• The estimated glomerular filtration rate (eGFR) is a well-established biomarker of CKD and is associated with adverse cardiac events. (minervamedica.it)
  • In practice, the estimated glomerular filtration rate (eGFR) is most often used. (medscape.com)
  • Several eGFR formulas that employ easily obtainable values have been developed (eg, Modification of Diet in Renal Disease (MDRD) formula , Cockcroft-Gault formula ). (medscape.com)
  • Currently, the National Kidney Foundation no longer recognizes the terms chronic renal insufficiency (CRI) or chronic kidney disease (CKD), but rather it recognizes the 5 stages of CKD based on the estimated GFR (eGFR), as calculated by the MDRD formula. (medscape.com)
  • G F R = Urine Concentration × Urine Flow Plasma Concentration {\displaystyle GFR={\frac {{\mbox{Urine Concentration}}\times {\mbox{Urine Flow}}}{\mbox{Plasma Concentration}}}} There are several different techniques used to calculate or estimate the glomerular filtration rate (GFR or eGFR). (wikipedia.org)
  • Thus, this study aims to examine the concordance of SCr to estimated glomerular filtration rate (eGFR) in detecting early CKD. (upm.edu.my)
  • Previous studies have reported an association between a significant decline in estimated glomerular filtration rate (eGFR) over time and an increased risk of cardiovascular disease (CVD). (bvsalud.org)
  • The aim of this study was therefore to evaluate the plasma levels of FABP3 at different stages of estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus (T2DM). (medsci.org)
  • A total of 334 subjects with T2DM who enrolled in a disease management program were included in this study and stratified according to eGFR. (medsci.org)
  • We studied here the independent associations of estimated glomerular filtration rate (eGFR) and albuminuria with mortality and end-stage renal disease (ESRD) in individuals with chronic kidney disease (CKD). (ox.ac.uk)
  • METHODS: We assessed estimated glomerular filtration rate (eGFR) with Cockcroft-Gault (C-G) and Modification of Diet in Renal Disease (MDRD) formulae in 46,942 NSTE ACS patients from 408 CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the American College of Cardiology/American Heart Association Guidelines) hospitals. (wustl.edu)
  • 5.7%) with estimated glomerular filtration rate (eGFR) using linear regression. (cdc.gov)
  • [ 4 ] Kidney function is usually normal during adolescence but frequently becomes subnormal as chronic kidney disease progresses. (medscape.com)
  • The diagnosis of chronic kidney disease (CKD) in patients with sickle cell disease (SCD) generally occurs between 30 and 40 years of age, with ESRD developing in approximately 11% of patients. (medscape.com)
  • Glomerular disease (chronic kidney disease ) occurs quite commonly in dogs . (pethealthnetwork.com)
  • In other words, glomerular disease, particularly when left untreated, hastens the progression of chronic kidney disease . (pethealthnetwork.com)
  • Chronic kidney disease (CKD) and cardiovascular disease (CVD) together result in an enormous burden on global healthcare. (minervamedica.it)
  • Nieuwhof, CMG 1999, ' Idiopathic glomerular disease : a prospective study of chronic haematuria and nephrotic syndrome ', Doctor of Philosophy, Maastricht University, Maastricht. (maastrichtuniversity.nl)
  • Glomerular diseases account for a significant proportion of acute and chronic kidney disease. (enetmd.com)
  • We examined the alterations in gene expression associated with the development of crescentic glomerulonephritis in murine chronic graft-versus-host disease, a model for human systemic lupus erythematosus. (tmu.edu.tw)
  • The National Kidney Foundation (NKF) recommends using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation to estimate GFR. (medscape.com)
  • Small kidneys usually indicate chronic, irreversible damage from diseases such as hypertensive nephrosclerosis, ischemic nephropathy, or any other long-standing kidney disease. (medscape.com)
  • Staging of chronic kidney disease is based on categories of GFR as well as albuminuria and cause of kidney disease. (wikipedia.org)
  • Little is known about the accuracy of serum creatinine (SCr) in identifying early chronic kidney disease (CKD) in the primary care setting. (upm.edu.my)
  • In most cases, kidney disease is a chronic and gradually progressing disease. (healthline.com)
  • While it's possible to improve your GFR, you're more likely to do so with acute kidney injuries rather than with chronic kidney disease. (healthline.com)
  • For most people with chronic disease, positive lifestyle changes may help slow the loss of kidney function. (healthline.com)
