Glucose transporter type 5. Medical search. Frequent questions

Sodium-Glucose Cotransporter Type 2 Inhibitors (SGLT2 Inhibitors) initially entered the market to treat hyperglycemia in patients with type 2 diabetes mellitus (T2DM), however the discovery of the cardiovascular benefits in patients with HF, regardless of the presence or absence of T2DM positioned it as a new pillar in clinical management. (iberoamjmed.com)
Los inhibidores del cotransportador de sodio-glucosa tipo 2 (SGLT2) ingresaron inicialmente al mercado para tratar la hiperglucemia en pacientes con diabetes mellitus tipo 2 (DMT2), sin embargo, el descubrimiento de los beneficios cardiovasculares en pacientes con IC, independientemente de la presencia o ausencia de DMT2, lo posicionó como un nuevo pilar en manejo clínico. (iberoamjmed.com)
Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition. (org.ua)
SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function. (org.ua)
We also discuss evidence from recent large clinical trials of thiazolidinedione (TZD) and new antidiabetic medications such as dipeptidyl peptidase-4 (DPP4) inhibitors, sodium-glucose cotransporter-2 (SGLT2) inhibitors, and glucagonlike peptide-1 (GLP1) analogues, which suggest the potential of these agents in primary and secondary stroke prevention. (j-stroke.org)
SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials. (cjgim.ca)
SGLT2 inhibitors as adjunctive therapy for type 1 diabetes: balancing benefits and risks. (cjgim.ca)
FRG is a rare disorder due mainly to mutations in the sodium-glucose cotransporter 2 gene ( SGLT2 ) that are responsible for the majority of cases. (medscape.com)
Forxiga (dapagliflozin) is a first-in-class, oral once-daily selective inhibitor of human sodium-glucose co-transporter 2 (SGLT2) indicated as both monotherapy and as part of combination therapy to improve glycaemic control, with the additional benefits of weight loss and blood pressure reduction, as an adjunct to diet and exercise in adults with T2D. (worldpharmanews.com)
SGLT2 inhibitors are a new class of oral drugs for the treatment of type 2 diabetes mellitus currently in phase III studies. (bjcardio.co.uk)
SGLT2 inhibitors represent a novel 'glucuretic' therapeutic strategy for the treatment of type 2 diabetes, and are currently in phase III trials. (bjcardio.co.uk)
Approximately 10% of renal glucose re-absorption occurs via SGLT1, and the remaining 90% occurs via SGLT2, which is found in the early proximal tubule. (bjcardio.co.uk)
SGLT2, a high-capacity, low-affinity transporter of glucose and sodium is found in high concentration at the brush border membrane of the S1 and S2 segment of the proximal convoluted tubule (PCT). (bjcardio.co.uk)
SGLT2 binds to sodium and glucose in the filtrate and these compounds are translocated across the apical cell membrane, an active process driven by the electrochemical sodium gradient between tubular filtrate and the cell. (bjcardio.co.uk)
For example, the use of a sodium-glucose cotransporter 2 (SGLT2) inhibitor combined with a ketogenic/low-carbohydrate diet increases the risk for euglycemic diabetic ketoacidosis . (medscape.com)

