• Glomus Tumors are relatively uncommon benign neoplasms that differentiate to become modified smooth muscle cells called glomus cells. (dermpathdiagnostics.com)
  • About 75% of glomus tumors occur in the hand, and 60% are subungual. (medscape.com)
  • Most glomus tumors occur in the hand, especially in the subungual region, as it is rich in blood vessels. (amjcaserep.com)
  • About 80% of all glomus tumors are carotid body tumors or glomus jugulare tumors. (naqlafshk.com)
  • Nonchromaffin paragangliomas (chemodectomas) arise in the temporal bone from glomus bodies in the jugular bulb (glomus jugulare tumors) or the medial wall of the middle ear (glomus tympanicum tumors). (msdmanuals.com)
  • Cranial nerve palsies of the 9th, 10th, or 11th nerve may accompany glomus jugulare tumors that extend through the jugular foramen. (msdmanuals.com)
  • A glomus tumour (glomangioma, tumors of Popoff, or Barré-Masson syndrome) is a benign mesenchymal neoplasm composed of cells which resemble the modified smooth muscle cells of the normal glomus body (glomocytes) [1]. (jbstjournal.com)
  • Extra-digital location of glomus tumour is uncommon [2]. (jbstjournal.com)
  • Considering the rarity of this site, we present this case of Glomus tumour (GT) of the knee. (jbstjournal.com)
  • Histologically, GT are divided into 3 subtypes: The classical glomus tumour, glomangiomas and glomangiomyomas, the last being least common. (jbstjournal.com)
  • Glomus tumors, also known as non-chromaffin cell paraganglioma, arise from the neural crest cells [1]. (otolaryngrhinojournal.com)
  • A blue-red, extremely painful paraganglioma involving a glomeriform arteriovenous anastomosis (glomus body), which may be found anywhere in the skin, most often in the distal portion of the fingers and toes, especially beneath the nail. (wordinfo.info)
  • Glomus tumors are part of "paraganglioma" family of tumors. (neuroangio.org)
  • In a glomus tumor, elements of the normal glomus body, vascular structures, nerve cells, and smooth-muscle cells are affected by marked hypertrophy, which leads to a nodulelike structure. (medscape.com)
  • A few case reports have described glomus tumors possessing malignant potential. (medscape.com)
  • The treatment of choice for solitary glomus tumors is surgical excision. (dermpathdiagnostics.com)
  • For multiple glomus tumors, excision may be more difficult because of their poor circumscription and the large number of lesions. (dermpathdiagnostics.com)
  • Glomus tumor, Knee, excision biopsy. (jbstjournal.com)
  • A glomus tympanum tumor grows in the temporal bone of the skull, behind the eardrum (tympanic membrane). (medlineplus.gov)
  • Dall′Igna, C., Antunes, M.B. and Dall′Igna, D.P. (2005) Radiation Therapy for Glomus Tumors of the Temporal Bone. (scirp.org)
  • The arteriovenous shunt of the glomus body is a normal anatomic shunt as opposed to an abnormal arteriovenous fistula. (wikipedia.org)
  • Glomus tumors are uncommon benign tumors that originate in the neuromyoarterial elements of the glomus body, an arteriovenous shunt specialized in thermoregulation. (cdlib.org)
  • Glomus Tumors are rare benign tumors of the glomus body, often occurring in the subungual region. (orthobullets.com)
  • Glomus tumors are uncommon benign tumors. (cdlib.org)
  • Although glomus tumors usually appear as solitary lesions at 1 site, multiple lesions at multiple sites are not uncommon (see the image below). (naqlafshk.com)
  • Glomus tumors are rare, benign, soft-tissue lesions, usually occurring in the hand, but they can occur in other regions of the body, such as the thigh. (amjcaserep.com)
  • Glomus tumors are rare, benign, soft-tissue lesions, representing around 1% to 2% of all soft-tissue tumors. (amjcaserep.com)
  • En bloc resection of the ear canal with sparing of the facial nerve is done when lesions are limited to the canal and have not invaded the middle ear. (msdmanuals.com)
  • The glomus body is a small arteriovenous anastomosis surrounded by a capsule of connective tissue. (wikipedia.org)
  • [ 1 ] The glomus body is a neuromyoarterial apparatus composed of vascular structures, nerve cells, and smooth-muscle cells. (medscape.com)
