Global cyclic amp receptor protein. Medical search. Frequent questions

Many of these proteins take part in pathways that stimulate calcium mineral release (for instance, calcium-calmodulin G proteins signaling) and the forming of intracellular junctions, resulting in arousal of contractions. (researchensemble.com)
The channels are primarily activated by voltage but are receptors as well, binding the intracellular ligand cyclic AMP. (nature.com)
Anticholinergics prevent the increases in intracellular concentration of cyclic guanosine monophosphate (cyclic GMP) which are caused by interaction of acetylcholine with the muscarinic receptor on bronchial smooth muscle. (theodora.com)
Activation of beta 2 -adrenergic receptors on airway smooth muscle leads to the activation of adenylyl cyclase and to an increase in the intracellular concentration of cyclic-3',5'-adenosine monophosphate (cyclic AMP). (theodora.com)
Neurotransmitters released from cardiac sympathetic nerves bind to alpha- and beta-adrenergic receptors, eliciting a cascade of intracellular responses. (medscape.com)
Thus, our discovery of the role of functional interaction between intracellular signaling pathways mediated by calcium ions (Ca 2+) and cyclic adenosine monophosphate (cAMP) (Ca 2+ /cAMP signaling interaction) in these cellular responses, opened a great avenue for the development of new antitumor therapeutic strategies. (researchgate.net)
Sperm intracellular cAMP levels depend on the activity of adenylyl cyclases, mostly SACY, though transmembrane-containing adenylyl cyclases are also present, and on the activity of cyclic nucleotide phosphodiesterases (PDE) whose role is to degrade cAMP into 5'-AMP. (plos.org)
As in somatic cells, sperm intracellular cAMP concentration is regulated by the opposite action of two enzymes: the adenylyl cyclases (AC), which synthesize cAMP from ATP, and the phosphodiesterases (PDE), which break the phosphodiester bond of cAMP to form 5'-adenosine monophosphate (AMP). (plos.org)
Both AEA and 2-AG are generated "on demand" from membrane phospholipid precursors in response to elevated intracellular calcium or metabotropic receptor activation [ 20 ]. (degruyter.com)
Regarded as constitutively active enzymes, known to participate in many, diverse biological processes, the intracellular regulation bestowed on the CK1 family of serine/threonine protein kinases is critically important, yet poorly understood. (inamericawithgrace.com)

The pathways that control protein translation were investigated by immunoblotting explant lysates for PKR, PERK (PKR like endoplasmic reticulum kinase), eIF2a (eukaryotic initiation factor 2a), eEFs (eukaryotic elongation factors), and AMP-dependent kinase. (ox.ac.uk)
Explants were also loaded in the presence of inhibitors of PKR, the fibroblast growth factor (FGF) receptor and PI3 kinase. (ox.ac.uk)
Even muscle contraction is certainly inhibited with the phosphorylation of myosin light-chain kinase with the cAMP-dependent proteins kinase. (researchensemble.com)
On the other hand, interestingly, one of the key downstream insulin signaling molecules, protein kinase-B (PKB, or Akt) and its phosphorylation (pAkt) were significantly increased for cyclically stretched adipocytes relative to unstretched control. (unl.edu)
Moreover, cyclic stretch upregulated the phosphorylation of 5'-AMP-activated protein kinase (pAMPK). (unl.edu)
GW786034 is a vascular endothelial growth factor receptor-focused multi-tyrosine kinase inhibitor involved in inhibiting the angiogenesis pathway. (gw786034inhibitor.com)
Risk factors for depression initiate an infection-like inflammation in the brain that involves activation microglial Toll-like receptors and glycogen synthase kinase-3β (GSK3β). (mdpi.com)
This protein complex has also been implicated in regulating a number of signaling pathways, including Wnt, mammalian target of rapamycin (mTOR), STAT3, cMET, phosphoinositide 3-kinase (PI3K)/AKT, G protein-coupled receptor (GPCR), and epidermal growth factor receptor (EGFR), as well as in the localization and activity of cystic fibrosis transmembrane conductance (CFTR). (basicmedicalkey.com)
Increased cAMP promotes protein kinase A activity, among other effectors, and, in turn, leads to cyst growth by promoting proliferation and fluid secretion of cyst-lining cells through chloride and aquaporin channels in ADPKD kidneys. (basicmedicalkey.com)
V-Raf murine sarcoma viral oncogene homolog B1 ( B-RAF) is a gene that codes a protein B-Raf, which is a serine/ threonine-protein kinase. (inamericawithgrace.com)
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. (inamericawithgrace.com)
STRAP (Serine/Threonine Kinase Receptor Associated Protein) is a Protein Coding gene. (inamericawithgrace.com)
A topological analysis predicted PknB, the serine/threonine protein kinase of S. The serine/threonine-specific protein kinase Akt (protein kinase B), when phosphorylated by phosphotidylinositol-3-kinase, is a key mediator of tolerance. (inamericawithgrace.com)
Akt is a serine/threonine-specific protein kinase that plays a critical role in controlling the balance between survival and death pathways in cells. (inamericawithgrace.com)
In order to assess the importance of S/T kinases to Neurospora biology, we embarked on a global analysis of 86 S/T kinase genes in Neurospora. (inamericawithgrace.com)
The kinases of this family that have been suggested to play a role in apoptosis are the mitogen-activated protein kinase (MAPK) family, specifically p42/44 ERK, p38 MAPK and c-Jun N-terminal kinase (JNK), cyclic AMP-dependent protein kinase (PKA), protein kinase B (PKB), or Akt and protein kinase C (PKC). (inamericawithgrace.com)