The gene is mapped to chromosome 20q12-q13.1, a region that has been shown to be linked to type 2 diabetes. (diabetesjournals.org)
None of the variants were associated with type 2 diabetes. (diabetesjournals.org)
These results suggest that variation in the coding region of SLC2A10 does not contribute substantially to the pathogenesis of type 2 diabetes in the examined study population. (diabetesjournals.org)
Mutation in ZnT8 has been associated with type 2 diabetes. (scirp.org)
In type 1 diabetes, there is a lack of insulin production, in type 2 diabetes, resistance of the effect of insulin is predominant. (scirp.org)
The role of zinc deficiency which could at least potentially exacerbate the cytokinine-induced damage in autoimmune attack which destroys the islet cell in type 1 diabetes is still not clear. (scirp.org)
It has been shown that there appears to be a complex interrelationship between zinc and type 1 and 2 diabetes. (scirp.org)
Type 2 diabetes mellitus (T2DM) is one of the common metabolic diseases in the world. (frontiersin.org)
Type 2 diabetes mellitus (T2DM) is a progressive metabolic disease characterized by pancreatic β-cell dysfunction and peripheral insulin resistance, leading to defects in glucose metabolism and chronic low-grade inflammation. (frontiersin.org)
Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)
Type 1 diabetes mellitus is a metabolic disease resulting from the destruction of insulinproducing β cells in the pancreas, that leads to hyperglycemia [1,2,20]. (researchgate.net)
Type 1 diabetes mellitus (insulin-dependent diabetes) is characterized by hyperglycemia caused by an insulin deficiency. (researchgate.net)
Sodium-glucose cotransporter 2 inhibitor (SGLT2i) use reduces body weight (BW) in patients with type 2 diabetes mellitus (T2DM). (biomedcentral.com)
However, much subsequent research in this area was focused on the role of pulmonary SGLT transport as a modifier of lung liquid volume [ 3 , 4 ], and the effects of starvation and diabetes on glucose transport [ 1 , 5 ]. (ersjournals.com)
Jiao H, Hu G, Gu D, Ni X. Having a promising efficacy on type II diabetes, it's definitely a green tea time. (voedingsgeneeskunde.nl)
Zunino S. Type 2 diabetes and glycemic response to grapes or grape products. (voedingsgeneeskunde.nl)
Patients with hyperglycemia or diabetes mellitus (DM) are at high risk of cerebrovascular ischemic stroke [ 4 , 5 ]. (j-stroke.org)
Importantly, we observed that enteroids from post-BS non-obese patients exhibited low dietary glucose absorption, indicating that altered glucose absorption is a potential mechanism for the immediate and clinically significant improvement in glucose homeostasis after BS, represented clinically by resolution of Type 2 Diabetes (T2D) within weeks to months of surgery. (mayo.edu)
Type 1 diabetes (clinical diagnosis and/or positive GAD antibodies). (mayo.edu)
The development of type 2 diabetes mellitus (T2DM) is highly influenced by complex interactions between genetic and environmental (dietary and lifestyle) factors. (researchsquare.com)
Type 2 diabetes mellitus (T2DM) is a major medical problem worldwide, and its development is highly affected by complex interactions between genetic and environmental (dietary and lifestyle) factors 1 . (researchsquare.com)
Temporal Trends in Incident Hospitalization for Diabetes-Related Foot Ulcer in Type 2 Diabetes: The Fremantle Diabetes Study. (tangello.com.au)
Haider KS, Haider A, Saad F, Doros G, Hanefeld M, Dhindsa S, Dandona P, Traish A. Remission of type 2 diabetes following long‐term treatment with injectable testosterone undecanoate in patients with hypogonadism and type 2 diabetes: 11‐year data from a real‐world registry study. (tangello.com.au)
The actions of the proteins that control the uptake, storage, and distribution of zinc, the zinc transporters, are under intense investigation due to their emerging role in type 2 diabetes. (hindawi.com)
Type 2 diabetes (T2D) is a disease that is largely associated with increased rates of obesity and reduced physical activity [ 1 ]. (hindawi.com)
Type 2 diabetes mellitus and heart failure, both reduced and preserved ejection fraction phenotypes, are indi-vidually associated with significant morbidity and mortality and, when co-morbid, compound their risks for poor outcomes. (cjgim.ca)
This article will explore the evidence for managing heart failure and type 2 diabetes patients and identify opportunities to improve outcomes. (cjgim.ca)
9. Chu L, Fuller M, Jervis K, Ciaccia A, Abitbol A. Prevalence of chronic kidney disease in type 2 diabetes: The Canadian REgistry of Chronic Kidney Disease in Diabetes Outcomes (CREDO) Study. (cjgim.ca)