  • De Smet et al [ 2 ] and Brems et al [ 5 ] postulated that the glomus cell (the tumor cell in glomus tumors) is of neural crest origin, just like Schwann cells (the tumor cells in neurofibromas). (cdlib.org)
  • This hypothesis takes into account an origin in the pluripotent stem cells of the neural crest that can form three distinct cellular lines: neurons, Schwann cells, and smooth muscle-like myofibroblasts positive for αSMA, just like the αSMA positive glomus cells in the glomus tumors. (cdlib.org)
  • Only αSMA-positive glomus cells harbor somatic and germline NF1 mutations. (cdlib.org)
  • In addition, a similar two-hit mechanism, with bi-allelic inactivation of the tumor suppressor gene NF1 in αSMA-positive glomus cells, just like the one described in neurofibroma-derived Schwann cells, could explain an increased rate of these tumors in NF1 patients [ 5 ]. (cdlib.org)
  • Sensing the level of O2 and CO2 is an essential factor for the brain to know how fast the lungs need to fill and empty to keep the O2 levels high enough and the CO2 levels low enough to keep all of the cells of the body healthy. (khanacademy.org)
  • Direct link to Eduardo Albo's post "Sir, the glomus cells are. (khanacademy.org)
  • Sir, the glomus cells are in the carotid and aortic body like Rishi mentioned in the video. (khanacademy.org)
  • We investigated the effect of almitrine on ionic currents of chemoreceptor cells isolated from the carotid body of rat and rabbits by using the whole-cell and inside-out configurations of the patch-clamp technique. (aspetjournals.org)
  • Glomus tumors are neoplasms caused by a proliferation of glomus cells, which make up a portion of the glomus body. (dermpathdiagnostics.com)
  • Paragangliomas tumors (sometimes referred to as glomus, as glomus cells are the place of origin) are a typically benign abnormal cell growth. (knowcancer.com)
  • Another form of tumor with kinship to fibroblasts, the boring cells that hold many parts of our body together. (sarctrials.org)
  • Histological examination revealed a well-circumscribed benign lesion with several vascular spaces (Fig. 3a) and solid aggregates of regular round glomus cells with darkly staining basophilic nucleus in a hyaline stroma. (jbstjournal.com)
  • Structurally plump endothelial cells line a centrally coiled canal which is surrounded by longitudinal and circular muscle fibres containing rounded epithelial appearing glomus cells (glomocytes) [1,2]. (jbstjournal.com)
  • It is composed of specialized pericytes (sometimes termed glomus cells), usually in single encapsulated nodular masses which may be several millimeters in diameter. (wordinfo.info)
  • Differential effects of halothane and sevoflurane on hypoxia-induced intracellular calcium transients of neonatal rat carotid body type I cells. (ox.ac.uk)
  • BACKGROUND: The purpose of this study was to investigate the effects of halothane and sevoflurane on the magnitude of the increase in intracellular calcium with hypoxia in carotid body type I (glomus) cells. (ox.ac.uk)
  • METHODS: We studied single glomus cells from neonatal rat carotid bodies. (ox.ac.uk)
  • CONCLUSIONS: The actions of the agents in single cells reflect their known influence on human hypoxic ventilatory response, consistent with the notion that the cellular process underlies the whole-body effect. (ox.ac.uk)
  • Hydrogen sulfide and hypoxia-induced changes in TASK (K2P3/9) activity and intracellular Ca(2+) concentration in rat carotid body glomus cells. (uams.edu)
  • The complex architecture of the human body requires an efficient life-support system that transports gases, liquids, and other nutrients as well as circulating cells that play important roles in body defense systems. (basicmedicalkey.com)
  • Gastric glomus tumor is a rare mesenchymal tumor that originates from modified smooth muscle cells of the glomus body. (e-jyms.org)
  • Nitric oxide inhibits L-type Ca2+ current in glomus cells of the rabbit carotid body via a cGMP-independent mechanism. (uchicago.edu)
  • Patch-clamping glomus cells of the carotid bodies allowed us to uncover new ionic determinants of sensitivity to hypoxia and low pH. (uiowa.edu)
