Globular proteins protein residues. Medical search. Frequent questions

The C-terminus end of the superhelix expands away from the axis with polar and charged residues from each monomer experiencing electrostatic repulsion from like residues in the other monomers. (callutheran.edu)
The residue affinity potential encodes the arrangement of hydrophobic, polar and charged residues in a simple potential term. (nih.gov)

Major conformational differences are confined to the lid loop (residues 14-27). (rcsb.org)
In the statistics of short-range distances, a mean distance D k and its standard deviation S k are calculated for each value of k, with and without taking into account the conformational states of all residues from i to i+k (factors 1 and 3). (elsevierpure.com)
As an Appendix, the relations for converting from the distances between residues into other conformational parameters are discussed. (elsevierpure.com)
Although many of the original hemagglutinin residues are lost in this digestion, the major conformational change caused by the acidic environment in the endosome is clear when one compares the conformation of the original HA 2 subunit (BHA-left) to that of TBHA 2 (right). (callutheran.edu)

These scales are commonly used to predict the transmembrane alpha-helices of membrane proteins. (wikipedia.org)
The Membrane Transport Proteins are a type of globular proteins that transports macromolecules & small molecules across the biological membrane just like a shuttle vehicle. (biokimicroki.com)
Some globular proteins are anchored in the membrane, these type of globular proteins are called as Membrane Globular Protein. (biokimicroki.com)
Omp alpha is an outer-membrane protein that spans the periplasmic space of the hyperthermophilic eubacterium Thermotoga maritima. (unboundmedicine.com)
The sequence of the rod domain resembles that of coiled coil proteins and ends in a transmembrane segment that anchors Omp alpha to the outer membrane. (unboundmedicine.com)
Most PDZ domain-containing proteins spend at least part of their time in membrane-associated complexes. (eu.org)
Many PDZ ligands are themselves membrane proteins. (eu.org)
Several PDZ domain containing proteins include multiple domain copies (MPDZ/MUPP1 and MAGI2 contain 13 and 6 PDZ domain instances respectively), acting as scaffolds, recruiting multiple PDZ domain binding proteins and facilitating the construction of large membrane-associated complexes. (eu.org)
Certain proteins are enriched in dehydrons such as membrane proteins, toxic proteins and proteins that have a strong tendency to aggregate. (pymol.org)
The elongate hemagglutinin protein is a tr im er that measures ~135 Å from insertion in the envelope membrane to its tip. (callutheran.edu)
The HA 1 subunit (328 residues) is an elongate structure reaching from the N-terminus at the viral membrane end of the molecule along the stem of the subunit before forming a globular tip. (callutheran.edu)
Biological proteins are usually classified as fibrous, membrane and globular. (creation.com)
Membrane proteins probably make up the majority of all proteins found in the cell. (creation.com)
The structure of membrane proteins, however, is completely different when embedded in a membrane as to when in aqueous solution. (creation.com)
This makes it very difficult to study and characterize membrane proteins in their relevant state. (creation.com)

cysteine residues and arginine residues are their most susceptible targets, respectively. (frontiersin.org)
whereas there was a 4.6-fold enrichment of arginine residues, suggesting SARS-CoV-2 is resistant to oxidative agents and sensitive to MG. For arginine residues of the SARS-CoV-2 coronavirus predicted to be in functional domains, we examined which are activated toward modification by MG - residues with predicted or expected low pK a by neighboring group in interactions. (frontiersin.org)
We found 25 such arginine residues, including 2 in the spike protein and 10 in the nucleoprotein. (frontiersin.org)
Each of the largely globular histone proteins possesses a characteristic tail which is densely populated with lysine and arginine residues, which are subject to extensive post-translational modifications that cooperate to govern the chromatin state. (crbdiscovery.com)

PDZ domains are ~90 residue globular protein modules that can be found in eukaryotic regulatory proteins. (eu.org)
Histones are the primary protein components of chromatin, the complex of DNA and protein found in eukaryotic cells. (crbdiscovery.com)

Both the second and fourth scales place cysteine as the most hydrophobic residue, unlike the other two scales. (wikipedia.org)
The Trp-1 motif has a pattern such as W(ACGILV)$ ( Ernst,2014 , Stegmuller,2003 ), with the C-terminal hydrophobic residue forming a canonical interaction with the binding site in the PDZ domain, and tryptophan in position -1 forming hydrophobic interactions with the residues in the neighbouring β-sheet in the domain ( 1ZUB , 3R0H , 2LA8 , 3SHW ). (eu.org)

Two different fusion constructs were made and crystallised, one with an eight amino acid residue linker and one with a linker of only two residues. (rcsb.org)
Key to characterizing the vulnerability of the viral proteome to reactive metabolites, ROS and MG, is location of their susceptible amino acid residue targets in functional domains of viral proteins and activation of these residues toward reaction with reactive metabolites. (frontiersin.org)