Cyclic mechanical load causes global translational arrest in articular chondrocytes: a process which is partially dependent upon PKR phosphorylation. (ox.ac.uk)
Phosphorylation of PKR occurred in explants following cyclic load and inhibition of PKR modestly reversed suppression of newly synthesised proteins suggesting that PKR, at least in part, was responsible for loading induced translational arrest. (ox.ac.uk)
It is known to act through protein phosphorylation via PRKA and through the activation of guanine nucleotide exchange factors like EPAC. (plos.org)

As a postdoctoral fellow and research faculty member, he made major contributions to understanding cyclic AMP-dependent protein kinases and contributed significantly to work that later led to the Nobel Prize for Dr. Krebs. (aspet.org)
Serine/threonine (S/T) protein kinases are crucial components of diverse signaling pathways in eukaryotes, including the model filamentous fungus Neurospora crassa. (inamericawithgrace.com)

Dr. Beavo is being recognized for his research on the identification, regulation and functions of cyclic nucleotide phosphodiesterases, work on cyclic nucleotides, and for his strong commitment to mentoring. (aspet.org)
In 1977, Dr. Beavo joined the department of pharmacology at the University of Washington, where his research revealed 11 diverse families of cyclic-nucleotide phosphodiesterases with different substrate specificity and regulation. (aspet.org)

Although many marker genes have already been identified, small is well known approximately the underlying global gene appearance pathways and patterns that orchestrate these striking adjustments. (researchensemble.com)
Conclusions These outcomes implicate CA-074 Methyl Ester novel inhibtior the myometrium as an important regulator of endocrine hormone (cortisol and progesterone synthesis) and signaling pathways (cyclic AMP and cyclic GMP arousal) that immediate quiescence via the transcripitional upregulation of both book and previously linked regulators. (researchensemble.com)
Several these regulators induce cyclic AMP (cAMP)- and cGMP-mediated signaling pathways. (researchensemble.com)
RNA-Seq analysis revealed that more severe disease in line W was associated with significant up-regulation of pathways involved in inflammation, cytoskeletal regulation by Rho GTPases, nicotinic acetylcholine receptor signaling, and Wnt signaling in the bursa compared to line 15I. (imperial.ac.uk)
Dr. Martemyanov is being recognized for his research on how G protein signaling pathways are organized and regulated in the retina, heart and brain. (aspet.org)
An author of over 100 publications, his lab has made key contributions in elucidation of structure/functional organization of RGS protein complexes, their role in controlling ion channels and second messenger pathways and implications for physiology of the nervous and cardiovascular systems. (aspet.org)
Both CB 1 and CB 2 receptors, which share a low level (44%) of sequence homology [6], are G protein-coupled receptors that mainly signal via G i /G o proteins, even though they may also activate G s , G q/11 , and G protein-independent signaling pathways [ 7 ]. (degruyter.com)

While it is recognized that beta 2 -adrenergic receptors are the predominant receptors on bronchial smooth muscle, recent data indicate that there is a population of beta 2 -receptors in the human heart which comprise between 10% and 50% of cardiac beta-adrenergic receptors. (theodora.com)

Ingram, S.L. & Williams, J.T. Modulation of the hyperpolarization-activated current ( I h) by cyclic nucleotides in guinea-pig primary afferent neurons. (nature.com)

