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  • diseases
  • 1) Robert Drapkin, M.D. , a board-certified physician in Internal Medicine, Medical Oncology and Palliative Care, warns against the dangers of poor health habits, and encourages American's to become a good example of health through knowledge, to prevent and eliminate metabolic diseases. (prweb.com)
  • Rather than taking another pill, I want to educate and show examples of how good health through knowledge can prevent and even eliminate metabolic diseases. (prweb.com)
  • Although accidents and suicide account for just a portion of this high mortality rate, more than two-thirds of the rate is caused by different forms of comorbid physical diseases such as cardiovascular and metabolic syndrome [ 3 ]. (hindawi.com)
  • The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell dysfunction has further highlighted the significance of inflammation in metabolic diseases. (jci.org)
  • overweight
  • The incidence of overweight and obesity is dramatically rising and, according to WHO predictions, approximately 2.3 billion of people will be overweight and more than 700 million will be obese by the year 2015 ( http://www.who.int/features/factfiles/obesity/en/index.html ). (hindawi.com)
  • Humans
  • Humans have 48 nuclear receptors that all possess an N-terminal transactivation domain, a highly conserved central region DNA-binding domain, and a C-terminal ligand-binding domain. (jci.org)
  • inflammation
  • The UC Davis study found that fat stored in the buttock area also known as gluteal adipose tissue secretes abnormal levels of chemerin and omentin-1, proteins that can lead to inflammation and a prediabetic condition know as insulin resistance in individuals with early metabolic syndrome. (bio-medicine.org)
  • As it's also an indicator of inflammation and insulin resistance, it could also emerge as part of a biomarker panel to define high-risk obesity states. (bio-medicine.org)
  • and therapeutic approaches to modulate inflammation in the context of obesity and metabolic syndrome. (jci.org)
  • The finding that obesity and metabolic disorder are accompanied by chronic low-grade inflammation has fundamentally changed our view of the underlying causes and progression of obesity and metabolic syndrome. (jci.org)
  • We now know that an inflammatory program is activated early in adipose expansion and during chronic obesity, permanently skewing the immune system to a proinflammatory phenotype, and we are beginning to delineate the reciprocal influence of obesity and inflammation. (jci.org)
  • Over the last years, hypothalamic inflammation has been linked to the development and progression of obesity and its sequelae. (jci.org)
  • There is accumulating evidence that this inflammation not only impairs energy balance but also contributes to obesity-associated insulin resistance. (jci.org)
  • individuals
  • The UC Davis team found that in individuals with early metabolic syndrome, gluteal fat secreted elevated levels of chemerin and low levels of omentin-1 proteins that correlate with other factors known to increase the risk for heart disease and diabetes. (bio-medicine.org)
  • Individuals with the former are more susceptible to metabolic syndrome. (scielo.br)
  • Such state in human medicine is called leptin resistance , the failure, in obese individuals with elevated leptin levels, for suppressing feeding and mediating weight loss [ 17 , 18 ] due to LEPR polymorphisms associated with food preferences and obesity [ 19 ]. (hindawi.com)
  • study
  • "This study shows that anthocyanins have a significant potency of antiobesity and ameliorate adipocyte function in ​ in vitro and ​ in vivo systems and also that they have important implications for preventing metabolic syndrome," ​ wrote Takanori Tsuda from Chubu University (Aichi, Japan). (nutraingredients-usa.com)
  • A daily supplement of cinnamon extract may boost antioxidant defences and reduce the oxidative stress linked to the metabolic syndrome, suggest results from a small US study. (health24.com)
  • Twenty-four participants with impaired fasting glucose were recruited for the placebo-controlled, double-blind study, led by Dr Anne-Marie Roussel from the Joseph Fourier University in France. (health24.com)
