Glioblastoma using stem cells. Medical search. Frequent questions

Glioblastoma multiforme (GBM) remains incurable despite aggressive implementation of multimodal treatments after surgical debulking. (nih.gov)
Background: Glioblastoma multiforme (GBM) continues to devastate patients and outfox investigators and clinicians despite the preponderance of research directed at its biology, pathogenesis and therapeutic advances. (benthamscience.com)
Glioblastoma also known as glioblastoma multiforme (GBM) is one of the most lethal and commonly identified forms of brain tumor [ 1 ]. (biomedcentral.com)
Glioblastoma multiforme (GBM) is the most common brain tumour, characterized by a central and partially necrotic (i.e., hypoxic) core enriched in cancer stem cells (CSCs). (omicsdi.org)
Temozolomide (TMZ)-resistance in glioblastoma multiforme (GBM) has been linked to upregulation of O(6)-methylguanine-DNA methyltransferase (MGMT). (omicsdi.org)
Glioblastoma multiforme (GBM) is one of the most hypoxic tumors of the central nervous system. (omicsdi.org)
Glioblastoma multiforme (GBM) contains a population of cells that exhibit stem cell phenotypes. (omicsdi.org)
Introduction: Glioblastoma multiforme (GBM) is the most common brain malignancy in adults, and currently available GBM treatments present several unique challenges. (tmu.edu.tw)
High recurrence rate and failure of conventional treatments in patients with glioblastoma multiforme is attributed to the presence of stem-like cells in these tumors. (gitlab.io)
Only partial data are available for the human tumor glioblastoma multiforme (GBM). (biomedcentral.com)
Glioblastoma multiforme (GBM) is the most common and malignant type of brain tumor in adults and is characterized on histologic examination according to hypercellularity, nuclear atypia, mitotic figures, and evidence of angiogenesis and/or necrosis. (biomedcentral.com)
Glioblastoma multiforme (GBM) is a rare, yet devastating, primary brain tumor in adults. (hal.science)
Glioblastoma multiforme (GBM) is an aggressive brain tumor with a poor overall prognosis. (biomedcentral.com)
Glioblastoma, previously known as glioblastoma multiforme, is the most aggressive among infiltrative gliomas, a group of primary tumors arising from the central nervous system (CNS). (cancernetwork.com)
The term 'glioblastoma multiforme' was introduced in the 1926 classification system devised by Cushing and Bailey. (cancernetwork.com)
1] 'Multiforme,' which refers to a heterogenous histologic appearance and proliferation of multiple cell types, was abandoned from the revised nomenclature in the 2007 World Health Organization Classification of Tumors of the Central Nervous System, and is now simply called 'glioblastoma. (cancernetwork.com)
Glioblastoma multiforme (GBM) may be termed as the most common and aggressive form of brain tumor in humans. (healthjockey.com)
Glioblastoma multiforme (GBM) the highest-grade glioma and deadliest brain tumor occurs in pediatric as well as adult patients. (lu.se)

Since then they were systematically cultured as tumorospheres in defined stem cell culture conditions, allowing them to keep their GSC properties including their capacity to generate intracerebral tumors in immunodeficient mice (Supplementary Fig. S1 A). (nature.com)
Conclusions: Glioma stem cells have thus become a prevalent focus in GBM research for their presumed role in development, maintenance and recurrence of tumors. (benthamscience.com)
Glioma stem cells infiltrate the white matter surrounding tumors and often evade resection. (benthamscience.com)
GBM stem-like cells (GSCs) present in tumors are felt to be highly tumorigenic and responsible for tumor recurrence. (oncotarget.com)
Recent studies have suggested that many solid tumors, including GBM, are maintained by a subset of cells termed cancer stem cells (CSCs). (johnshopkins.edu)
The Brain Tumor Stem Cell Research Lab studies genetic controls and mediators of tumor growth, invasion, and migration to understand how tumors move into the healthy brain. (mayo.edu)
Glioblastomas remain the most lethal primary brain tumors. (bvsalud.org)
Moreover, NK cell localization in peri-vascular regions in glioblastoma tissues and their close contact with GSLCs in tumorospheres suggests their ability to infiltrate glioblastoma tumors and target GSLCs. (bvsalud.org)
A nanoparticle carrying the p53 gene targets tumors including cancer stem cells, sensitizes glioblastoma to chemotherapy and improves survival. (omicsdi.org)
We have shown recently that in breast and prostate tumors, as well as in breast tumor cell lines, HIF-1α has a crucial role in regulating, either directly or indirectly, the expression of pro-inflammatory genes. (biomedcentral.com)
We injected GS 522 cells intracranially into athymic mice to evaluate their ability to generate stable xenografts, and saw tumors form within 1 months' time (Fig. 1 e). (biomedcentral.com)
Conclusions: These data highlight that, while CLIC1 is dispensable for the development of a subset of glioblastomas, it acts as a booster of proliferation in the majority of these tumors and its functional expression is required for biguanide antitumor class-effects. (unimi.it)
Molecular data have indicated a direct progression from diffuse astrocytoma to anaplastic astrocytoma to glioblastoma in patients whose tumors bear mutations in the IDH1/2 genes and TP53 genes, a finding that marks the pathogenic pathway of 5% of all glioblastomas. (medscape.com)
[ 6 ] A majority of these tumors will exhibit polysomy of the epidermal growth factor receptor ( EGFR ) genetic locus on chromosome 7 in subsets of tumor cells. (medscape.com)
The cancer stem cell theory holds that tumors also contain stem-like cells that drive tumor growth and metastasis formation. (medscape.com)
Tumor cells with stem cell characteristics are thought to be responsible for therapeutic resistance in brain tumors. (lu.se)
Using mouse models of glioma and primary human glioma cultures, we aim to characterize phenotypic intratumoral heterogeneity specifically with regards to radiation resistant stem-like tumor cells, the molecular signaling pathways underlying therapeutic resistance, and microenvironmental control over tumor cell phenotypes with the overall goal of developing novel therapeutic strategies targeting therapy-resistant cells in malignant brain tumors. (lu.se)
Both primary and secondary glioblastomas have distinct genetic characteristics, which can change as the tumors evolve. (msdmanuals.com)
Treatment of recurrent primitive neuroectodermal tumors (PNET) in children and adolescents with high-dose chemotherapy (HDC) and stem cell support: results of the HITREZ 97 multicentre trial. (medscape.com)