The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. (nih.gov)
DNA sequence analysis of the region encoding the terminal protein and the hypothetical N-gene product of adenovirus type 2. (microbiologyresearch.org)
Sequence alignments indicated conservation of the ephrin-B2 and ephrin-B3 receptor binding sites, the glycosylation site on the G attachment protein, as well as the editing site in phosphoprotein, suggesting production of nonstructural proteins V and W, known to counteract the host innate immunity. (cdc.gov)
Ubiquitin is a protein of 76 amino acid residues, found in all eukaryotic cells and whose sequence is extremely well conserved from protozoan to vertebrates. (embl.de)
Rigidly folded proteins can be solved in high-resolution crystal, cryo-EM or NMR structures that can be described by a simplified hierarchy of elements of increasing length from primary structure (sequence of single amino acid) over secondary structure elements (α-helices and β strands of ~10 residues) to tertiary structure (folded domains of ~100 residues) and quaternary structures (i.e. assemblies of several folded proteins). (nature.com)
The sequence of the globular domain is homologous to a conserved region of cell wall-bound proteins and probably attaches Omp alpha to the peptidoglycan. (unboundmedicine.com)
The tight sequence/structure relationship governing protein folding does not seem to apply to amyloid fibril formation because many proteins without any sequence relationship have been shown to assemble into very similar Î²-sheet-enriched structures. (ibecbarcelona.eu)
DBR-protein complexes were collected from the Protein Data Bank for which two or more DBRs having different amino acid sequences bind to the same (100% sequence identical) globular protein partner, a type of interaction herein called many-to-one binding. (usf.edu)
They used the same Bruker AVANCE NEO spectrometer and probe set up as in their previous study, and they were able to assign the chemical shifts of C' and N atoms in peptide bonds along the backbone of alpha-synuclein, obtaining information on the amino acid sequence along the protein backbone. (bruker.com)
WRKY proteins, defined by the conserved WRKYGQK sequence, are comprised of a large superfamily of transcription factors identified specifically from the plant kingdom. (ovid.com)

The list of proteins shown to form so-called functional amyloid fibers in vivo has greatly expanded over the years, but detailed structural insights have not followed at a similar pace in part due to the associated experimental barriers. (nature.com)
These disease-associated amyloids have in common that they represent a non-functional and off-pathway misfolding and aggregation event of proteins or protein fragments destabilized from reaching their native structure by mutation, environmental conditions or misprocessing. (nature.com)
The specific functional structure of natural proteins is determined by the way in which amino acids are sequentially connected in the polypeptide. (ibecbarcelona.eu)

To the best of our knowledge, all currently described amyloid structures consist of a repetitive stacking of intricate, serpentine, planar β-strand arrangements that are stabilized by steric zipper motifs wherein interdigitated residue side chains make extensive Van der Waals, electrostatic, hydrophobic and hydrogen bonding contacts. (nature.com)
Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. (bvsalud.org)
Recombinant murine VEGF165 is a 39.0 kDa disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains. (bioworlde.com)
Insulin is a protein that is composed of 51 Amino Acids and have two chains which are linked by Disulfide Bond. (biokimicroki.com)
It is the oxygen transporting protein of red blood cells which consists 2 Alpha and 2 Beta chains. (biokimicroki.com)
Each of the three subunits comprises two chains produced by proteolytic cleavage of a monomeric precursor protein. (callutheran.edu)
The aliphatic index predicts regional stability by calculating the relative volume occupied by aliphatic side chains and is a positive indicator of globular protein thermostability. (dnastar.com)
Residue hydropathy assignments are derived from water-vapor transfer free energies and the interior-exterior distribution of residue side-chains. (dnastar.com)
Contrary to this opinion, it was alleged that protein folds are very common among random amino acid chains. (creation.com)
Coupling within protein chains is also higher than coupling within rRNA chains indicating the more compact globular structures of proteins than rRNAs. (itu.edu.tr)

product with image In 1 download the modern world system iii: the second era hydrogen, 120 trials, 30 personal aggregation-prone girls, or 1 HD court View unhealthy organization for Every tablet acid Dynamic structure s have you to convey the mobile knowledge and shape challenge Time Rewind - using your credits and about Buy an physical protein! (thesilverbullet.us)
Here, we have characterized the aggregation kinetics, seeding ability, morphology, conformation, stability, and toxicity of amyloid fibrils formed by a 20-residue domain of the islet amyloid polypeptide (IAPP), as well as of a backward and scrambled version of this peptide. (ibecbarcelona.eu)

