Glucose uptake by insulin. Medical search. Frequent questions

Growing evidence indicates that the herb may have antidiabetic effects, such as improving glucose tolerance and insulin resistance , which may be beneficial for managing and treating type 2 diabetes . (medicalnewstoday.com)
Ginsenosides may decrease insulin resistance, which is a source of inflammation . (medicalnewstoday.com)
It occurs when a person develops insulin resistance, meaning the person's cells are unable to respond effectively to insulin. (medicalnewstoday.com)
They can improve glucose uptake by cells but sometimes cause insulin resistance . (medicinenet.com)
tension,glucoseintolerance,insulin afterful explanationoftheobjectives resistance[3]andhyperlipidaemia[4]. (who.int)
Over time, resistance to insulin can develop. (medscape.com)
Insulin resistance is the hallmark of type 2 diabetes and occurs when tissues in the body are not able to respond to insulin resulting in sustained elevations in blood sugar, also known as hyperglycemia. (scienceblogs.com)
Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of a number of diseases, including type 2 diabetes. (jci.org)
In this review, we discuss potential mechanisms by which brief nutrient excess and obesity lead to insulin resistance and propose that these mechanisms of action are different but interrelated. (jci.org)
We then discuss how obesity leads to insulin resistance via a complex interplay among systemic fatty acid excess, microhypoxia in adipose tissue, ER stress, and inflammation. (jci.org)
In particular, we focus on the hypothesis that the macrophage is an important cell type in the propagation of inflammation and induction of insulin resistance in obesity. (jci.org)
Insulin resistance is defined as an inadequate response by insulin target tissues, such as skeletal muscle, liver, and adipose tissue, to the physiologic effects of circulating insulin. (jci.org)
The causes of insulin resistance can be genetic and/or acquired. (jci.org)
Nonetheless, it is likely that any genetic component must interact with environmental factors in order for insulin resistance to develop into a pathophysiologically meaningful abnormality. (jci.org)
In the presence of a robust compensatory insulin secretory response to insulin resistance, glucose levels can remain relatively normal. (jci.org)
In this, insulin is present, but the muscle and fatty tissue do not adequately respond to the available insulin (insulin resistance). (rxlist.com)
Insulin resistance states are associated with endothelial dysfunction, but the molecular mechanisms underlying this association are incompletely understood. (endocrine-abstracts.org)
Notably, recent experimental studies have strongly implicated ceramides in the development of numerous metabolic diseases such as insulin resistance, diabetes, cardiomyopathy, hepatic-steatosis, and atherosclerosis. (frontiersin.org)
Notably, recent studies suggest that the accumulation of sphingolipids, namely ceramides and it's metabolites, play essential roles in the development of insulin resistance in tissues such as skeletal muscle, liver and, adipose tissue in obese rodents, and humans ( 6 - 20 ). (frontiersin.org)
Obesity is associated with insulin resistance. (cambridge.org)
Insulin resistance underlies a constellation of adverse metabolic and physiological changes (the insulin resistance syndrome) which is a strong risk factor for development of type 2 diabetes and CHD. (cambridge.org)
Lipodystrophy, lack of adipose tissue, is also associated with insulin resistance. (cambridge.org)
Any plausible explanation for the link between excess adipose tissue and insulin resistance needs to be able to account for this observation. (cambridge.org)
Accumulation of triacylglycerol in skeletal muscles and in liver is associated with insulin resistance. (cambridge.org)
This view of the link between adipose tissue and insulin resistance emphasises the important role of adipose tissue in 'buffering' the daily influx of dietary fat entering the circulation and preventing excessive exposure of other tissues to this influx. (cambridge.org)
Björntorp , P ( 1994 ) Fatty acids, hyperinsulinemia, and insulin resistance: which comes first? (cambridge.org)
Liver transplant recipients are at high risk of developing insulin resistance, new-onset diabetes, and post-transplantation metabolic syndrome that is highly associated with immunosuppressive treatment. (wjgnet.com)
In insulin resistance there is a decrease level of GLUT4 expression in skeletal muscle. (cdc.gov)
Recent statistics indicate that number of epidemiological studies standing of the role of excessive fat dep- nearly 50% of the total Arab population from each country, we did not set any osition in promoting insulin resistance, are less than 25 years of age. (who.int)
Diabetes mellitus is impaired insulin secretion and variable degrees of peripheral insulin resistance leading to hyperglycemia. (msdmanuals.com)
Fat accumulation in skeletal muscle combined with low mitochondrial oxidative capacity is associated with insulin resistance (IR). (medscape.com)
Fat accumulation in skeletal muscle strongly associates with the development of muscle insulin resistance (IR), the main risk factor in the development of type 2 diabetes (T2D). (medscape.com)
A missense variation has been found in the N-terminal SH2 domain (N-SH2) of p85α, leading to a severe insulin resistance. (lu.se)
Insulin resistance (IR) and type 2 diabetes are becoming common among children and adolescents, are related to cardiometabolic risk and have been presented as a public health problem, requiring attention from the early stages of life 1,2 . (bvsalud.org)

