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  • Receptors
  • In rat models, ZJ43 and 2-PMPA reduce perception of inflammatory and neuropathic pain when administered systemically, intracerebrally, or locally, suggesting that NAAG modulates neurotrasmission in pain circuits via mGlu3 receptors. (wikipedia.org)
  • however
  • Stimulation of the mGluR3 by NAAG has been, however, questioned, finding relevant glutamate contamination in commercially available NAAG. (wikipedia.org)
  • system
  • NAAG was discovered as a nervous system-specific peptide in 1965 by Curatolo and colleagues [2] but initially disregarded as a neurotransmitter and not extensively studied. (wikipedia.org)