A minor subpopulation of cancer cells, known as glioma stem-like cells (GSCs), are thought to play a major role in tumor relapse due to their stem cell-like properties, their high resistance to conventional treatments and their high invasion capacity. (nature.com)
Since cancer stem cells have been hypothesized to play a role in refractory/relapsing cancers, in the present work we investigated if autophagy could represent a constitutive cytoprotection mechanism for glioblastoma stem-like cells (GSCs) and if the modulation of autophagic process could affect GBM growth and survival. (nature.com)
Death of GSCs was apparently due to the iron dependent form of programmed cell death characterized by the accumulation of lipid peroxides called ferroptosis. (nature.com)
These results underscore the relevance of the modulation of autophagy in the GSC survival and death and suggest that triggering of ferroptosis in GSCs could represent a novel and important target for the management of glioblastoma. (nature.com)
Almost all patients with GBM relapse within a narrow margin around the initial resected lesion due to postsurgery residual glioma stem cells (GSCs). (nih.gov)
GBM stem-like cells (GSCs) represent a subpopulation of the tumor which is responsible for tumor initiation, progression, and re-growth after chemoradiation [ 5 , 6 ], as well as supporting tumor vessel growth and function [ 7 ]. (oncotarget.com)
MV1035 was used on both U87-MG and two patient-derived (PD) glioma stem cells (GSCs): in combination with TMZ, it has a significant synergistic effect in reducing cell viability and sphere formation. (unimib.it)
Moreover, MV1035 induces a reduction in MGMT expression in PD-GSCs cell lines most likely through a mechanism that acts on MGMT promoter methylation. (unimib.it)
GBM are formed by GBM stem-like cells (GSCs) - a major contributor to tumor recurrence and a natural focus for therapeutic development. (sbir.gov)
BACKGROUND: Glioma stem cells (GSCs) have self-renewal and tumor-initiating capacities involved in drug resistance and immune evasion mechanisms in glioblastoma (GBM). (providence.org)
GSCs are implicated for recurrence due to resistance to therapy, thereby allowing cell renewal and tumor re-initiation, while physically, GSCs are difficult to target because of their presence in the perivascular space [ 24 ]. (biomedcentral.com)
Within GBM, exists a population of self-sustaining transformed cells with stem-like properties (GSCs), which are thought to be responsible for tumor initiation, growth, and invasion, as well as recurrence. (hal.science)
In the tumor microenvironment, GSCs might be found in the vicinity of brain endothelial cells, which provide a protective habitat. (hal.science)
Here, we investigated whether placenta-derived MSCs (P-MSCs) are a superior cellular vector for systemic targeting of glioblastoma stem-like cells (GSCs), with an imaging modality to real-time monitor the trafficking P-MSCs to glioblastoma sites. (tmu.edu.tw)
This study suggests the possibility of innovative systemic P-MSC-based cell therapy for aggressive GSCs, developing a state-of-the-art theranostic technique for real-time tracking of therapeutic P-MSCs tumor infiltration through cellular MRI. (tmu.edu.tw)
Here, we sought to identify and characterize ALT+ GBM by screening through a panel of 24 patient-derived GBM stem cell lines (GSCs). (biomedcentral.com)
ALT+ GSCs were detected by quantifying telomere ( a ) and DNA C-Circle content ( b ) in a panel of 24 cell lines. (biomedcentral.com)
Metformin exerts antitumor effects in glioblastoma stem cells (GSCs) inhibiting CLIC1 activity, but its low potency hampers its translation in clinical settings. (unimi.it)
Methods: We synthesized a small library of novel biguanide-based compounds that were tested as antiproliferative agents for GSCs derived from human glioblastomas, in vitro using 2D and 3D cultures and in vivo in the zebrafish model. (unimi.it)
Finally, we characterized GSCs from GBMs spontaneously expressing low CLIC1 protein, demonstrating their ability to grow in vivo and to retain stem-like phenotype and functional features in vitro. (unimi.it)