  • Sympathetic paraganglia consist of chromaffin cells and are involved in the secretion of catecholamines (norepinephrine, epinephrine, and dopamine), while parasympathetic paraganglia consist of glomus (nonchromaffin) cells and act as chemoreceptors [ 1 ] . (encyclopedia.pub)
  • The glomus body is not to be confused with the glomus cell which is a kind of chemoreceptor found in the carotid bodies and aortic bodies. (wikipedia.org)
  • They are generally located in the carotid and aortic bodies. (khanacademy.org)
  • In fact in some book they are referred as Glomus caroticum (carotid body) and Glomus aorticum (aortic body) be careful with this one no to mistake with para-aortic bodies which are chromaffin cell which manufacture catecholamine. (khanacademy.org)
  • Glomus tumors are most commonly found in distal extremities in the nail bed and subcutaneous tissues of the distal phalanx. (medscape.com)
  • The only similar case was described by Brems et al [ 5 ], but it reported the association of a single, distal glomus tumor and SN. (cdlib.org)
  • This area contains nerve fibers (glomus bodies) that normally respond to changes in body temperature or blood pressure. (medlineplus.gov)
  • This neurotransmitters cause depolarization of the afferent pathway of Glossopharingeal Nerve(carotid body) and Vagus nerve (aortic body). (khanacademy.org)
  • Glomus tumors of the head and neck are associated with 4 primary locations, the jugular bulb, middle ear cavity, vagus nerve, and carotid body. (naqlafshk.com)
  • they arise from the glomus bodies that run with the tympanic branch of the glossopharyngeal nerve. (naqlafshk.com)
  • Tumors in region of the vagus nerve are commonly called glomus vagale tumors because of their usual close association with the vagus nerve (see the image below). (naqlafshk.com)
  • Here is a typical glomus tumor in a patient presenting with facial nerve palsy and pulsatile tinnitus. (neuroangio.org)
  • This work provided a mechanistic background in support of clinical trials of carotid sinus nerve stimulation and carotid body resection in hypertensive patients. (uiowa.edu)
  • Parasympathetic paraganglia include supracardiac paraganglia, paraganglia of the carotid body, middle ear, and larynx, as well as paraganglia distributed along the vagus nerve and several other smaller paraganglia [ 2 ] . (encyclopedia.pub)
  • Imaging is the primary investigative modality for glomus tumors of the head and neck (paragangliomas). (naqlafshk.com)
  • Haller introduced glomus tumors of the head and neck into the medical record in 1762 when he described a mass at the carotid bifurcation that had a glomus body-like structure. (naqlafshk.com)
  • This is the most common type of glomus tumor of the head and neck. (naqlafshk.com)
  • These paraganglia are common throughout the body, but most are found in the head and neck area [ 3 ] . (encyclopedia.pub)
  • The most common sites for head and neck paragangliomas (HNPGLs) include the carotid body followed by middle ear and vagal glomus [ 4 ] . (encyclopedia.pub)
  • Rarely, glomus tumours may have a malignant potential [3]. (jbstjournal.com)
  • There are two different types of glomus tumors: Solitary and Multiple glomus tumors, which are also known as glomangiomas or glomulovenous malformations. (dermpathdiagnostics.com)
  • A glomus tympanum tumor is a tumor of the middle ear and bone behind the ear (mastoid). (medlineplus.gov)
  • While it does not appear particularly aggressive under the microscope, it travels very early to other sites of the body, including lung, chest cavity, liver, and bone, and occasionally to the brain. (sarctrials.org)
  • [ 13 ] but the tumor can occur anywhere in the body. (medscape.com)
  • Glomus tumors mostly occur in middle age, especially in the fourth and fifth decades of life. (medscape.com)
  • Glomus tumors can occur in other regions of the body, and this is considered a very rare situation. (amjcaserep.com)
  • Glomus tumors can rarely occur in unusual locations. (jbstjournal.com)
  • Glomus tumours are the most frequent perivascular tumours of the hand. (springer.com)