This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3‐L1 adipocytes, as well as the mechanism involved. (researchgate.net)
Conclusions Our findings suggest that DIM may improve insulin sensitivity through the activation of the insulin signaling pathway, leading to enhanced glucose uptake. (researchgate.net)
DIM, a major metabolite of indole-3-carbinol, which is naturally produced in broccoli and cabbage, enhances glucose uptake through the improvement of insulin sensitivity in 3T3-L1 cells [13] . (researchgate.net)
In ZDF rats, KBP-088 significantly reduced fasting blood glucose and improved insulin sensitivity (GIR, vehicle: 1.5, KBP-088: 16.5 mg glucose/kg/min) , independent on weight loss. (diabetesjournals.org)
In summary, KBP-088 significantly improved insulin sensitivity in both pre-diabetic and diabetic rats and markedly increased tissue specific glucose uptake. (diabetesjournals.org)
Study demonstrates that exercising before eating breakfast burns more fat, improves insulin sensitivity, & increases glucose uptake into muscle. (foundmyfitness.com)
Exercise promotes the uptake of glucose into muscle cells and increases insulin sensitivity. (foundmyfitness.com)
Previous research has demonstrated that training in the fasted state promotes greater glucose tolerance and insulin sensitivity and induces higher fatty acid oxidation compared to training in the fed state. (foundmyfitness.com)
These findings suggest that exercising before eating breakfast burns more fat, improves insulin sensitivity, and increases glucose uptake into muscle tissue compared to exercising after eating breakfast. (foundmyfitness.com)
The results support the theory that adiponectin might be part of a feedback mechanism improving insulin sensitivity and cardiovascular health in pre-eclamptic patients. (who.int)
Overall, we provide our integrative perspective regarding how nutrients and obesity interact to regulate insulin sensitivity. (jci.org)
The hallmarks of impaired insulin sensitivity in these three tissues are decreased insulin-stimulated glucose uptake into skeletal muscle, impaired insulin-mediated inhibition of hepatic glucose production in liver, and a reduced ability of insulin to inhibit lipolysis in adipose tissue. (jci.org)
This tests is one method for determining insulin sensitivity (or resistant). (myhealth.gov.my)
In mice, blocking ceramide production improves insulin sensitivity, prevents β-cell failure, resolves hepatic steatosis, hypertriglyceridemia, and prevents atherosclerosis, and heart failure ( 6 - 22 ). (frontiersin.org)
As it is apparent in this series, numerous studies have shown that manipulation of ceramide synthesis or degradation pathways in rodents through pharmacologic and genetic interventions have profound effects on insulin sensitivity ( 6 , 12 , 26 , 27 ). (frontiersin.org)
The amount of exogenous glucose infused to counter this drop is indicative of insulin sensitivity. (jove.com)
Overweight youth are more susceptible to metabolic disorders, since the accumulation of body fat, especially in the abdominal region, generates an increase in fatty acids circulating in the bloodstream, which consequently impairs insulin signaling and leads to a reduction in sensitivity of receptors and tissue response to cellular actions that are mediated by this hormone 1,3,4 . (bvsalud.org)