In E. coli (and other Gram-negative bacteria) the cyclic AMP receptor protein (CRP/CAP) regulates more than 500 genes. (ku.dk)
Of the seven most-global regulators, together affecting expression of about half of all E. coli genes, two were previously shown to exert direct, positive control on gltBDF transcription: Lrp and IHF. (biomedcentral.com)
Analyses of transcriptional gusA reporter fusions revealed that besides showing similar properties to Fnr proteins reported in other bacteria, MgFnr is involved in the repression of the expression of denitrification genes nor and nosZ under aerobic conditions, possibly owing to several unique amino acid residues specific to MTB-Fnr. (biomedcentral.com)
The quantitative expression of ESBLs, outer membrane protein and multidrug efflux systems encoding genes of UE210113, Δpk1 and Δpk1-C were performed by using qRT-PCR analysis. (bvsalud.org)
The expression levels of ESBLs-enconding genes blaTEM and blaCTX-M-14 in Δpk1 were significantly down-regulated compared with UE210113, but the expression was not restored in Δpk1-C. The expression of outer membrane protein gene omp F in Δpk1 was significantly up-regulated, while the expression of omp A and omp C were down-regulated. (bvsalud.org)
In this study, we investigated the adjuvant activities of combinations of Toll-like receptor 9 (TLR9) and stimulator of interferon genes (STING) agonists in a SARS-CoV-2 receptor binding domain protein vaccine. (ijbs.com)
We have learned that genes in mammalian cells are transcribed into messenger RNAs (mRNAs), which are to be translated into polypeptides (proteins). (intechopen.com)
For example, steroid and thyroid hormones directly bind to nuclear receptors, which induce expression of specific genes. (intechopen.com)

Beta-adrenergic stimulation activates adenylate cyclase, which increases cyclic adenosine monophosphate (AMP) levels and causes increased calcium influx into myocardial cells. (medscape.com)

These agents stimulate beta2-adrenergic receptors in bronchial smooth muscle, causing bronchodilation. (medscape.com)
It relaxes bronchial smooth muscle by action on beta2-receptors, with little effect on cardiac muscle contractility. (medscape.com)

His primary areas of investigation include Cell biology, Immunology, Toll-like receptor, Signal transduction and Receptor. (research.com)

Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages. (ox.ac.uk)
Normally, activation of the CB 1 receptor regulates renal vascular hemodynamics and stimulates the transport of ions and proteins in different nephron compartments. (degruyter.com)
The PC1/2 protein complex serves as a mechanosensor or chemical sensor and regulates calcium and G-protein signaling. (basicmedicalkey.com)

Global regulation of DNA molecules containing the gene for sucrose phosphorylase is performed by catabolite repression. (wikipedia.org)
The rcrB gene encodes a hypothetical membrane protein, deletion of which substantially increases UPEC's susceptibility to HOCl. (bvsalud.org)
Regulatory proteins, namely the Transcription Factors (TFs), bind in a sequence-specific manner to TFBSs to activate or suppress gene transcription (gene expression). (biomedcentral.com)
Whereas regulating gene expression in multicellular organisms allows for cellular differentiation, in single-celled organisms like prokaryotes, it primarily ensures that a cell's resources are not wasted making proteins that the cell does not need at that time. (pressbooks.pub)
Although a high level of PDE10A gene expression is observed in the testis, information on the identity of the isoforms or on the cell type that express the PDE10 protein is lacking. (plos.org)
in an operon with an upstream PurR/LacI-type transcriptional regulator gene, named amlR ( ACSP50_2475 ), and a gene downstream ( ACSP50_2473 ) encoding a GGDEF-EAL-domain-containing protein putatively involved in c-di-GMP signaling. (frontiersin.org)
Recent global analyses of gene transcripts revealed that specific transcription factors (TFs) and their networking systems physiologically correspond to the onset of human diseases, including cancer. (intechopen.com)

A small number of global regulatory proteins appear to play a central role in integrating the regulatory architecture of Escherichia coli, so as to promote coherent transcriptional responses to environmental changes. (biomedcentral.com)
In Escherichia coli and other bacteria, Fnr (fumarate and nitrate reduction regulator) proteins are known to be involved in controlling the switch between microaerobic and aerobic metabolism. (biomedcentral.com)
Mutations that alter the ability of Escherichia coli cyclic AMP receptor protein to activate transcription. (microbiologyresearch.org)

Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are tetrameric membrane proteins that generate electrical rhythmicity in specialized neurons and cardiomyocytes. (nature.com)
Goupil S, Maréchal L, El Hajj H, Tremblay M-È, Richard FJ, Leclerc P (2016) Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa. (plos.org)

