Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a condition in which red blood cells break down when the body is exposed to certain drugs or the stress of infection. (medlineplus.gov)
G6PD deficiency occurs when a person is missing or does not have enough of an enzyme called glucose-6-phosphate dehydrogenase. (medlineplus.gov)
Glucose-6-phosphate dehydrogenase in western Islamic Republic of Iran) to [G6PD] deficiency is a common X-linked find the prevalence of G6PD deficiency. (who.int)
Incidence and molecular polymerase-chain-reaction amplification analysis of glucose-6-phosphate dehyd- of the entire coding region from genomic rogenase deficiency in the province of DNA. (who.int)
Genetic of glucose-6-phosphate dehydrogenase blood disorders survey in the Sultanate deficiency in the Fars province of Iran. (who.int)
dehydrogenase deficiency in some ethnic recommended screening test for glucose- groups of Pakistan. (who.int)
6-phosphate dehydrogenase (G6PD) of Physicians and Surgeons Pakistan , deficiency. (who.int)
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked enzymatic defect common in people with African ancestry that can result in hemolysis after acute illnesses or intake of oxidant drugs (including salicylates and sulfonamides). (merckmanuals.com)
Glucose-6-phosphate dehydrogenase deficiency causes haemolytic anaemia in the presence of simple infection, ingestion of fava beans or reaction with certain medicines, antibiotics, antipyrectics and anti- malarial. (scirp.org)
Background The World Health Organization recommends that primaquine should be given once weekly for 8-weeks to patients with Plasmodium vivax malaria and glucose-6-phosphate dehydrogenase (G6PD) deficiency, but data on its antirelapse efficacy and safety are limited. (tropmedres.ac)
BackgroundX-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. (tropmedres.ac)
Title : Glucose-6-Phosphate Dehydrogenase Deficiency In Project Head Start Children Personal Author(s) : Kelly, S.;Almy, R. (cdc.gov)
Deficiency of glucose-6-phosphatase dehydrogenase is associated with hemolytic anemia in two different situations. (lu.se)
First, in areas in which malaria has been endemic, glucose-6-phosphatase dehydrogenase deficiency alleles have reached high frequencies (1% to 50%) and deficient individuals, though essentially asymptomatic in the steady state, have a high risk of acute hemolytic attacks. (lu.se)
Sporadic cases of glucose 6-phosphate dehydrogenase deficiency occur at a very low frequencies, and they usually present a more severe phenotype, namely chronic nonspherocytic hemolytic anemia (CNSHA). (lu.se)
Connect with other caregivers and patients with Glucose-6-phosphate dehydrogenase deficiency and get the support you need. (rareguru.com)
What are the signs and symptoms of glucose-6-phosphate dehydrogenase (G6PD) deficiency? (rareguru.com)
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is caused by mutations in the G6PD __ gene. (rareguru.com)
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited genetic disorder that can result in destruction of red blood cells (hemolysis) after an acute illness or use of certain drugs. (msdmanuals.com)
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect and one of the most common genetic disorders worldwide, with an estimated 400 million people worldwide carrying a mutation in the G6PD gene that causes deficiency of the enzyme. (tau.ac.il)
Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients? (rcsi.com)
Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is known to suppress the antioxidant system and is likely to aggravate severity of COVID-19, which results in a pro-oxidant response. (rcsi.com)
Phenotypic and genotypic characterization of glucose-6-phosphate dehydrogenase deficiency in Argentina. (bvsalud.org)
Glucose-6-phosphate dehydrogenase deficiency is an erythrocyte enzyme disorder caused by mutations in the G6PD gene , which has an X-linked inheritance . (bvsalud.org)
The importance of glucose-6-phosphate dehydrogenase deficiency in the causation of severe neonatal jaundice in Israel was investigated. (openu.ac.il)
The overall results suggest that although a few such cases may occur in this country, glucose-6- phosphate dehydrogenase deficiency cannot be considered an important aetiological factor in the causation of severe haemolytic neonatal jaundice in Israel, in spite of the existence of population groups with a very high frequency of the enzyme deficiency. (openu.ac.il)
BACKGROUND:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency state in humans. (ox.ac.uk)
Multiple acyl-CoA dehydrogenase deficiency- (MADD-), also called glutaric aciduria type 2, associated leukodystrophy may be severe and progressive despite conventional treatment with protein- and fat-restricted diet, carnitine, riboflavin, and coenzyme Q10. (nature.com)
