Glucose ribose phosphate pyrophosphokinase. Medical search. Frequent questions

The enzyme is involved in the synthesis of nucleotides (purines and pyrimidines), cofactors NAD and NADP, and amino acids histidine and tryptophan, linking these biosynthetic processes to the pentose phosphate pathway, from which the substrate ribose 5-phosphate is derived. (wikipedia.org)

The ribose 5-phosphate binding site consists of residues Asp220-Thr228, located in the C-terminal domain of one subunit. (wikipedia.org)
18874) imidazoleglycerol phosphate synthase%2C cyclase subunit CP001857 CDS Arcpr_0021 19046. (go.jp)

These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached. (ymdb.ca)

Ribose-phosphate diphosphokinase (or phosphoribosyl pyrophosphate synthetase or ribose-phosphate pyrophosphokinase) is an enzyme that converts ribose 5-phosphate into phosphoribosyl pyrophosphate (PRPP). (wikipedia.org)

The enzymatic reaction begins with the binding of ribose 5-phosphate, followed by binding of Mg-ATP to the enzyme. (wikipedia.org)
The catalytic site of the enzyme binds ATP and ribose 5-phosphate. (wikipedia.org)
At normal concentrations, phosphate activates the enzyme by binding to its allosteric regulatory site. (wikipedia.org)
It has been shown that at lower concentrations of the substrate ribose 5-phosphate, ADP may inhibit the enzyme competitively. (wikipedia.org)

Ribose 5-phosphate is produced by the HMP Shunt Pathway from Glucose-6-Phosphate. (wikipedia.org)

protein_coding" "AAC74185","ptsG","Escherichia coli","fused glucose-specific PTS enzymes: IIB component/IIC component [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC74850","yeaD","Escherichia coli","D-hexose-6-phosphate epimerase-like protein [Ensembl]. (ntu.edu.sg)

Because its product is a key compound in many biosynthetic pathways, ribose-phosphate diphosphokinase is involved in some rare disorders and X-linked recessive diseases. (wikipedia.org)

Ribose-phosphate diphosphokinase transfers the diphosphoryl group from Mg-ATP (Mg2+ coordinated to ATP) to ribose 5-phosphate. (wikipedia.org)
Experiments using oxygen 18 labelled water demonstrate that the reaction mechanism proceeds with the nucleophilic attack of the anomeric hydroxyl group of ribose 5-phosphate on the beta-phosphorus of ATP in an SN2 reaction. (wikipedia.org)

Ribose-phosphate pyrophosphokinase is also inhibited by some of its downstream biosynthetic products. (wikipedia.org)
Because its product is a key compound in many biosynthetic pathways, ribose-phosphate diphosphokinase is involved in some rare disorders and X-linked recessive diseases. (wikipedia.org)

The catalytic site of the enzyme binds ATP and ribose 5-phosphate. (wikipedia.org)

When interpreting lab results, consult with your doctor and pay attention to: Units (nmol/L vs. ng/mL) As B vitamins, thiamine pyrophosphate, or TPP, plays a vital role in healthy tissue respiration, the appropriate metabolism of cells, and the efficient oxidation of glucose. (ferienwohnung-gluecksburg.net)

Examples: ADA for adenosine deaminase UMPK for uridine monophosphate kinase Gd for glucose~6-phosphate dehydrogenase (Obviously, when lower case letters are used to designate one locus, it is undesirable to use the same letters but in capi- tals (e.g. (nih.gov)
De novo pyrimidine biosynthesis is achieved by cytosolic carbamoyl-phosphate synthetase II, aspartate transcarbamylase and dihydroorotase (CAD) and uridine 5'-monophosphate synthase (UMPS), and mitochondrial dihydroorotate dehydrogenase (DHODH). (bvsalud.org)

PRPP provides the ribose sugar in de novo synthesis of purines and pyrimidines, used in the nucleotide bases that form RNA and DNA. (wikipedia.org)

It has been shown that at lower concentrations of the substrate ribose 5-phosphate, ADP may inhibit the enzyme competitively. (wikipedia.org)