AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
HypertrophyKidney GlomerulusDiabetic NephropathiesGlomerulosclerosis, Focal SegmentalAlbuminuriaHypertrophy, Left VentricularPodocytesDiabetes Mellitus, ExperimentalNephronsProteinuriaKidneyOrgan SizeCardiomegalyGlomerular MesangiumNephrectomyCollagen Type IVMesangial CellsGlomerular Filtration RateTransforming Growth Factor betaTransforming Growth Factor beta1StreptozocinDisease Models, AnimalKidney DiseasesBlood PressureRats, Sprague-DawleyBody WeightMice, Inbred C57BLCreatinineHypertrophy, Right VentricularBlood GlucoseRNA, MessengerMyocardiumMyocytes, CardiacEchocardiographyVentricular RemodelingHeart VentriclesCardiomyopathy, HypertrophicHypertensionCell EnlargementHeartFibrosisAtrial Natriuretic FactorCell SizeAngiotensin IICalcineurinMyocardial ContractionHeart FailureMice, TransgenicCells, CulturedAdenoidsSignal TransductionMyosin Heavy ChainsRats, Inbred SHRMonocrotalineRats, WistarEndomyocardial FibrosisVentricular Function, LeftVentricular PressureRats, Inbred WKYHemodynamicsElectrocardiographyPhenylephrineAnimals, NewbornMice, KnockoutCardiomegaly, Exercise-InducedEndothelin-1IsoproterenolMuscle ProteinsAntihypertensive AgentsDiastoleConstrictionTime FactorsHypertension, PulmonaryGene Expression RegulationVentricular Dysfunction, Left
Reduced glomerular filtRenal plasDiabetes-induced glomerularMesangialProteinuriaEGFRTubularImpaired glomerular filtrationKidneysVentricular hypertrophyRateHyperfiltrationFiltration barrierHematuriaDiabetic1.73Bowman'sDiseasesDiseaseBenignCapillaryAlbuminuriaIncidenceEnlargementCardiacGlomeruliMyocardialNephropathyMechanismGrowth
Reduced glomerular filt3
  • Avolio, Alberto 2022-12-01 00:00:00 Elevated central aortic pressure indices (e.g., systolic pressure and pulse pressure) predict cardiovascular (CV ) events and mortality in addition to structural changes (e.g., left ventricular hypertrophy, carotid intima-media thickness and reduced glomerular filtration rate). (deepdyve.com)
  • Serum FGF23 increase in the setting of functional iron deficiency anemia, inflammation, reduced glomerular filtration rate and extra-osseous synthesis. (renalfellow.org)
  • In addition, elderly subjects tend to experience modifications in other cardiovascular and renal parameters that regulate arterial blood pressure, such as increased catecholamine levels, reduced renal blood flow, reduced renal natriuretic capacity, reduced glomerular filtration rate and reduced baroreceptor sensitivity. (who.int)
Renal plas2
  • In patients with SCD, supranormal renal hemodynamics-including increased renal blood flow, renal plasma flow, and glomerular filtration rate-occur as early as infancy, but decrease with age. (medscape.com)
  • Project Summary Approximately 30 million adults in the United States suffer with chronic kidney disease (CKD), which is characterized by a progressive loss of functional renal mass and subsequent compensatory changes, such as increased renal plasma flow, increased single nephron glomerular filtration rate, and renal cellular hypertrophy. (nih.gov)
Diabetes-induced glomerular2
  • it decreases urinary albumin excretion and prevents or decreases diabetes-induced glomerular changes secondary to mesangial matrix expansion. (wikipedia.org)
  • 14. Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy. (nih.gov)
Mesangial1
  • We previously showed that 3-week old CD2AP-deficient mice have significant proteinuria, glomerular hypertrophy and mesangial expansion. (nih.gov)
Proteinuria2
  • Inhibitors of the renin-angiotensin system inhibitors are commonly used to decrease glomerular hyperfiltration, reduce proteinuria and delay progression of diabetic nephropathy [7]. (heraldopenaccess.us)
  • RESULTS: The results showed that QHYS significantly reduced 24-h proteinuria, blood urea nitrogen, kidney index, and ameliorated glomerular hypertrophy and collagen fiber deposition in the kidney of DN rats. (harvard.edu)
EGFR4
Tubular8
  • The renal manifestations of SCD range from various tubular and glomerular functional abnormalities to gross anatomic alterations of the kidneys. (medscape.com)
  • tubular and glomerular hypertrophy. (nih.gov)
  • This hypertrophy is particularly striking in proximal tubular cells. (nih.gov)
  • Consequently, these substances may be taken up more readily by hypertrophied proximal tubular cells. (nih.gov)
  • The increased exposure to, and probable uptake of, xenobiotics, wastes, and nephrotoxicants likely enhances the risk of hypertrophied proximal tubular cells being affected adversely by these substances. (nih.gov)