  • Some people with chronic glomerulonephritis have no history of kidney disease. (medlineplus.gov)
  • The symptoms of chronic kidney disease may develop over time. (medlineplus.gov)
  • What Is Hypertension-Induced Chronic Kidney Disease? (medicinenet.com)
  • Hypertension -induced chronic kidney disease (CKD) is a long-standing kidney condition that develops over time due to persistent or uncontrolled high blood pressure ( hypertension ). (medicinenet.com)
  • What are the signs and symptoms of hypertension-induced chronic kidney disease? (medicinenet.com)
  • Early chronic kidney disease (CKD) also may not have symptoms. (medicinenet.com)
  • How do doctors diagnose hypertension-induced chronic kidney disease? (medicinenet.com)
  • Anyone who has high blood pressure is more likely to develop chronic kidney disease (CKD) in the absence of treatment. (medicinenet.com)
  • There is no cure for hypertension-induced chronic kidney disease (CKD). (medicinenet.com)
  • e aim of this study was to investigate the relationship between LVH, estimated glomerular filtration rate (GFR), and inflammatory markers in patients with chronic kidney disease (CKD). (hippokratia.gr)
  • Chronic Kidney Disease is a major cause of morbidity and interventions now exist which can reduce risk. (nih.gov)
  • In addition, 40 subjects from the Fabry Registry, matched for age, sex, chronic kidney disease stage and previous transient ischaemic attack (TIA), served as a comparison group. (nih.gov)
  • Fatty acid-binding protein 3 (FABP3) located in renal mesangial and distal tubular cells, and had been shown to be a sensitive marker of renal injury, potentially be a mediator in pathogenesis of chronic kidney disease (CKD). (medsci.org)
  • Chronic kidney disease (CKD) is a chronic complication of diabetes, characterized by the presence of pathological quantities of urine albumin excretion and/or accompanied by a gradual deterioration in the glomerular filtration rate (GFR). (medsci.org)
  • Coresh J., Chronic Kidney Disease Prognosis Consortium None. (ox.ac.uk)
  • The prevalences of chronic kidney disease (CKD) and end-stage renal disease (ESRD) are continuously increasing around the world. (biomedcentral.com)
  • Cockcroft-Gault versus modification of diet in renal disease: importance of glomerular filtration rate formula for classification of chronic kidney disease in patients with non-ST-segment elevation acute coronary syndromes. (wustl.edu)
  • Formula agreement was shown continuously and by chronic kidney disease (CKD) stages. (wustl.edu)
  • Chronic kidney disease (CKD) is defined according to the presence or absence of kidney damage and level of kidney function -- irrespective of the type of kidney disease. (medscape.com)
  • The continuing disadvantage is evident in the higher incidence, prevalence, morbidity and mortality of chronic kidney disease (CKD) among First Nations Australians. (mja.com.au)
  • The resultant social injustices continue to affect the determinants of health, leading to subsequent chronic disease. (mja.com.au)
  • The incidence, prevalence and burden of chronic kidney disease (CKD) in First Nations Australians is one of the highest in the world, which is reflective of the social gradient of disadvantage. (mja.com.au)
  • Addressing the social determinants of health to achieve equity has been emphasised by the World Health Organization 3 and underpins chronic disease prevention. (mja.com.au)
  • Background: There is an increasing recognition of epidemics of primarily tubular-interstitial chronic kidney disease (CKD) clustering in agricultural communities in low- and middle-income countries (LMICs). (lu.se)
  • International comparisons have provided the first steps in understanding many chronic diseases, but such comparisons rely on the. (lu.se)
  • Rates of anemia among agricultural workers, who are also at risk for kidney injury and chronic kidney disease of unknown cause (CKDu), are unknown. (cdc.gov)
  • Anemia was present among 13% of workers, 70% of which were normochromic normocytic, a type of anemia suggesting potential underlying chronic disease. (cdc.gov)
  • Association Between Proton Pump Inhibitor Use and Risk of Progression of Chronic Kidney Disease. (janusinfo.se)
  • Evans M, Carrero JJ, Bellocco R, Barany P, Qureshi AR, Seeberger A, Jacobson SH, Hylander-Rössner B, Rotnitzky A, Sjölander A. Initiation of erythropoiesis-stimulating agents and outcomes: a nationwide observational cohort study in anaemic chronic kidney disease patients. (janusinfo.se)
