Metabolic Clearance RateGlucagonAndrostanes17-KetosteroidsIodine IsotopesHalf-LifeInsulinBlood GlucoseInfusions, ParenteralInjections, IntravenousGlucose Clamp TechniqueLiverInfusions, IntravenousKineticsRadioimmunoassayGlucoseTritiumDogsTestosteroneReceptors, GlucagonMicrosomes, LiverCarbon IsotopesGrowth HormonePharmaceutical PreparationsHepatocytesGlucuronidesAldehyde OxidaseTime FactorsInsulin ResistanceCytochrome P-450 Enzyme SystemGlucuronatesDealkylationCytochrome P-450 CYP3AAntipyrineBiotransformationMucociliary ClearanceKidneyPregnancyDrug InteractionsPharmacokineticsArea Under CurveAdministration, OralC-PeptideMidazolamBiological AvailabilityThyroxineRats, Inbred StrainsTissue DistributionFatty Acids, NonesterifiedTechnetium Tc 99m PentetateChromatography, High Pressure LiquidRats, Sprague-DawleyHormonesGlucuronosyltransferaseHydrocortisoneHydroxylationCytochrome P-450 CYP2D6Models, BiologicalKetoconazoleDose-Response Relationship, DrugAryl Hydrocarbon HydroxylasesLactic AcidBileGlucose Tolerance TestGlucagon-Secreting CellsReference ValuesPituitary GlandCryopreservationTriiodothyronineDrug Evaluation, PreclinicalMononuclear Phagocyte SystemRecombinant ProteinsProtein BindingIodine RadioisotopesCreatinineStereoisomerism