Loading...
  • Plasma Glucose
  • Cardiometabolic risk (CMR), also known as metabolic syndrome or insulin resistance syndrome, comprises obesity (particularly central or abdominal obesity), high triglycerides, low HDL, elevated blood pressure, and elevated plasma glucose. (mdpi.com)
  • First described by Reaven in 1988 as "Syndrome-X" [ 1 ], the constellation of obesity (particularly central or abdominal obesity), high triglycerides, low high density lipoprotein (HDL), elevated blood pressure, and elevated plasma glucose has been variously described as "insulin resistance syndrome", "metabolic syndrome" and "cardiometabolic risk" (CMR). (mdpi.com)
  • insulinotropic polypeptide
  • Glucose-dependent Insulinotropic Polypeptide (GIP) Stimulates Cell Growth and Promotes Survival of INS-1 Cells (Abstract). (springer.com)
  • Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. (springer.com)
  • A DPP-4 inhibitor, des-fluoro-sitagliptin (DFS), acts by inhibiting the breakdown of regulatory peptides including incretins such as glucagon-like peptide-1 (GLP-1) or glucose-dependent insulinotropic polypeptide (GIP) and increasing insulin release ( 8 ). (diabetesjournals.org)
  • acute
  • 1 . A method for improving β-cell capacity to secrete insulin in response to increased glucose levels comprising increasing the availability of islet cell growth hormone to pancreatic cells wherein said islet cell growth hormone circulates at a level which is substantially unresponsive to acute changes in glucose level. (google.com)
  • Acute effects of 17 beta-estradiol and genistein on insulin sensitivity and spatial memory in aged ovariectomized female rats. (springer.com)
  • peripheral
  • Enantioselectivity in the tissue distribution of perhexiline contributes to different effects on hepatic histology and peripheral neural function in rats. (nih.gov)
  • Pancreas
  • 1.5 mg/kg p.o. twice daily), during which an oral glucose tolerance test (OGTT) (on day 19 of dosing) was performed and insulin secretion from an in situ perfused pancreas preparation (on day 21) was measured. (diabetesjournals.org)
  • decrease
  • a-linolenic acid and exercise training independently, and additively, decrease blood pressure and prevent diastolic dysfunction in obese Zucker rats. (uoguelph.ca)
  • In vivo studies have demonstrated that caffeine ( 10 , 11 ) and aminophylline ( 12 ) decrease glucose tolerance, so that a reduction in insulin sensitivity can be anticipated. (diabetesjournals.org)
  • There was a strong correlation between the decrease in blood glucose level (0 to 6 hours post treatment) and the excretion of urinary glucose. (marketwired.com)
  • metabolic
  • Taking niacin can't "switch" the choice of metabolic fuel to fats when you are already using fats as a fuel, but it can reduce the ability of cells to use glucose, which is why some people have a small increase in blood glucose when they use niacin. (life-enhancement.com)
  • Wild blueberry (Vaccinium angustifolium) consumption improves inflammatory status in the obese Zucker rat model of the metabolic syndrome. (nih.gov)
  • Intragastric feeding (40 kJ) produced a 17% rise in metabolic rate in lean Zucker rats but only an 8% increase in obese (fa/fa) rats, and both of these responses were significantly reduced by β-adrenergic blockade with propranolol (10 mg/kg, s.c. (springer.com)
  • Parasympathetic blockade with atropine (0.5 mg/kg, s.c.) caused a doubling of the response to food in lean rats and a threefold increase in the obese mutants, such that all atropinised animals showed the same increase in metabolic rate after food. (springer.com)
  • normal
  • A study in normal rats also confirmed that SBM-TFC-039 triggered elimination of glucose through the urine (glycosuria) in a dose dependent manner. (marketwired.com)
  • effects
  • However, either the short duration of these studies or the adverse effects of glucose-lowering agents do not allow us to (dis)prove the causal relationship between the prevention of microvascular complications and the subsequent improvements in cardiovascular outcomes. (diabetesjournals.org)
  • Hirano T, Niijima A (1980) Effects of 2-deoxy- d -glucose, glucose and insulin on efferent activity in gastric vagus nerve. (springer.com)