• Glial cell line-derived neurotrophic factor (GDNF) is a protein that, in humans, is encoded by the GDNF gene. (wikipedia.org)
  • The GDNF gene encodes a highly conserved neurotrophic factor. (wikipedia.org)
  • In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. (wikipedia.org)
  • GDNF also promotes hair follicle formation and cutaneous wound healing by targeting resident hair follicle stem cells (BSCs) in the bulge compartment. (wikipedia.org)
  • Glial cell line-derived neurotrophic factor has been shown to interact with GFRA1 and GDNF family receptor alpha 1. (wikipedia.org)
  • In cells that lack RET, some GDNF family ligand members also have the ability to be activated through the neural cell adhesion molecule (NCAM). (wikipedia.org)
  • The GDNF family ligands (GFLs) function through a glycosyl-phosphatidylinositol-(GPI) anchored coreceptor, GDNF family receptor alpha (GFRα), and rearranged during transfection (RET), a well-known receptor tyrosine kinase involved in kidney development, spermatogonial stem cell maintenance, and the development and maintenance of the sympathetic, parasympathetic, and enteric nervous systems [ 1 , 2 ]. (medsci.org)
  • Lin LF, Doherty DH, Lile JD, Bektesh S, Collins F: GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. (drugbank.com)
  • Angrist M, Bolk S, Halushka M, Lapchak PA, Chakravarti A: Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient. (drugbank.com)
  • Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-β superfamily. (yeasen.com)
  • Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells. (yeasen.com)
  • E.coli-derived mouse GDNF, Ser78-Ile211. (yeasen.com)
  • Effects of glial cell line-derived neurotrophic factor (GDNF) were studied in transgenic (Tg) mice model for amyotrophic lateral sclerosis. (elsevierpure.com)
  • We report that glial cell-line-derived neurotrophic factor (GDNF) signaling through the RET tyrosine kinase/GFRA1 receptor complex is required for spermatogonial self-renewal in mice. (wustl.edu)
  • Our results demonstrate that GDNF-mediated RET signaling is critical for the fate of undifferentiated spermatogonia and that abnormalities in this pathway may contribute to male infertility and testicular germ cell tumors. (wustl.edu)
  • Here we show that these neurons express the receptor components for glial-derived neurotrophic factor (GDNF) signaling (RET, GFRα-1, and GFRα-2). (jneurosci.org)
  • GDNF, but not nerve growth factor (NGF), can prevent several axotomy-induced changes in these neurons, including the downregulation of IB4 binding, TMP activity, and somatostatin expression. (jneurosci.org)
  • GDNF also prevents the slowing of conduction velocity that normally occurs after axotomy in a population of small diameter DRG cells and the A-fiber sprouting into lamina II of the dorsal horn. (jneurosci.org)
  • This study aimed to investigate whether there are differences in serum brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and neurotrophin-3 (NTF3) levels between children with ADHD and healthy controls. (springer.com)
  • Kotyuk E, Keszler G, Nemeth N, Ronai Z, Sasvari-Szekely M, Szekely A (2013) Glial cell line-derived neurotrophic factor (GDNF) as a novel candidate gene of anxiety. (springer.com)
  • Artemin is one of four members of the glial cell line-derived-neurotrophic factor (GDNF) family of proteins. (nyu.edu)
  • 4. Gill SS, … Brooks DJ, … Heywood P. Direct brain infusion of glial cell line-derived neu rotrophic factor (GDNF) in Parkinson's Disease. (ncl.ac.uk)
  • The aim of this study is to learn if rat BMSC express brain-derived neurotrophic factor (BDNF) and glia-derived nerve factor (GDNF) and determine if this expression varies according to the number of culture passages. (sld.cu)
  • GDNF production in individual cells in the culture was analyzed by Immunocytochemistry. (sld.cu)
  • El objetivo de este trabajo consistió en demostrar si las CEMO expresan los factores neurotróficos derivados de cerebro y de línea de células gliales (BDNF y GDNF, respectivamente) y determinar si esta expresión varía en relación con el número de pases en cultivo. (sld.cu)
  • La producción de GDNF por las células individuales en cultivo se analizó mediante Inmunocitoquímica. (sld.cu)