  • Persistent proteinuria (increased protein within the urine) is a hallmark characteristic of glomerular disease. (pethealthnetwork.com)
  • If a dog demonstrates persistent proteinuria (repeatable on multiple tests over the course of a few weeks), a battery of tests is typically recommended to rule out non-glomerular causes of excess protein within the urine such as urinary tract infection , stones, or bleeding. (pethealthnetwork.com)
  • Nephrotic syndrome is typically caused by diseases which damage the filtration barrier at the glomerular basement membrane and is defined by a triad of proteinuria, hypoalbuminemia and oedema. (shiken.ai)
  • Laboratory analysis of the urine from people who have glomerular disease often shows protein in the urine (proteinuria) and blood in the urine (hematuria). (unckidneycenter.org)
  • Sparc was detected early before the onset of proteinuria and continued to increase throughout the course of the disease. (tmu.edu.tw)
  • However, the results contribute to the understanding of the poor renal survival in patients with glomerular diseases and nonselective proteinuria. (uaeu.ac.ae)
  • Minimal change disease causes abrupt onset of edema and heavy proteinuria, mostly in children. (msdmanuals.com)
  • The renal manifestations of SCD range from various tubular and glomerular functional abnormalities to gross anatomic alterations of the kidneys. (medscape.com)
  • Glomerulopathies can further be classified as primary or secondary, with primary diseases directly affecting the kidneys and secondary diseases caused by another disease or process. (shiken.ai)
  • Glomerular diseases include a number of conditions that can damage the kidneys' filtering units, the glomeruli, resulting in protein and red blood cells leaking into the urine. (mayocliniclabs.com)
  • We envision a future where all people with glomerular kidney disease can access accurate, early diagnosis and suitable treatment to preserve the health of their kidneys. (is-gd.org)
  • [ 2 ] As people with SCD grow older, the kidneys progress to end-stage renal disease (ESRD). (medscape.com)
  • Large kidneys are associated with diseases such as early diabetic nephropathy, multiple myeloma, polycystic kidney disease, and human immunodeficiency virus (HIV)-associated glomerulonephritis. (medscape.com)
  • The glomerular filtration rate measurement comes from the name of the filtering units inside your kidneys, called the glomeruli. (healthline.com)
  • Glomerulonephritis is a type of kidney disease in which the part of your kidneys that helps filter waste and fluids from the blood is damaged. (medlineplus.gov)
  • The condition causes the immune system to mistakenly attack a specific part of the kidneys called the glomerular basement membrane (GBM) with IgG-antibodies, severely damaging the kidneys and in some cases the lungs. (hansabiopharma.com)
  • Albumin measurements are used in the diagnosis and treatment of diseases involving the liver and/or kidneys. (cdc.gov)
  • Podocyte injury is central to many forms of kidney disease, but transcriptional signatures reflecting podocyte injury and compensation mechanisms are challenging to analyze in vivo. (jci.org)
  • Classic FSGS is characterized by glomerular hypertrophy, glomerular capillary hypertension, podocyte damage, and mesangial destruction. (medscape.com)
  • Patients with renal involvement had a significantly shorter disease duration compared with patients without renal abnormalities. (nephronpower.com)
  • Point mutations in the WT1 gene result in loss of its regulatory function, with the consequent abnormalities in glomerular formation and gonadal differentiation seen in Denys-Drash syndrome. (medscape.com)
  • Mutations that disrupt the second alternative splicing site of the WT1 gene alter the normal ratio of KTS-positive/negative isoforms from 2:1 to 1:2 and result in abnormalities in glomerular formation and gonadal differentiation seen in Frasier syndrome. (medscape.com)
  • The primary management goals in sickle cell nephropathy (SCN) are the prevention of complications and the reduction of morbidity, primarily from progression to end-stage renal disease (ESRD). (medscape.com)
  • Genetic factors such as APOL-L1 mutations are associated with an increased risk of FSGS and progression to end-stage kidney disease. (shiken.ai)
  • Our menu of clinically validated assays assists with diagnosis, monitors disease progression, and guides clinical outcomes. (mayocliniclabs.com)
  • However, with early diagnosis and careful management, you may be able to at least slow down the progression of your kidney disease. (healthline.com)