Attempts to glean further insight into GBM point increasingly toward a subpopulation of cells with a stem-like phenotype. (benthamscience.com)
Glioblastoma Embryonic-like Stem Cells Exhibit Immune-Evasive Phenotype. (providence.org)
and Marzese, Diego M, "Glioblastoma Embryonic-like Stem Cells Exhibit Immune-Evasive Phenotype. (providence.org)
Response of primary glioblastoma cells to therapy is patient specific and independent of cancer stem cell phenotype. (omicsdi.org)
In this study, we show that human glioblastoma cells secrete soluble factors that alter the phenotype and cytokine secretion profile of both macrophages and mesenchymal stem cells (MSCs). (edu.pl)
The aim of our study was to analyze the hypoxic and pro-inflammatory microenvironment in GBMs and to demonstrate that in a stem/progenitor cell line derived from human glioblastoma (GBM-SCs), hypoxia activates a coordinated inflammatory response, evidencing an invasive and migratory phenotype. (biomedcentral.com)
We suggest that, as has been previously described for prostatic and mammary carcinoma, in human glioblastoma acquisition of a proinflammatory phenotype may be relevant for malignant progression. (biomedcentral.com)
C-Met Signaling Induces a Reprogramming Network and Supports the Glioblastoma Stem-Like Phenotype. (hopkinsmedicine.org)
To study and optimize lead compounds with multi-kinase activity against existing glioma stem cells and radiation-induced phenotype conversion of non-stem glioma cells into induced glioma stem cells. (ca.gov)
Our data indicate that the stem cell marker CD44 modulates the hypoxic response of glioma cells and that the pseudo-hypoxic phenotype of stem-like glioma cells is achieved by stabilization of HIF-2α through interaction with CD44, independently of oxygen. (lu.se)

For example, temozolomide (TMZ), of use for glioblastoma (GBM) treatment, appears as capable of inducing autophagy partially inhibiting cancer cell proliferation. (nature.com)
Here we show that TGF-beta regulates proliferation, migration, and tumorigenicity of mesenchymal GBM cancer stem cells (CSCs) in vivo and in vitro. (uni-regensburg.de)
Wnt signaling pathway is mediated by Wnt family of 19 secreted glycoproteins (bearing22 or 24 cysteine residues) which are essential for cell proliferation, embryonic development, cell polarity, and tissue homeostasis [ 9 ]. (biomedcentral.com)
Cell proliferation involves the replication of all cellular contents with the required energy for this to happen. (hindawi.com)
To prevent aberrant cell proliferation, these pathways are tightly regulated. (hindawi.com)
This activation is necessary for both cell proliferation as well as glucose uptake and use. (hindawi.com)
Enhancement of head andneck squamous cell carcinoma proliferation, invasion, andmetastasis by tumor-associated fibroblasts in preclinicalmodels. (edu.pl)
DHODH inhibition impedes glioma stem cell proliferation, induces DNA damage, and prolongs survival in orthotopic glioblastoma xenografts. (amedeo.com)
Polyethylene glycol-coated superparamagnetic iron oxide (PEG-SPIO) was synthesized for cellular labelling and imaging P-MSCs, displaying high cellular uptake and no cytotoxic effect on P-MSCs cell proliferation or stemness property. (tmu.edu.tw)
Background: Chloride intracellular channel-1 (CLIC1) activity controls glioblastoma proliferation. (unimi.it)
Compounds were compared to metformin for both potency and efficacy in the inhibition of GSC proliferation in vitro (MTT, Trypan blue exclusion assays, and EdU labeling) and in vivo (zebrafish model), migration (Boyden chamber assay), invasiveness (Matrigel invasion assay), self-renewal (spherogenesis assay), and CLIC1 activity (electrophysiology recordings), as well as for the absence of off-target toxicity (effects on normal stem cells and toxicity for zebrafish and chick embryos). (unimi.it)
2] Glioblastoma is histologically defined by neoplastic cells with astrocytic characteristics and the presence of either endothelial proliferation-often in a glomeruloid morphology-and/or necrosis, which may resemble a pseudopalisading pattern (a false fence of neoplastic cells surrounding an area of necrotic tissue). (cancernetwork.com)
Here, we identified tranylcypromine, which is used to treat refractory depression, caused human-induced pluripotent stem cell-derived brain organoids neurotoxicity, leading to decreased proliferation activity and apoptosis induction. (frontiersin.org)
According to experts from the Friedrich Miescher Institute for Biomedical Research, the amount of MNK1 kinase is greatly increased in GBM and its inhibition decreases cell proliferation for substantially sensitizing glioma cells to rapamycin. (healthjockey.com)