In cases of hypoglycemia, however, increased glucagon secretion is the primary counterregulatory mechanism through which normal levels of plasma glucose are restored. (medscape.com)
Insulin is the primary hormone responsible for controlling glucose metabolism, and its secretion is determined by plasma glucose concentration. (cdc.gov)
They're known to increase insulin secretion, but excessive intake leads to prevention of insulin release. (medicinenet.com)
Here, the effects of these alkaloids on cell survival, the activity of superoxide dismutase, catalase, and glutathione peroxidase, factors associated with oxidative stress such as malondialdehyde and dityrosine, carbohydrate-hydrolyzing enzymes alpha-amylase and alpha-glucosidase, insulin secretion levels and glucose uptake ability were investigated. (ijpsonline.com)
Furthermore, glucose uptake and insulin secretion were enhanced by these compounds. (ijpsonline.com)
Joan Domingo-Espín J, Lindahl M, Nilsson-Wolanin O, Cushman S W, Stenkula K G, Lagerstedt J O. Dual Actions of Apolipoprotein A-I on Glucose-Stimulated Insulin Secretion and Insulin-Independent Peripheral Tissue Glucose Uptake Lead to Increased Heart and Skeletal Muscle Glucose Disposal. (lu.se)

The BCAAs have variable effects on glucose metabolism, insulin levels, and response. (medicinenet.com)
In healthy adults, fasting increases CBF, reflecting increased delivery of oxygen and glucose to support brain metabolism. (frontiersin.org)
Of the numerous lipid classes implicated in eliciting lipotoxicity, sphingolipid: ceramides are among the most deleterious as they modulate signaling pathways involved in regulating glucose metabolism, triglyceride synthesis, apoptosis, and fibrosis. (frontiersin.org)
However, the potential of statin use to affect glucose metabolism has been controversial [ 6 ]. (hindawi.com)
The present article discusses how accumulation of triacylglycerol in adipocytes can lead to deterioration of the responsiveness of glucose metabolism in other tissues. (cambridge.org)
However, larger, adequately powered, randomized, placebo-controlled, double-blind trials examining multiple measures of carbohydrate and lipid metabolism and insulin homeostasis are needed. (lww.com)
Glucagon is an initial precursor in the metabolism of glucose increasing cAMP, gluconeogenesis, and ketogenesis. (medscape.com)
After conducting several cross-sectional surveys with schoolchildren and observing their high prevalence of overweight and other risk factors , supported with scientific evidence, it was decided to carry out intervention programs with this population and evaluate their effects on health parameters, including those associated with glucose metabolism. (bvsalud.org)

It helps convert glucose to a storage product called 'glycogen. (rxlist.com)
Insulin acts to stimulate the body's cells (muscle and fat cells) to absorb sugar found in the blood for energy or be stored as glycogen and insulin will act to inhibit the breakdown of glycogen to glucose in the liver into the blood until blood sugar levels in the blood back to normal. (myhealth.gov.my)
Glucagon works against the anabolic effects of insulin to catabolize glycogen. (medscape.com)
In untrained subjects, lipid infusion reduced oxidative and nonoxidative glucose disposal (NOGD), whereas trained subjects were completely protected against lipid-induced reduction in NOGD, supported by dephosphorylation of glycogen synthase. (medscape.com)
Signaling data support the notion that high glucose uptake in trained subjects is maintained by shuttling glucose toward storage as glycogen. (medscape.com)
The class Ia PI3-kinase plays a pivotal role in signal transduction pathways linking insulin with many of its specific cellular responses, including GLUT4 vesicle translocation to the plasma membrane and the inhibition of glycogen synthase kinase-3. (lu.se)
Moreover, PI3-kinase is necessary, if not sufficient, for the insulin-stimulated increase in glucose uptake, and glycogen synthesis in insulin-sensitive tissues. (lu.se)

Direct assessment of tissue specific glucose uptake showed, that KBP-088 significantly increased glucose uptake in both muscles and adipose tissues when compared to vehicle. (diabetesjournals.org)
Effect of insulin on glucose uptake by normal and neoplastic mouse mammary tissues in organ culture. (jax.org)
Glucagon works along with insulin to balance glucose distribution in the serum for transport to body tissues. (medscape.com)
Insulin stimulates glucose and amino acid uptake from the blood to tissues for functional use. (medscape.com)
The principal function of insulin is to control the uptake and utilization of glucose in the peripheral tissues. (cdc.gov)
One of the common things that happen during aging is that tissues - such as of the heart, brain, and muscle - lose the ability to metabolize glucose effectively. (medscape.com)
Insulin is involved in the absorption of these nutrients by the cells of the body and used for a variety of uses such as supply of energy to the muscles of the body, repairing the muscle tissues that have been damaged, and supplying cell membrane with essential fatty acids. (myhealth.gov.my)
Accumulation of neutral lipids, such as triglycerides, in key insulin target tissues, has been postulated to inhibit metabolic functions, however, they are less likely to be deleterious. (frontiersin.org)