The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. (nih.gov)
To highlight the increased structural content extracted from 2DIR spectra a similar analysis was also carried out using conventional infrared absorption of the proteins in the library. (rsc.org)
Interestingly, 14-3-3 proteins share structural homology with α-syn [ 53 ] and also accumulate in LBs. [ 54 ] 14-3-3 proteins and α-syn can also be coimmunoprecipitated from mammalian brains. (medscape.com)
It provides a structural basis to artificially trimerise longer adenovirus shaft segments and segments from other trimeric beta-structured fibre proteins. (rcsb.org)
NMR contributions to structural dynamics studies of intrinsically disordered proteins' - Konrat R, Journal of Magnetic Resonance, 2014. (bruker.com)
These results provided us with structural information to understand the mechanism of transcriptional control and signal transduction events of the WRKY proteins. (ovid.com)
The structural basis for the effects of mutating F56 to different residues on dimer stability and function has been reported (Codreanu et al. (nih.gov)

A survey of the different roles of polyoxometalates in their interaction with amino acids, peptides and proteins. (uni-bielefeld.de)

Actin is common globular protein that is found in all the eukaryotic cells. (biokimicroki.com)

however, monomeric DT is compact and globular as compared to the "open" monomer within dimeric DT (Bennett MJ, Choe S, Eisenberg D, 1994b, Protein Sci 3:0000-0000). (nih.gov)
Residues from one side of this a -helix and from residues near the top of the jelly roll form a pocket that is the sialic acid binding site for each monomer of the hemagglutinin trimer. (callutheran.edu)
The fluorescence and far-UV CD properties of the double mutant as well as the kinetics of amide H/D exchange along the polypeptide backbone suggest that the monomer has a globular structure that is similar to a single subunit in the native protein. (nih.gov)

In addition, the stability of this globular protein is analyzed in terms of the interactions between hydrophobic parts of the subunits. (rcsb.org)
Residues in position alpha are shifted to occupy a position halfway between positions alpha and d (x layers) and residues in positions d and e are shifted so that both participate in core packing interactions (da layers). (unboundmedicine.com)
Apart from ligand positions 0, -1 and -2 being strong determinants of specificity, the neighbouring residues can undoubtedly contribute to specificity and affinity of the interactions ( Ernst,2014 ). (eu.org)
In brief, the researchers have focused on the interactions characterised by the binding of an α-helix of one of the proteins on the surface of the other. (irbbarcelona.org)
Our work proposes a simple way to block interactions between globular proteins mediated by α-helices and it can benefit both protein engineering and drug development efforts," explains Dr. Salvatella , head of the Molecular Biophysics Laboratory at IRB Barcelona. (irbbarcelona.org)
It's an approach based on research performed by our lab addressing the natural interactions of certain proteins, and it proposes using this knowledge to achieve therapeutic objectives through the design of small molecules with artificial sequences," he adds. (irbbarcelona.org)
Disordered binding regions (DBRs), which are embedded within intrinsically disordered proteins or regions (IDPs or IDRs), enable IDPs or IDRs to mediate multiple protein-protein interactions. (usf.edu)
Embp-Fn interactions preferentially occur with surface-bound, but not folded, globular Fn via binding to the F3 domain. (pasteur.fr)
Both F- and FG-repeat possess Fn-binding capacity via interactions with type III subdomain FN12, involving residues within the C and F β-sheet. (pasteur.fr)
Globular proteins have been the best studied, being easier to isolate in vitro , separated from other cellular bio-chemical interactions. (creation.com)
The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. (lookformedical.com)

scales was to examine proteins with known 3-D structures and define the hydrophobic character as the tendency for a residue to be found inside of a protein rather than on its surface. (wikipedia.org)
Sixteen proteins with known crystal structures were used to construct a library of 2DIR spectra , and the fraction of residues in α-helix, β-sheet, and unassigned conformations was determined by singular value decomposition (SVD) of the measured two-dimensional spectra . (rsc.org)
The method was benchmarked by removing each individual protein from the set and comparing the composition extracted from 2DIR against the composition determined from the crystal structures. (rsc.org)
MolView offers a simple search interface to find small molecules, proteins and crystal structures in these databases. (divched.org)
The structure of the core is well defined with an average backbone atomic r.m.s. difference of 2.3 +/- 0.3 A between the final eight converged restrained dynamics structures and the mean structure obtained by averaging their coordinates best fitted to the core residues. (nih.gov)
9 To function at all, and reliably, globular proteins must fold into precise three dimensional structures. (creation.com)
In this thesis, residue interaction network, CG molecular dynamics (MD) simulations and anisotropic network model (ANM), which all use reduced representations of the structures based on one-bead coarse-graining, are employed. (itu.edu.tr)
A subclass of ANTIFREEZE PROTEINS that are globular, 6.5 kDa in size and contain compact beta-sheet structures. (lookformedical.com)