This leads to a secondary functional deficiency of a number of ETF-dependent dehydrogenases and results in a combined disorder of both fatty acid oxidation and amino acid metabolism (especially lysine, tryptophan, and branched-chain amino acids). (nature.com)
Abnormal nerve conduction velocities have been recorded in patients with long-chain 3-hydroxy acyl-coenzyme A dehydrogenase deficiency and peripheral neuropathy. (medscape.com)
A metabolic specialist needs to confirm or exclude diagnosis of long-chain 3-hydroxy acyl-coenzyme A dehydrogenase deficiency by requesting an acylcarnitine profile and urine organic acid analysis. (medscape.com)
G6PD2
Glucose-6-phosphate dehydrogenase (G6PD) deficient individuals are at risk of developing drug-induced acute hemolysis, after exposure to the antimalarial drug, primaquine (PQ). (confex.com)
La deficiencia de glucosa-6-fosfato deshidrogenasa es la enzimopatía eritrocitaria causada por mutaciones en el gen G6PD , cuya herencia está ligada al cromosoma X . Se analizan las características clínicas y de laboratorio de 24 individuos con deficiencia de G6PD durante 25 años. (bvsalud.org)
Lactate dehydrogenase4
Selecting the Plasmodium falciparum l-lactate dehydrogenase (pfLDH) for its high kinetic efficiency, strain IBB14LA1 was derived from IBB10B05 by placing the pfldh gene at the pdc1 locus under control of the pdc1 promotor. (elsevierpure.com)
The lactate dehydrogenase activity was more distinctly decreased than the glucose-6-phosphate dehydrogenase activity. (msk.ru)
Drel' K.A., Shelest Iu.P. (1976) Lactate dehydrogenase and glucose-6-phosphate dehydrogenase activity in the erythrocytes in diabetes mellitus. (msk.ru)
Tests to rule out hemolysis include CBC with differential, reticulocyte count, peripheral blood smear, lactate dehydrogenase (LDH), bilirubin, serum haptoglobin, free serum hemoglobin and Heinz body preparation. (cdc.gov)
Characterization2
Glucose-6-phosphate dehydrogenase has been purified from pigeon pea (Cajanus cajan) seeds and subjected to characterization. (scirp.org)
Keeping in view the clinical significance of the enzyme and less studied from plant sources the present study has been aimed with purification and characterization of glucose-6-phosphate dehydrogenase from pigeon pea seeds. (scirp.org)
Phosphate dehydrogenase10
Academy of Sciences of the United States phosphate dehydrogenase phenotypes of America , 1988, 85:5171-5. (who.int)
Affinity chromatography (2', 5'-ADP Sepharose 4B) first used by De Flora [20] is a common tech- nique for purification of glucose-6-phosphate dehydrogenase. (scirp.org)
Glucose-6-phosphate dehydrogenase is the first enzyme in the pentose phosphate pathway and the main intracellular source of reduced nicotidamineadenine nucleotidephosphate (NADPH), involved in diverse physiological processes such as antioxidant defense, (for instance in the erythrocyte) endothelial growth modulation, erithropoyesis, vascularization and phagocitosis. (univalle.edu.co)
Scholars@Duke publication: Cytologic studies of glucose-6-phosphate dehydrogenase in malignancy. (duke.edu)
It occurs when a person is missing or has low levels of the enzyme glucose-6-phosphate dehydrogenase. (rareguru.com)
An anomaly in the level of glucose-6-phosphate dehydrogenase in tissue. (nih.gov)
Macrophage glucose-6-phosphate dehydrogenase stimulates proinflammatory responses with oxidative stress. (nih.gov)
Here, we have examined the role of glucose-6-phosphate dehydrogenase (G6PDH) activity in the pathogenesis of insulin resistance in skeletal muscle. (edu.au)
We identified increased glucose-6-phosphate dehydrogenase (G6PDH) activity as a common intracellular adaptation that occurs in parallel with the induction of insulin resistance in skeletal muscle and is present across animal and human disease states with an underlying pathology of insulin resistance and glucose intolerance. (edu.au)
Dosage compensation in the regulation of erythrocyte glucose-6-phosphate dehydrogenase activity. (mcmaster.ca)
Alcohol dehydrogenase1
Since L. reuteri excretes high amounts of 3-HPA outside the microcompartment, the organism is likely to have alternative alcohol dehydrogenase(s) in the cytoplasm for transformation of the aldehyde. (lu.se)
1.471
In enzymology, a glucose 1-dehydrogenase (EC 1.1.1.47) is an enzyme that catalyzes the chemical reaction beta-D-glucose + NAD(P)+ ⇌ {\displaystyle \rightleftharpoons } D-glucono-1,5-lactone + NAD(P)H + H+ The 3 substrates of this enzyme are beta-D-glucose, NAD+, and NADP+, whereas its 4 products are D-glucono-1,5-lactone, NADH, NADPH, and H+. (wikipedia.org)
NADP3
K m value for glucose-6-phos- phate and NADP + was found to be 2.68 mM and 0.75 mM respectively whereas V max value was found to be 0.11 U/mL and 0.13 U/mL respectively. (scirp.org)
The enzyme shows more affinity towards NADP + than glucose-6-phosphate. (scirp.org)