In an orthotopic patient-derived glioblastoma humanized mouse model, the combined treatment with nanoporter-hydrogel superstructure and CD47 antibody increased the frequency of positive immune responding cells and suppressed the negative immune regulating cells, conferring a robust tumoricidal immunity surrounding the postsurgical cavity and inhibiting postoperative glioblastoma relapse. (nih.gov)
Immunotherapy with super-charged NK cells has a potential as antitumor approach since we found their efficiency to kill patient -derived GSLCs in 2D and 3D models, potentially reversing the immunosuppression also seen in the patients . (bvsalud.org)
Materials and methods: We used irradiation to treat patient-derived GBM (Par) cells and then purified radioresistant GBM (R2M2) cells through two rounds of irradiation and an invasion assay. (tmu.edu.tw)
We found that patient-derived cells massively invade the collagen matrix. (hal.science)

It has been shown that these cells are inherently radio- and chemotherapy resistant, and may be maintained in vivo in a niche characterized by reduced oxygen tension (hypoxia). (johnshopkins.edu)
Glioblastoma remains to be a highly destructive type of tumor despite availability of treatment strategies like surgery, chemotherapy, and radiation. (biomedcentral.com)
Infiltrating natural killer cells bind, lyse and increase chemotherapy efficacy in glioblastoma stem-like tumorospheres. (bvsalud.org)
The standard-of-care for patients with glioblastoma is surgery, followed by radiotherapy and chemotherapy and the median survival is only 15-18 months. (ca.gov)
Yamada A, Moritake H, Kamimura S, Yamashita S, Takeshima H, Nunoi H. Proposed strategy for the use of high-dose chemotherapy with stem cell rescue and intrathecal topotecan without whole-brain irradiation for infantile classic medulloblastoma. (medscape.com)

The current review focuses on the importance of Wnt signaling pathway in glioblastoma stem cell progression and explores targeting of Wnt signaling molecules as a potential therapy for glioblastoma. (biomedcentral.com)
What we have done is the basic characterization of what we believe is an important signaling pathway in glioblastoma. (healthjockey.com)

In addition, autophagy interpheres with cell cycle progression, de facto exerting a cytostatic activity. (nature.com)
The lab is creating models to better understand cancer migration and progression, to study invasive cell populations, and to uncover novel therapeutic targets to impact tumor progression. (mayo.edu)
In this review, we discuss about the significance of glioblastoma stem cells in cancer progression through Wnt signaling pathway and highlight the clinical targets being potentially considered for therapy in glioblastoma. (biomedcentral.com)
Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. (hindawi.com)
Our results suggest that the orchestrated response of macrophages and stromal elements to neoplastic cells enhances tumor progression through the release of soluble factors. (edu.pl)

In vivo, a substantially increased infiltration of immune cells was observed in mesenchymal GBMs, while immune infiltrates were rare in proneural GBMs. (uni-regensburg.de)
Although the goal of Glioblastoma is not only to treat the disease but to cure it, current animal in vivo studies have shown promising therapeutic effects in mesenchymal stem cells, induced neural stem cells, and induced pluripotent stem cells. (genesispub.org)
These stem cells have self-renewal capabilities, and stem cells, like the mesenchymal stem cells, can differentiate into various lineages from the mesoderm. (genesispub.org)
The Brain Tumor Stem Cell Research Lab at Mayo Clinic engineers human mesenchymal stem cells with nanotechnology to serve as Trojan horses for the treatment of cancer. (mayo.edu)
Dr. Quinones-Hinojosa's lab is evaluating the efficacy of a gel for administering human fat-derived mesenchymal stem cells within the brain cancer resection cavity during surgery. (mayo.edu)
Mesenchymal stem cells (MSCs) that display homing and infiltration properties towards tumor cells are a promising cellular targeting vector for brain tumor therapy but are limited to local-regional delivery in current preclinical models. (tmu.edu.tw)

Lin A, Gallicchio VS. (2023) Stem Cell Therapy for Glioblastoma. (genesispub.org)
ImmunoCellular Therapeutics has decided to use Progenitor Cell Therapy (PCT) to produce its Phase II glioblastoma vaccine, ICT-107. (genengnews.com)
Dr. Quinones-Hinojosa's lab has research platforms on novel therapeutics for glioblastoma, cell migration and invasion, cellular therapy, and models of brain and spine cancers, and maintains a human tissue bank. (mayo.edu)
Dr. Quinones-Hinojosa's lab at Mayo Clinic has developed a self-assembling nanofiber hydrogel system for local therapy of glioblastoma and is investigating options for a local route of administration. (mayo.edu)
Dr. Quinones-Hinojosa's lab is studying how the NKCC1 protein maneuvers the cell during migration and using findings to develop new molecular targets for targeted cancer therapy. (mayo.edu)
A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. (hindawi.com)
Natural killer (NK) cell -based therapy is a promising immunotherapeutic strategy in the treatment of glioblastomas , since these cells can select and lyse therapy -resistant glioblastoma stem -like cells (GSLCs). (bvsalud.org)
CSCs) GBM cells were resistant to Temozolomide (TMZ) in vitro, owing to a particularly high expression of O6-methylguanine-DNA-methyltransferase (MGMT), the most important factor associated to therapy resistance in GBM. (omicsdi.org)
Despite aggressive therapy, the average median survival of patients with glioblastoma is approximately 15 months. (hopkinsmedicine.org)
Cell Replacement Therapy for Parkinson's Disease - Evaluating the potential of autologous grafting. (lu.se)

