Glutamate carboxypeptidase II (GCPII, EC 3.4.17.21) is a membrane peptidase expressed in a number of tissues such as kidney, prostate and brain. (johnshopkins.edu)
On prostate cancer (PC) cells, the cell surface enzyme prostate-specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II or N -acetyl- l -aspartyl- l -glutamate peptidase, is highly upregulated, whereas it shows low or no expression in the normal prostate ( 3 ). (snmjournals.org)
In peptidase family M20 (glutamate carboxypeptidase family). (enzyme-database.org)
Darmin encodes a secreted protein of 56 kDa containing a peptidase M20 domain characteristic of the glutamate carboxypeptidase group of zinc metalloproteases. (xenbase.org)
NAAG is inactivated by extracellular peptidase activity yielding glutamate and N-acetylaspartate. (utmb.edu)
Other responsible enzymes include dispase, and glutamate carboxy peptidase II (also known as prostate-specific membrane antigen). (cellgs.com)
PSMA3
Intriguingly, nicastrin ECD is structurally similar to a large family of peptidases exemplified by the glutamate carboxypeptidase PSMA. (nature.com)
Several radiolabeled prostate-specific membrane antigen (PSMA) inhibitors based on the lysine-urea-glutamate (KuE) motif as the pharmacophore proved to be suitable tools for PET/SPECT imaging of the PSMA expression in prostate cancer patients. (tum.de)
PURPOSE: [68Ga]Trishydroxypyridinone (THP)-prostate-specific membrane antigen (PSMA) is a novel tracer that can be labeled in one step by cold reconstitution of a kit with unprocessed generator eluate, targeting PSMA via the lysine-urea-glutamate (KuE) motif. (tum.de)
GCPII5
The brain form of GCPII (also known as NAALADase) cleaves N-acetyl-aspartyl glutamate to yield free glutamate. (johnshopkins.edu)
GCPII thus represents an important target for the treatment of neuronal damage caused by excess glutamate. (johnshopkins.edu)
Assist with evaluating new glutamate carboxypeptidase II (GCPII) inhibitors and other identified therapeutic targets in organoid models and preclinical models of IBD and pain using cell culture, immunohistochemistry, enzymatic and biochemical assays. (gobgc.org)
Pomper's interest in imaging prostate cancer began in 1996 when he came across a journal article about an inhibitor of glutamate carboxypeptidase II (GCPII), a brain enzyme that generates glutamate - a chemical that nerve cells use to send signals to other cells. (jhu.edu)
Excess glutamate has been found in people with various neurological diseases, and researchers have learned that blocking GCPII in animals can limit excess glutamate and provide therapeutic benefits. (jhu.edu)
NAALADase2
N-acetylated-α-linked-acidic-dipeptidase (NAALADase or glutamate carboxypeptidase II) cleaves the neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to glutamate and N-acetyl-aspartate (NAA). (johnshopkins.edu)
Thomas, AG, Olkowski, JL & Slusher, BS 2001, ' Neuroprotection afforded by NAAG and NAALADase inhibition requires glial cells and metabotropic glutamate receptor activation ', European Journal of Pharmacology , vol. 426, no. 1-2, pp. 35-38. (johnshopkins.edu)
Metabotropic3
In addition, group II metabotropic glutamate receptors (mGlu2/3R) have been suggested as a new therapeutic target for drug addiction. (nature.com)
In this report, we examined the involvement of glial cells and metabotropic glutamate (mGlu) receptors in neuroprotection mediated by NAAG and 2-PMPA in an in vitro model of metabolic inhibition. (johnshopkins.edu)
The peptide neurotransmitter N-acetylaspartylglutamate (NAAG) acts as an agonist at group II metabotropic glutamate receptors (mGluRs). (utmb.edu)
Enzyme1
This enzyme catalyses the following chemical reaction Release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups This zinc enzyme is produced by pseudomonads, Flavobacterium sp. (wikipedia.org)
Protein1
This diploma thesis revolves around the preparation of biocompatible polymeric conjugates called "iBodies" that will be used to induce targeted lysosomal degradation of two model enzymes - Fibroblast activation protein α, and Glutamate carboxypeptidase II. (nusl.cz)
NAAG1
