• The Transporter Classification Database (or TCDB) is an International Union of Biochemistry and Molecular Biology (IUBMB)-approved classification system for membrane transport proteins, including ion channels. (wikipedia.org)
  • Activation from the NLRP3 inflammasome needs set up of NLRP3 and caspase-1 (casp-1) bridged jointly through the adaptor proteins ASC, wherein casp-1 undergoes autoproteolytic digesting. (cancercurehere.com)
  • Cuproptosis causes proteotoxic stress and ultimately results in cell death by the binding of Cu ions to lipid-acylated proteins during the tricarboxylic acid cycle of mitochondrial respiration. (ijbs.com)
  • Glycine Plasma Membrane Transport Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • This graph shows the total number of publications written about "Glycine Plasma Membrane Transport Proteins" by people in this website by year, and whether "Glycine Plasma Membrane Transport Proteins" was a major or minor topic of these publications. (childrensmercy.org)
  • Below are the most recent publications written about "Glycine Plasma Membrane Transport Proteins" by people in Profiles. (childrensmercy.org)
  • The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport. (lookformedical.com)
  • Kinetic studies of the inhibition of L-alanine uptake also indicated the presence of a second neutral amino acid transport system capable of transporting this amino acid. (docksci.com)
  • However, it is unlikely that this second uptake system contributes greatly to L-alanine uptake. (docksci.com)
  • Inhibition of the uptake of L-leucine indicated that this transport system has a similar specificity to the '%''-system initially described for Ehrlich ascites carcinoma cells. (docksci.com)
  • Amino acids constitute one of the largest and most diverse groups of compounds commonly concentrated by active transport, and their uptake has been studied in a wide variety of microbial and mammalian systems. (docksci.com)
  • 68) via uptake systems specific for single amino acids or groups of structurally related amino acids. (docksci.com)
  • D . M . SCOTT AND J. A. PATEMAN ever, L-alanine also appeared to be capable of transport via a second "leucine preferring" uptake system. (docksci.com)
  • Uptake assay procedure Amino acid uptake was examined using a modification of the method described by Hatanaka et al. (docksci.com)
  • L-Citrulline - participates in the synthesis of nitric oxide (NO) and phosphocreatine and oxygen metabolism of glucose, thereby increasing the uptake of oxygen, glucose, amino acids and creatine, and energy production through muscle cells. (crossthelimits.co.uk)
  • We then combined the search algorithm with system-level kinetic modeling, requiring the construction and characterization of 73 variants to build a sequence-expression-activity map (SEAMAP) for a biosynthesis pathway. (omictools.com)
  • Different amino acid transporters at cell membranes work together to facilitate the movement of amino acids into and out of the brain. (edu.au)
  • In the framework of this thesis, the effects of exogenous administration of several non-essential amino acids and the participation of their specific transporters in brain metabolism were investigated in Guinea pig cortical brain slices and mouse brain tissues using a targeted neuropharmacological and metabolomic strategy. (edu.au)
  • All the amino acid transporters mentioned in this study were addressed by the existing solute carrier (SLC) gene nomenclature system for amino acid transporters. (edu.au)
  • Similar trends hold true for the expression profiles of transporters in different cell lines, suggesting that cell lines exhibit largely similar transport behaviour to that of tissues. (biorxiv.org)
  • A family of sodium chloride-dependent neurotransmitter symporters that transport the amino acid GLYCINE. (childrensmercy.org)
  • The homeostatic regulation of amino acid concentrations is crucial for optimal brain function and development. (edu.au)
  • Using this system for the in vivo analysis of the spatial and temporal patterns of cell cycle dynamics, we demonstrated that Inhibitors,Modulators,Libraries Tax expressing cells arrest in the G1 phase of the cell cycle and proceeded to apop tosis, and we found that Tax induced changes in the expression of genes related to cell cycle regulation and apoptosis correlated well with the morphological changes observed in the cells. (thrombininhibitors.com)
  • Developing predictive models of multi-protein genetic systems to understand and optimize their behavior remains a combinatorial challenge, particularly when measurement throughput is limited. (omictools.com)
  • We validated the algorithm's predictions by characterizing 646 genetic system variants, encoded in plasmids and genomes, expressed in six gram-positive and gram-negative bacterial hosts. (omictools.com)
  • Different feeding practices and genetic variation within and between breeds influences the amount of IMF and fatty acid (FA) composition in meat. (biomedcentral.com)
  • The genomic regions and genes identified contribute to a better understanding of the genetic control of fatty acid deposition and can lead to DNA-based selection strategies to improve meat quality for human consumption. (biomedcentral.com)