  • Sin embargo, la producción de GDNF solo tuvo lugar en los pases 7 y 12. (sld.cu)
  • On the other hand, the glial cell line-derived neurotrophic factor (GDNF) has the strongest trophic effect on dopaminergic neurons (10). (sld.cu)
  • The glial cell-line derived neurotrophic factor (GDNF) and neurturin (NTN) belong to a structurally related family of neurotrophic factors. (mit.edu)
  • Gene-expression analysis revealed that glial cell line-derived neurotrophic factor ( Gdnf ) is highly expressed in Lin - CD24 + c-Kit + Sca1 + stem cells. (jci.org)
  • Administration of GDNF improved saliva production and enriched the number of functional acini in submandibular glands of irradiated animals and enhanced salisphere formation in cultured salivary stem cells, but did not accelerate growth of head and neck cancer cells. (jci.org)
  • Anti-NCAM1 autoantibody disrupts both NCAM1-NCAM1 and NCAM1-glial cell line-derived neurotrophic factor (GDNF) interactions. (neurosciencenews.com)
  • We developed modified Herpes Simplex Virus (HSV-1) particles that contain chimeric glycoprotein C (gC) - glial cell line-derived neurotrophic factor (GDNF) or brain-derived neurotrophic factor (BDNF) proteins. (harvard.edu)
  • 2000). We of glial cell line-derived neurotrophic factor (GDNF) in models of have recently reported that this vector directs transgene expression to Parkinson's disease (Georgievska et al. (lu.se)
  • Meng WD, Sun SJ, Yang J, Chu RX, Tu W, Liu Q (2016) Elevated serum brain-derived neurotrophic factor (BDNF) but not BDNF gene Val66Met polymorphism is associated with autism spectrum disorders. (springer.com)
  • Wysokinski A (2016) Serum levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in depressed patients with schizophrenia. (springer.com)
  • It has been described that the brainderived neurotrophic factor (BDNF) regulates neurotransmitter release and dendritic and axonal growth. (sld.cu)
  • Brain-derived neurotrophic factor (BDNF) has several functions in the central nervous system, where it contributes to brain development and its functionality through affecting neuronal survival and activity and also modulating neurotransmitter levels. (hindawi.com)
  • Brain-derived neurotrophic factor (BDNF) contributes to brain development [ 1 , 2 ] and is related to neuronal survival and activity since it acts as a modulator of neurotransmitter levels and participates in neuronal plasticity [ 3 , 4 ]. (hindawi.com)
  • Neurotrophins, particularly brain-derived neurotrophic factor (BDNF), have been implicated in the pathophysiology of ADHD and response to stimulant treatment. (bvsalud.org)
  • It can be secreted by astrocytes, oligodendrocytes, Schwann cells, motor neurons, and skeletal muscle during the development and growth of neurons and other peripheral cells. (wikipedia.org)
  • citation needed] It prevents apoptosis in motor neurons during development, decreases the overall loss of neurons during development, rescues cells from axotomy-induced death, and prevents chronic degeneration. (wikipedia.org)
  • Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. (drugbank.com)
  • Monocytes deliver bioactive nerve growth factor through a brain capillary endothelial cell-monolayer in vitro and counteract degeneration of cholinergic neurons. (uibk.ac.at)
  • Rotenone induces cell death of cholinergic neurons in an organotypic co-culture brain slice model. (uibk.ac.at)
  • Using whole‐cell patch‐clamp recordings, we characterised the maturation of the grafted cells into functional GABAergic inter-neurons in the host brain, and we confirmed the presence of functional inhibitory synaptic connections from grafted cells onto the host neurons. (lu.se)
  • These data represent a proof‐of‐concept that hESC‐derived GABAergic neurons can exert a therapeutic effect on epileptic animals presumably through establishing inhibitory synapses with host neurons. (lu.se)
  • In addition, the addition of VEGF to the culture medium can increase the survival rate of neurons in the cerebral cortex as well as the number and length of ganglion cell processes, to promote nerve growth. (spandidos-publications.com)
  • Several neurotrophic factors were detected in the pre-transfected hONPs which have potential roles in the maintenance, survival and proliferation of dopaminergic neurons. (scirp.org)
