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  • hepatic
  • In the fasting state, this is due to the continuous release of insulin from the pancreas, which results in steady plasma insulin, thus restraining hepatic glucose production and thereby preventing fasting hyperglycemia. (diabetesjournals.org)
  • Currently we are studying the acute effects of HIV protease inhibitors on peripheral glucose disposal, hepatic glucose production, and insulin secretion using both in vitro and in vivo model systems. (wustl.edu)
  • These compartments, like the body as a whole, are protected by specialized systems that minimize accumulation of both endogenous and foreign cations through their active transport into the plasma for subsequent clearance from the body via the renal and hepatic systems ( Pritchard and Miller, 1993 ). (aspetjournals.org)
  • vitro
  • The objective of this study was to develop and evaluate a primary culture system for choroid plexus epithelial cells as an in vitro model for studying organic cation transport. (aspetjournals.org)
  • The objective of this study was to evaluate the morphological and physiological properties of a primary culture system of choroid plexus epithelial cells and its capacity to serve as an in vitro model to access the cellular mechanisms of organic cation transport across the CSF-blood barrier. (aspetjournals.org)
  • lipid
  • This PXR-mediated lipid accumulation was independent of the activation of the lipogenic transcriptional factor SREBP-1c (sterol regulatory element-binding protein 1c) and its primary lipogenic target enzymes, including fatty-acid synthase (FAS) and acetyl-CoA carboxylase 1 (ACC-1). (isharonline.org)