  • Genetic ablation of ASC prevented DPP8/DPP9 inhibition-induced caspase-1 maturation and partially hampered pyroptosis and inflammasome-dependent cytokine release, whereas deletion of caspase-1 or gasdermin D triggered apoptosis in the absence of IL-1beta and IL-18 secretion. (inra.fr)
  • This alanine transport system was shown to exhibit a broad substrate specificity and appeared to be capable of transporting most naturally occurring neutral a-amino acids. (docksci.com)
  • have been carried out to determine the characteristics of the active transport of neutral amino acids by either isolated mammalian cells or cells in culture. (docksci.com)
  • The studies reported in this paper describe the transport characteristics of certain neutral amino acids in monolayer cultures of the baby hamster kidney cell line BHK21-Cl3.Lalanine, which has been previously shown to be transported via the three major neutral amino acid transport systems in Ehrlich ascites carcinoma cells (Christensen, '69) was consequently examined in most detail. (docksci.com)
  • Conversely, web host cells want lipids for mounting a solid immune system response to infections through conserved design identification receptors (Castrillo et al. (cancercurehere.com)
  • The triangle composed of nutrition, inflammation and immunity, and cancer illustrates how qualitative and quantitative imbalances in food intake predispose organisms, in a manner dependent on or independent of the immune system, to a time-dependent deterioration in function that culminates in the development and progression of cancer. (nature.com)
  • IMPORTANCE The immune system must be able to tailor its response to different types of pathogens in order to eliminate them and protect the host. (biomed.news)
  • When confronted with bacterial pathogens, macrophages, frontline defenders in the immune system, switch to a glycolysis-driven metabolism to carry out their antibacterial functions. (biomed.news)
  • Abnormalities of the immune system are also considered an essential component of PD susceptibility and progression, and this area of research has received increasing attention over the past decade. (biomedcentral.com)
  • It is known that bacteriocins, most successfully used today are products of secondary metabolism of lactic acid bacteria. (mdpi.com)
  • It reduces the concentration of lactic acid and ammonia in the muscles, allowing the body to recover energy faster by increasing the level of creatine phosphate and resynthesis ATP. (crossthelimits.co.uk)
  • In control cells, saturable carnitine transport was energized by the electrochemical gradient of Na+. (qxmd.com)
  • In cortical tissue slices L-aspartate increased brain metabolism concentration-dependently, L-ornithine significantly slowed it at higher concentrations (100 μmol/L), and the effects of LOLA was largely dependent on the balance of its two constituent amino acids. (edu.au)
  • D-aspartate, another isoform of aspartate, produced a range of metabolic impacts, particularly on glutamatergic and GABAergic systems, with varying concentrations. (edu.au)
  • Despite countless in vitro and in vivo research on these amino acids' activities, many fundamental concerns about their metabolic function in different brain areas and pathophysiological conditions remain unanswered. (edu.au)
  • Competitive antagonism of TLR8 with non-targeting locked nucleic acids was found to prevent native LDL-induced macrophage polarization in vitro, and re-organize lesion macrophage phenotypes in vivo, as determined by single-cell RNA sequencing. (biomed.news)
  • Considerable progress has been made in the characterisation of the various amino acid transport systems in bacteria and fungi, but the number and specificity of similar transport systems in mammalian cells is less clear. (docksci.com)
  • This amino acid appears to be transported essentially via a relatively low affinity, high capacity, sodium ion dependent transport system. (docksci.com)
  • Primary carnitine deficiency is an autosomal recessive disorder caused by defective carnitine transport which impairs fatty acid oxidation and manifests as nonketotic hypoglycemia or skeletal or heart myopathy. (qxmd.com)
  • Human consumption of fat that contains high levels of monounsaturated fatty acids (MUFA) can reduce the concentration of undesirable cholesterol (LDL) in circulating blood. (biomedcentral.com)
  • However, it is difficult and costly to determine fatty acid composition, which has precluded beef cattle breeding programs from selecting for a healthier fatty acid profile. (biomedcentral.com)
  • Many consumers associate consumption of fat from beef with coronary heart disease, diabetes and obesity, due to the presence of cholesterol, high concentration of saturated fatty acids (SFA), and low concentration of polyunsaturated fatty acids (PUFA). (biomedcentral.com)
  • Beef has high nutritional value from children to seniors, is a rich source of protein (essential amino acids), iron, zinc, B vitamins and essential polyunsaturated fatty acids such as linoleic and linolenic acid [ 2 ]. (biomedcentral.com)
