Furthermore, urinary Clusterin may also help to differentiate between tubular and glomerular forms of proteinuria. (biovendor.com)
While tubular and glomerular functions generally remain intact, pre-renal AKI may be caused by systemic hypoperfusion (decreased blood flow) or selective hypoperfusion to the kidney, caused by renal artery stenosis or aortic dissection 3 . (randox.com)
Renal3
Another interesting observation obtained in rat model suggests that measurement of urinary Clusterin levels may be a useful clinical marker for the severity of renal tubular damage. (biovendor.com)
citation needed] Kidney ischemia can be diagnosed by checking the levels of several biomarkers such as clusterin and cystatin C. While the duration of ischemia was used as a biomarker, it was found that it has significant flaws in predicting renal function outcomes. (wikipedia.org)
Blood pressure in the glomerulus is high, causing water and dissolved substances to filter out the blood in the glomerular capillaries, across the Bowman's capsule and into the renal tubules. (randox.com)
Diabetic2
Recent study demonstrates, that serum Clusterin level increases significantly in diabetic type II patients and in patients with developing coronary heart disease, or myocardial infarction. (biovendor.com)
First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro. (universiteitleiden.nl)
Protein1
Moreover, it was proposed that Clusterin functions as an extracellular chaperon that stabilizes stressed proteins in a folding-competent state, and that the protein is involved in programmed cell death. (biovendor.com)
Functions1
Due to its wide breath of tissue distribution many diverse physiological functions have been attributed to Clusterin including sperm maturation, membrane recycling, lipid transportation, tissue remodelling, complement inhibition and cell-cell or cell-substratum interactions. (biovendor.com)
Levels4
These data raise the possibility that elevated Clusterin levels in serum may represent a strong indication of vascular damage. (biovendor.com)
In patients with systemic lupus erythematosus (SLE), reduced serum Clusterin levels correlated inversely with disease activity. (biovendor.com)
Lowered Clusterin levels could be involved in the pathogeneses of SLE on account of decreased protective effects. (biovendor.com)
Kropáčková T, Šléglová O, Růžičková O, Vencovský J, Pavelka K, Šenolt L. Lower serum clusterin levels in patients with erosive hand osteoarthritis are associated with more pain. (biovendor.com)
Data1
42 A. Conventional theories of glomerular barrier size selectivity cannot fully explain these data since they would predict that our patients would have had nephrotic range proteinuria. (jci.org)
Filtration5
Comparison of equations for estimating glomerular filtration rate in screening for chronic kidney disease in asymptomatic black Africans: a cross sectional study. (medscape.com)
GlycA, a marker of protein glycosylation, is related to albuminuria and estimated glomerular filtration rate: the ELSA-Brasil study. (medscape.com)
Prevalence and determinants of differences in cystatin C and creatinine-based estimated glomerular filtration rate in community-dwelling older adults: a cross-sectional study. (medscape.com)
Podocytes are a specialized type of epithelial cell that encase the glomerular capillaries with interdigitated foot processes to regulate filtration into the nephron [ 8 ]. (biomedcentral.com)
Since renal cell arrest usually occurs 24-48 h before sCr rises due to a significant fall in the glomerular filtration rate, TIMP-2 and IGFBP7 are thought to be earlier AKI biomarkers than sCr. (springeropen.com)
Cystatin1
citation needed] Kidney ischemia can be diagnosed by checking the levels of several biomarkers such as clusterin and cystatin C. While the duration of ischemia was used as a biomarker, it was found that it has significant flaws in predicting renal function outcomes. (wikipedia.org)
Renal2
One tempting hypothesis says that clusterin is an extracellular chaperone protecting cells from stress induced by degraded and misfolded protein precipitates.Clus-terin is up- or downregulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others. (biovendor.com)
Persistent hematuria in patients with antineutrophil cytoplasmic antibody-associated vasculitis during clinical remission: chronic glomerular lesion or low-grade active renal vasculitis? (medscape.com)
12. Analysis of TNF-mediated recruitment and activation of glomerular dendritic cells in mouse kidneys by compartment-specific flow cytometry. (nih.gov)