12. Liu XY, Zhang N, Chen R, Zhao JG, Yu P. Efficacy and safety of sodium-glucose co-transporter 2 inhibitors in type 2 diabetes: a meta-analysis of randomized controlled trials for 1 to 2 years. (cjgim.ca)
To evaluate the evidence of effectiveness and safety of sodium glucose co-transporter inhibitors type 2 (iSGLT2) in patients with type 2 diabetes mellitus. (revistaendocrino.org)
Elucidating the function of the mutated gene, ALMS1 , is critical for the development of specific treatments and may uncover pathways relevant to a range of other disorders including common forms of obesity and type 2 diabetes. (springer.com)
The Japanese Ministry of Health, Labour and Welfare (MHLW) has approved Forxiga (dapagliflozin) as an oral adjunct treatment to insulin for adults with type-1 diabetes (T1D). (worldpharmanews.com)
Elisabeth Björk, Senior Vice President, Head of late Cardiovascular, Renal and Metabolism, R&D BioPharmaceuticals, said: "This approval of Forxiga in Japan means that people with type-1 diabetes whose glucose levels are not adequately controlled with insulin alone now have a new oral treatment option available to them. (worldpharmanews.com)
Forxiga will help address a significant unmet need in this patient population, and this approval in type-1 diabetes builds on the well-established clinical profile of Forxiga. (worldpharmanews.com)
The safety profile of Forxiga in these T1D trials was consistent with its well-established profile in type-2 diabetes (T2D), with the exception of a higher number of diabetic ketoacidosis (DKA) events in Forxiga-treated patients versus placebo. (worldpharmanews.com)
Approximately five percent of people living with diabetes have type-1. (worldpharmanews.com)
4) Different factors, including genetics and some viruses, may contribute to type-1 diabetes. (worldpharmanews.com)
The DEPICT (Dapagliflozin Evaluation in Patients with Inadequately Controlled Type 1 Diabetes) clinical trial programme consists of two trials: DEPICT-1 and DEPICT-2 which are 24-week, randomised, double-blinded, parallel-controlled trials designed to assess the effects of Forxiga 5mg or 10mg on glycaemic control in patients with T1D inadequately controlled by insulin. (worldpharmanews.com)
Efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes (DEPICT-1): 24-week results from a randomised controlled trial. (worldpharmanews.com)
This review summarized the associations between various types of diabetes and cancers and updated available evidence of underlying mechanisms between diabetes and cancers. (frontiersin.org)
The risk of cancers appears to be increased in both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) ( 2 ). (frontiersin.org)
Further, previous studies have suggested that diabetes is associated with increased risk of cancer mortality ( 5 , 6 ). (frontiersin.org)
However, the underlying mechanisms between various types of diabetes and cancers have not yet been summarized. (frontiersin.org)
Type 2 diabetes mellitus is a major risk factor for developing both microvascular (retinopathy, nephropathy and neuropathy) and macrovascular complications (coronary heart disease, cerebrovascular disease and peripheral vascular disease). (bjcardio.co.uk)
7 The increasing prevalence of type 2 diabetes, in combination with limitations of current therapies, has led to the search for newer alternatives. (bjcardio.co.uk)
A multi-pronged approach built on a foundation of strong educational and behavioral support and psychosocial care is essential to help improve the health of patients with type 2 diabetes (T2D). (medscape.com)
The ADA/European Association for the Study of Diabetes T2D algorithm (included in the ADA SOC) emphasizes the use of medications with high dual efficacy in lowering glucose and promoting weight loss, such as semaglutide and tirzepatide . (medscape.com)
Data-driven subgroups of newly diagnosed type 2 diabetes and the relationship with cardiovascular diseases at genetic and clinical levels in Chinese adults. (cdc.gov)
Association of Met420del Variant of Metformin Transporter Gene SLC22A1 with Metformin Treatment Response in Ethiopian Patients with Type 2 Diabetes. (cdc.gov)
The Predisposition for Type 2 Diabetes Mellitus and Metabolic Syndrome. (cdc.gov)
RS3480 Polymorphism of FNDC5/Irisin Is Associated with Type 2 Diabetes Mellitus in Maya-Mestizo Women. (cdc.gov)
There are different, new drugs for the armamentarium in diabetes, especially in type 2 diabetes . (medscape.com)
In combination with insulin, the GLP-1 analogs are another new way of treating type 2 diabetes. (medscape.com)
so in theory, it can be used in combination with any drug for type 2 diabetes. (medscape.com)