Given the physiological importance of gltBDF , and the potential opportunity to learn about integration of global regulatory signals, a combination of in vivo and in vitro approaches was used to investigate the involvement of additional regulatory proteins, and to determine their relative binding positions and potential interactions with one another and with RNA polymerase (RNAP). (biomedcentral.com)
The involvement of nearly half of E. coli 's most-global regulatory proteins in the control of gltBDF transcription is striking, but seems consistent with the central metabolic role of this operon. (biomedcentral.com)
We have identified and thoroughly characterized the first regulatory protein mediating denitrification growth and magnetite biomineralization in response to different oxygen conditions in a magnetotactic bacterium. (biomedcentral.com)

His studies in Receptor integrate themes in fields like Secretion, Gut flora and Carbohydrate. (research.com)
We demonstrate here that PDE4 inhibitors enhance the anti-inflammatory cytokine interleukin-1 receptor antagonist (IL-1Ra) secretion in LPS-activated mouse peritoneal macrophages, and this response was regulated at the transcriptional level rather than an increased IL-1Ra mRNA stability. (ox.ac.uk)
Vasopressin promotes cell growth and fluid secretion via the cyclic AMP pathway, which leads to increase in the size and number of cysts in polycystic kidney disease. (msdmanuals.com)

Among PRRs, cyclic GMP-AMP synthase (cGAS) is a recently identiﬁed DNA sensor, which plays a pivotal role in recognizing cytosolic DNA [3]. (gw786034inhibitor.com)
His work in the fields of TLR7, Chemokine and Innate lymphoid cell overlaps with other areas such as Cyclic GMP-AMP synthase. (research.com)

On the horizon, novel insights into metabolism and energy homeostasis reveal guanosine 3′,5′-cyclic monophosphate (cGMP) signaling circuits as emerging targets for antiobesity pharmacotherapy. (eddoctor24h.com)

The selectin adhesion molecules and chemoattractant receptors synergistically regulate leukocyte migration into lymphoid tissues and sites of inflammation, but little is known about how these families of receptors modulate each other's function. (upenn.edu)
PC1 and PC2 bind to each other via their respective C-terminal tails to form a receptor-channel complex and regulate each other's function. (basicmedicalkey.com)

Similarly, indices of cell loss (reduced DNA), cell size and neuritic outgrowth (protein/DNA and membrane/total protein ratios) were distinct for each region and did not necessarily follow the rank order of nAChR upregulation, suggesting the involvement of additional mechanisms such as oxidative stress. (nature.com)
Cells were differentiated on the stretchable membrane and then exposed to cyclic equibiaxial stretching using the Flexcell FX-5000 device at a frequency of 1 Hz and a strain of 5% for 2 h. (unl.edu)

RNA viruses may escape acquired humoral and cellular immune responses by mutations in protective antigenic epitopes (e.g., avian influenza viruses), while accessory nonstructural proteins or multifunctional structural proteins interfere with the interferon system (e.g. (imperial.ac.uk)
Here, we show that the African Rhinolophus bat clade 3 sarbecovirus PRD-0038 S has a broad angiotensin-converting enzyme 2 (ACE2) usage and that receptor-binding domain (RBD) mutations further expand receptor promiscuity and enable human ACE2 utilization. (uw.edu)
Mutations in these proteins may alter the function of renal cilia, which enable tubular cells to sense flow rates. (msdmanuals.com)

PC2 and FPC both interact with kinesin 2 (KIF 3A/B). Localization of disease proteins in the cilium, the transition zone, and the basal body is color coded. (basicmedicalkey.com)

Elements previously from the legislation of myometrial activation are the oxytocin receptor, difference junction proteins connexin-43, voltage-gated calcium mineral stations, prostaglandin receptor subtypes, estrogen, transcription and cortisol elements c-Jun and c-Fos. (researchensemble.com)
Fetal brain regions and peripheral tissues were examined for nAChR subtypes, other neurotransmitter receptors, and indices of cell signaling and cell damage. (nature.com)

Because the therapeutic potential of globally acting CB 1 receptor antagonists in these conditions is limited due to their neuropsychiatric adverse effects, the recent development of peripherally restricted CB 1 receptor antagonists may represent a novel pharmacological approach in treating renal diseases. (degruyter.com)