This was associated with DIM‐enhanced phosphorylation of the signaling intermediates Akt, insulin receptor substrate‐1, and insulin receptor early in differentiation. (researchgate.net)
As a critical node for insulin/IGF signaling, insulin receptor substrate 1 (IRS-1) is essential for metabolic regulation. (nature.com)
Insulin receptor substrate (IRS) proteins play essential roles in mediating insulin/IGF signaling by recruiting a series of downstream effectors 23 . (nature.com)
Metz H, Busch SE, Hanke ML, Kargl J, Kim KH and Houghton M (2014) Insulin receptor substrate-1 regulates immune cell content in lung adenocarcinoma. (scielo.br)
Metz HE and Houghton AM (2011) Insulin receptor substrate regulation of phosphoinositide 3-kinase. (scielo.br)
Sesti G, Federici M, Hribal ML, Lauro D, Sbraccia P and Lauro R (2001) Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. (scielo.br)
Ma Z, Gibson SL, Byrne MA, Zhang J, White MF and Shaw LM (2006) Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. (scielo.br)
In addition to binding to the insulin receptor, IRS1 also binds to and transmits signals from the receptors of prolactin, growth hormone (GH), leptin, vascular endothelial growth factor (VEGF), tropomyosin receptor kinase B (TrkB), anaplastic lymphoma kinase (ALK), insulin like growth factor (IGF1), and integrins ( Vuori and Ruoslathi , 1994 Vuori K and Ruoslahti E (1994) Association of insulin receptor substrate-1 with integrins. (scielo.br)
In cultured human aortic endothelial cell (HAEC) models, insulin stimulates an intracellular signalling cascade resulting in activating phosphorylation of Insulin Receptor Substrate-1 (IRS-1), Protein kinase B (PKB. (endocrine-abstracts.org)

Manganese Acts upon Insulin/IGF Receptors to Phosphorylate AKT and Increase Glucose Uptake in Huntington's Disease Cells. (purdue.edu)

Insulin concentrations are severely reduced in insulin-dependent diabetes mellitus (IDDM) and some other conditions, while insulin concentrations are raised in non-insulin-dependent diabetes mellitus (NIDDM), obesity, and some endocrine disorders. (cdc.gov)
For someone who has obesity or polycystic ovarian syndrome (PCOS), insulin tolerance test test (ITT) is the best method to measure insulin levels in the blood. (myhealth.gov.my)
Adipose tissue in obesity becomes refractory to suppression of fat mobilization by insulin, and also to the normal acute stimulatory effect of insulin on activation of lipoprotein lipase (involved in fat storage). (cambridge.org)
One potential benefit of fenugreek is improving elevated blood glucose and lipid levels associated with chronic conditions such as diabetes and obesity. (lww.com)
Human gut microbiota after bariatric surgery alters intestinal morphology and glucose absorption in mice independently of obesity. (ulaval.ca)
Elevated levels of uric acid (hyperuricemia) also have implications for the pathogenesis of obesity and have been linked to deteriorated glucose tolerance, impaired fasting glucose and type 2 diabetes 5 . (bvsalud.org)
Clinical diagnosis is made on the basis of the presence of 3 of 5 conditions: 1) high triglyceride level, 2) low high-density lipoprotein (HDL) cholesterol level, 3) high fasting blood glucose level, 4) presence of central obesity (ie, high waist circumference), and 5) high blood pressure ( 1 ). (cdc.gov)

Diabetes describes a group of chronic metabolic conditions that interfere with the body's ability to produce or respond to the hormone insulin. (medicalnewstoday.com)
Our findings delineate a mechanism in which LLPS of IRS-1-mediated signalosomes serves as an organizing center for insulin/IGF-1 signaling and implicate the role of aberrant IRS-1 LLPS in metabolic diseases. (nature.com)
The IRS proteins (IRS1-4) are the family of adaptors regulating metabolic and mitogenic signaling pathways ( Hanke and Mann , 2009 Hanke S and Mann M (2009) The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2. (scielo.br)
These are all metabolic functions of insulin. (rxlist.com)
Enhancing ceramide degradation also endows these metabolic benefits, and adiponectin exerts their antidiabetic, cardioprotective, and insulin-sensitizing actions through activating its receptors, which are ligand-activated ceramidases ( 23 ). (frontiersin.org)
Expressed mainly in skeletal muscle it dramatically increases the muscle's uptake of glucose from the blood in response to insulin or metabolic demand. (cdc.gov)
Participants were designated as having metabolic syndrome if they met criteria for 3 of 5 variables: 1) high blood pressure, 2) low high-density lipoprotein cholesterol level, 3) high fasting blood glucose level, 4) high waist circumference, and 5) high triglyceride level. (cdc.gov)