Sodium-glucose cotransporter 2 inhibitors (SGLT2is) are a new class of antidiabetic drug that inhibits renal tubular sodium-glucose reabsorption without stimulating insulin release in patients with type 2 DM (T2DM) [ 5 ]. (biomedcentral.com)
Currently, results are available from two studies with TZD focusing on cardiovascular diseases, including stroke, and from 12 cardiovascular outcome trials focusing on major adverse cardiovascular events associated with new antidiabetic agents (four with dipeptidyl peptidase-4 inhibitors, three with sodium-glucose cotransporter-2 inhibitors, and five with glucagon-like peptide-1 analogues). (j-stroke.org)
Sodiumglucose co-transporter 2 inhibitors have demonstrated significant risk reduction in important clinical outcomes in both conditions and should be utilized as foundational therapy to simultaneously target these two diseases. (cjgim.ca)
5,6 Dipeptidylpeptidase-4 (DPP-4) inhibitors are well tolerated, but are merely weight neutral. (bjcardio.co.uk)
Can you explain sodium glucose co-transporter-2 (SGLT-2) inhibitors? (medscape.com)

This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3‐L1 adipocytes, as well as the mechanism involved. (researchgate.net)
DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. (researchgate.net)
Conclusions Our findings suggest that DIM may improve insulin sensitivity through the activation of the insulin signaling pathway, leading to enhanced glucose uptake. (researchgate.net)
DIM, a major metabolite of indole-3-carbinol, which is naturally produced in broccoli and cabbage, enhances glucose uptake through the improvement of insulin sensitivity in 3T3-L1 cells [13] . (researchgate.net)
3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)
Since the mid-1960s, it has been known that there are energy-dependent, sodium-coupled glucose transporter (SGLT) and energy-independent, facilitative glucose transporter (GLUT) pathways for glucose uptake in the lung [ 1 ], and that glucose can permeate the alveolar epithelial barrier [ 2 ]. (ersjournals.com)
Glucose removal is determined by cellular glucose uptake and metabolism ( fig. 1 ) [ 4 , 12 - 14 ]. (ersjournals.com)
Cocoa flavonoids attenuate high glucose-induced insulin signalling blockade and modulate glucose uptake and production in human HepG2 cells. (voedingsgeneeskunde.nl)
In males, in physiological conditions, testosterone acts via androgen receptors (AR) to increase insulin receptor (IR) expression and glycogen synthesis, and to decrease glucose uptake controlled by liver-specific glucose transporter 2 (GLUT-2). (nih.gov)
Erythrocyte 3-O-methyl-D-glucose uptake essay for diagnosis of glucose-transporter-protein syndrome. (thieme-connect.com)

Homozygous null mice exhibit disrupted glucose homeostasis, transient neutropenia associated with impaired neutrophil trafficking and function. (jax.org)
Understanding of mechanisms underlying lung glucose homeostasis could identify new therapeutic targets for control of ASL glucose and prevention and treatment of lung infection. (ersjournals.com)
Here, we discuss the mechanisms underlying the relationship between glucose homeostasis and stroke development, and provide an overview of the efficacy of glucose-lowering treatment in stroke management. (j-stroke.org)
Recent studies have highlighted zinc's dynamic role as a "cellular second messenger" in the control of insulin signaling and glucose homeostasis. (hindawi.com)
The kidneys play an important role in glucose homeostasis. (medscape.com)
It helps to maintain glucose homeostasis by at least two mechanisms. (medscape.com)
Glycogen storage disease (GSD) type I, also known as von Gierke disease, is a group of inherited autosomal recessive metabolic disorders of the glucose-6- phosphatase system which helps maintain glucose homeostasis. (medscape.com)

The SLC2A10 gene encodes the GLUT10 facilitative glucose transporter, which is expressed in high amounts in liver and pancreas. (diabetesjournals.org)
The gene was examined in 61 Danish type 2 diabetic patients, and a total of six variants (−27C→T, Ala206Thr, Ala272Ala, IVS2 + 10G→A, IVS4 + 18T→G, and IVS4 + 26G→A) were identified and investigated in an association study, which included 503 type 2 diabetic patients and 510 glucose-tolerant control subjects. (diabetesjournals.org)
The recently cloned SLC2A10 gene encodes a 541 amino acid putative facilitative glucose transporter (GLUT10) of the GLUT family class III with between 30 and 34% amino acid homology with the known GLUT proteins ( 1 , 2 ). (diabetesjournals.org)
This gene provides instructions for producing a protein called the glucose transporter protein type 1 (GLUT1). (medlineplus.gov)
The article "Differential expression of the glucose transporter gene glcH in response to glucose and light in marine picocyanobacterial" by Moreno-Cabezuelo et al. (peerj.com)
Von Gierke disease may be explained by mutations of the phosphohydrolase catalytic unit gene of the G-6-P complex, unlike GSD type Ib and GSD type Ic. (medscape.com)
Correction of glycogen storage disease type 1a in a mouse model by gene therapy. (medscape.com)
Mutation of the SoLute Carrier 37a4 (slc37a4) or glucose-6-phosphate transporter (G6PT) gene responsible for the distribution of G-6-P across this membrane leads to, hypoglycemia, hepatic glycogen accumulation, hyperlipidemia, resulting in life-limiting outcomes including growth retardation and neutropeni. (endocrine-abstracts.org)
We have previously showed that genetic polymorphisms in glucose transporter 10 (GLUT10) gene are associated with a T2DM intermediate phenotype in non-diabetic population, and GLUT10 G128E mice (carrying human orthologous GLUT10 G128E variant) are highly sensitive to HFD-induced metabolic dysregulation. (researchsquare.com)
Within the main glucose transporter families, glucose transporter 1 (GLUT1) and its corresponding gene SLC2A were identified in 1985 [ 2 ]. (thieme-connect.com)
Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. (pharna.com)
Particularly involved in glucose-dependent regulation of insulin gene transcription. (pharna.com)
Type 1 results from mutations in the integrin beta-2 gene ( ITGB2 ), encoding CD18 beta-2 integrins. (msdmanuals.com)
Type 2 results from mutations in the glucose diphosphate (GDP)-fucose transporter gene. (msdmanuals.com)
Type 3 is caused by mutations in the FERMT3 gene (11q13.1), which encodes kindlin-3 in hematopoietic cells. (msdmanuals.com)
A very natural place to study gene detecting and metabolizing lactose, it is known that the overall regulation is in the metabolism of the cell, and then specifically in effect of expressing the lac genes in vain is a drop in the growth rate the regulation of genes that code for enzymes and transporter of as much as 5% [1,6]. (lu.se)

