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  • neuronal cells
  • In accordance, the two splice isoforms responded differently to KCl-induced depolarization that is known to trigger the secretion of neurotrophin family members in neuronal cells. (helsinki.fi)
  • protein
  • To elucidate, whether secreted proGDNF has any biological activity, the recombinant cleavage-resistant proGDNF mutant protein was expressed in mammalian CHO cells and next purified from the media. (helsinki.fi)
  • synaptic
  • During development, establishment of the mature pattern of neuronal connectivity is achieved by the formation, differentiation, refinement and maintenance of specialized synaptic contacts between pre-, peri- and post-synaptic cells. (plos.org)
  • The vertebrate neuromuscular junction (NMJ), a synapse between pre-synaptic motor axons, peri-synaptic Schwann and postsynaptic skeletal muscle cells, has been an excellent model to understand synapse formation and maintenance [ 1 , 2 ]. (plos.org)
  • Moreover, a growing amount of evidence indicates that uncontrolled hemichannel opening could impair glial cell functions, affecting synaptic transmission and neuronal survival. (nih.gov)
  • lineages
  • NSCs are self-renewing multipotent stem cells that can be proliferated in vitro in supportive culture systems such as Gibco StemPro NSC SFM and can further be differentiated into downstream lineages. (thermofisher.com)
  • Using genetic fate mapping, we here demonstrate that mouse neural crest cells marked by SRY box-containing gene 10 (Sox10) generate the neuronal and glial lineages of enteric ganglia. (jci.org)
  • Biology
  • Before this study, we didn't know what physiological role the proNGF molecule played in the eye," said coauthor Dr. Adriana Di Polo, a professor at the Universite de Montreal Department of Pathology and Cell Biology. (medindia.net)
  • The next step for researchers is to explore whether proNGF signals can be controlled", said Frederic Lebrun-Julien, first author and a PhD student at the Universite de Montreal's Department of Pathology and Cell Biology. (medindia.net)
  • More is known about astrocytic biology than about that of other glial cell types. (frontiersin.org)
  • role
  • The researchers discovered that differentiation involves three stages and that three proteins in the cell nucleus, so-called transcription factors, play a key role in organizing glia-specific transcription of the genes in the cell nucleus. (innovations-report.com)
  • In this manuscript, we discuss how glial cells may contribute to the enhanced sympathetic drive observed in MS, and shed light about the possible role of hemichannels in this process. (nih.gov)
  • evidence
  • Within the last decade, a growing body of evidence has indicated that glial cells can also communicate with neurons via the release of vesicles (e.g., exosomes, microparticles, and apoptotic bodies), containing different cellular messengers (e.g., mRNA, viruses, and organelles) (7). (nih.gov)
  • function
  • Our research shows that we can increase the production and maintenance of glial cells that are important for supporting neurons, providing an enriched environment for proper neuronal function. (kurzweilai.net)
  • An underlying molecular mechanism was also identified when the data showed that antidepressants increase glial generation and function via increasing FGF2 signaling. (kurzweilai.net)
  • our studies demonstrate that DLX3 physically interacts with GCM1 and inhibits its transactivation activity, suggesting that DLX3 and GCM1 may form a complex to functionally regulate placental cell function through modulation of target gene expression. (nih.gov)
  • Although glial cells in the PNS have similar functions to their CNS counterparts, there are enough differences in the morphology, biochemistry, and function between PNS and CNS glia that they appear to be more analogs rather than homologs, and we need to be careful about making too many generalizations. (pubmedcentralcanada.ca)
  • Glial cells in neuronal network function. (semanticscholar.org)
  • types
  • This acrylic painting was inspired by multi-coloured fluorescent proteins which are used to label different types of cells and different compartments inside a cell (e.g. nucleus, membrane, cytoplasm). (wellcomecollection.org)
  • Of course that will vary greatly from condition to condition and between tissue types - there are other contributing causes for the chronic inflammation that characterizes old age, and in any specific case senescent cells may or may not be the most important cause. (fightaging.org)
  • This may or may not reflect actual senescence, but it is a much higher proportion of cells in comparison to other aged tissues examined to date - sufficiently high to raise doubt over whether this is in fact the same phenomenon observed in better characterized types of senescent cells. (fightaging.org)
  • However, many applications in tissue engineering like cell growth studies and drug transportation are better investigated using a 3D culture system.In this study we investigated the growth, survival, and interactions of NSCs, OECs, and NSC/OEC co-culture with different alginate types (UP MVM, UP MVG, M-RGD, G-RGD, MREDV and VAPG) and Matrigel. (bibsys.no)
  • abundant
  • In previous studies, Kokoeva and her colleagues found that the majority of cells dividing in the hypothalamus-a whopping 80 percent-were NG2-glia, which sparked their interest in finding out why the cells were so abundant. (scientificamerican.com)
  • NSCs
  • The protocols described are primarily optimized with NSCs derived from human embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC). (thermofisher.com)
  • This study showed that different alginate matrices differentially affect proliferation, survival, and network formation of the cells over time, while the cell morphologies of NSCs and OECs appear round in a 3D matrix. (bibsys.no)
  • human
  • Title: DLX3 interacts with GCM1 and inhibits its transactivation-stimulating activity in a homeodomain-dependent manner in human trophoblast-derived cells. (nih.gov)
  • generate
  • Since senescent cells generate chronic inflammation , removing the accumulation of such cells in old tissues should improve matters for all age-related conditions with an inflammatory component. (fightaging.org)
  • normally
  • Glial cells, which normally protect neurons in the retina can also kill them, resulting in vision loss and blindness has been discovered by scientists from University of Montreal and McGill University's Montreal Neurological Institute. (medindia.net)
  • transcription
  • As Professor Benedikt Berninger and his team have now discovered using RNA sequencing, which is a method of profiling all genes in a cell that are undergoing transcription at a particular point in time, the differentiation process involves three stages. (innovations-report.com)
  • radial
  • During development of the murine telencephalon, the germinal zone contains a population of specialized cells called radial glial cells (RGCs), which appear at approximately embryonic day (E) 13 ( Kriegstein and Götz, 2003 ). (jneurosci.org)
  • RGCs have their cell soma within the embryonic germinal zone, display a bipolar morphology with a single, elongated process that extends basally to the pial surface, and are distinguished from other radial cell populations, such as neuroepithelial cells, by displaying neuroepithelial and astroglial characteristics ( Kriegstein and Götz, 2003 ). (jneurosci.org)