  • A new study elucidates the connection between an enzyme involved in blood pressure control and symptoms of the metabolic syndrome. (medicalnewstoday.com)
  • This study assesses whether oxidative stress, using oxidized LDL (ox-LDL) as proxy, is associated with metabolic syndrome (MS), whether ox-LDL mediates the association between central obesity and MS, and whether insulin resistance mediates the association between ox-LDL and MS. We examined baseline data from 3987 non-diabetic subjects in the Progression of Early Subclinical Atherosclerosis (PESA) Study. (diabetesjournals.org)
  • In this study, higher ox-LDL concentrations were associated with MS and its components independently of central obesity and insulin resistance. (diabetesjournals.org)
  • The study of the metabolic syndrome is particularly challenging during the transition period to adulthood given the rapid change in body composition and the gender-related developmental changes in insulin resistance [ 7 , 8 ]. (hindawi.com)
  • Fat in the abdomen has long been considered the most detrimental to health, and gluteal fat was thought to protect against diabetes, heart disease and metabolic syndrome," said Ishwarlal Jialal, lead author of the study and a professor of pathology and laboratory medicine and of internal medicine at UC Davis. (bio-medicine.org)
  • Other authors of the study, entitled "Increased Chemerin and Decreased Omentin-1 in Both Adipose Tissue and Plasma in Nascent Metabolic Syndrome," include Sridevi Devaraj of Baylor College of Medicine, Harmeet Kaur of UC Davis, Beverley Adams-Huet of the University of Texas Southwestern Medical Center, and Andrew A. Bremer of Vanderbilt University. (ucdavis.edu)
  • A recent study investigated the effects of omega-3 fats, given as krill oil, on endocannabinoids, which have been linked to metabolic syndrome. (mercola.com)
  • The study revealed that the omega-3 fats in krill oil helped to reduce endocannabinoid precursor availability in the mice, and in so doing reduced their risk of metabolic syndrome and therefore heart disease. (mercola.com)
  • The first study, published in January , found that the metabolic effects of the two oils are "essentially similar," but that krill oil is as effective as fish oil despite the fact that it contains less EPA and DHA. (mercola.com)
  • B. Brummett, S. Austin, K. Welsh-Bohmer, R. Williams and I. Siegler, "Long-Term Impact of Caregiving and Metabolic Syndrome with Perceived Decline in Cognitive Function 8 Years Later: A Pilot Study Suggesting Important Avenues for Future Research," Open Journal of Medical Psychology , Vol. 2 No. 1, 2013, pp. 23-28. (scirp.org)
  • The study protocol was seen and approved by the central ethics committee, and informed consent was given by study subjects. (diabetesjournals.org)
  • diabetic
  • Preclinical animal studies have shown proof of concept, with improved glucose tolerance and weight reduction reported in many diabetic and obese mouse models treated with 11β-HSD1 inhibitors ( 3 - 6 ). (diabetesjournals.org)
  • regulation
  • A down-regulation of plasminogen activator inhibitor-1 (PAI-1), said to be associated with both obesity and type 2 diabetes, was observed after incubation, "suggesting that regulation of PAI-1 expression is one of the important therapeutic targets for the metabolic syndrome," ​ states the research. (nutraingredients-usa.com)
  • Research is ongoing on just how far its impact on your health reaches, but to date it's known that cannabinoid receptors play an important role in many body processes, including metabolic regulation, cravings, pain, anxiety, bone growth, and immune function. (mercola.com)
  • identifies
  • 2) Dr. Drapkin identifies the case as "metabolic syndrome," a modern disease associated with the man-made (processed) food Americans have grown accustomed to eating in their daily diets. (prweb.com)
  • adipose
  • The finding over 20 years ago that the inflammatory mediator TNF is overexpressed in adipose fundamentally changed our understanding of obesity and metabolic syndrome. (jci.org)
  • We now know that an inflammatory program is activated early in adipose expansion and during chronic obesity, permanently skewing the immune system to a pro-inflammatory phenotype. (jci.org)