Glucose is removed from ASL in proximal airways via facilitative glucose transporters, down a concentration gradient generated by intracellular glucose metabolism. (ersjournals.com)
In this study, we examined AA effects on metabolism in wild-type (WT) mice and GLUT10 G128E mice fed with a normal diet (CD) or HFD, as we previously showed that GLUT10 G128E mice are highly sensitive to HFD-induced T2DM 9 . (researchsquare.com)
Association of the fibronectin type III domain-containing protein 5 rs1746661 single nucleotide polymorphism with reduced brain glucose metabolism in elderly humans. (cdc.gov)

The small intestine converts dietary fructose into glucose and organic acids. (nature.com)
Its use as a therapeutic target is limited by side effects from malabsorption of glucose and galactose in the small intestine. (bjcardio.co.uk)

In insulin-dependent peripheral tissues such as skeletal muscle, adipose, and liver, zinc ions play a role in insulin-induced glucose transport and glycemic control [ 9 - 16 ]. (hindawi.com)
Because skeletal muscle is the major site of insulin-mediated glucose utilization (up to 80% in the postprandial state), losses in skeletal muscle mass may lead to metabolic impairments [ 12 ]. (biomedcentral.com)

Brain communications 2023 8 5 (4): fcad216. (cdc.gov)

Significant upregulation of major intestinal sugar transporters, including SGLT1, GLU2 and GLUT5 was responsible for hyper-absorptive phenotype and their pharmacologic inhibition significantly decreased glucose absorption. (mayo.edu)

A newly described form, GSD type Ic, does not appear to be related to mutations within the transporter protein. (medscape.com)
Seydewitz HH, Matern D. Molecular genetic analysis of 40 patients with glycogen storage disease type Ia: 100% mutation detection rate and 5 novel mutations. (medscape.com)
Although the pattern of inheritance that best fits FRG is one of co-dominance, increased glucose excretion was not observed in all individuals with similar or identical mutations. (medscape.com)
Heterozygosity for mutations suggest a role of nongenetic factors or other genes involved in renal glucose transport. (medscape.com)
For practical purposes, depending on the enzyme activity and the presence of mutations in the G6Pase and T genes, respectively, GSD type I may be subdivided into 2 major forms. (medscape.com)

Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. (org.ua)
Using serum samples of diabetic patients whose glucose concentrations were above the threshold (10.0 mmol/l), spectroscopic methods were used to determine the concentration of glucose and zinc. (scirp.org)
6. Shimabukuro M, Higa N, Oshiro Y, Asahi T, Takasu N. Diagnostic utility of brain-natriuretic peptide for left ventricular diastolic dysfunction in asymptomatic type 2 diabetic patients. (cjgim.ca)

Schwahn B, Rauch F, Wendel U, Schönau E. Low bone mass in glycogen storage disease type 1 is associated with reduced muscle force and poor metabolic control. (medscape.com)
Glycogen storage disease type 1b is a metabolic disorder resulting in an inability to shuttle glucose-6-phosphate across the sarcoplasmic/endoplasmic reticulum (SR/ER) lumen. (endocrine-abstracts.org)
We investigated the impacts of AA on high-fat diet (HFD)-induced metabolic dysregulation in wild type (WT) and GLUT10 G128E mice. (researchsquare.com)
Overweight and obese adults have about 5 times higher odds of having ation in the magnitude or direction of outcome, indicating the lack metabolic syndrome than adults with normal or low body weight. (cdc.gov)
Research demonstrates that either of these approaches improves glucose regulation via weight loss, with additional metabolic benefits depending on mechanism of action. (medscape.com)

Two means of glucose transport are noted: facilitative and secondary active transport. (medscape.com)

Milder phenotypes of glucose transporter type 1 deficiency syndrome. (thieme-connect.com)
7 Klepper J, Voit T. Facilitated glucose transporter protein type 1 (Glut 1) deficiency syndrome: impaired glucose transporter into brain - a review. (thieme-connect.com)