  • Thus, the aim of this study was to determine whether ERT in patients with advanced Fabry disease affects progression towards 'hard' clinical end-points in comparison with the natural course of the disease. (nih.gov)
  • Although the pathogenesis of CKD remains unclear, evidence indicates that early recognition and interventions may delay the progression to ESRD and cardiovascular disease [ 3 ]. (medsci.org)
  • Proteinuric glomerular diseases often are associated with tubulointerstitial injury, which imposes on the progression of renal failure. (uaeu.ac.ae)
  • Nephropathy: Patients with Denys-Drash syndrome develop early-onset nephrotic syndrome, have a high prevalence of severe hypertension, and experience rapid progression to end-stage renal disease (ESRD). (medscape.com)
  • Sixteen patients (27%) had laboratory evidence of tubular and/or glomerular dysfunction. (nephronpower.com)
  • Blood cadmium and moderate-to-severe glomerular dysfunction in Korean adults: analysis of KNHANES 2005-2008 data. (cdc.gov)
  • Purpose: The objective of this study was to evaluate the association between blood cadmium (Cd) and moderate-to-severe glomerular dysfunction in a Korean population using a representative sample. (cdc.gov)
  • Methods: A cross-sectional study was used to evaluate the association between blood Cd and glomerular dysfunction. (cdc.gov)
  • A clear-cut diagnosis of glomerular disease requires a kidney biopsy. (pethealthnetwork.com)
  • More importantly, detection of Sparc, OPN and Lcn2 in urine may mean that these molecules could serve as important biomarkers for non-invasive diagnosis of glomerular crescents. (tmu.edu.tw)
  • Creatinine measurement is useful in the diagnosis and treatment of renal diseases, in monitoring renal dialysis, and as a calculation basis for other urinary analytes (e.g., total protein and microalbumin). (cdc.gov)
  • When describing diseases of the glomerulus, terminology can be confusing. (shiken.ai)
  • Diseases that injure glomeruli (plural for glomerulus) are called glomerular diseases . (unckidneycenter.org)
  • Nephritic syndrome occurs due to inflammation and damage to endothelial cells of glomerular capillaries and can be triggered by several disease processes. (shiken.ai)
  • It is flanked by the podocytes and glomerular endothelial cells that both synthesize it and adhere to it. (wustl.edu)
  • The urinalysis may be falsely positive for protein, Additionally, it is not always sensitive enough to detect the very earliest stages of glomerular damage. (pethealthnetwork.com)
  • Measurements of urine concentrations of IgG, albumin, and protein HC were performed in 56 proteinuric patients (33 males and 23 females) with nondiabetic glomerular diseases at the time of the diagnostic renal biopsy and at a mean of 49 follow-up months. (uaeu.ac.ae)
  • The findings of the study suggest that the urinary protein HC concentration correlates to the degree of IgG-uria but not to the degree of albuminuria during the course of proteinuric glomerular disease. (uaeu.ac.ae)
  • 3 g of protein/day due to a glomerular disorder plus edema and hypoalbuminemia. (msdmanuals.com)
  • I like to think of glomeruli as a tiny sieve or colander because the size of glomerular pores dictate which substances within the blood are allowed to enter into the fluid that ultimately becomes urine . (pethealthnetwork.com)
  • Ten dogs which formed the control group, and 20 dogs which had elevated serum creatinine levels and a low urine specific gravity due to renal disease, constituted the study material. (vin.com)
  • After extensive crescent formation at week 9 of disease, cDNA microarray analysis was performed and highly expressed genes were evaluated as molecular markers by real-time reverse transcription-polymerase chain reaction (RT-PCR), in situ hybridization, immunohistochemistry and immunoassay of urine proteins. (tmu.edu.tw)
  • Various types of biospecimens are collected at baseline and during follow-up: serum, urine, buffy coat, stool, glomerular complementary DNA (cDNA), tubulointerstitial cDNA. (biomedcentral.com)
  • Albumin is lost in the urine of patients with minimal change disease more so than larger serum proteins, probably because the disease causes changes in the charge barrier that affect albumin selectively. (msdmanuals.com)
  • It is also associated with hypertension and cardiac disease. (cdc.gov)
  • Human kidney organoids derived from pluripotent stem cells (PSCs), a potentially new model for disease and regeneration, present an opportunity to explore the transcriptional plasticity of podocytes. (jci.org)