In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. (gentaur.com)
Amino2
In this paper we report expression of an extracellular portion of human glutamate carboxypeptidase II (amino acids 44-750) in Drosophila Schneider's cells and its purification to homogeneity. (johnshopkins.edu)
Peptidases and proteinases hydrolyse peptide bonds, and can be simply divided on the basis of whether terminal peptide bonds are cleaved (exopeptidases and exoproteinases) at the amino terminus (aminopeptidases) or carboxy terminus (carboxypeptidases). (guidetoimmunopharmacology.org)
Glial1
Pallottie A, Ratnayake A, Ni L, Acioglu C, Li L, Mirabelli E, Heary RF, Elkabes S . A toll-like receptor 9 antagonist restores below-level glial glutamate transporter expression in the dorsal horn following spinal cord injury. (neurotree.org)
Therapeutic1
Expression of microbial glutamate carboxypeptidase was lower in the duodenum of celiac patients, and its decrease in mice also correlated with impaired gluten degradation, suggesting a potential candidate for future therapeutic development. (metabiom.org)
Gene1
Glutamate carboxypeptidase II gene polymorphisms and neural tube defects in a high-risk Chinese population. (cdc.gov)
Activity2
Wolf, D.H. and Ehmann, C. Carboxypeptidase S from yeast: regulation of its activity during vegetative growth and differentiation. (enzyme-database.org)
A new sensitive assay used to quantitate FXIII activity is based on monitoring the amount of ammonia (NH 3 ) released by using glutamate dehydrogenase and nicotinamide adenine dinucleotide phosphate during the transamidation reaction (cross-linking) by FXIII. (medscape.com)
Properties1
Purification and properties of carboxypeptidase G2 from Pseudomonas sp. (wikipedia.org)
Unknown2
however, it has also been shown that high doses of modafinil can affect several other neurotransmitter pathways (that are also involved in addictive behaviors such as glutamate, GABA serotonin, and orexin) by unknown mechanisms ( Minzenberg and Carter, 2008 ). (nature.com)
The peptide neurotransmitter N-acetylaspartylglutamate (NAAG) is reported to suppress neurotransmitter release through selective activation of presynaptic group II metabotropic glutamate receptors. (johnshopkins.edu)
We hypothesized that the NAAG peptidase inhibitor, ZJ-43 would elevate extracellular NAAG levels and reduce extracellular levels of amino acid neurotransmitters following TBI by a group II metabotropic glutamate receptor (mGluR)-mediated mechanism. (johnshopkins.edu)
Inhibits1
Carboxypeptidase E (CPE) inhibits the secretion and activity of Wnt3a. (nih.gov)
17.111
The release of C-terminal glutamate from folylpoly-gamma-glutamates is also catalyzed by EC 3.4.17.11 and EC 3.4.19.9. (cathdb.info)
Purification1
Purification and properties of carboxypeptidase G2 from Pseudomonas sp. (wikipedia.org)
Carboxypeptidase Q (CPQ) mRNA expression was higher in glioblastoma (GBM) tissues than in normal tissues. (amegroups.org)
Degradation1
It has been shown to act as a carboxypeptidase, involved in the degradation of proteasomal products to preferentially yield di- and tripeptides, with subsequent and final degradations to free amino acid residues by tricorn interacting factors, F1, F2 and F3. (nih.gov)
Unit of measure is \"L\".", "Language": "en", "Country": "XG", "Code": "CB - Order Information" }, { "Name": "Positioning", "Value": "Dehydrogenase that catalyzes the conversion of glutamate to α-ketoglutarate. (roche.com)
Brain1
Traumatic brain injury (TBI) produces a rapid and excessive elevation in extracellular glutamate that induces excitotoxic brain cell death. (johnshopkins.edu)
Release1
Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates. (cathdb.info)
Shows1
This graph shows the total number of publications written about "Glutamate Carboxypeptidase II" by people in this website by year, and whether "Glutamate Carboxypeptidase II" was a major or minor topic of these publications. (wakehealth.edu)
Role1
The role of carboxypeptidase Q (CPQ) in GBM remains unknown. (amegroups.org)
Levels1
ZJ-43 treatment also reduced the rise of dialysate glutamate, aspartate, and GABA levels. (johnshopkins.edu)