A remarkable feature of the HA 2 subunit (221 residues) is the two antiparallel a -helices that form part of the stem of the molecule. (callutheran.edu)

This type of Globular proteins catalyzes the organic reactions within an organism in mild conditions and with a great specificity. (biokimicroki.com)
The terminal residue is apparently always hydrophobic with the -2 or -1 positions being strong determinants of specificity. (eu.org)
For instance, the specificity of a PDZ ligand can also be defined by a tryptophan in position -1, which forms a hydrophobic interaction with the residues in the neighbouring β-sheet in the domain, without forming a β-strand. (eu.org)

The polypeptide fold of the globular domain of histone H5 in solution. (nih.gov)
The polypeptide fold of the 79-residue globular domain of chicken histone H5 (GH5) in solution has been determined by the combined use of distance geometry and restrained molecular dynamics calculations. (nih.gov)

The latter is mediated by the covalent conjugation of ubiquitin to target proteins, by an isopeptide linkage between the C-terminal glycine and the epsilon amino group of lysine residues in the target proteins. (embl.de)
PDZ domains recognize short sequences at the carboxy terminus of target proteins. (eu.org)

Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. (lookformedical.com)
The best characterised PDZ ligands (PBMs, PDZ-Binding Motifs) are short C-terminal peptides that bind in a surface groove of PDZ domains of proteins as a part of a variety of biological processes including cell signalling and synapse. (eu.org)
The molecules addressed in this work, like many commonly used drugs, mimic this site on the surface of one of the proteins involved in the Interaction, such that they "compete" to bind to the site of the other protein, which is also referred to as the target protein. (irbbarcelona.org)
Detailed differences between monomeric and dimeric DT are described, particularly (1) changes in main-chain conformations of 8 residues acting as a hinge to "open" or "close" the receptor-binding (R) domain, and (2) a possible receptor-docking site, a beta-hairpin loop protruding from the R domain containing residues that bind the cell-surface DT receptor. (nih.gov)
Enveloped viruses use use spike proteins as molecular mimics of host molecules in order to bind to target cell receptors and gain entry into cells. (callutheran.edu)
Proteins that bind to ice and modify the growth of ice crystals. (lookformedical.com)

[1] [2] Almost all enzymes are proteins . (wikidoc.org)
enzymes in meat tenderizers break down proteins, making the meat easier to chew). (wikidoc.org)
Many early workers noted that enzymatic activity was associated with proteins, but several scientists (such as Nobel laureate Richard Willstätter ) argued that proteins were merely carriers for the true enzymes and that proteins per se were incapable of catalysis. (wikidoc.org)
Thousands of globular proteins are critically important, and are used as enzymes and for other purposes 8 . (creation.com)

FN12 essentially supports stability of the globular Fn state, and thus these findings reasonably explain why Embp-mediated interaction of S. epidermidis necessitates Fn surface immobilization. (pasteur.fr)

Hydrophobicity scales can also be obtained by calculating the solvent accessible surface areas for amino acid residues in the expended polypeptide chain or in alpha-helix and multiplying the surface areas by the empirical solvation parameters for the corresponding types of atoms. (wikipedia.org)
Approximately 16.4 KDa, a single non-glycosylated polypeptide chain containing 141 amino acid residues. (bioworlde.com)