In this study we show that exposure of isolated dimeric CRP-cAMP to UV modifies specific Met, Trp, Tyr, and Pro side-chains, induces inter-protein Tyr63-Tyr41 cross-links, and decreases DNA binding via oxidation of Met114/Pro110 residues in close proximity at the CRP dimer interface. (ku.dk)

Studies in developing rodents indicate that nicotine is a neuroteratogen that disrupts brain development by stimulating nicotinic acetylcholine receptors (nAChRs) that control neural cell replication and differentiation. (nature.com)

Alpha-adrenergic receptor stimulation produces a cascade of second messenger systems that subsequently regulate calcium channels and in turn elicit increases in cytosolic calcium. (medscape.com)
The incidence of target organ damage associated to CVD increases with age, and gender studies show global higher incidence in men for stroke and coronary artery disease (CAD) [ 10 ]. (hindawi.com)

In addition to the brain-type CB 1 receptor, a second cannabinoid receptor was identified in lymphoid tissue and was named CB 2 [ 6 ]. (degruyter.com)

There was indirect evidence for involvement of a third global regulator, Crp. (biomedcentral.com)
We report here direct evidence that three of these seven proteins, plus a more specific regulator, cooperate to control an operon critical to nitrogen metabolism. (biomedcentral.com)
Our findings reveal that the global oxygen regulator MgFnr is a genuine O 2 sensor. (biomedcentral.com)

PC2 is a calcium-permeable six-transmembrane protein that structurally belongs to the transient receptor potential (TRP) cation channel family. (basicmedicalkey.com)
One hypothesis is that loss of ciliary function of PC1 and PC2 leads to reduced calcium signaling and a subsequent increase of adenylyl cyclase activity and decrease of phosphodiesterase activity, which, in turn, causes increased cellular cyclic AMP (cAMP). (basicmedicalkey.com)

These agents block effects of released histamine at H2 receptors, thereby treating vasodilation, possibly some cardiac effects, and glandular hypersecretion. (medscape.com)

First discovered in Gram-negative bacteria, both Cyclic AMP (cAMP) and cAMP Receptor Protein (CRP) function in sucrose phosphorylase regulation. (wikipedia.org)
The cellular mechanisms by which articular cartilage responds to load are poorly understood, but such responses may involve regulation at the level of protein translation rather than synthesis of mRNA. (ox.ac.uk)
Our results provide a mechanism for global regulation of excitatory synapses, presumably to maintain synaptic and behavioral plasticity in a dynamic range. (ox.ac.uk)

Endocannabinoids (eCBs) are endogenous lipid ligands that bind to cannabinoid receptors that also mediate the effects of marijuana. (degruyter.com)

As a proof-ofconcept test, we applied cyclic stretch loading to the adipocyte model, differentiated adipocytes from 3T3-L1 preadipocytes, and evaluated stretch-induced activation of key insulin signaling molecules. (unl.edu)
Dynamic changes in airway epithelial paracellular permeability allow for receptor-ligand access across the airway epithelium, and thereby regulate cell signaling [11] . (plos.org)
Dr. Martemyanov will deliver the John J. Abel Award in Pharmacology Lecture titled "Molecular Control of G protein Signaling" on Sunday, April 22, 2018 from 8:30 am - 9:15 am. (aspet.org)

The eCB system is comprised of eCBs, anandamide, and 2-arachidonoyl glycerol, their cannabinoid-1 and cannabinoid-2 receptors (CB 1 and CB 2 , respectively), and the enzymes involved in their biosynthesis and degradation. (degruyter.com)

Adjuvants formulated with a TLR9 agonist, CpG-2722, with various cyclic dinucleotides (CDNs) that are STING agonists increased germinal center B cell response and elicited humoral immune responses in immunized mice. (ijbs.com)
ASFV utilizes multiple self-encoding proteins to evade the host's innate and adaptive immune responses [9e13]. (gw786034inhibitor.com)

The PC1/2 protein complex may also directly regulate a number of cellular functions including the cell cycle, the actin cytoskeleton, planar cell polarity (PCP), and cell migration. (basicmedicalkey.com)

In bacteria and archaea , structural proteins with related functions are usually encoded together within the genome in a block called an operon and are transcribed together under the control of a single promoter , resulting in the formation of a polycistronic transcript ( Figure 12.30 ). (pressbooks.pub)
Although Rhinolophus bats harbor diverse clade 3 sarbecoviruses, the structural determinants of receptor tropism along with the antigenicity of their spike (S) glycoproteins remain uncharacterized. (uw.edu)