  • In a retrospective multicenter study that included 72 patients with surgically excised digital glomus tumors (mean follow-up, 5.4 years), Kim et al investigated risk factors for recurrence and assessed complication and recurrence rates according to surgical approach and method. (medscape.com)
  • The mainstay of glomus treatment used to be surgical resection. (neuroangio.org)
  • A glomus body (or glomus organ) is a component of the dermis layer of the skin, involved in body temperature regulation. (wikipedia.org)
  • The role of the glomus body is to shunt blood away (heat transfer) from the skin surface when exposed to cold temperature, thus preventing heat loss, and allowing maximum blood flow to the skin in warm weather to allow heat to dissipate. (wikipedia.org)
  • Histologically GT arises from glomus bodies that are specialised form of arteriovenous anastomosis involved in temperature regulation. (jbstjournal.com)
  • The glomus functions as a shunt-or bypass-regulating mechanism in the flow of blood, temperature, and conservation of heat in the part as well as in the indirect control of the blood pressure and other functions of the circulatory system. (wordinfo.info)
  • Glomus tumors are commonly observed in peripheral soft tissue, such as dermis or subungal region, but rarely in the gastrointestinal tract. (e-jyms.org)
  • It descends in front of the vertebral column and ends on the body of the fourth lumbar vertebra, commonly a little to the left of the midline, by dividing into the 2 common iliac arteries. (medscape.com)
  • Even rarer tumors can arise from the sensory organs that regulate blood flow to different parts of the body. (sarctrials.org)
  • 2. A highly organized arteriolovenular anastomosis (a vessel that directly interconnects an artery and a vein) forming a tiny nodular focus in the nailbed, pads of the fingers and toes, ears, hands, and feet and many other organs of the body. (wordinfo.info)
  • The distribution of the systemic arteries is like a ramified tree, the common trunk of which, formed by the aorta, commences at the left ventricle, while the smallest ramifications extend to the peripheral parts of the body and the contained organs (see the image below). (medscape.com)
  • Glomus tympanum tumors are rarely cancerous and do not tend to spread to other parts of the body. (medlineplus.gov)
  • After review of the literature, we could verify that, although rarely reported, there is a well established relationship between NF1 and glomus tumors, single or multiple. (cdlib.org)
  • The glomus body is a specialised form of arteriovenous anastomosis localised in the dermal soft tissue and acts as a thermoregulator. (jbstjournal.com)
  • Glomus jugulare ones grow in the jugular foramen, and therefore present with symptoms related to destruction/invasion of adjacent structures. (neuroangio.org)
  • The glomus body is responsible for thermoregulation. (medscape.com)
  • Common locations for extra-adrenal pheochromocytomas include the organ of Zuckerkandl (close to the origin of the inferior mesenteric artery), bladder wall, heart, mediastinum, and carotid and glomus jugulare bodies. (medscape.com)
  • Most of the time, extradigital glomus tumors are difficult to diagnose, and symptoms can persist for a long time. (amjcaserep.com)
  • If it is in fact a glomus, usually other symptoms are present as well. (neuroangio.org)
  • Almitrine is a drug used in the treatment of hypoxemic chronic lung diseases such as bronchitis and emphysema because it is a potent stimulant of the carotid bodies in human and different animal species that produces a long-lasting enhancement of alveolar ventilation, ameliorating arterial blood gases. (aspetjournals.org)
  • There are no differences in systolic and diastolic blood pressure, heart rate, and body mass index (BMI) between groups [ 16 ] . (encyclopedia.pub)
  • The glomus body has high sympathetic tone and potentiation leads to near complete vasoconstriction. (wikipedia.org)
  • Glomus tumors are rare, and the majority do not present with isolated pulsatile tinnitus. (neuroangio.org)
  • 2. De Smet L, Sciot R, Legius E. Multifocal glomus tumours of the fingers in two patients with neurofibromatosis type 1. (cdlib.org)
  • The glomus cell are Type I and II. (khanacademy.org)