  • Beef fat also has a high concentration of monounsaturated fatty acids (MUFA), whose melting point is low and can reduce the concentration of bad cholesterol (LDL) in blood circulation [ 3 ]. (biomedcentral.com)
  • However, studies documenting the genetics of fatty acid deposition and composition in Bos indicus breeds are limited. (biomedcentral.com)
  • In this study we performed a GWAS using high-density single nucleotide polymorphism (SNP) chips (770 k) and Bayesian methods (Bayes B) to identify genomic regions associated with fat deposition and fatty acid composition (FA) in Nellore beef. (biomedcentral.com)
  • Copper (Cu) plays a crucial and diverse function in biological systems, acting as a cofactor at numerous sites of enzymatic activity and participating in various physiological processes, including oxidative stress regulation, lipid metabolism, and energy metabolism. (ijbs.com)
  • The dissociated HCO 3 ¯ in the cell is transported to cortical e.c.f. by basolateral membrane Na+HCO¯ symporter resulting in net reabsorption of NaHCO 3 . (pharmacy180.com)
  • Amino acid metabolism is essential for cell survival, while the byproduct ammonia is toxic and can injure cellular longevity. (biomed.news)
  • The transport of L-alanine by the hamster kidney cell line BHK-21-C13. (docksci.com)
  • The present invention provides a simple and robust human liver cell-based system in which persistent hepatitis C infection, persistent hepatitis B infection or ethanol exposure induces a clinical Prognostic Liver Signature (PLS) high-risk gene signature. (sumobrain.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Tissue homogenates, cell lysates and other biological fluids. (lotuskringpoeldijk.nl)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Excitatory Amino Acid Transporter 2 (EAAT2) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (lotuskringpoeldijk.nl)
  • Description: A sandwich ELISA kit for detection of Excitatory Amino Acid Transporter 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lotuskringpoeldijk.nl)
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Excitatory Amino Acid Transporter 2 (EAAT2) in samples from tissue homogenates, cell lysates or other biological fluids. (lotuskringpoeldijk.nl)
  • Investigating biological and ecological aspects of the plant-herbivore system that will assist in determination of potential establishment, efficacy and the ability to build up good populations in the recipient environment are some of the important factors. (seals.ac.za)
  • These results identify LDL-msRNA as instigators of atherosclerosis-associated inflammation and support alternative functions of LDL beyond cholesterol transport. (biomed.news)
  • The cellular model system for hepatocellular carcinoma (HCC)/cirrhosis development and progression may be used in the screening of compounds useful in the treatment and/or prevention of cirrhosis and/or HCC as well as in the identification biomarkers for the prediction of liver disease (especially cirrhosis) progression and HCC. (sumobrain.com)
  • A c-jun amino-terminal kinase that is found predominantly within NEURONS of the BRAIN, suggesting a role in stress-induced neuronal APOPTOSIS. (lookformedical.com)
  • Four mechanisms of Na+ transport have been defined in this segment. (pharmacy180.com)
  • This draws in water from the descending limb of loop of Henle (this thin segment has high osmotic water permeability but lacks active NaCl transport) so that the fluid that enters AscLH becomes hypertonic. (pharmacy180.com)
  • This system with the two main parts and their groups makes it possible to combine two (or more) distinct searches into one search result, while being flexible in removing results from the final list. (diva-portal.org)
  • The α-Syn protein is a small acidic synaptic protein made up of 140 amino acids with a tendency to misfold and aggregate [ 7 ]. (biomedcentral.com)
  • This amino acid was demonstrated to be preferentially transported into BHK2l -C13 cells via a relatively low affinity, high capacity active transport system of broad specificity. (docksci.com)
  • A family of high molecular weight GTP phosphohydrolases that play a direct role in vesicle transport. (lookformedical.com)
  • It is believed that their efficacy is hampered by the presence of highly eutrophic systems in South Africa in which plant growth is prolific and the negative effects of herbivory are therefore mitigated. (seals.ac.za)
  • d) The disproportionately large HCO 3 ¯, acetate, PO 4 3 ¯, amino acid and other anion reabsorption create passive driving forces for Cl¯ to diffuse through the paracellular pathway (in between tubular cells), particularly in the later PT. (pharmacy180.com)
  • Inhibition studies using other amino acids or their analogues provided information about the specificity of this system. (docksci.com)
  • 69)for sugar transport studies. (docksci.com)
  • Saturable carnitine transport was absent in cells from patients with primary carnitine deficiency. (qxmd.com)
  • Prior to amino acid transport assay cells were harvested during exponential growth, inoculated into 60 mm petri dishes (Gibco-Biocult) a t a density of 5.3 x lo3 cells/cm' and incubated as above for 48 hours. (docksci.com)
  • The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)