  • The pathogenesis of HIVAN requires local HIV infection of the kidney, with the virus infecting tubular and glomerular epithelial cells. (medscape.com)
  • The cellular target in the development of HIVAN is probably the renal glomerular and tubular epithelium. (medscape.com)
  • When kidney function becomes compromised by disease, the processes of glomerular filtration and tubular reabsorption and secretion become affected to different extents. (encyclopedia.com)
Impaired glomerular filtration1
  • In this study, we assessed the early signs of impaired glomerular filtration in children with a SK from birth or from early infancy. (springer.com)
Kidneys1
  • Histological changes in kidneys included glomerular shrinkage, severe degeneration in the tubules cells, interstitial tissue and glomerulus, increase in interstitial tissue cells and macrophages aggregation.The most severe alternation of the gill, liver and kidney were in third weeks at 0.5 mg/l concentration. (aquadocs.org)
Ventricular hypertrophy9
  • Reduction of the risk of stroke in patients with hypertension and left ventricular hypertrophy. (nih.gov)
  • Serum phosphate and left ventricular hypertrophy in young adults: the coronary artery risk development in young adults study. (nih.gov)
  • BACKGROUND/AIMS: A relationship with vascular dysfunction in chronic kidney disease suggests a possible association of phosphate level with left ventricular hypertrophy development in people with normal kidney function. (nih.gov)
  • Phosphate levels were measured at year 0, and left ventricular hypertrophy assessed by echocardiography at year 5. (nih.gov)
  • Left ventricular hypertrophy was present in 4.5% of the population. (nih.gov)
  • CONCLUSION: Phosphate level may be a risk factor for left ventricular hypertrophy in community-dwelling young adults. (nih.gov)
  • Left ventricular hypertrophy (LVH) is causally related to increased morbidity and mortality following acute myocardial infarction (AMI) via still unknown mechanisms. (portlandpress.com)
  • For instance, one of the non-classic effects of FGF23 is mediated by FGFR4 and PLCγ/calcineurin/NFAT signaling pathway, which induces left ventricular hypertrophy and fibrosis in animal models . (renalfellow.org)
  • Bedside 2-dimensional transthoracic echocardiogram demonstrated left ventricular hypertrophy, a preserved left ventricular ejection fraction of 60% by Simpson rule, without any regional wall motion abnormalities and estimated pulmonary artery systolic pressure was 45 mm Hg. (hvt-journal.com)
Rate3
  • The 2012 KDIGO CKD classification recommends details about the cause of the CKD and classifies it into 6 categories based on glomerular filtration rate (G1 to G5 with G3 split into 3a and 3b). (nih.gov)
  • Secretion allows substances such as hydrogen ions to be eliminated at a rate that exceeds glomerular filtration. (encyclopedia.com)
  • forearm blood flow increases while renal blood flow and glomerular filtration rate are preserved. (nih.gov)
Hyperfiltration2
  • However, both their higher blood pressure and RI and the correlation of 24-h albumin urinary excretion with length of follow-up time underline the need for monitoring to detect early signs of glomerular hyperfiltration and, if necessary, implement timely intervention. (springer.com)
  • Also, early diabetic nephropathy is associated with glomerular hyperfiltration, cytokine release and tissue proliferation, processes that have been linked to progression of the kidney disease [5,6]. (heraldopenaccess.us)
Filtration barrier2
  • Whereas knockdown of Clic5a resulted in leakiness of the glomerular filtration barrier, Clic5b deficient embryos displayed defective ciliogenesis, leading to ciliopathy-associated phenotypes such as ventral body curvature, otolith deposition defects, altered left-right asymmetry and formation of hydrocephalus and pronephric cysts. (bvsalud.org)
  • They are part of the glomerular filtration barrier, the loss of their characteristic architecture leads to effacement of foot processes and detachment. (uni-greifswald.de)
Hematuria1
  • Various types of glomerular diseases should be differentiated from each other based on associations, presence of pitting edema , hematuria , hypertension , hemoptysis , oliguria , peri-orbital edema , hyperlipidemia , type of antibodies , light and electron microscopic features. (wikidoc.org)
Diabetic1