It catalyzes the transformation of glucose-6-phosphate to 6-phosphogluconolactone concomitant with conversion of NADP to NADPH. (scirp.org)
Metabolism4
Lactobacillus reuteri, a heterofermentative bacterium, metabolizes glycerol via a Pdu (propanediol-utilization) pathway involving dehydration to 3-hydroxypropionaldehyde (3-HPA) followed by reduction to 1,3-propandiol (1,3-PDO) with concomitant generation of an oxidized cofactor, NAD+ that is utilized to maintain cofactor balance required for glucose metabolism and even for oxidation of 3-HPA by a Pdu oxidative branch to 3-hydroxypropionic acid (3-HP). (lu.se)
We have identified a novel, previously unrecognized role for G6PDH in the regulation of skeletal muscle glucose metabolism. (edu.au)
Glucose measurements are used in the diagnosis and treatment of pancreatic islet cell carcinoma and of carbohydrate metabolism disorders, including diabetes mellitus, neonatal hypoglycemia, and idiopathic hypoglycemia. (cdc.gov)
Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme. (novusbio.com)
Protein1
The deficient activity of long-chain 3-hydroxy acyl-coenzyme A dehydrogenase may be diagnosed in fibroblasts, as well as the other enzyme activities of the trifunctional protein. (medscape.com)
Substrate2
Finally, the space-time yield of l -tle catalyzing by GDH-R3-LeuDH whole cells could achieve 2136 g/L/day in a 200 mL scale system under the optimal catalysis conditions (pH 9.0, 30 ° C, 0.4 mM of NAD + and 500 mM of a substrate including trimethylpyruvic acid and glucose). (biomedcentral.com)
Although SORD is closely related to the class I long-chain alcohol dehydrogenases, it differs in substrate specificity, catalyzing polyols such as sorbitol and xylitol but having no activity towards primary alcohols. (novusbio.com)
Deshidrogenasa1
Caracterización fenotípica y genotipica de la deficiencia de glucosa-6-fosfato deshidrogenasa en Argentina. (bvsalud.org)
Archaeon1
The enzyme from the archaeon Picrophilus torridus is involved in glucose and galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. (expasy.org)
Cofactor1
The cofactor regeneration system of leucine dehydrogenase (LeuDH) and glucose dehydrogenase (GDH) has showed great coupling catalytic efficiency in the synthesis of l -tle, however the multi-enzyme complex of GDH and LeuDH has never been constructed successfully. (biomedcentral.com)
Severe2
In human erythrocytes activities of glucose-6-phosphate and lactate dehydrogenases were decreased approximately 2-fold in moderately severe and critical forms of diabetes mellitus, as compared with normal state. (msk.ru)
In cases of severe cyanosis, urgent supportive therapy (i.e. intravenous fluids, "thermoneutral" environment, glucose infusions/monitoring, airway or assisted ventilation depending on clinical presentation of patient/level of respiratory distress, etc.) should be provided while a diagnosis is established [Steinhorn 2008]. (cdc.gov)
Ethanol1
Moreover, evaluation of ADH6 deletion mutant showed strong decrease in ethanol level, supporting the role of this bifuctional alcohol/aldehyde dehydrogenase in ethanol production. (lu.se)
Purification1
The reports on purification of glucose-6-phos- phate dehydrogenase from plant sources are very less. (scirp.org)
Oxidation1
The oxidation of D-glucose and D-galactose is catalyzed at a comparable rate (cf. (expasy.org)
Genetic1
Furthermore, attenuation of G6PDH activity in skeletal muscle cells via (a) increased nNOSμ/NOS activity, (b) pharmacological G6PDH inhibition, or (c) genetic G6PDH inhibition increases insulin-independent glucose uptake. (edu.au)
Determination1
The enzyme is useful for the determination of D-glucose in clinical analysis and self-monitoring blood glucose meters. (sekisuidiagnostics.com)
Humans1
Multiple mouse disease states exhibiting insulin resistance and glucose intolerance, as well as obese humans defined as insulin-sensitive, insulin-resistant, or pre-diabetic, were examined. (edu.au)
Species1
In this study, diversity of alcohol dehydrogenases in Lactobacillus species was investigated with a focus on L. reuteri. (lu.se)
Activity1
Succinic-dehydrogenase activity was increased in the lungs but not in the kidneys. (cdc.gov)
Hemoglobin1
The red blood cells of individuals with defective or inactive glucose dehidrogenase tend to undergo hemolysis (the loss of hemoglobin through the damaged membrane) causing anemia. (lu.se)
Efficiency1
Among those biocatalysts, leucine dehydrogenase (LeuDH, EC 1.4.1.9) exhibited an outstanding conversion efficiency and enantioselectivity which became the main method of l -tle synthesis in the market [ 11 ]. (biomedcentral.com)
Production1
l-Lactic acid is an important platform chemical and its production from the lignocellulosic sugars glucose and xylose is, therefore, of high interest. (elsevierpure.com)