
  • Elevated levels of the transaminases can indicate myocardial infarction, hepatic disease, muscular dystrophy, or organ damage. (cdc.gov)
Alkaline phosphatase1
  • hemoglobin, 13.25±0.3 vs 13.27 ±0.36%, for experimental and control rats, respectively) or blood biochemistry (serum glutamic oxaloacetic transaminase, 11.5±1.29 vs 11.75±1.25IU L -1 , serum glutamate pyruvate transaminase, 8.25±1.26 vs 7.25±1.5IU L -1 , serum alkaline phosphatase 41.25 ±1.89 vs 44.25 ± 3.3IU L -1 . (scialert.net)
Oxaloacetate5
  • 11. Glutamate-Oxaloacetate Transaminase 1 Impairs Glycolysis by Interacting with Pyruvate Carboxylase and Further Inhibits the Malignant Phenotypes of Glioblastoma Cells. (nih.gov)
  • 19. Direct measurement of backflux between oxaloacetate and fumarate following pyruvate carboxylation. (nih.gov)
  • 11, glutamate * oxaloacetate transaminase. (nih.gov)
  • Aspartate aminotransferase (AST), formerly termed glutamate oxaloacetate transaminase (GOT), and alanine aminotransferase (ALT), formerly termed glutamate pyruvate transaminase (GPT), are the two aminotransferases of greatest clinical significance. (yemialadeworld.com)
  • In this investigation, the effect of two steroid hormones on phenoloxidase activity, O 2 - production in the haemocytes, total haemocyte count (THC), superoxide dismutase (SOD) activity, glutamate oxaloacetate transaminase (GOT) activity, glutamate pyruvate transaminase (GPT) activity, and plasma cholesterol concentrations in white shrimps ( Litopenaeus vannamei ). (atlasofscience.org)
Enzyme7
  • In enzymology, a glutamine-pyruvate transaminase (EC 2.6.1.15) is an enzyme that catalyzes the chemical reaction L-glutamine + pyruvate ⇌ {\displaystyle \rightleftharpoons } 2-oxoglutaramate + L-alanine Thus, the two substrates of this enzyme are L-glutamine and pyruvate, whereas its two products are 2-oxoglutaramate and L-alanine. (wikipedia.org)
  • This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. (wikipedia.org)
  • The systematic name of this enzyme class is L-glutamine:pyruvate aminotransferase. (wikipedia.org)
  • This enzyme participates in glutamate metabolism. (wikipedia.org)
  • A related enzyme is 4-aminobutyrate aminotransferase (EC 2.6.1.19), also called GABA transaminase. (nih.gov)
  • use ACYLTRANSFERASES 1973-1979, use COENZYME A & PHOSPHOLIPIDS 1973-1978 MH - 1-Pyrroline-5-Carboxylate Dehydrogenase UI - D050842 MN - D8.811.682.662.693 MS - An enzyme that catalyzes the oxidation of 1-pyrroline-5-carboxylate to L-GLUTAMATE in the presence of NAD. (nih.gov)
  • HN - 2006(1981) MH - 2-Aminoadipate Transaminase UI - D051307 MN - D8.811.913.477.700.120 MS - A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the transfer of amino group of L-2-aminoadipate onto 2-OXOGLUTARATE to generate 2-oxoadipate and L-GLUTAMATE. (nih.gov)
Aspartate-transaminase1
  • Serum ALT level, serum AST ( aspartate transaminase ) level, and their ratio ( AST/ALT ratio ) are commonly measured clinically as biomarkers for liver health. (wikidoc.org)
Transamination1
  • ALT catalyzes the transfer of an amino group from L-alanine to α-ketoglutarate , the products of this reversible transamination reaction being pyruvate and L-glutamate . (wikidoc.org)
Liver2
  • ProductData": { "ID": "3.1.3.3.7.5", "ProductType": "Others", "BrandName": "Glutamate Dehydrogenase (NAD(P))", "ProductNameAddition": "from beef liver, solution", "RegulatoryDisclaimer1": "For further processing only. (roche.com)
  • The term transaminase is outdated and no longer used in liver disease. (wikidoc.org)
Dehydrogenase2
  • animals were sacrificed at 30, 60, or 90 days for chemical analyses (serum glutamate-oxalacetate-transaminase, lactic-dehydrogenase, blood urea nitrogen, serum glutamate-pyruvate-transaminase, and serum triglycerides). (cdc.gov)
  • Unit of measure is \"L\".", "Language": "en", "Country": "XG", "Code": "CB - Order Information" }, { "Name": "Positioning", "Value": "Dehydrogenase that catalyzes the conversion of glutamate to α-ketoglutarate. (roche.com)
Biosynthesis1
  • This general designation covers both 2.6.1.76 (diaminobutyrate-2-oxoglutarate transaminase, which uses glutamate as the amino donor in DABA biosynthesis), and 2.6.1.46 (diaminobutyrate--pyruvate transaminase, which uses alanine as the amino donor). (nih.gov)
Tumors1
  • 3. The ubiquitous expression of pyruvate carboxylase among human prostate tumors. (nih.gov)
Glucose2
  • 12. Enhanced rat beta-cell proliferation in 60% pancreatectomized islets by increased glucose metabolic flux through pyruvate carboxylase pathway. (nih.gov)
  • 13. Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets. (nih.gov)
Malate2
  • Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats. (nih.gov)
  • 18. Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. (nih.gov)
Reaction2
  • 8. The role of biotin and oxamate in the carboxyltransferase reaction of pyruvate carboxylase. (nih.gov)
  • 17. Insights into the carboxyltransferase reaction of pyruvate carboxylase from the structures of bound product and intermediate analogs. (nih.gov)
Lesions1
  • Hepatic lesions were associated with an increase in plasma glutamate-pyruvate transaminase activity, a marked infiltration of lipid and depletion of glycogen concentrations. (nih.gov)
Oxidation1
  • The oxidation of L-glutamate is stimulated by ADP and inhibited by GTP. (roche.com)
Cofactor1
  • As a prototypical transaminase, AST relies on PLP (Vitamin B6) as a cofactor to transfer the amino group from aspartate or glutamate to the corresponding ketoacid. (yemialadeworld.com)
Tissues1
  • 5. Anaplerotic roles of pyruvate carboxylase in mammalian tissues. (nih.gov)
Acid2
  • Other names in common use include glutaminase II, L-glutamine transaminase L, and glutamine-oxo-acid transaminase. (wikipedia.org)
  • This family consists of L-diaminobutyric acid transaminases. (nih.gov)
Highly1
  • 4. Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells. (nih.gov)
Human2
  • 1. Expression of pyruvate carboxylase in cultured human astrocytoma, glioblastoma and neuroblastoma cells. (nih.gov)
  • 6. Roles of pyruvate carboxylase in human diseases: from diabetes to cancers and infection. (nih.gov)
Cells3
  • 7. Pyruvate carboxylase is required for glutamine-independent growth of tumor cells. (nih.gov)
  • 15. Expression of pyruvate carboxylase in cultured oligodendroglial, microglial and ependymal cells. (nih.gov)
  • 20. Differential contribution of pyruvate carboxylation to anaplerosis and cataplerosis during non-gluconeogenic and gluconeogenic conditions in HepG2 cells. (nih.gov)