This is in contrast to conditions in the gut and kidney, where luminal glucose concentrations regularly exceed plasma glucose concentrations [ 6 , 7 ]. (ersjournals.com)
0.01 mM and plasma glucose 0.19 mM [ 3 ]. (ersjournals.com)
As plasma glucose concentration increases, there is concordant increase in the filtered load of glucose. (medscape.com)

The percentage of PAS-positive glycogen areas were correlated with the immunoexpression of GLUT-2, serum levels of T and DHT were correlated with GLUT-2, IR, and AR transcript levels, and serum glucose concentration was correlated with the age of animals and with the GLUT-2 mRNA by Spearman's rank correlation coefficients. (nih.gov)
More water than glucose is reabsorbed resulting in an increase in the glucose concentration in the urine along the tubule. (medscape.com)
In health individuals this equates to a blood glucose concentration of approximately 200mg/dL (11mmol/L), which is believed to be threshold for the appearance of glucosuria. (medscape.com)
Glucose is then transported passively by GLUT2 along its concentration gradient into the interstitium. (bjcardio.co.uk)

These enzymes normally catalyze reactions that ultimately convert glycogen compounds to glucose. (medscape.com)
Interestingly, GSD type 0, which is due to defective glycogen synthase, also is recognized. (medscape.com)
Glucose-6-phosphate is an intermediate in the glycogen pathway. (medscape.com)
Early diagnosis and treatment may prevent the development of complications in an adult patient with glycogen storage disease type Ia. (medscape.com)
Hepatic anaplerotic outflow fluxes are redirected from gluconeogenesis to lactate synthesis in patients with Type 1a glycogen storage disease. (medscape.com)
Increased de novo lipogenesis and delayed conversion of large VLDL into intermediate density lipoprotein particles contribute to hyperlipidemia in glycogen storage disease type 1a. (medscape.com)
Natural history of hepatocellular adenoma formation in glycogen storage disease type I. J Pediatr . (medscape.com)
A monocentric pilot study of an antioxidative defense and hsCRP in pediatric patients with glycogen storage disease type IA and III. (medscape.com)
Nutritional deficiencies in a patient with glycogen storage disease type Ib. (medscape.com)
Contrast-enhanced ultrasonography in patients with glycogen storage disease type Ia and adenomas. (medscape.com)
Bijvoet AG, Van Hirtum H, Vermey M. Pathological features of glycogen storage disease type II highlighted in the knockout mouse model. (medscape.com)
Geberhiwot T, Alger S, McKiernan P, Packard C, Caslake M, Elias E. Serum lipid and lipoprotein profile of patients with glycogen storage disease types I, III and IX. (medscape.com)
GSD type IV, also known as amylopectinosis, Glycogen Branching enzyme deficiency (GBE) or Andersen disease, is a rare disease that leads to early death. (medscape.com)

In the brain, the GLUT1 protein is involved in moving glucose, which is the brain's main energy source, across the blood-brain barrier. (medlineplus.gov)
The GLUT1 protein also moves glucose between cells in the brain called glia, which protect and maintain nerve cells (neurons). (medlineplus.gov)
Having less functional GLUT1 protein reduces the amount of glucose available to brain cells, which affects brain development and function. (medlineplus.gov)
which looked at 101 patients with GLUT1-DS in the United States, found a documented history of paroxysmal abnormal eye movements in 32% of the patients with GLUT1-DS, with episodes preceding the onset of seizures in 63% of them [ 5 ]. (thieme-connect.com)

This research is designed to assess whether insulin resistance is associated with a stronger preference for sugar-sweetened, thus elevating blood glucose responses in obese people with varying degrees of insulin resistance. (bvsalud.org)
Objective Indole‐3‐carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3′‐diindolylmethane (DIM) reduce body mass and serum glucose levels in high‐fat‐diet‐induced obese mice. (researchgate.net)
We identified that enteroids from obese patients were characterized by glucose hyper-absorption (~ 5 fold) compared to non-obese patients. (mayo.edu)
Thus, our results and other published data led us to the current hypothesis: an intestinal glucose hyper-absorptive phenotype in obese patients may be a predictor for successful outcome of BS. (mayo.edu)