Long-acting insulins, short-acting insulins, regular insulins, and mixed insulin are several types of insulin available in the market. (rxlist.com)

DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. (researchgate.net)
3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)

Pancreatic glucagon employs gluconeogenesis and glycogenolysis to regulate plasma glucose levels. (medscape.com)

Type 1 diabetes mellitus (insulin-dependent diabetes) is characterized by hyperglycemia caused by an insulin deficiency. (researchgate.net)

We investigated the role of CaMKII in insulin signalling in a rat skeletal muscle cell line, demonstrating that CaMKII modulates the insulin action on DNA synthesis and the negative feedback that down regulates glucose uptake. (cnr.it)
We discuss how pathways that "sense" nutrients within skeletal muscle are readily able to regulate insulin action. (jci.org)
The fusion of insulin-stimulated GLUT4-containing vesicles (GSV) with the plasma membrane (PM) of adipose or skeletal muscle cells is governed by regulated exocytosis. (endocrine-abstracts.org)

An alternative mechanism for lowering blood sugar is muscle contraction as it stimulates a pathway distinct from insulin in the muscles to cause glucose uptake from the blood. (scienceblogs.com)
This causes the blood glucose level to rise and thus stimulates the pancreas to release insulin into the blood. (myhealth.gov.my)
When blood sugar levels dropped, insulin stimulates the pancreas to secrete the glucagon. (myhealth.gov.my)

Dual amylin and calcitonin receptor agonists (DACRAs) are known to induce a significant weight loss and improve glucose tolerance and glucose control in rats. (diabetesjournals.org)
An oral glucose tolerance test (OGTT) continued. (cdc.gov)
At the same time, a glucose-tolerance test in the same rats was also performed. (lu.se)
An oral glucose tolerance test after 10 d of thylakoid- or control-food intake resulted in significantly reduced plasma insulin levels in the thylakoid-fed rats compared with the control-fed rats, while no difference was observed for blood glucose levels. (lu.se)

Type 1 diabetes is well established as an autoimmune disease, where the body attacks its own pancreatic beta cells, a primary source of insulin. (zerohedge.com)
For example, the pancreatic release of insulin in response to glucose is partially mediated by the binding of glucose to sweet-taste receptors on cells of the intestine and subsequent activation of the signaling cascade. (the-scientist.com)

The lack of insulin in the body or inefficient action of insulin at the cellular levels can cause the blood sugar levels to spike ( hyperglycemia ). (rxlist.com)
Insulin is the only hormone in the body that can prevent hyperglycemia. (rxlist.com)
Main role of insulin is to regulate glucose level in the blood from persistently rising (hyperglycemia) or persistently low (hypoglycemia). (myhealth.gov.my)
These data indicate that simvastatin intervention rats may cause hyperglycemia by impairing the function of islet β cells and have an adverse effect on glucose homeostasis, especially on FPG level. (hindawi.com)

Also, our mutants induced proliferation, glucose uptake, inhibited the migration of 293T cells and affected the responsiveness of the cells to cisplatin and radiation. (scielo.br)
Phosphoinositide 3-kinase (PI3K) signaling contributes to a variety of processes, mediating many aspects of cellular function, including nutrient uptake, anabolic reactions, cell growth, proliferation, and survival. (mdpi.com)

[ 5 ] In a state of hypoglycemia (blood glucose less than 70 mg/dL), a patient will experience autonomic dysfunction (shaking, palpitations, sweating, nervousness) and central nervous system dysfunction (confusion, unresponsiveness, seizures). (medscape.com)
Persistent hypoglycemia can be associated with an insulinoma, overmedication of insulin or oral hypoglycemia drugs, or prolonged fasting. (medscape.com)
Hypoglycemia is considered when glucose value is less than 70mg/dL. (medscape.com)
Similarly, low levels of glucagon are seen when patient is having hypoglycemia (blood glucose less than 70mg/dL). (medscape.com)