These stem cells create an extremely heterogenous tumor that to date has had an answer for every therapeutic question, with continued dismal patient survival. (benthamscience.com)
Targeting this population of glioma stem cells may hold the long-awaited key to durable therapeutic efficacy in GBM. (benthamscience.com)
The epidermal growth factor receptor (EGFR) is frequently overexpressed in the most common malignant glioma, glioblastoma (GBM), and represents an important therapeutic target. (oncotarget.com)
While research has shown that each stem cell poses its own risk to the disease, their therapeutic effects have also shown encouraging and promising results. (genesispub.org)
This review outlines the research, progress, and potential therapeutic effects different stem cells have on Glioblastoma. (genesispub.org)
This study aimed to review the current progress researchers have made regarding stem cell therapeutic effects for Glioblastoma, how it is applied, and to discover the potential future progress and treatments these stem cells can create. (genesispub.org)
Breast malignancy cells were transduced with lentiviruses for 12C16?h. an intriguing therapeutic approach to malignancy treatment, but requires better chemical tools than HMBA. (sipurpashut.net)
It is known that GBM involves cancer stem-like cells (CSCs) and tumor cells that aggressively invade normal brain tissues, and both cell types may cause resistance to radiotherapy (RT) and are thus responsible for therapeutic failure. (tmu.edu.tw)
These cells, typically referred to as glioma stem-like cells (GBM SCs) or glioma-initiating cells, are considered to be responsible for the propagation, recurrence, and therapeutic resistance of glioma. (hopkinsmedicine.org)
Despite the crucial role of radiation resistance in patient mortality, few viable therapeutic strategies have been identified to target these resistant cells. (lu.se)

On a functional level, proneural CSC lines caused a significantly stronger TGF-beta-dependent suppression of NKG2D expression on CD8(+) T and NK cells in vitro providing a mechanistic explanation for the reduced immune infiltration of proneural GBMs. (uni-regensburg.de)

While radiotherapy prolongs survival in glioblastoma it has hit a critical barrier. (ca.gov)
The proposed studies aim to develop novel compounds against glioblastoma that will enhance the efficacy of radiotherapy to improve survival for patients with GBM, thereby improving value-based care and the life of Californians. (ca.gov)

We showed that the imidazobenzoxazin-5-thione MV1035 is able to significantly reduce GBM U87-MG cells migration and invasiveness through inhibition of the RNA demethylase ALKBH5. (unimib.it)
Bone morphogenetic proteins (BMPs), and in particular BMP2, are known to promote differentiation and growth inhibition in GBM cells. (omicsdi.org)

Pivotal studies defining our current standard of care will be highlighted, as will key ongoing trials that may influence our management of glioblastoma in the near future. (cancernetwork.com)

Highly invasive GBM cells are known to infiltrate the surrounding normal brain, making complete resection impossible [ 3 , 4 ]. (oncotarget.com)
Immunohistological studyof mononuclear cell infiltrate in malignant gliomas. (edu.pl)

Human glioblastoma (GBM) is the most common primary malignant brain tumor. (nature.com)
The most common malignant glioma, known as glioblastoma (GBM), is characterized by necrosis, hypoxia, and extensive angiogenesis [ 2 ]. (oncotarget.com)
Our data, therefore, propose a reliable approach to explore invasive properties of patient glioma cells ex vivo and identify NRP1 as a mediator in this malignant process. (hal.science)
Glioblastoma is highly malignant. (reachmd.com)
We take advantage of the similarity between neural developmental processes and cancer hierarchy to mitigate, if not completely abolish, the malignant nature of tumor cells and pave the way for new intervention strategies. (lu.se)

Here, we demonstrate that scL crosses the BBB and efficiently targets GBM, as well as cancer stem cells (CSCs), which have been implicated in recurrence and treatment resistance in many human cancers. (omicsdi.org)
scL-p53 also sensitized both CSCs and bulk tumor cells to TMZ, increasing apoptosis. (omicsdi.org)