  • A second approach to achieve neuronal type-specific expression is to use a cell type-specific promoter, and we have used the tyrosine hydroxylase (TH) promoter to restrict expression to catecholaminergic neurons or a modified neurofilament heavy gene promoter to restrict expression to neurons, and both of these promoters support long-term expression from HSV-1 vectors. (harvard.edu)
  • However, it is becoming increasingly clear that these factors and their receptors are also widely found to express across many different cancers with further research. (medsci.org)
  • In recent years, the MAPK family has been found to be an important signal-regulating enzyme between cell surface receptors and determinants of gene expression ( 8 ). (spandidos-publications.com)
  • P-glycoprotein/MDR1, multidrug resistance-associated proteins), nuclear receptors (e.g., glucocorticoid nuclear receptor, pregnane xenobiotic nuclear receptor), and other regulatory factors that control pharmacokinetic and pharmacodynamic phenomena during drug biotransformation in disease states. (ccf.org)
  • The glial cell line-derived neurotrophic factors (GDNFs), a family of neurotrophic factors, were initially thought to be able to regulate the growth, survival, and differentiation of neural-derived cell types. (medsci.org)
  • A family of closely related nerve growth factors that promote NEURON survival. (childrensmercy.org)
  • Like other FGF family members, basic fibroblast growth factor possess broad mitogenic and cell survival activities, and is involved in a variety of biological processes, including embryonic development , cell growth , morphogenesis , tissue repair , tumor growth and invasion. (wikidoc.org)
  • It is essential for cell homeostasis and survival and has been related to various diseases and pathophysiology. (helsinki.fi)
  • Neurotrophic factors promote neuronal survival and stimulate axonal growth (6). (sld.cu)
  • Artemin, a neuronal survival factor in the glial cell line-derived neurotrophic factor family, binds the glycosylphosphatidylinositol-anchored protein GFRα3 and the receptor tyrosine kinase Ret. (jneurosci.org)
  • Therefore, the MAPK family governs almost all the physiological functions and processes such as cell adaptation, proliferation, differentiation, survival, and programmed cell death. (spandidos-publications.com)
  • [ 18 ] A study by Alt et al found that complete resection of multiple renal cell carcinoma metastases may be associated with long-term survival. (medscape.com)
  • This applies as well in the adjuvant treatment of surgically resected renal cell carcinoma, for which no therapy has yet been found to offer survival benefit. (medscape.com)
  • HSP90 inhibition may also enhance synaptic protein expression via activation of heat shock factor 1 (HSF-1) transcriptional regulation 16 . (nature.com)
  • FGF2 , also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene . (wikidoc.org)
  • Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated basic FGF, Heparin-binding growth factor-2, and Endothelial cell growth factor-2. (wikidoc.org)
  • Basic fibroblast growth factor has been shown to interact with casein kinase 2, alpha 1 , [13] RPL6 [14] and ribosomal protein S19 . (wikidoc.org)
  • In a study published last month in Cell Reports Medicine , researchers from Tokyo Medical and Dental University (TMDU) have identified an autoantibody-a protein that is produced by the immune system to attach to a specific substance from the individual's own body, rather than to a foreign substance like a virus or bacteria-in some patients with schizophrenia. (neurosciencenews.com)
  • Furthermore, it was revealed that treatment with vitexin induced hypoxia inducible factor 1α subunit (HIF‑1α) and vascular endothelial growth factor (VEGF) protein expression, and suppressed phosphorylated‑p38 MAP kinase (p38) protein expression in sevoflurane‑induced newborn rat. (spandidos-publications.com)
  • Here we describe a different method of transgene regulation by the use of the human glial ®brillary acidic protein (GFAP) promoter. (lu.se)
  • In animals receiving excitotoxic lesions of the striatum we detected an eightfold increase of green ¯uorescent protein (GFP)-expressing cells. (lu.se)