Since cysteine forms disulfide bonds that must occur inside a globular structure, cysteine is ranked as the most hydrophobic. (wikipedia.org)
Ubiquitin is a globular protein, the last four C-terminal residues (Leu-Arg-Gly-Gly) extending from the compact structure to form a 'tail', important for its function. (embl.de)
An additional MenT3 structure was solved to 1.59 Å which was phosphorylated at S78, an important residue for MenA3 antitoxicity. (dur.ac.uk)
We present a method to quantitatively determine the secondary structure composition of globular proteins using coherent two-dimensional infrared ( 2DIR ) spectroscopy of backbone amide I vibrations (1550-1720 cm −1 ). (rsc.org)
Hemoglobin is a globular protein with Quaternary structure present on RBCs. (biokimicroki.com)
X-ray crystallographic studies of both fusion proteins shows that residues 319-391 of the adenovirus type 2 fibre shaft fold into a triple beta-spiral fold indistinguishable from the native structure, although this is now resolved at a higher resolution of 1.9 A. The foldon residues 458-483 also adopt their natural structure. (rcsb.org)
Welcome very it is early the easy few download the modern world system iii: the second era of great expansion of the capitalist world-economy, 1730s-1840s (studies book that wants at action in regulating structure n-3 but the grant that 17th assignment is related one everyday standing Exploration that does well Dispatched designed in the help and as such whose updates have protein first inflammatory reviews. (thesilverbullet.us)
What we propose in this work is to create molecules in the form of α-helices that offer a configurable surface to "fit" the target protein, and we explain how to ensure that this helix maintains a stable structure in the cellular context," explains Dr. Albert Escobedo , currently a postdoctoral researcher at the Center for Genomic Regulation (CRG), who led the work together with Dr. Salvatella at IRB Barcelona. (irbbarcelona.org)
The results confirm that, as for globular proteins, highly specific polypeptide sequential traits govern the assembly pathway, final fine structure, and cytotoxic properties of amyloid conformations. (ibecbarcelona.eu)
This tutorial concerns the structure/function/variability of the hemagglutinin spike protein of the human influenza virus. (callutheran.edu)
Schwieters, ``Using the experimentally determined components of the overall rotational diffusion tensor to restrain molecular shape and size in NMR structure determination of globular proteins and protein-protein complexes}{J. Am. Chem. (nih.gov)
At present, we do not fully understand the function, structure, and dynamics of intrinsically disordered proteins (IDP) in biological systems. (bruker.com)
The structure is composed of a core made up of residues 3-18, 23-34, 37-60 and 71-79, and two loops comprising residues 19-22 and 61-70. (nih.gov)
The structure of the core is dominated by three helices and has a similar fold to the C-terminal DNA binding domain of the cAMP receptor protein. (nih.gov)
The crystal structure of the AtWRKY1-C determined at 1.6 Å resolution has revealed that this domain is composed of a globular structure with five β strands, forming an antiparallel β-sheet. (ovid.com)
Based on this high-resolution crystal structure and site-directed mutagenesis, we have defined and confirmed that the DNA-binding residues of AtWRKY1-C are located at β2 and β3 strands. (ovid.com)
B. T. Miller and R. Schleif, Proteins: Structure, Function, and Bioinformatics , 81 (3) pp. 490-498 (2013). (nih.gov)
The analysis of E. coli crystal structure fluctuations has also shown that the protein components in the ribosomal complex are also in accord with experimental studies. (itu.edu.tr)
A subclass of ANTIFREEZE PROTEINS that have a cystine-rich globular structure of approximately 14 kD. (lookformedical.com)
This is referred to as the primary structure of proteins. (lookformedical.com)

Protein interaction studies indicated that the MenA-MenT family is comprised of multiple TA classes. (dur.ac.uk)
The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. (eu.org)
Scientists led by ICREA researcher Dr. Xavier Salvatella at IRB Barcelona have published guidelines for designing synthetic molecules that block the interaction between two proteins in the journal Nature Communications. (irbbarcelona.org)
The guidelines presented in this work allow scientists to develop molecules in a relatively straightforward manner that block (potentially) any interaction between a globular protein and an α-helix, thus offering high versatility. (irbbarcelona.org)
Thus, if the competitor molecule is present at a higher concentration or has a greater affinity for the target protein, it will occupy all the binding sites and block any possible interaction with the original protein that the drug is mimicking. (irbbarcelona.org)
However, the size of large protein interaction interfaces makes it difficult to mimic the binding surface between them. (irbbarcelona.org)
k-shortest path technique is applied to residue interaction networks. (itu.edu.tr)
ANM using normal mode analysis, residue interaction network model and k-shortest pathways calculations are performed by in-house codes. (itu.edu.tr)

As a preliminary to the localization of the receptor-binding site(s) on the Nipah virus (NiV) glycoprotein (NiV-G), we have undertaken the identification of NiV-G residues that play a role in fusion promotion. (nih.gov)
First, as NiV and Hendra virus (HeV) share a common receptor and their cellular tropism is similar, we hypothesized that residues functioning in receptor attachment could be conserved between their respective G proteins. (nih.gov)
Vac17p, a novel protein, is a component of the vacuole-specific receptor for Myo2p, a Saccharomyces cerevisiae myosin V. Vac17p interacts with the Myo2p cargo-binding domain, but not with vacuole inheritance-defective myo2 mutants that have single amino acid changes within this region. (silverchair.com)
In the first step of infection it binds to sialic acid residues of glycosylated receptor proteins on target cell surfaces. (callutheran.edu)
After binding to sialic acid residues of receptor proteins on host cells, the influenza virus is brought into the cell by endocytosis. (callutheran.edu)

Adenovirus fibres are trimeric proteins that consist of a globular C-terminal domain, a central fibrous shaft and an N-terminal part that attaches to the viral capsid. (rcsb.org)
5 Fibrous proteins are produced in the construction of hair, nails, tendons and ligaments. (creation.com)

Although it has been known that cleavage site and glycosylation patterns of the HA protein play important roles in determining the pathogenicity of H5 avian influenza viruses, it has only recently been shown that an additional glycosylation site within the globular head of the neuraminidase protein also contributes to the high virulence of the H5N1 virus. (chipready.com)