Here, we consider a newly identified role for pulmonary glucose transport in maintaining low airway surface liquid (ASL) glucose concentrations and propose that this contributes to lung defence against infection. (ersjournals.com)
These processes vary between species but universally maintain ASL glucose at 3-20-fold lower concentrations than plasma. (ersjournals.com)
ASL glucose concentrations are increased in respiratory disease and by hyperglycaemia. (ersjournals.com)
1 mM in nasal ASL [ 8 ] and mean± sd 0.4±0.2 mM in the lower respiratory tract, 12.5 times lower than plasma concentrations, which are normally maintained at ∼5 mM [ 9 ]. (ersjournals.com)
ASL glucose concentrations are the net result of diffusion of glucose from blood and interstitial fluid across the respiratory epithelium into the ASL, and removal of glucose from ASL by epithelial glucose transport processes. (ersjournals.com)
Current model of the mechanisms controlling glucose concentrations in the surface liquid lining the airway and distal lung epithelium. (ersjournals.com)
Renal glucosuria is the excretion of glucose in the urine in detectable amounts at normal blood glucose concentrations in the absence of any signs of generalized proximal renal tubular dysfunction due to a reduction in the renal tubular reabsorption of glucose. (medscape.com)
Physicians now recognize that zinc supplementation can reduce the incidence and severity of diarrheal disease, and an ORS of reduced osmolarity (i.e., proportionally reduced concentrations of sodium and glucose) has been developed for global use. (cdc.gov)

RhoA activation triggers a glycolytic burst through the translocation of the glucose transporter SLC2A3/GLUT3 to fuel the cellular contractile machinery, as demonstrated across multiple endothelial cell types. (nature.com)

Zinc has "mimetic" activity where it is involved in a range of functions including insulin receptor signal transduction, insulin storage, secretion and tissues/organelle distribution, and inhibition of protein tyrosine phosphatases [ 5 - 8 ]. (hindawi.com)
Patients on combination therapy with a glucagon-like peptide 1 (GLP-1) receptor agonist/glucose-dependent insulinotropic polypeptide (GIP) will probably require dose reduction or withholding of glucose-lowering agents (sulfonylureas or insulin) to avoid low blood glucose. (medscape.com)

Glucose is the main energy source of the brain and crosses the blood-brain barrier through glucose transporter proteins [ 1 ]. (thieme-connect.com)

Under normal circumstances, the kidney filters and reabsorbs 100% of glucose, approximately 180 g (1 mole) of glucose, each day. (medscape.com)
Under normal physiological conditions, approximately 180 g of glucose is filtered by the kidney daily. (bjcardio.co.uk)

DIM decreased STZ-increased high blood glucose levels and food and water intake in diabetic mice. (researchgate.net)

The aim of this study was to investigate the impact of glucose (Glu), fructose (Fru), glucose and fructose (GluFru) and sucralose on blood glucose response in healthy individuals. (mdpi.com)
The glucose/fructose:H+ symporter, STP13 (sugar transport protein 13). (lbl.gov)
The fructose/xylose:H+ symporter, PMT1 (polyol monosaccharide transporter-1). (lbl.gov)

where it transports a simple sugar called glucose into cells from the blood or from other cells for use as fuel. (medlineplus.gov)
Renal glucosuria has also been reported in patients with acute pyelonephritis in the presence of a normal blood glucose level. (medscape.com)
Results showed that Forxiga, when given as an oral treatment in addition to adjustable insulin in patients with inadequately-controlled T1D, demonstrated significant and clinically-meaningful reductions from baseline in average blood glucose levels HbA1c (primary endpoint), weight and total daily insulin dose (secondary endpoints) at 24 weeks(1,2,3), at both 5mg and 10mg doses. (worldpharmanews.com)
They inhibit glucose re-absorption in the proximal renal tubules providing an insulin independent mechanism to lower blood glucose. (bjcardio.co.uk)
2-4 Guidelines recommend a target glycosylated haemoglobin (HbA 1c ) of 7% or less, but a large number of patients fail to meet this target and, as of yet, no ideal pharmacological blood glucose-lowering agent exists. (bjcardio.co.uk)
Cardiovascular risk factors, including hypertension, hyperlipidaemia, obesity and smoking, were studied as well as degree of blood glucose control. (who.int)
We aim in our work to study the prevalence risk factors and degree of blood glucose of CVD risk factors in diabetics in two dif- control. (who.int)
1. Weight management is an important part of achieving and maintaining healthy blood glucose levels in patients with T2D. (medscape.com)
It is also important to be aware of concomitant medications that promote weight gain and may increase blood glucose (eg, certain antidepressants and pain medications). (medscape.com)
Individuals should be assessed for episodes of hypoglycemia and hypoglycemia unawareness , and they should be educated on potential triggers and how to detect and respond to low blood glucose. (medscape.com)

Here, discover the type of medical professionals that can help, tools for finding them, and tips for getting the most out of your care as you navigate to a diagnosis. (nih.gov)

Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production. (org.ua)