  • [3] [5] FGF2 binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins which themselves constitute a family of closely related molecules. (wikidoc.org)
  • Since rate of autophagy in cells was not detected, it is impossible to determine, if there were changes in autophagy that were not reflected as changes in colocalization of these two proteins. (helsinki.fi)
  • To characterize hCMEC/D3 cells for the presence of specific endocytic pathways, proteins involved into each pathway were selected. (helsinki.fi)
  • In the affected ventral spinal cord, resveratrol enhanced the expression of several vascular endothelial growth factor family proteins (VEGFs) and increased the phosphorylation of p300 through Akt signaling, indicating activation of p300 acetyltransferase. (vinomis.com)
  • Ghosh, C. Heat Shock Proteins Accelerate the Maturation of Brain Endothelial Cell Glucocorticoid Receptor in Focal Human Drug-Resistant Epilepsy. (ccf.org)
  • These vectors have a number of appealing features including the expression by using the machinery of the host cell instead of depending abilities to ef®ciently transduce cells in the central nervous system, on recombinant regulatory proteins. (lu.se)
  • Since neurotrophic factors are the primary architects of neurogenesis, synaptic plasticity, learning, and memory, the findings from preclinical and clinical studies that assess changes in neurogenesis and neurotrophic factors and their relationship to cognitive performance in schizophrenia, and how these mechanisms might be impacted by APD treatment, may provide valuable clues in developing therapies to combat cognitive deficit in schizophrenia. (benthamscience.com)
  • The therapeutic approach to renal cell carcinoma (RCC) is guided by the probability of cure, which is related directly to the stage or degree of tumor dissemination. (medscape.com)
  • To view a multidisciplinary tumor board case discussion, see Memorial Sloan Kettering e-Tumor Boards: Metastatic Clear Cell Renal Cell Carcinoma . (medscape.com)
  • ROCKVILLE, Md., Feb. 15 29, 2022 (GLOBE NEWSWIRE) - Circulating tumor cells (CTCs) are a hot topic of oncology conferences and research due to their enormous potential in the diagnosis and treatment of cancer. (resourcekt.co.uk)
  • Examples are CRISPR/Cas9-mediated mutagenesis, genetic mouse models, cell-fate-mapping, organoids and tumor explants, as well as GMP production of pharmaceuticals and many years of experience in conducting clinical studies. (mdc-berlin.de)
  • One of the research areas at the MDC is immunology and inflammation, which covers tumor immunology, DNA repair in B lymphocytes, the role of tumor stroma-immune cell interaction in cancers, the role of innate immune cells in gliomas and neurodegenerative diseases, and the development of immunotherapy strategies. (mdc-berlin.de)
  • Renal cell carcinoma is an immunogenic tumor, and spontaneous regressions have been documented. (medscape.com)
  • Recombinant Mouse Glial Cell Line-der. (yeasen.com)
  • Hypoxia inducible factor-1 (HIF-1) is an oxygen-sensitive transcriptional regulator that regulates more than 70 downstream target genes, including vascular endothelial growth factor, erythropoietin, glucose transporter and so on ( 5 ). (spandidos-publications.com)
  • Human embryonic kidney cells 293 (HEK-293) and hPREP knockout cell line created from them by using CRISPR/Cas9-silencing were used in the experiments. (helsinki.fi)
  • We generated GABAergic interneuron precursors from human embryonic stem cells (hESCs) and grafted them in the hippocampi of rats developing chronic SRSs after kainic acid‐induced status epilepticus. (lu.se)
  • Transcription factors (nurr1, pitx3 and lmx1a) that promote embryonic mouse or chicken dopaminergic development were employed to determine if they would modulate lineage restriction of these adult human progenitors. (scirp.org)
  • The use of olfactory progenitors as a cell-based therapy for Parkinson's disease (PD) would allow harvest without invasive surgery, provide an autologous cell population, eliminate need for immunosuppression and avoid the ethical concerns associated with embryonic tissues. (scirp.org)