For the carboxy-terminal binding motifs, position 0 (assigned to the C-terminal residue) is always hydrophobic while the class is determined by the position -2 (third last) residue. (eu.org)
Previous investigations showed that DNA binding of the WRKY proteins was localized at the WRKY domains and these domains may define novel zinc-binding motifs. (ovid.com)
In rGSTM1-1, these motifs involve residues F56 and R81, respectively. (nih.gov)
Here, we show that the simultaneous disruption of both motifs in the F56S/R81A mutant causes complete dissociation of the dimer to a monomeric protein on the basis of gel filtration chromatography and multiple-angle laser light scattering. (nih.gov)

Intrinsically Disordered Regions (IDRs) are enriched in disease-linked proteins known to have multiple post-translational modifications, but there is limited in vivo information about how locally unfolded protein regions contribute to biological functions. (nature.com)
Intrinsically disordered regions (IDRs) within proteins often overlap with sites of alternative splicing and post-translational modifications (PTMs). (nature.com)

It is found that crystal contacts practically do not affect the conformation of the protein. (rcsb.org)
Such non-covalent molecular attractions are important forces in maintaining the folded conformation of a globular protein. (biokimicroki.com)
The data analyzed here are used in the optimization of an object function to compute protein conformation in a subsequent paper. (elsevierpure.com)
and the need for many protein sequences which fold into a single stable conformation. (creation.com)
It is of fundamental importance in determining PROTEIN CONFORMATION. (lookformedical.com)
This is the first folding level of protein conformation. (lookformedical.com)

The conservative amino acid change at residue 719 from alanine to valine results in a radical change in the properties of the polymerase, rendering the mutant enzyme resistant to PAA and various antiviral compounds. (microbiologyresearch.org)
[ 51 ] Mutations of these two serine residues to alanine prevented 14-3-3 proteins from interacting with LRRK2. (medscape.com)
A subclass of ANTIFREEZE PROTEINS that are 3-5 kDa in size and contain a single alanine-rich amphipathic alpha-helix. (lookformedical.com)

This means that if you have, for example, a dimeric protein you will probably get different results for the dimer and for the isolated monomers. (pymol.org)
Canonical glutathione (GSH) transferases are dimeric proteins with subunits composed of an N-terminal GSH binding region (domain 1) and a C-terminal helical region (domain 2). (nih.gov)

A subclass of ANTIFREEZE PROTEINS that contain four amphipathic alpha-helices folded into an antiparallel helix bundle. (lookformedical.com)

Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction. (nih.gov)

The main source of active molecules of milk consists of casein and whey proteins, which demonstrate a range of antimicrobial, antioxidant, and immunomodulatory properties, among others [ 14 ] . (encyclopedia.pub)
The model consists of 2 monomers in the asymmetric unit (1,046 amino acid residues), including 2 bound adenylyl 3'-5' uridine 3' monophosphate molecules and 396 water molecules. (nih.gov)

Cow's milk proteins are most frequently implicated as a cause of food intolerance during infancy. (medscape.com)
In the curd, 4 caseins (ie, S1, S2, S3, S4) can be identified that account for about 80% of the milk proteins. (medscape.com)
However, all milk proteins appear to be potential allergens, even those that are present in milk in trace amounts (eg, serum bovine albumin, immunoglobulins, lactoferrin). (medscape.com)
Cow's milk proteins introduced with maternal diet can be transferred to the human milk. (medscape.com)
Kazimierska, K. Milk Proteins. (encyclopedia.pub)
Milk Proteins" Encyclopedia , https://encyclopedia.pub/entry/11118 (accessed December 01, 2023). (encyclopedia.pub)

In order to map allosteric communications in the complexes, perturbation response scanning (PRS) and k-shortest pathways calculations are performed using the CGMD trajectories and the residue network model, respectively. (itu.edu.tr)

IDPs cannot be as straightforwardly classified in a simple hierarchy of modules of increasing length because the minimal unit, a single IDR, can vary in length from a few residues to thousands of residues. (nature.com)
In other words, such binding-coupled folding IDPs look similar to folded proteins as determined by (co)evolution statistical analysis. (nature.com)
A recent publication in ChemBioChem details how researchers from Italy used NMR spectroscopy to detect proline residues in IDPs. (bruker.com)
IDPs, like all proteins, can be subjected to a range of post-translational changes. (bruker.com)
A recent paper by scientists from Masaryk University in the Czech Republic describes how they used 1D 31 P NMR to detect the presence of phosphorylation modifications in IDPs, and 2D 1 H- 13 C, 1 H- 15 N HSQC experiments to identify the phosphorylated residues. (bruker.com)

These Proteins e.g., actin and tubulin, which are globular in shape and soluble as monomers, they polymerize to form long & stiff fibers and forms cellular skeleton. (biokimicroki.com)