On one hand, autophagy allows cancer cell to survive in unfavorable environmental conditions, on the other hand, once internal energy resources are exhausted, it leads to cell death. (nature.com)
Hence, thanks to this complex mechanism, autophagy can provide energy supply to the cell and can represent a key cytoprotection mechanism allowing cell survival in unfavorable microenvironmental conditions such as those often found by cancer cells 7 . (nature.com)
Autophagy may represent a mechanism of resistance to oxidative stress induced by chemotherapeutic drugs and may potentiate cancer cell survival to hypoxia and nutrient starvation due to the frequently defective tumor vascularization. (nature.com)
Engineering NK cells to resist immune suppression could be a path toward using NK cell-based immunotherapies for glioblastoma brain cancer. (neurosciencenews.com)
A new study in the Journal of Experimental Medicine report Zika virus could be used to target and treat glioblastoma brain cancer. (neurosciencenews.com)
Therefore, our work establishes a locoregional treatment strategy for priming cancer stem cell-specific tumoricidal immunity with broad application in patients suffering from recurrent malignancies. (nih.gov)
These cancer stem cells, similar to those now described in a variety of malignancies, are capable of tumorigenesis from a population of susceptible cells. (benthamscience.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Multifunctional magnetic iron-oxide nanoparticles (IONPs) can be directly imaged by magnetic resonance imaging (MRI) and designed to therapeutically target cancer cells. (oncotarget.com)
Glioblastoma is a devastating grade IV cancer that affects the central nervous system and the spinal cord primarily in older adults but can also affect youth. (genesispub.org)
Glioblastoma (GB) is considered a grade IV cancer of the central nervous system, according to the World Health Organization [1]. (genesispub.org)
PCT served as primary manufacturer for Dendreon during seven years of clinical trials for its prostate cancer cell-based treatment, Provenge. (genengnews.com)
Dr. Quinones-Hinojosa's lab is studying ways to engineer human fat cells to turn them into cancer-fighting Trojan horses and evaluating a gel to locally administer to patients during brain cancer surgery. (mayo.edu)
In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)
In contrast to normal cells, most cancer cells predominantly produce energy by a high rate of glycolysis followed by lactate fermentation, even in the presence of oxygen, a less efficient metabolism compared to a low rate of glycolysis followed by mitochondrial oxidation of pyruvate [ 2 ]. (hindawi.com)
In contrast, cancer cells shift their metabolism toward lactate production even in the presence of oxygen [ 4 ], partly through genetic modifications that stabilize the transcription factor Hypoxia Inducible Factor (HIF) involved in the adaptation of the cells to hypoxia, under nonhypoxic conditions as well as generating an adaptive response to the hypoxic microenvironment (Figure 1 ). (hindawi.com)
Metabolic adaptations of cancer cells. (hindawi.com)
Glucose and glutamine are the 2 major substrates used by cancer cells. (hindawi.com)
The indication that, similarly to prostate cancer, ALDH7A1 activity in glioblastoma may correlate with tumour invasiveness, is of potential diagnostic importance. (gitlab.io)
The techniques used are a wide array of state-of-the-art cancer research methods including molecular and cell biology, biochemistry, gene differential expression, gene knock-down and delivery techniques and animal studies. (hopkinsmedicine.org)
Using genetically engineered human pluripotent stem cells, University of California San Diego School of Medicine researchers created a new type of cancer model to study in vivo how glioblastoma, the most common and aggressive form of brain cancer, develops and changes over time. (reachmd.com)
According to the cancer stem cell (CSC) concept, the cellular hierarchy in normal tissues is preserved in a number of hematological and solid malignancies. (medscape.com)
The CSC is defined as a cancer cell with self-renewing capacity that can regenerate the original tumor in all its differentiated heterogeneity. (medscape.com)
Cancer stem cell-associated proteins revealed by proteomics. (medscape.com)
At the end of 2023, researchers at Lund Stem Cell Center received funding amounting to SEK 77.5 million from the Swedish Research Council, the Swedish Cancer Society, and the Swedish Childhood Cancer Fund. (lu.se)
The project funded by Cancerfonden, will focus on using exhaled breath particles as a non-invasive method for diagnosing and monitoring non-small-cell lung cancer. (lu.se)
Direct cellular reprogramming has recently gained attention of cancer researchers for the possibility to convert undifferentiated cancer cells into more differentiated, postmitotic cell types. (lu.se)

Canonical Wnt signaling pathway is essential for embryonic development [ 10 ] and non-canonical Wnt pathway regulates cell movement and tissue polarity [ 11 ]. (biomedcentral.com)
This protein is constitutively expressed in mature B cells, plasma cells and plasmacytoid dendritic cells, and in many other cells, it is only expressed as a response to stimuli from IFN pathway. (wikipedia.org)
When the presence of virus and viral components is detected by recognition molecules such as (RIG-I), a cascades of interactions happen between signaling molecules, eventually the signal reaches the nucleus to upregulate the expression of interferon-stimulated genes (ISGs), this in turn activates IFN-α pathway to send the signal to neighboring cells, which causes upregulation in the expression of other ISGs and many viral restriction factors, such as tetherin. (wikipedia.org)
Although Tetherin is localized to the lipid rafts on the surface of the cells, they are endocytosed to be sorted through TGN by clathrin-dependent pathway. (wikipedia.org)

The classification of each glioma is based on its cell origin and molecular characteristics, which includes acquired mutations [4]. (genesispub.org)
Importantly, both GS 5-22 and GS 8-18 were derived from patients with secondary glioblastoma with concurrent IDH mutations. (biomedcentral.com)
[ 10 ] TERT mutations are found consistently in both oligodendrogliomas as well as glioblastomas occurring in patients with no previous history of astrocytomas (primary glioblastoma). (medscape.com)
[ 10 ] Interestingly, while IDH1/2 mutations and TERT mutations occur together in oligodendrogliomas, they are mutually exclusive in glioblastomas, further supporting the distinction between primary and secondary glioblastomas. (medscape.com)
The resulting avatars are unique in that they behave like a grade 4 glioma-a fast-growing type of tumor that starts in the glial cells of the brain-in their level of pathology, transcriptome signatures, engineered genetic alterations and evolution of genetic mutations, such as the emergence of extrachromosomal DNA and chromosomal rearrangements. (reachmd.com)
Secondary glioblastomas typically have mutations in the IDH1 or IDH2 genes. (msdmanuals.com)

