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  • proteins
  • Proteins expressed and released by muscle that have autocrine, paracrine, and endocrine bioactivities have been termed myokines. (frontiersin.org)
  • Recent data suggest humoral factors such as muscle-derived secretory proteins may mediate the beneficial effects of exercise in the treatment of metabolic diseases. (frontiersin.org)
  • Skeletal muscle has recently been identified as an endocrine organ that synthesizes and secretes proteins known as myokines ( 1 ). (frontiersin.org)
  • Little is known about the effect on insulin action and key proteins in skeletal muscle, and the necessary volume of strength training is unknown. (diabetesjournals.org)
  • Quantitative proteomic analysis in rectus abdominus skeletal muscle tissue collected at delivery revealed reduced protein content of mitochondrial complex I (C-I) subunits (NDUFS3, NDUFV2) and altered content of proteins involved in calcium homeostasis/signaling (calcineurin A, α1-syntrophin, annexin A4) in OGDM (n = 6) vs. ONGT (n = 6). (plos.org)
  • OBJECTIVE TBC1D1 is a member of the TBC1 Rab-GTPase family of proteins and is highly expressed in skeletal muscle. (diabetesjournals.org)
  • Taken together, these findings suggest that there may be one or more additional Rab-GAP proteins expressed in skeletal muscle that also function to regulate glucose transport. (diabetesjournals.org)
  • soleus muscle
  • The electrical stimulation of isolated soleus muscle in vitro increased the rate of glucose transport, but this required 20 min to reach maximum. (edu.au)
  • In an attempt to further clarify a role for PKc in the mechanism of glucose transport activation isolated soleus muscle was depleted ("downregulated") of PKc activity by prolonged TPA treatment. (edu.au)
  • Thus, it is concluded that treatment of isolated soleus muscle with TPA gives rise to a marked loss of contraction-induced glucose transport. (edu.au)
  • Stimulation
  • Thus, it is concluded that a "causal" relationship between electrical stimulation and the increase in glucose transport involving PKc activation may exist. (edu.au)
  • Approximately 80% of the myotubes were observed to contract microscopically, and the contractions lasted for at least 3 h with electrical stimulation. (harvard.edu)
  • Physiology
  • Wagenmakers, AJM and Strauss, JA and Shepherd, SO and Keske, MA and Cocks, M, Increased muscle blood supply and transendothelial nutrient and insulin transport induced by food intake and exercise: effect of obesity and ageing , Journal of Physiology, 594, (8) pp. 2207-2222. (edu.au)
  • C2C12
  • Here we employed the mouse SKM C2C12 cell line to examine potential downstream targets of IL-15-induced alterations in glucose uptake. (frontiersin.org)
  • C2C12 myotubes seeded into 4-well rectangular plates were placed in a contraction system equipped with a carbon electrode at each end. (harvard.edu)
  • activation
  • Talmadge RJ, Otis JS, Rittler MR, Garcia ND, Spencer SR, Lees SJ et al (2004) Calcineurin activation influences muscle phenotype in a muscle-specific fashion. (springer.com)
  • The hypothesis that a PI3K dependant signalling pathway, leading to activation of eNOS and the production of NO, is involved in the hemodynamic actions of insulin in muscle was examined. (edu.au)