The effect of glucose and insulin on the uptake of non-esterified palmitic acid in adipose tissue. (eurekamag.com)

Diabetes mellitus was assessed by measures of fasting plasma glucose, two-hour glucose (OGTT) and serum insulin in participants aged 12 years and over in the morning (AM) examination session only. (cdc.gov)

Ginsenosides might be able to stabilize insulin and the hormone glucagon to maintain levels of glucose. (medicalnewstoday.com)
The result of a lack of this hormone is especially seen in persons with diabetes after a meal in which glucose values elevate extremely high, unless endogenous insulin can inhibit glucagon's effect for producing more glucose through the process of glycogenolysis. (medscape.com)
Image of sheep from Wikimedia Commons Insulin is a major hormone responsible for regulating blood sugar. (scienceblogs.com)
Insulin is a hormone (a chemical substance that acts as a messenger in the human body) that is secreted by an abdominal organ called the pancreas. (rxlist.com)
Insulin is a hormone secreted by the beta cells of the pancreas. (myhealth.gov.my)
Insulin is a hormone made by the beta-cells of the pancreas. (theconversation.com)
Abnormalities in glucose levels are the most common reason to measure glucagon levels in serum to see if the hormone is the source versus insulin levels, which tend to be more difficult to interpret. (medscape.com)

Inhibition of CaMKII abrogated the insulin-induced Erk-1/2 activation, DNA synthesis and phosphorylation of IRS-1 at S612. (cnr.it)
Inhibition of CaMKII also abrogated the down-regulation of insulin-stimulated Akt phosphorylation, Glut-4 membrane translocation and glucose uptake. (cnr.it)
Expression of the mutants differentially affected insulin-induced phosphorylation of IRS1, AKT, ERK, and STAT3. (scielo.br)

To investigate the effect of simvastatin on glucose homeostasis in streptozotocin induced type 2 diabetic rats. (hindawi.com)
Abscisic acid (ABA) can improve glucose homeostasis and reduce inflammation in mammals by activating lanthionine synthetase C-like 2 (LANCL2). (mdpi.com)

Cellular growth and glucose uptake are regulated by multiple signals generated by the insulin receptor. (cnr.it)
Resistin suppresses the ability of INSULIN to stimulate cellular GLUCOSE uptake. (bvsalud.org)

As we ingest Gymnema Sylvestre along with the supplement GlucoRedi, the Gymnemic acid is able to fill in the taste-bud receptors taking advantage of its similarity in molecular structure with that of glucose. (timesofisrael.com)

Objective Indole‐3‐carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3′‐diindolylmethane (DIM) reduce body mass and serum glucose levels in high‐fat‐diet‐induced obese mice. (researchgate.net)
The serum level of glucose is the driving force through which these two hormones are either being activated or inhibited. (medscape.com)

Relationship of heart rate to oxygen uptake during weight lifting exercise. (springer.com)
Insidiously, skipping insulin doses becomes an easy way to independently regain weight control without the constraint of diet or exercise. (theconversation.com)
Treatment is diet, exercise, and medications that reduce glucose levels, including insulin , oral antihyperglycemic medications, and non- insulin injectable medications. (msdmanuals.com)
To this end, the current study examined the development of lipid-induced IR in endurance-trained athletes, who were selected based on a high maximal oxygen uptake in a graded exercise test and compared with untrained, but otherwise healthy, subjects. (medscape.com)

Thylakoids also decrease the intestinal in vitro uptake of methyl-glucose in the rat. (lu.se)

Insulin increases the protein content in the muscles to prevent muscle wasting. (rxlist.com)

Then, we analyzed the effects on waist circumference, glucose, insulin, HOMA-IR index and uric acid compared to a control group of 19 overweight adolescents who did not receive any intervention. (bvsalud.org)

However, it is unknown if DACRAs has an insulin sensitizing effect beyond that induced by weight loss and if DACRAs affect tissue specific glucose uptake. (diabetesjournals.org)
The muscles and fatty tissue are especially dependent on insulin for glucose uptake and use. (rxlist.com)

Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)
Some of these include: cell cultures chemical reactors cogeneration (power and heat) distillation columns drilling automation essential oil steam distillation friction stir welding hydrate formation in deep-sea pipelines infectious disease spread oscillators severe slugging control solar thermal energy production solid oxide fuel cells space shuttle launch simulation Unmanned Aerial Vehicles (UAVs) Models for a direct current (DC) motor and blood glucose response of an insulin dependent patient are listed below. (wikipedia.org)
These compounds may help the body properly transport glucose into cells, preventing it from building up in the blood. (medicalnewstoday.com)
Its main function is to lower sugar by increasing glucose uptake into muscle and fat cells. (scienceblogs.com)
It is a 'key' that unlocks the cell gates so that glucose from the blood enters the cells. (rxlist.com)
Only then can the cells utilize this glucose as a fuel for their functions. (rxlist.com)
Glucose is the primary fuel for most body cells. (rxlist.com)
Glucose from the blood can enter the muscle cells only in the presence of insulin. (rxlist.com)
Insulin is stored inside the beta cells of the pancreas which known as Islet of Langerhans. (myhealth.gov.my)
Without insulin treatment, their glucose fails to enter cells normally, instead remaining stuck in the blood. (theconversation.com)

Exocytosis mechanisms underlying insulin release and glucose uptake: conserved roles for Munc18c and syntaxin 4. (jax.org)

2 - after the initial stimulation of the IRS-1/Akt pathway, CaMKII mediates the down-regulation of stimulated glucose uptake. (cnr.it)

Its key function is to facilitate the uptake of glucose and fat out of the bloodstream after eating. (theconversation.com)

The insulin molecule is synthesized in the pancreas as pro-insulin and is later cleaved to form C-peptide and insulin. (cdc.gov)
The Merocodia Insulin ELISA is a two-site enzyme immunoassay utilizing the direct sandwich technique with two monoclonal antibodies directed against separate antigenic determinants of the insulin molecule. (cdc.gov)
This is possible due to an astounding similitude between gymnemic acid and the glucose molecule structures. (timesofisrael.com)

In both studies, KBP-088 increased the rate of glucose clearance, likely be increasing glucose storage, but without altering the endogenous glucose production. (diabetesjournals.org)

Impairment of IRS-1 LLPS attenuated its positive effects on insulin/IGF-1 signaling. (nature.com)

Since these intrinsically disordered regions, which are conformationally dynamic and do not adopt stable secondary or tertiary structures, are often essential for mediating the phase transition of proteins 9 , it is therefore of interest to consider if the C-terminus of IRS-1 is involved in phase separation and to further delineate such implications upon insulin/IGF signaling. (nature.com)
We further identified that the 301-600 residues, as a self-association region (SAR), is essential to the formation of IRS-1 droplets and the transduction of insulin/IGF signaling. (nature.com)

PURPOSE: GLUT4 is the most regulated glucose transport protein in mammalian muscles. (cdc.gov)

Insulin also suppresses pathways that trigger the release of glucose and fat back into the blood when we're not eating. (theconversation.com)

Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice. (ulaval.ca)

We measured body weight, fasting plasma glucose, cholesterol, high-density lipoprotein cholesterol, and triglyceride after an overnight fast. (hindawi.com)
Glucose, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) test kits were detected using automatic biochemistry analyzer. (hindawi.com)

Anatomy25

Organisms11

Diseases19

Chemicals and Drugs132

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Psychiatry and Psychology1

Phenomena and Processes49

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science3

Health Care3

Resistance34

Sensitivity17

Secretion6

Metabolism8

Glycogen7

Tissues8

Receptor substrate9

Increase glucose uptake1

Obesity7

Metabolic7

Short-acting i1

Adipocytes2

Gluconeogenesis1

Characterized by hyperglycemia caus1

Skeletal3

Stimulates3

Tolerance4

Pancreatic2

Hyperglycemia4

Proliferation2

Hypoglycemia4

Adipose tissue1

Diabetes mellitus1

Hormone7

Phosphorylation3

Homeostasis2

Cellular2

Receptors1

Serum2

Exercise4

Decrease1

Increases1

Waist circumference1

Tissue2

Cells10

Mechanisms1

Regulation1

Bloodstream1

Molecule3

Endogenous1

Effects on insulin1

Signaling2

Muscles1

Pathways1

Obese1

High-density lip2