  • Petersén Å, Hansson O, Emgård M and Brundin P.Cell Transplantation 9: 577-584 (2000)AbstractTransplantation of embryonic ventral mesencephalon is a potential therapy for patients with Parkinson's disease. (lu.se)
  • Brundin P, Karlsson J, Emgård M, Kaminski Schierle GS, Hansson O, Petersén Å and Castilho RF.Cell Transplantation 9: 179-195 (2000)AbstractNeural transplantation is developing into a therapeutic alternative in Parkinson's disease. (lu.se)
  • Bone marrow stromal cells (BMSC) are adult stem cells with characteristics that make them an attractive candidate in cellular therapy for neurological diseases (1). (sld.cu)
  • Stem cell-based regenerative therapy is a promising treatment for head and neck cancer patients that suffer from chronic dry mouth (xerostomia) due to salivary gland injury from radiation therapy. (jci.org)
  • However, despite having the promising outcome of preclinical studies, the clinical application of stem cell therapy remained elusive due to little or no progress in clinical trials. (hindawi.com)
  • The objective of this study was to provide a generalized critique for the role of mesenchymal stem cell therapy in ischemic stroke injury, its underlying mechanisms, and constraints on its preclinical and clinical applications. (hindawi.com)
  • Thus, we attempted to present an overview of previously published reports to evaluate the progress and provide molecular basis of mesenchymal stem cells (MSCs) therapy and its application in preclinical and clinical settings, which could aid in designing an effective regenerative therapeutic strategy in the future. (hindawi.com)
  • The recent decade has seen encouraging outcomes of mesenchymal stem cell therapy that holds promise to alleviate the burden of neurological disorders Moreover, initial study data of preclinical trials have also indicated the effectiveness, tolerance, and safety of MSC-based therapy [ 10 ]. (hindawi.com)
  • However, effective dose and appropriate time of MSCs delivery are the main challenges in the clinical translation of stem cell therapy. (hindawi.com)
  • Herein, we presented an overview of a previously published work regarding the role of stem cell therapy in ischemic stroke and its underlying molecular mechanisms. (hindawi.com)
  • We aim to provide the basis for establishing a future study to promote the clinical translation of stem cell therapy in ischemic brain diseases. (hindawi.com)
  • Aloe L, Rocco ML, Bianchi P, Manni L (2012) Nerve growth factor: from the early discoveries to the potential clinical use. (springer.com)
  • Circulating nerve growth factor in primary and secondary Raynaud's syndrome - Results of a pilot study. (uibk.ac.at)
  • Time-dependent changes in the levels of transcripts of … nerve growth factor (NGF) and apolipoprotein E (ApoE) genes were monitored by RT-PCR. (iospress.com)
  • The vast majority of these cells did not divide, suggesting that the transgene was indeed regulated in a similar fashion as the endogenous GFAP gene. (lu.se)
  • There are a number of hypothesized that regulating the transgene with a GFAP promoter in a different vectors that transduce cells in the brain in a slightly different viral vector would give rise to a high transgenic expression in the manner (for a review see, e.g. (lu.se)
  • Li Q, Cao Z, Zhao S. The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers. (medsci.org)
  • Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. (medsci.org)
  • Based on whether it cooperates with the second receptor RET, GFRα has also been widely linked to the mechanisms that contribute to cell growth, differentiation and migration and tissue maturation. (medsci.org)
  • It was also shown to act on preosteoblasts - in the form of an increased proliferation - after binding to fibroblast growth factor receptor 1 and activating phosphoinositide 3-kinase . (wikidoc.org)
  • [9] It is necessary in mouse-feeder cell dependent culture systems, as well as in feeder and serum-free culture systems. (wikidoc.org)
  • Serum from patients with anti-NCAM1 autoantibody react only to green cells (framed in red). (neurosciencenews.com)
  • Growth factors and cytokines/ chemokines as surrogate biomarkers in cerebrospinal fluid and blood for diagnosing Alzheimer´s disease and mild cognitive impairment. (uibk.ac.at)