  • In recent years, we have been witnessing dramatically increased interest in the treatment of chronic kidney disease, e.g., diabetic kidney disease, glomerular disease, or autosomal dominant polycystic kidney disease, but also aimed more generally on the progression of chronic kidney disease and the complications of chronic kidney disease, such as anemia, or hyperkalemia. (mdpi.com)
1.731
  • Final postoperative estimated glomerular filtration rates (eGFRs) were 79.4, 41.4, and 61.2 ml/minute/1.73 m2, respectively ( p = 0.003). (biomedcentral.com)
Bowman's2
  • In the mouse, sexual dimorphism of the glomerular parietal epithelium of Bowman's capsule exists. (nih.gov)
  • Glomerular metaplasia of Bowman's capsule should be diagnosed and given a severity grade. (nih.gov)
Diseases2
  • Because of binding to a subtype EDG-2 of LPA receptor, an EDG-2 antagonist is useful in treating and/or preventing chronic diseases (for example, diseases caused by the progress of chronic asthma, glomerular nephritis, obesity, arteriosclerosis, rheumatoid and atopic diseases) induced and made chronic by tissue cells whose proliferation is accelerated by LPA mediated by EDG-2. (justia.com)
  • More specifically, the present invention relates to a remedy and/or a preventive for a chronic disease selected from diseases induced by the progress of chronic asthma, glomerular nephritis, obesity, prostate hyperplasia, arteriosclerosis which are induced and made chronic by the sthenia of cell proliferation, rheumatoid, atopic dermatitis, comprising an EDG-2 antagonist. (justia.com)
Disease1
  • In this study, 120 patients with primary glomerular disease were included, including 84 in the training and 36 in the test cohorts. (bvsalud.org)
Benign1
  • Objective -To determine the effect of the 5α-reductase inhibitor finasteride on prostatic diameter and volume, semen quality, and serum dihydrotestosterone (DHT) and testosterone concentrations in dogs with spontaneous benign prostatic hypertrophy (BPH). (avma.org)
Capillary2
  • CKD causes continuous overstimulation of the RAAS, leading to increased glomerular capillary pressure and activation of proinflammatory pathways that can cause glomerular hypertrophy ( 6 ). (diabetesjournals.org)
  • Blood leaves the glomerular capillaries through an efferent arteriole which forms a capillary network, the vasa recta, that follows the path of the tubules. (encyclopedia.com)
Albuminuria2
  • The goal of this study is to use morphometry to establish the temporal sequence of podocyte foot process effacement, glomerular volume expansion and albuminuria in Cd2ap -/- mice by measuring these parameters at the 2-week time point. (nih.gov)
  • Our purpose is to examine whether particular genetic variants, including those in MYH9, influence the ability of the kidney to undergo hypertrophy following renal donation or the propensity to manifest albuminuria as a sign of glomerular stress. (nih.gov)
Incidence1
  • Okuda S, Motomura K, Sanai T, Onoyama K, Fujishima M (1988) High incidence of glomerular sclerosis in rats subjected to uninephrectomy at young age. (springer.com)
Enlargement1
Cardiac3
  • Pressure overload induced cardiac hypertrophied mice and sham-operated controls were exposed to AMI by coronary artery ligation, and treated with vehicle or rapamycin 10 min before reperfusion. (portlandpress.com)
  • Rapamycin produced marked cardioprotection in normal control mice, whereas pressure overload induced cardiac hypertrophied mice manifested enhanced myocardial injury, and was refractory to rapamycin-elicited cardioprotection evidenced by augmented infarct size, aggravated cardiomyocyte apoptosis, and worsening cardiac function. (portlandpress.com)
  • The pathophysiology of essential hypertension is characterized by increased peripheral vascular resistance due to hypertrophy of arterial vessel walls, which in the elderly is usually associated with a reduction in cardiac output. (who.int)
Glomeruli1
  • An average of 415.2 (range 268-716) grid points were counted for all the glomeruli, and quantification of glomerular volume from each kidney. (nih.gov)
Myocardial1
  • The myocardial vasocongestion lymphocytes propose oriented from self-efficacy in the vein and already inherited with function or hypertrophy. (siriuspixels.com)
Nephropathy1
  • Although FSGS is the predominant glomerular lesion in HIVAN, other reported glomerular lesions in patients with HIV include IgA nephropathy, cryoglobulinemia, amyloidosis, and a lupuslike immune complex glomerulopathy. (medscape.com)
Mechanism1
Growth1