Injectable polymer-nanoparticle (PNP) hydrogels are leveraged as a depot technology for the sustained delivery of a nanoparticle antigen (RND-NP) displaying multiple copies of the SARS-CoV-2 receptor-binding domain (RBD) and potent adjuvants including CpG and 3M-052. (uw.edu)

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)

Glu is one of the small minority of amino acids for which the great bulk of the molecules are used for purposes other than direct incorporation into proteins [2]. (biomedcentral.com)
The existence of specific receptors for plant-derived molecules in mammalian cells initiated a search for specific endogenous ligands. (degruyter.com)

The covalent complex was experimentally isolated by chemical modification of the protein using NaIO4 after addition of the substrate, supporting the hypothesis that reaction catalyzed by sucrose phosphorylase proceeds through the ping-pong mechanism. (wikipedia.org)
It was observed that expressions of insulin receptor substrate-1 (IRS-1) and glucose transport-4 (GLUT4) were less influenced by stretch under the given conditions. (unl.edu)

FIGURE 339-1 Scheme of the primary cilium and cystic kidney disease proteins. (basicmedicalkey.com)

Messenger RNA was extracted for real time polymerase chain reaction (RT-PCR) and newly synthesised proteins were measured by their incorporation of radiolabelled 35S[methionine/cysteine] or 35SO4. (ox.ac.uk)

It has been postulated that DP96R is a potential immune evasion protein, although its mechanism of action remains virtually unknown [9,22]. (gw786034inhibitor.com)

The mammalian immune system utilizes pattern recognition receptors (PRRs) to detect pathogen-associated molecular patterns (PAMPs) from invading pathogens and activate the host innate immune response [1,2]. (gw786034inhibitor.com)
In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate CB 1 receptors and contribute to the development of oxidative stress, inflammation, and renal fibrosis. (degruyter.com)

Immunology, Immune system, Cell biology, Innate immune system and Toll-like receptor are his primary areas of study. (research.com)
His Immunology study incorporates themes from Receptor and Flagellin. (research.com)

We have recently shown that several PDEs, the insulin receptor and the insulin-sensitive glucose-transporter GLUT4 are expressed in inner ear sensory epithelia and now we wants to examine in more detail the role of these systems to understand the molecular connection between diabetes and inner ear dysfunction using cell and animal models and also performing clinical research. (lu.se)

The others are the site-specific TFs or the DNA sequence-specific binding proteins. (intechopen.com)

The cAMP analogue 8-Br-cAMP-AM (8-Br) confers marked protection against global ischaemia/reperfusion of isolated perfused heart. (mdpi.com)
In mammals, adenosine 3', 5'-cyclic monophosphate (cAMP) is known to play highly important roles in sperm motility and acrosomal exocytosis. (plos.org)
In addition to its PRKA-dependent effects, different studies have clearly demonstrated that cAMP also activates EPAC ( E xchange P roteins directly A ctivated by c AMP) during capacitation and acrosome exocytosis [ 15 - 17 ]. (plos.org)

His Innate immune system research is mostly focused on the topic Pattern recognition receptor. (research.com)

Proteins are major chromophores and targets for damage due to their abundance, but the role of proteins in inducing damage to bound DNA, and the effects on DNA-protein interactions is less well characterized. (ku.dk)
Here, we report on an Fnr-like protein (MgFnr) and its role in growth metabolism and magnetite biomineralization in the alphaproteobacterium Magnetospirillum gryphiswaldense . (biomedcentral.com)

There was a rebound increase in protein synthesis when labelling was performed after load had been withdrawn. (ox.ac.uk)

Organisms4

Chemicals and Drugs22

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes22

Information Science3

Intracellular10

Kinase16

Phosphorylation3

Kinases2

Phosphodiesterases2

Pathways7

Beta-adrenergic receptors1

Nucleotides1

Genes8

Adenosine monophosphate1

Bronchial smooth muscle2

Signal Transduction1

Regulates3

Gene7

Escherichia3

Nucleotide2

Regulatory3

Secretion3

Synthase2

Guanosine1

Other's function2

Membrane2

Mutations3

Localization1

Subtypes2

Antagonists1

Oxidation1

Nicotinic1

Increases2

Lymphoid1

Regulator3

Calcium2

Cardiac1

Regulation3

Bind1

Signaling3

Biosynthesis1

Responses2

Regulate1

Structural2

Adjuvants1

Stability1

Molecules2

Substrate2

Cystic1

Incorporation1

Mechanism of act1

Activate2

Immunology2

Insulin1

Sequence-specific1

CAMP3

Innate1

Role2

Increase in protein1