  • Soluble cell adhesion molecules in monocytes of Alzheimer´s disease and mild cognitive impairment. (uibk.ac.at)
  • both neurotrophic factors only are present after passage 7 which should be taken into account for their utilization as a therapeutic option of neurodegenerative diseases. (sld.cu)
  • Recently, a growing number of studies are focusing on mesenchymal stem cell-based therapies for neurodegenerative disorders. (hindawi.com)
  • NGF peptide levels retained in the crushed nerves of rats 5 days after surgery and in the culture medium of IMS32 cells, a mouse Schwann cell line, incubated for 24 h with high or low doses of MS-818, were measured by enzyme immunoassay. (iospress.com)
  • [10] FGF2, in conjunction with BMP4 , promote differentiation of stem cells to mesodermal lineages. (wikidoc.org)
  • After differentiation, BMP4 and FGF2 treated cells generally produce higher amounts of osteogenic and chondrogenic differentiation than untreated stem cells. (wikidoc.org)
  • Of the different cells isolated from the submandibular gland, this specific population, Lin - CD24 + c-Kit + Sca1 + , possessed the highest capacity for proliferation, self renewal, and differentiation during serial passage in vitro. (jci.org)
  • In 2012, the University of Bristol began a five-year clinical trial on Parkinson's sufferers, in which surgeons introduced a port into the skull of each of the 41 participants through which the drug could be delivered, in order to enable it to reach the damaged cells directly. (wikipedia.org)
  • Domingos da Silveira da Luz AC, Pereira Dias G, do Nascimento Bevilaqua MC, Cocks G, Gardino PF, Thuret S, Nardi AE (2013) Translational findings on brain-derived neurotrophic factor and anxiety: contributions from basic research to clinical practice. (springer.com)
  • In this context, results from initial clinical trials with neurotrophic factors and their future potential to improve cognition and psychosocial functioning in schizophrenia are discussed. (benthamscience.com)
  • The DKFZ is a multidisciplinary center covering cancer biology from basic molecular and cell biology to clinical research and care. (mdc-berlin.de)
  • The treatment of metastatic renal cell carcinoma is problematic, and, whenever possible, patients should be directed to approved and controlled clinical trials. (medscape.com)
  • Previous research has suggested that neural cell adhesion molecule (NCAM1), which helps cells in the brain talk to one another via specialized connections known as synapses, may have a role in the development of schizophrenia. (neurosciencenews.com)
  • Healthcare Satellite Connectivity Market Details of 2022 Growth Factors for Business Development Forecast to 2028: Globalstar, Expedition Communications, X2nSat, SES SA, Hughes, Inmarsat plc. (resourcekt.co.uk)
  • Our laboratory investigates the role of the blood-brain barrier (a type of cell "shield" that prevents harmful substances from crossing into the brain) in health and disease. (ccf.org)
  • Anderson, L. and Caldwell, M.A. (2007) Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's disease. (scirp.org)
  • Normal spermatogenesis is essential for reproduction and depends on proper spermatogonial stem cell (SSC) function. (wustl.edu)
  • Numerous evidence produced over the years suggests a deficit in a wide spectrum of neurotrophic factors in schizophrenia. (benthamscience.com)
  • Since schizophrenia is considered a neurodevelopmental disorder, early intervention with neurotrophic factors may be more effective in ameliorating the cognitive deficits and psychopathological symptoms associated with this pathology. (benthamscience.com)
  • They also had fewer synapses and dendritic spines, which are structures that are important for the connections between brain cells, and are also affected in schizophrenia. (neurosciencenews.com)
  • However it remains unknown which endocytic pathways are active in brain endothelial cells. (helsinki.fi)
  • In present study we characterized human brain endothelial cells, hCMEC/D3, which are widely utilized as BBB in vitro model. (helsinki.fi)