Immune cell infiltration varies widely between different glioblastomas (GBMs). (uni-regensburg.de)
How do doctors differentiate between different glioblastomas? (genesispub.org)

Hypoxia modulation of peroxisome proliferator‐activated receptors (PPARs) in human glioblastoma stem cells. (growkudos.com)
Biological assays showed that invasive and migratory behavior was strengthened by hypoxia only in GBM stem cells. (biomedcentral.com)
Increasing tumor size requires that GBM tumor cells maintain a balance between adaptation to hypoxia and cell death (apoptosis and central necrosis) through activation of hypoxia-inducible transcription factor 1 (HIF-1). (biomedcentral.com)
Hypoxia-inducible factors enhance glioma stemness, and glioma stem cells have an amplified hypoxic response despite residing within a perivascular niche. (lu.se)
We show that the intracellular domain of stem cell marker CD44 (CD44ICD) is released at hypoxia, binds HIF-2α (but not HIF-1α), enhances HIF target gene activation, and is required for hypoxia-induced stemness in glioma. (lu.se)

Novavax to Use Vivalis' Duck Embryonic Stem Cell Line for Vaccine. (genengnews.com)
Glioblastoma Embryonic-like Stem Cells Exhibit Immune-Evasive Phenotyp" by Borja Sesé, Sandra Íñiguez-Muñoz et al. (providence.org)
RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus. (nih.gov)

Glioblastoma (GBM) is the most common and aggressive type of primary brain tumor 1 . (nature.com)
Glioblastoma is the most common form of primary brain tumor. (biomedcentral.com)

recommending flaws in the Compact disc34+ hematopoietic stem and progenitor cell (HSPC) pool. (sipurpashut.net)

Recent breakthroughs in human pluripotent stem cell-derived cerebral organoids provide a valuable platform for investigating the human brain after different drugs treatments and for understanding the complex genetic background to human pathology. (frontiersin.org)

PCT's competencies in autologous cell therapies, cell manufacturing, cell processing, and delivery make it ideally suited as a manufacturer for ImmunoCellular Therapeutics as we look forward to completing this Phase II trial and seek to secure a strategic partner in connection with a future potential Phase III trial for ICT-107 and its commercialization," states Manish Singh, Ph.D., ImmunoCellular Therapeutics president and CEO. (genengnews.com)

Northwestern Medicine scientists have identified how one gene connects glioblastoma stem cell self-renewal to microglia immunosuppression in glioblastoma, according to a new study published in Nature Immunology. (ground.news)
SCs are not only capable of maintaining themselves (self-renewal) but also give rise to a proliferative 'transit amplifying' compartment and ultimately to postmitotic differentiated cells with specialized functions. (medscape.com)
By contrast, transit amplifying cells and differentiated cells are incapable of self-renewal and tissue regeneration. (medscape.com)

Scientists debate whether GBs arise from a subculture of neural stem cells or from the transformation of differentiated astrocytes [6]. (genesispub.org)

BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1? (omicsdi.org)

With such a severe and devasting prognosis and little ability to extend or cure the disease, researchers have been trying to find the best treatments to help patients suffering from Glioblastoma. (genesispub.org)
The dendritic cells are harvested from patients, then programmed to attack tumor-specific antigens before they are injected them back into patients' bodies. (genengnews.com)
Glioblastoma (GBM) prognosis remains dismal, with most patients succumbing to disease within 1 or 2 years of diagnosis. (johnshopkins.edu)
Glioblastoma (GBM, grade IV glioma) represents the most aggressive brain tumor and patients with GBM have a poor prognosis. (unimib.it)
Researchers in the Brain Tumor Stem Cell Research Lab are investigating the oncostatic effects of melatonin on glioblastoma to improve treatment and provide better quality of life for patients. (mayo.edu)
Up to 10% of patients with glioblastoma harbor a mutation in the IDH1 or IDH2 genes, an early event in gliomagenesis. (cancernetwork.com)
Imaging findings and cognitive function in glioblastoma patients. (lu.se)
This brings as oral dopamine therapies with the advantage that with it continued infective risks for the patients the cells can be targeted to the site where dopamine with DBS which is not so for patients with trans- is most needed, namely the striatum. (lu.se)

The majority of glioblastomas are IDH wild-type and correspond to the longstanding clinical description of primary glioblastomas, which arise rapidly from non-neoplastic brain cells and progress quickly. (cancernetwork.com)
this metabolite can modify DNA methylation of normal neural and glial progenitor cells causing them to produce neoplastic glioma cells. (msdmanuals.com)

Glioblastoma (GBM) is the most lethal form of adult brain cancers with a median survival of andlt;15 months despite aggressive standard chemoradiation. (sbir.gov)

Early fate decisions in hematopoietic stem and progenitor cells. (lu.se)