  • We conclude that cells in human PSC-derived kidney organoids reliably recapitulate the developmental transcriptional program of podocytes and other cell lineages in the human kidney and that transcriptional profiles seen in developing podocytes are reactivated in glomerular disease. (jci.org)
  • To understand glomerular disease, it's important to first understand glomeruli. (pethealthnetwork.com)
  • Glomerulonephropathies are diseases which cause inflammation in the glomeruli. (shiken.ai)
  • Diseases that injure the glomeruli are known as glomerular diseases. (unckidneycenter.org)
  • The disease was induced in (C57BL/6X DBA/2) F 1 hybrids by injection of DBA/2 lymphocytes leading to deposition of auto-antibodies in the glomeruli, and a lupus type of nephritis morphologically. (tmu.edu.tw)
  • Renal biopsies from nine patients showed tubulo ‐ interstitial nephritis in six and glomerular disease in three. (nephronpower.com)
  • A more recent study in CJASN looked at more number of patients and at least 24 biopsies of SS patients showing mostly tubular interstitial disease but the glomerular disease was a mixed bag: FSGS, mild mesangial sclerosis, MPGN, minimal change disease( 1 case), membranous, were the ones reported. (nephronpower.com)
  • No glomerular or interstitial signal was found with either antibody. (asn-online.org)
  • Surprisingly, marked glomerular and interstitial LRP1 expression was seen in all glomerulopathies. (asn-online.org)
  • Our findings demonstrate an association of interstitial LRP1 with glomerular disease and kidney development. (asn-online.org)
  • Hemolysis, vaso-occlusion, and ischemia-reperfusion injury are the clinical hallmarks of sickle cell disease (SCD). (medscape.com)
  • Extensive clinical, laboratory, and pathologic evaluation accurately identifies the underlying etiology of different types of glomerular disease. (mayocliniclabs.com)
  • We are bringing together glomerular experts to unite our subspecialty and address major challenges in clinical care. (is-gd.org)
  • There are currently more than 60 clinical trials in progress for glomerular disease-an unimaginable number just a few years ago. (is-gd.org)
  • To gain insight into pathophysiology and novel treatment targets of glomerular disease, various types of biospecimens linked to deep clinical phenotyping including clinical information, digital pathology, and well-defined outcomes are required. (biomedcentral.com)
  • To better understand the pathophysiology, biomarkers, and treatment targets of glomerular diseases and ultimately to improve clinical outcomes, it is imperative to translate and integrate research with various types of biospecimen linked to deep clinical phenotyping, including clinical information, self-questionnaires, digital pathology and outcomes from the electronic health record (EHR) and administrative data. (biomedcentral.com)
  • To that end, a multicentre prospective cohort based on deep clinical phenotypes, biospecimens, and digital pathology has been established in Korea, the 'KORNERSTONE', which is supported by the Korea Centers for Disease Control and Prevention (KCDC). (biomedcentral.com)
  • Hansa Biopharma AB, "Hansa" (Nasdaq Stockholm: HNSA), today announces its decision to initiate a pivotal Phase 3 clinical study of imlifidase to treat anti-GBM disease, following a successful pre-IND (Investigational New Drug) meeting with the U.S. Food and Drug Administration (FDA). (hansabiopharma.com)
  • The planned pivotal Phase 3 clinical study is expected to enroll approximately 50 patients with anti-GBM disease across the U.S. and Europe and is expected to enroll the first patient in 2022. (hansabiopharma.com)
  • See Wilms Tumor: A Pediatric Oncology Success Story , a Critical Images slideshow, to help identify the clinical features, staging evaluation, prognostic factors, and therapeutic options for this disease. (medscape.com)
  • Glomerular disease specialists around the world lead these efforts in all aspects of research and treatment, and form a vital subspecialty of nephrology. (is-gd.org)
  • The International Society of Glomerular Disease is a medical society founded in 2022 to provide a physician- and researcher-centric professional home for glomerular disease experts. (is-gd.org)
  • Immunohistochemistry with two antibodies targeted towards the intracellular and extracellular domains of LRP1 were used to assess spatial distribution of LRP1 in healthy human renal tissue and in biopsies of minimal change disease, focal segmental glomerulosclerosis, and membranous nephropathy. (asn-online.org)
  • BACKGROUND AND OBJECTIVES: Shared decision making in patients with glomerular disease remains challenging because outcomes important to patients remain largely unknown. (monash.edu)