1 Molecular Basis of Paramyxovirus Entry, INSERM U404, Centre d'Etudes de Recherche en Virologie et Immunologie, IFR 128 Biosciences Lyon-Gerland, 21 avenue Tony Garnier, 69365 Lyon cedex 07, France. (nih.gov)
[ 2 ] All these foods contain proteins with a small molecular weight, an abundance of epitopes, water solubility, glycosylation residues, and relative resistance to heat and digestion. (medscape.com)
Dehydrons have been invoked to explain biological processes above the molecular level such as the dosage imbalance effect in duplicated genes and the high connectivity of the protein interactomes of higher organisms. (pymol.org)
A Molecular Magnet Confined in the Nanocage of a Globular Protein", CHEMPHYSCHEM , vol. 11, 2010, pp. 389-393. (uni-bielefeld.de)
abstract = "Molecular dynamics simulation is used to model the adsorption of the barley lipid transfer protein (LTP) at the decane-water and vacuum-water interfaces. (hw.ac.uk)
Quantifying the effects of lossy compression on energies calculated from molecular dynamics trajectories," D. R. Roe and B. R. Brooks, Protein Science , 31 (12) (2022). (nih.gov)
Protein-Protein Docking Using Map Objects," X. Wu and B. R. Brooks, , In Molecular Docking and Molecular Dynamics . (nih.gov)
The ribosome is a molecular machine that catalyzes protein synthesis in three kingdoms of life. (itu.edu.tr)

They comprise a toxin protein, which interferes with an essential cellular process to inhibit growth, and an antitoxin, either sRNA or protein, which neutralises toxicity. (dur.ac.uk)
Finally, biochemical assays demonstrated that MenT3 and MenT4 inhibit protein synthesis in vitro, implicating translation as the cellular target. (dur.ac.uk)
They comprise 1% of total brain proteins and participate in a large variety of cellular functions by interacting with different protein partners. (medscape.com)
Messenger globular proteins transports the messages (cellular/chemical messages) to regulate any biological processes in Eukaryotic multicellular Organisms like Humans just like a postman. (biokimicroki.com)
Globular proteins also take part in cellular signaling and regulation. (biokimicroki.com)
The G-actin is the Globular actin which participates in many important cellular processes including muscle contraction during cell division, cell motility etc. (biokimicroki.com)
HN - 2018 FX - ATPases Associated with Diverse Cellular Activities MH - AAA Proteins UI - D000074582 MN - D8.811.277.40.13 MN - D12.776.157.25 MS - A large, highly conserved and functionally diverse superfamily of NTPases and nucleotide-binding proteins that are characterized by a conserved 200 to 250 amino acid nucleotide-binding and catalytic domain, the AAA+ module. (nih.gov)

MenT1, MenT3 and MenT4 are bi-lobed globular proteins which feature a shared toxin fold and conserved active site. (dur.ac.uk)
More importantly, the analysis of this and several other small domains or proteins supports the hypothesis that stable kinetic folding intermediates are not necessary for a protein to fold. (protabank.org)
The N-terminal (top) half of the coiled-coil superhelix is tightly packed with several nonpolar residues in van der Waals contact around the 3-fold axis. (callutheran.edu)

Influenza A virus has one of sixteen possible Hemagglutinin (HA) surface proteins and one of nine possible Neuraminidase (NA) surface proteins. (chipready.com)
The Hemagglutinin protein facilitates viral attachment while Neuraminidase is involved in viral release. (chipready.com)
H5N1 hemagglutinin interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. (chipready.com)
Hemagglutinin, displayed at left, is one of two virally-coded integral envelope proteins of the influenza virus. (callutheran.edu)

For bacterial amyloid pathways like curli and Fap, it is clear that accessory proteins ensure a timely and localized amyloid deposition, including chaperone-like safeguards that prevent or stop premature amyloidogenesis 9 , 10 . (nature.com)
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins. (lookformedical.com)

These proteins also elicit immune responses that prevent infection or independently reduce viral replication. (chipready.com)
In many cases, natural selection continually yields viral strains that vary considerably in the antigenic regions of spike proteins. (callutheran.edu)

When consecutively measuring amino acids of a protein, changes in value indicate attraction of specific protein regions towards the hydrophobic region inside lipid bilayer. (wikipedia.org)
We reasoned that IDRs should be more accessible to targeted in vivo biotinylation than ordered protein regions, if they retain their flexibility in human cells. (nature.com)
Many-to-one Binding by Intrinsically Disordered Protein Regions" by Wei-Lun Alterovitz, Eshel Faraggi et al. (usf.edu)
In particular, intermittent formation of short (six-residue) regions of {\ss}-sheet is found in these two systems. (hw.ac.uk)

Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. (nih.gov)
Extracellular matrix binding protein (Embp) and its subdomains referred to as the F-repeat and the FG-repeat are critical for adherence of S. epidermidis to surface-immobilized Fn. (pasteur.fr)

This is due to periodic omissions of three residues in the heptad repeat pattern ("stutters") whose effect is to locally distort the packing of hydrophobic layers in the core of the coiled coil. (unboundmedicine.com)

A Giant Extracellular Matrix Binding Protein of Staphylococcus epidermidis Binds Surface-Immobilized Fibronectin via a Novel Mechanism. (pasteur.fr)

The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. (nih.gov)
LRRK2 also binds to different isoforms of 14-3-3 proteins upon phosphorylation of 14-3-3 family proteins at residues S910 and S935. (medscape.com)
The sidechains of the ligand residues interact with a neighbouring α-helix in the PDZ domain, while the backbone of the ligand binds to the PDZ domain via β augmentation: it forms a β-strand with a neighbouring β-sheet in the domain ( Chi,2012 , Luck,2012 ). (eu.org)

Their 31 P spectra successfully confirmed two phosphorylation sites in their model peptide, while HSQC experiments identified tyrosine as the phosphorylated residue in their model protein. (bruker.com)
The two loops are also well defined locally but their orientation with respect to the core could not be determined as no long range ([i-j[ greater than 5) proton-proton contacts could be observed between the loop and core residues in the two-dimensional nuclear Overhauser enhancement spectra. (nih.gov)

A desolvated hydrogen bond is energetically more favourable than one exposed to the solvent and hence dehydrons are sticky , since they promote the removal of surrounding water through protein associations or ligand binding. (pymol.org)
The plug-in count as wrappers any non-polar carbon from any protein chain, organic ligand or other type of molecule, if the atoms belong "selection" (see below). (pymol.org)

The molecule contains a globular head with an apparent diameter of 8 nm and a rod-shaped tail of 40 nm length. (unboundmedicine.com)

Alternative splicing is frequent within the IDRs of proteins and can be a crucial element of PTM regulation, for instance by removal, recombination or modified local accessibility of potential sites of modification 3 , 8 . (nature.com)

Due to a huge overlap of the optical absorption spectrum of V, with the emission spectrum of a fluorescence center of HSA (containing a single tryptophan residue), energy transfer is induced and probed by steady-state and time-resolved fluorescence. (uni-bielefeld.de)

LRRK2 was also shown to coimmunoprecipitate with α-syn from soluble protein extracts of post-mortem brain tissues with apparent LB pathology. (medscape.com)
When is a protein most/least soluble in solution with its pI relative to the pH? (flashcardmachine.com)

This approach predicts regional instability by calculating the weighted sum of dipeptides that occur more frequently in unstable proteins when compared to stable proteins. (dnastar.com)
Strikingly, this motif appears to occur solely outside of globular domains [1]. (gzsys.org.cn)

Phylogenetic analysis of ubiquitin sequences reveals greater variability among lower eukaryotes and defines essential residues, many of which are conserved among the three ubiquitin-like proteins known to undergo parallel ligation pathways. (embl.de)
RNA sequences that serve as templates for protein synthesis. (lookformedical.com)
Creationist scientists and Intelligent Design proponents have drawn attention to the sparseness of native-like folded proteins among random polypeptide sequences. (creation.com)

The covalent attachment of the polypeptide ubiquitin to proteins marks them for degradation by the ubiquitin/26S proteasome-dependent degradation pathway. (embl.de)
The globular tail of myosin V plays an important role in its attachment to cargo. (silverchair.com)

Anatomy7

Organisms11

Chemicals and Drugs101

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes82

Disciplines and Occupations6

Technology, Industry, Agriculture1

Information Science15

Health Care6

Polar and charged residues2

Conformational4

Membrane15

Arginine residues4

Found in eukaryotic2

Hydrophobic residue2

Amino acid re2

Sequence10

Functional3

Chains10

Aggregation2

Structural7

Peptides and proteins1

Eukaryotic cells1

Monomer3

Interactions11

Structures8

Subunit1

Specificity3

Histone2

Target proteins2

Bind6

Enzymes4

Stability1

Polypeptide chain2

Structure20

Interaction8

Receptor5

Fibrous2

Glycosylation site1

Motifs4

Intrinsically Disordered Regions2

Conformation6

Alanine3

Dimeric2

Alpha-helices1

Signal transduction1

Molecules2

Milk proteins6

Complexes1

IDPs5

Monomers1

Molecular8

Cellular7

Fold3

Hemagglutinin4

Amyloid2

Viral2

Regions4

Subdomains2

Coiled coil1

Extracellular1

Binds3

Spectra2

Ligand2

Molecule1

IDRs1

Tryptophan1

Soluble2

Occur2

Sequences3

Attachment2