Since these glioblastomas often arise from a prior lower-grade glioma, they are considered secondary glioblastomas. (cancernetwork.com)
In the past, both primary and secondary glioblastomas were considered to be the same clinical entity. (cancernetwork.com)
As such, secondary glioblastomas are to be classified as a distinct biological and molecular entity for which different treatment strategies will ultimately be proposed. (cancernetwork.com)
Anaplastic astrocytomas, in particular, can later evolve into glioblastomas (called secondary glioblastomas). (msdmanuals.com)

ICT-107 is a dendritic cell-based immunotherapy targeting multiple tumor-associated antigens. (genengnews.com)

While a few studies have attempted reprogramming of glioblastoma (GBM) cells toward a neuronal fate, this approach has not yet been used to induce differentiation into other lineages and in vivo data on reduction in tumorigenicity are limited. (lu.se)
Most importantly, forced differentiation substantially reduces tumorigenicity of GBM cells in an in vivo xenotransplantation model. (lu.se)

Gliomas often originate from three types of glial cells: oligodendrocytes, ependymal cells, and astrocytes - however, astrocytic gliomas hold 70% of all glioma origins [4]. (genesispub.org)
In addition, a subgroup of lower-grade gliomas may carry molecular features and signatures similar to glioblastoma, with a similarly aggressive natural course,[4] for which an intensive treatment strategy is advocated. (cancernetwork.com)

In normal cells, glucose participates in cellular energy production through glycolysis as well as through its complete catabolism via the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). (hindawi.com)
Tetherin is a human cellular protein which inhibits retrovirus infection by preventing the diffusion of virus particles after budding from infected cells. (wikipedia.org)

Emerging roles ofthe tumor-associated stroma in promoting tumor metastasis.Cell Adh Migr. (edu.pl)

Can Immunotherapy Succeed in Glioblastoma? (cdc.gov)

The Brain Tumor Stem Cell Research Laboratory has created a human tissue bank to preserve tissue and cell cultures for use in present and future experiments. (mayo.edu)
Cell-to-cell transmission through virological synapse in human retroviruses is also inhibited by tetherin. (wikipedia.org)
From each of 10 human solid glioblastomas, clinically and histopathologically characterized, we obtained three surgical samples taken from the center and the periphery of the tumor, and from adjacent host normal tissue. (biomedcentral.com)
In human solid glioblastoma we have observed a coordinated overexpression of a panel of pro-inflammatory genes as compared to host normal tissue. (biomedcentral.com)
Recent breakthroughs in human pluripotent stem cells (hPSCs)-derived cerebral organoids offer a promising approach for investigating the mystery of human brain ( 19 ). (frontiersin.org)
primary human leukemic stem cells and human glioblastoma models. (helsinki.fi)
City of Hope is a leader in the field of stem cell and regenerative medicine - the use of self-renewing cells to treat human disease - and its Alpha Stem. (cityofhope.org)
To this end, we overexpressed key transcriptional regulators of astroglial development in human GBM and GBM stem cell lines. (lu.se)
DBS is a widely used FDA-approved treatment and stem cell-derived dopamine neuron replacement has now evolved to the first in-human clinical trials. (lu.se)

Musashi-1 (MSI1) is a neural stem-cell marker and key oncogenic factor of GBM. (tmu.edu.tw)

Normal proliferative tissues contain multipotent stem cells (SCs) that drive tissue turnover. (medscape.com)

Several avenues of investigation are being explored in Dr. Quinones-Hinojosa's Brain Tumor Stem Cell Research Laboratory at Mayo Clinic. (mayo.edu)
Projects in the Brain Tumor Stem Cell Research Lab investigate the effect of ion transporters in brain tumor cell migration and the molecular engines that drive tumor invasion. (mayo.edu)
Wnt deregulation in brain is associated with congenital disorders [ 7 ], whereas it promotes malignancy in somatic cells of neuronal origin [ 8 ]. (biomedcentral.com)
Glioblastoma (GBM) is a very aggressive and fatal brain tumor. (hopkinsmedicine.org)
The use of stem cell-derived dopamine neurons or deep brain stimulation (DBS) represents two alternative approaches to treat Parkinson's Disease. (lu.se)

Anatomy47

Organisms13

Diseases18

Chemicals and Drugs64

Analytical, Diagnostic and Therapeutic Techniques and Equipment60

Phenomena and Processes53

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science3

Health Care7

Multiforme18

Tumors19

GSCs20

Phenotype10

Proliferation14

Patient-derived4

Chemotherapy5

Signaling pathway in glioblastoma2

Progression5

Mesenchymal6

Therapy10

Therapeutic10

Vitro1

Radiotherapy2

Inhibition2

Management of glioblastoma1

Infiltrate2

Malignant5

CSCs2

Cancer28

Pathway4

Mutations6

Different glioblastomas2

Hypoxia5

Embryonic3

Primary brain tumor2

Progenitor cell1

Pathology1

Therapeutics1

Self-renewal3

Neural stem1

Temozolomide1

Patients8

Neoplastic2

Survival1

Hematopoietic stem and progenitor1

Secondary4

Targeting1

Vivo2

Gliomas2

Cellular2

Tumor associated1

Immunotherapy1

Human9

Marker1

Tissues1

Brain5