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  • Hippocampus
  • As an early alteration, perinuclear deposits of EAAC1 protein were found mainly in the large pyramidal neurons at the hippocampus, neocortex, piriform cortex, and amygdala with the reduction of neuropil staining 6 hours after KA injection. (biomedsearch.com)
  • Slc1a1
  • In SN38-resistant HCT116 and LoVo cells, SLC1A1 expression was down-regulated ~60 % and up-regulated ~4-fold, respectively, at both mRNA and protein level, whereas SLC1A3 protein was undetectable. (biomedcentral.com)
  • DL-TBOA did not significantly alter cellular levels of p21, cleaved PARP-1, or phospho-Retinoblastoma protein, yet altered SLC1A1 subcellular localization, and reduced chemotherapy-induced p53 induction. (biomedcentral.com)
  • SLC1A1 expression and glutamate transporter activity are altered in SN38-resistant CRC cells. (biomedcentral.com)
  • mediates
  • Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. (uniprot.org)
  • Golgi
  • In yeast cells grown on either ammonia or urea medium, the general amino acid permease (Gap1p) is transported from the Golgi complex to the plasma membrane, whereas, in cells grown on glutamate medium, Gap1p is transported from the Golgi to the vacuole. (rupress.org)
  • In sec13 mutants grown on ammonia, Gap1p is transported from the Golgi to the vacuole, instead of to the plasma membrane. (rupress.org)
  • Together, these studies demonstrate that both a nitrogen-sensing mechanism and Sec13p control Gap1p transport from the Golgi to the plasma membrane. (rupress.org)
  • The trans -Golgi is a major branch point in the secretory pathway, where proteins directed to the cell surface are segregated from proteins that are destined for the lysosome. (rupress.org)
  • In some specialized mammalian cells, particular cargo proteins are segregated at the trans -Golgi into compartments that allow regulated delivery to the plasma membrane. (rupress.org)
  • Transport by all three post-Golgi mechanisms appears to be constitutive, and regulation of protein delivery to the plasma membrane has not been observed in yeast. (rupress.org)
  • Support for exocytotic models of ATP release has largely been predicated on the inhibitory actions of various reagents, such as brefeldin A, tetanus toxins, or dominant-negative soluble N -ethylmaleimide-sensitive-factor attachment receptor (SNARE) proteins that target particular steps in the standard Golgi → transport vesiclevesicle/plasma membrane fusion trafficking pathways, as reviewed in Ref. 19 . (physiology.org)
  • In a canonical pathway, proteins are synthesized and post-translationally modified in the somatic ER, transported to a perinuclear Golgi for additional modifications and targeted distally in long-haul post-Golgi vesicles. (biologists.org)
  • EAAT3
  • EAAT1 (GLAST) mRNA and protein, and EAAT2 (GLT-1) protein, were reduced in mGluR3-/- mice, whereas EAAT3 (EAAC1) mRNA was decreased in mGluR2-/- mice. (ox.ac.uk)
  • secretion
  • Interestingly, CNS proteins involved in secretion of the neurotransmitters and emitting their responses as well as the regulation of these processes, are also found in islet cells. (frontiersin.org)
  • cysteine
  • 1280334 ). Can also transport L-cysteine (By similarity). (uniprot.org)
  • Sections were double labeled with either a cystine antibody designed to detect free cystine (the oxidized form of cysteine) or an antibody against the light chain of Xc-, and the membrane marker wheat germ agglutinin. (arvojournals.org)
  • 2 GSH is a tripeptide synthesized from cysteine, glutamate, and glycine by the sequential actions of the enzymes γ-glutamylcysteine synthetase and glutathione synthetase. (arvojournals.org)
  • secretory
  • Secretory lysosomes have been recently proposed as a source of releasable ATP from astrocytes based on the ability of glycylphenylalanine 2-napthylamide (GPN), a substrate for lysosomal cathepsin C, to coordinately collapse lysosome integrity and repress the ATP release stimulated by metabolic stress or glutamate receptor activation ( 63 ). (physiology.org)
  • hippocampal
  • D) Quantitative analysis of the amount of VGAT protein in total (left) and synaptosomal (right) hippocampal lysates of wild-type and μ3B−/−ΔNeo mice (n = 4 each) as shown in C. Results are expressed as means ± SD. (nih.gov)