Results obtained showed a negative correlation between level of glucose and zinc. (scirp.org)
The animals from F1:Fin group have statistically elevated level of glucose. (nih.gov)

SGLTs transport sodium and glucose into cells using the sodium gradient created by sodium/potassium ATPase pumps at the basolateral cell membranes. (bjcardio.co.uk)

The glucose transporters expressed in the renal proximal tubule ensure that less than 0.5 g/day (range 0.03-0.3 g/d) is excreted in the urine of healthy adults. (medscape.com)
As the rate of glucose entering the nephron rises above 260-350mg/1.73m 2 /min (14.5-19.5mmol/1.73m 2 /min), the excess glucose exceeds the reabsorptive capacity of proximal tubule and is excreted in the urine (i.e. glucosuria). (medscape.com)

To date, T2DM still cannot be cured, and its intervention measures mainly focus on glucose control as well as the prevention and treatment of related complications. (frontiersin.org)
Obesity is frequently associated with WAT inflammation, which contributes to further ectopic fat accumulation and finally T2DM 5 . (researchsquare.com)
A comprehensive meta-analysis has concluded that the presence of T2DM is associated with approximately 10% increase of the risk to develop cancer ( 5 ). (frontiersin.org)

When expressed in Xenopus oocytes, human GLUT10 exhibited 2-deoxy- d -glucose transport with an apparent K m of ∼0.3 mmol/l ( 3 ). (diabetesjournals.org)

In immortalised human airway cells (line H441) with 10 mM glucose in the basolateral medium, apical ASL glucose was 0.24±0.07 mM [ 10 ]. (ersjournals.com)
In primary cultures of human bronchial epithelial cells (HBECs) with 16.6±0.4 mM glucose in the basolateral medium, ASL glucose was 2.2±0.5 mM [ 11 ]. (ersjournals.com)
The second stage of re-absorption is the transport of glucose through the utilisation of GLUT2 transporters in the basolateral membrane. (bjcardio.co.uk)

Our understanding of the role of glucose transport in the lung and the mechanisms that regulate glucose movement across the human lung epithelium lags far behind that of the gut and kidney. (ersjournals.com)

Consequently the affinity of the transporters for glucose along the tubule increases to allow for complete reabsorption of glucose from the urine. (medscape.com)

We have glucose transporters in the kidney and so the kidney is very good at reabsorbing glucose. (medscape.com)

In the present study, we test the hypothesis that reactivation of glucocorticoids, in peripheral tissues by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), is a major determinant of exogenous Cushing s syndrome.WT, global 11β-HSD1 knockout (GKO), liver-specific 11β-HSD. (endocrine-abstracts.org)

For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. (lbl.gov)
Because glucose cannot leave the hepatocyte phosphorylated, an increase in glycolytic pathway metabolites occurs. (medscape.com)

In a perfused, fluid-filled, adult rat lung model, ASL glucose was estimated to be 0.5 mM when perfusate glucose was 10 mM [ 4 ]. (ersjournals.com)

One form, von Gierke disease (GSD type Ia, glucose-6-phosphatase [G-6-P] deficiency), causes clinically significant end-organ disease with significant morbidity. (medscape.com)
Von Gierke described the first patient with GSD type I in 1929 under the name hepatonephromegalia glycogenica. (medscape.com)

It produces glucose by gluconeogenesis. (medscape.com)
The key enzymes of gluconeogenesis are phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase). (medscape.com)
Gluconeogenesis in the kidneys exceeds renal glucose consumption. (medscape.com)

Further works by [8] have established the fact that Zn transporter (ZnT8) is a key protein for the regulation of insulin secretion from pancreatic Beta-cells. (scirp.org)

Anatomy14

Organisms5

Diseases3

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Psychiatry and Psychology1

Phenomena and Processes13

Information Science3

SGLT215

Diabetes54

Inhibitors5

Uptake10

Homeostasis7

Gene16

Metabolism3

Small intestine2

Skeletal muscle2

20231

GLUT51

Mutations5

Diabetic patients3

Metabolic5

Facilitative1

Deficiency syndrome2

Plasma glucose3

Concentration4

Glycogen13

GLUT14

Obese4

Concentrations8

GLUT31

Receptor2

Proteins1

Approximately 1802

High blood glucose1

Fructose3

Blood10

Diagnosis1

Dapagliflozin1

Level of glucose2

Sodium and glucose1

Proximal2

T2DM3

GLUT101

Basolateral3

Mechanisms1

Reabsorption1

Kidney1

Syndrome1

Pathway2

Adult1

Gierke2

Gluconeogenesis3

Regulation of insulin1