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  • free glutamate
  • A new labeling rule proposed by the Food and Drug Administration would require food producers to disclose whether their products contain free glutamate--the active ingredient in monosodium glutamate. (latimes.com)
  • In fact, some foods that proudly advertise "No MSG" actually contain large amounts of free glutamate. (latimes.com)
  • Indeed, it is difficult to find a brand of canned tuna that does not include hydrolyzed soy protein--a particularly potent source of free glutamate. (latimes.com)
  • Under the proposed rule, manufacturers of prepared foods made with additives that contain free glutamate would have to disclose its presence on the label. (latimes.com)
  • Free glutamate is used as a flavoring, yet it has no flavor itself. (latimes.com)
  • The exact chemical basis for some people's reactions to free glutamate is still unclear. (latimes.com)
  • Free glutamate that occurs naturally in vegetables like tomatoes, they say, isn't harmful. (latimes.com)
  • And according to the agency's Advanced Notice of Proposed Rule-Making, or ANPR, on MSG, the new regulation would "apply to foods that contain free glutamate from any source. (latimes.com)
  • MSG--the first product making use of free glutamate--was first isolated in Japan in 1908 by Kikunae Ikeda, who had noticed that the seaweed kombu was used as a flavor enhancer. (latimes.com)
  • Critics say the presence of free glutamate can trigger reactions in people who are sensitive to it ranging from dizziness and shortness of breath to headaches and drowsiness. (latimes.com)
  • But at least one neuroscientist, Washington University's John W. Olney, a member of the National Academy of Sciences, claims free glutamate can cause brain damage--particularly in children. (latimes.com)
  • The proposed warning statement would carry with it the implication that the average consumer, who has been consuming free glutamate-containing products for years, should now, suddenly, be concerned," wrote one. (latimes.com)
  • Free glutamate exists in certain cheeses (such as parmesan), in tomato products, and in soy sauce. (sci-toys.com)
  • However, free glutamate, as found in soy sauce or prepared foods, enters the bloodstream much faster than the glutamates bound in proteins, where they are released slowly during digestion. (sci-toys.com)
  • calcium
  • Glutamate opens calcium channels. (change.org)
  • Glutamate is shown to be generated by mitochondria in response to glucose and directly stimulates exocytosis in permeabilized cells in which the concentration of calcium is held constant. (sciencemag.org)
  • Protein
  • It is most commonly found in food in its salt form, glutamate, which comes in two forms--that which is bound to protein and that which is free of protein. (latimes.com)
  • molecule
  • Researchers are working towards gene therapy approaches to deliver the glutamate transporter molecule to cells affected by ALS. (alsa.org)
  • 1993
  • The FDA's proposal is based, in part, on a two-day panel by the Federation of American Societies for Experimental Biology, or FASEB, that was called in 1993 to review the existing scientific literature on glutamate. (latimes.com)
  • nerve
  • Other studies have shown that the body uses glutamate as a nerve impulse transmitter in the brain. (latimes.com)
  • Neurobiologists recognize that the nerve cell messenger, glutamate, can cause harm when its messages are overwhelming. (alsa.org)
  • Normally glutamate is swiftly cleared from the nerve cell junctions to keep the messages brief. (alsa.org)
  • Prolonged excitation is toxic to nerve cells, and neurobiologists recognize that glutamate can cause harm when the messages are overwhelming, as in stroke or epilepsy. (alsa.org)
  • abundant
  • Abundant evidence points to glutamate as a destructive factor in ALS and investigators are working to find out how this can be changed. (alsa.org)
  • Abundant evidence points to glutamate as a destructive factor in ALS. (alsa.org)
  • foods
  • Glutamate is a natural element found in virtually all foods such as meat, fish, poultry, milk (including mother's milk) , and many vegetables. (fuzing.com)
  • Glutamates are added to a wide range of foods to enhance their flavour by giving them a "savoury" or "meaty" taste. (foodstandards.gov.au)
  • activity
  • Sodhi and her colleagues were intrigued by recent studies that found that a low dose of the drug ketamine, which alters glutamate system activity, can rapidly eliminate depression in two-thirds of patients who do not respond to conventional antidepressants . (medicalnewstoday.com)
  • 1999
  • Maechler, P., and Wollheim, C.B. (1999) Mitochondial glutamate acts as a messenger in glucose-induced insulin exocytosis. (sciencemag.org)
  • Pharmacological
  • Using a variety of pharmacological, biochemical, genetic, and brain imaging techniques, these investigators show precisely how glutamate is involved in the etiology of addictions and how blocking or activating certain elements of the glutamatergic system appear to alleviate particular components of addiction. (springer.com)
  • role
  • In Glutamate and Addiction, world-renowned scientific experts critically review all of this evidence and make the case for the role of glutamatergic systems in both the etiology and treatment of addiction disorders. (springer.com)
  • found
  • This entry contains type 1 glutamate-tRNA ligases, which are found in bacteria and in mitochondria in eukaryotes. (ebi.ac.uk)