  • We offer comprehensive renal testing services and concise results to deliver answers your practice needs to increase accuracy and improve outcomes for glomerular diseases. (mayocliniclabs.com)
  • Prompt identification of antineutrophil cytoplasmic antibodies, vasculitis, and anti-glomerular basement membrane antibodies allows for early initiation of treatment and may improve patient outcomes. (mayocliniclabs.com)
  • The primary outcomes are mortality and end-stage renal disease. (biomedcentral.com)
  • The rationale for including individuals with GFR ≥ 60 mL/min/1.73 m 2 is that GFR may be sustained at normal or increased levels despite substantial kidney damage and that patients with kidney damage are at increased risk for the 2 major outcomes of CKD: loss of kidney function and development of cardiovascular disease. (medscape.com)
  • Mutations that affect the GBM's collagen α3α4α5(IV) components cause Alport syndrome (kidney disease with variable ear and eye defects) and its variants, including thin basement membrane nephropathy. (wustl.edu)
  • Increased microalbuminuria is a sign of renal disease and may be predictive of nephropathy risk in patients with type 1 and type 2 diabetes. (cdc.gov)
  • This positive outcome served as Proof of Concept (PoC) for the potential of imlifidase to treat IgG-mediated serious autoimmune diseases. (hansabiopharma.com)
  • The FDA's valuable insight and guidance at the pre-IND meeting paves the way for Hansa to potentially bring a new treatment to patients with anti-GBM disease, a devastating autoimmune condition," says Christian Kjellman, Chief Scientific Officer at Hansa Biopharma. (hansabiopharma.com)
  • Anti-GBM disease is the first IgG-mediated disease outside transplantation where imlifidase has been shown to halt an ongoing autoimmune injury. (hansabiopharma.com)
  • Patients with CKD are at a high risk of cardiovascular disease and mortality and are associated with increased treatment costs [ 2 ]. (medsci.org)
  • Identifying the presence and stage of CKD in an individual is not a substitute for accurate assessment of the cause of kidney disease, extent of kidney damage, level of kidney function, comorbid conditions, complications of decreased kidney function, or risks for loss of kidney function or cardiovascular disease in that patient. (medscape.com)
  • The researchers suggest that loss of glomerular EHD3 expression in diabetes may lead to aberrant GNeC fenestration regulation and a consequent decline in glomerular filtration function. (nature.com)
  • As you advance through the stages of kidney disease, you will notice more and more symptoms, and your treatments may need to become more intense. (healthline.com)
  • However, the discovery of pathognomonic biomarkers and disease-specific therapeutic targets for glomerular diseases is limited. (biomedcentral.com)
  • The main outcome was a composite of stroke, end-stage renal disease (ESRD) and death. (nih.gov)
  • It affects approximately 20-40% of patients with diabetes mellitus and is recognized as the most common cause of end-stage renal disease (ESRD) [ 1 ]. (medsci.org)
  • Yet crucial needs of many patients with glomerular disease remain unmet. (is-gd.org)
  • The successful outcome of the meeting with the FDA marks an important milestone for Hansa Biopharma's efforts to develop potentially lifesaving and life-altering therapies for patients with rare immunological diseases where there is a significant unmet medical need. (hansabiopharma.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Glomerular damage may be present at the very earliest onset of kidney disease, well before there are other measurable laboratory changes or symptoms typically associated with kidney disease. (pethealthnetwork.com)
  • The adverse event may be an unfavourable or unintended sign, abnormal laboratory finding, symptom or disease. (medsafe.govt.nz)
  • Primary or secondary to HIV, drugs (e.g. pamidronate), urinary reflux, sickle cell disease. (shiken.ai)
  • The KORNERSTONE, which has been initiated by Korea Centres for Disease Control and Prevention, is designed as a multi-centre, prospective cohort study and biobank for glomerular diseases. (biomedcentral.com)
  • Alport's syndrome), metabolic stress (e.g. diabetes mellitus,), deposi-tion of extraneous materials (e.g. amyloid), or other direct injury to glomerular cells. (enetmd.com)
  • Reduced glomerular filtration in diabetes is attributable to loss of density and increased resistance of glomerular endothelial cell fenestrations. (nature.com)