  • As brain endothelial cells are polarized in vivo, the aim of the study was to demonstrate the cell polarization of hCMEC/D3 cells and to study the activity and functionality of different endocytic pathways as a function of cell polarization. (helsinki.fi)
  • VEGF is purified from bovine pituitary follicular cells in 1959 and is a vascular endothelial cell-specific mitogen that promotes the growth of vascular endothelial cells. (spandidos-publications.com)
  • D ) Quantification of salisphere number to seeding-cell number of each population at D7 and D14 in vitro. (jci.org)
  • Moreover, optogenetic stimulation of grafted hESC-derived interneurons reduced the rate of epileptiform discharges in vitro. (lu.se)
  • We use multifaceted approaches to study the neurovascular properties ex vivo and in vitro using a humanized dynamic neurovascular unit established with primary brain cells isolated from resected brain tissues post-epilepsy surgery, and in vivo by using rodent models of seizure/epilepsy. (ccf.org)
  • Constantinescu, Stefan N.. Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization . (uclouvain.be)
  • We are currently exploring the extent to which the non-neuronal pathologies described in animal models are also seen in human post-mortem material and are using cellular models to determine the vulnerabilities of SMA cells to hypoxic environments. (abdn.ac.uk)
  • Researchers are uncovering ever more details about the complex system of organs, tissues, and different cell types that make up the human immune system. (mdc-berlin.de)
  • Exploring the potential of human-derived cell lines and glial cell line-derived neurotrophic factor for network inhibition. (lu.se)
  • This study suggests that specific transcription factors and treatment with morphogens can restrict human adult olfactory-derived progenitors to a dopaminergic neuronal lineage. (scirp.org)
  • Cell Stem Cell. (lu.se)
  • Here, we identified and characterized a stem cell population from adult murine submandibular glands. (jci.org)
  • Serial transplantations of this stem cell population into the submandibular gland of irradiated mice successfully restored saliva secretion and increased the number of functional acini. (jci.org)
  • Stem Cell Discovery , 1 , 29-43. (scirp.org)
  • Experimental treatment approaches include vaccines and nonmyeloablative allogeneic peripheral blood stem cell transplantation. (medscape.com)
  • The characterization of BBB cells would help light on the exact mechanism of nanoparticle delivery into the brain, which would enable the design of targeted nanoparticles to deliver drugs to the CNS. (helsinki.fi)
  • Bone marrow stromal cells (BMSC) are multipotent stem cells and are considered good candidates for cell restoration in injured brain tissue. (sld.cu)
  • Homocysteine enhances transmigration of rat monocytes through a brain capillary endothelial cell monolayer via ICAM-1. (uibk.ac.at)
  • Go to Renal Cell Carcinoma Treatment Protocols , Clear Cell Renal Cell Carcinoma , and Sarcomatoid and Rhabdoid Renal Cell Carcinoma for complete information on these topics. (medscape.com)
  • Surgical resection remains the only known effective treatment for localized renal cell carcinoma, and it also is used for palliation in metastatic disease. (medscape.com)
  • Several lines of evidence suggest that neurotrophin administration may be of some therapeutic benefit in the treatment of peripheral neuropathy. (jneurosci.org)
  • Future studies will evaluate the utility of these unique cells in cell-replacement paradigms for the treatment of PD like animal models. (scirp.org)
  • Transplantation of cells releasing γ‐aminobutyric acid (GABA) could be used to counteract the imbalance between ex-citation and inhibition within epileptic neuronal networks. (lu.se)
  • [3] Generally, the 155 aa/18 kDa low molecular weight (LMW) form is considered cytoplasmic and can be secreted from the cell, whereas the high molecular weight (HMW) forms are directed to the cell's nucleus. (wikidoc.org)
  • The family members are a group of evolutionarily conserved enzymes in mammalian cells, including four subclasses: ERK1/2, JNK, p38 and ERK5 ( 7 ). (spandidos-publications.com)
  • These organic conductors provide safe electrical stimulation of tissue while avoiding undesirable chemical reactions and cell damage. (frontiersin.org)